BACKGROUND Tumoral calcinosis is a condition characterized by deposits of calcium phosphate crystals in extra-articular soft tissues,occurring in hemodialysis patients.Calcium phosphate crystals are mainly composed of...BACKGROUND Tumoral calcinosis is a condition characterized by deposits of calcium phosphate crystals in extra-articular soft tissues,occurring in hemodialysis patients.Calcium phosphate crystals are mainly composed of hydroxyapatite,which is highly infilt-rative to tissues,thus making complete resection difficult.An adjuvant method to remove or resolve the residual crystals during the operation is necessary.CASE SUMMARY A bicarbonate Ringer’s solution with bicarbonate ions(28 mEq/L)was used as the adjuvant.After resecting calcium phosphate deposits of tumoral calcinosis as much as possible,while filling with the solution,residual calcium phosphate deposits at the pseudocyst wall can be gently scraped by fingers or gauze in the operative field.A 49-year-old female undergoing hemodialysis for 15 years had swelling with calcium deposition for 2 years in the shoulders,bilateral hip joints,and the right foot.A shoulder lesion was resected,but the calcification remained and early re-deposition was observed.Considering the difficulty of a complete rection,we devised a bicarbonate dissolution method and excised the foot lesion.After resection of the calcified material,the residual calcified material was washed away with bicarbonate Ringer’s solution.CONCLUSION The bicarbonate dissolution method is a new,simple,and effective treatment for tumoral calcinosis in hemodialysis patients.展开更多
This paper is concerned with the following fourth-order three-point boundary value problem , where , we discuss the existence of positive solutions to the above problem by applying to the fixed point theory in cones a...This paper is concerned with the following fourth-order three-point boundary value problem , where , we discuss the existence of positive solutions to the above problem by applying to the fixed point theory in cones and iterative technique.展开更多
We gave the localized solutions,the interaction solutions and the mixed solutions to a reduced(3+1)-dimensional nonlinear evolution equation.These solutions were characterized by superposition formulas of positive qua...We gave the localized solutions,the interaction solutions and the mixed solutions to a reduced(3+1)-dimensional nonlinear evolution equation.These solutions were characterized by superposition formulas of positive quadratic functions,the exponential and hyperbolic functions.According to the known lump solution in the outset,we obtained the superposition formulas of positive quadratic functions by plausible reasoning.Next,we constructed the interaction solutions between the localized solutions and the exponential function solutions with the similar theory.These two kinds of solutions contained superposition formulas of positive quadratic functions,which were turned into general ternary quadratic functions,the coefficients of which were all rational operation of vector inner product.Then we obtained linear superposition formulas of exponential and hyperbolic function solutions.Finally,for aforementioned various solutions,their dynamic properties were showed by choosing specific values for parameters.From concrete plots,we observed wave characteristics of three kinds of solutions.Especially,we could observe distinct generation and separation situations when the localized wave and the stripe wave interacted at different time points.展开更多
Implementing machine learning algorithms in the non-conducive environment of the vehicular network requires some adaptations due to the high computational complexity of these algorithms.K-clustering algorithms are sim...Implementing machine learning algorithms in the non-conducive environment of the vehicular network requires some adaptations due to the high computational complexity of these algorithms.K-clustering algorithms are simplistic,with fast performance and relative accuracy.However,their implementation depends on the initial selection of clusters number(K),the initial clusters’centers,and the clustering metric.This paper investigated using Scott’s histogram formula to estimate the K number and the Link Expiration Time(LET)as a clustering metric.Realistic traffic flows were considered for three maps,namely Highway,Traffic Light junction,and Roundabout junction,to study the effect of road layout on estimating the K number.A fast version of the PAM algorithm was used for clustering with a modification to reduce time complexity.The Affinity propagation algorithm sets the baseline for the estimated K number,and the Medoid Silhouette method is used to quantify the clustering.OMNET++,Veins,and SUMO were used to simulate the traffic,while the related algorithms were implemented in Python.The Scott’s formula estimation of the K number only matched the baseline when the road layout was simple.Moreover,the clustering algorithm required one iteration on average to converge when used with LET.展开更多
We compare Newton’s force law of universal gravitation with a corrected simple approach based on Bhandari’s recently presented work, where the gravitation constant G is maintained. A reciprocity relation exists betw...We compare Newton’s force law of universal gravitation with a corrected simple approach based on Bhandari’s recently presented work, where the gravitation constant G is maintained. A reciprocity relation exists between both alternative gravity formulas with respect to the distances between mass centers. We conclude a one-to-one mapping of the two gravitational formulas. We don’t need Einstein’s construct of spacetime bending by matter.展开更多
The current study examines the important class of Chebyshev’s differential equations via the application of the efficient Adomian Decomposition Method (ADM) and its modifications. We have proved the effectiveness of ...The current study examines the important class of Chebyshev’s differential equations via the application of the efficient Adomian Decomposition Method (ADM) and its modifications. We have proved the effectiveness of the employed methods by acquiring exact analytical solutions for the governing equations in most cases;while minimal noisy error terms have been observed in a particular method modification. Above all, the presented approaches have rightly affirmed the exactitude of the available literature. More to the point, the application of this methodology could be extended to examine various forms of high-order differential equations, as approximate exact solutions are rapidly attained with less computation stress.展开更多
In this article, we prove the existence and obtain the expression of its solution formula of global smooth solution for non-homogeneous multi-dimensional(m-D) conservation law with unbounded initial value; our metho...In this article, we prove the existence and obtain the expression of its solution formula of global smooth solution for non-homogeneous multi-dimensional(m-D) conservation law with unbounded initial value; our methods are new and essentially different with the situation of bounded initial value.展开更多
This paper develops Euler ’loadlng formula of large deflection to be easy to measure in-situ and puts forward the differeuce quick iterative solution ror large deflection of beam and column, whick can solve the uon-l...This paper develops Euler ’loadlng formula of large deflection to be easy to measure in-situ and puts forward the differeuce quick iterative solution ror large deflection of beam and column, whick can solve the uon-linear equation like a kind of θ"+K(s)f(θ) =0.展开更多
Starting from the step-by-step iterative method, the analytical formulas of solutions of the geometrically nonlinear equations of the axisymmetric plates and shallow shells, have been obtained. The uniform convergence...Starting from the step-by-step iterative method, the analytical formulas of solutions of the geometrically nonlinear equations of the axisymmetric plates and shallow shells, have been obtained. The uniform convergence of the iterative method, is used to prove the convergence of the analytical formulas of the exact solutions of the equa- tions.展开更多
In practice, it is very difficult to find the solution of recurrence relation by using the characteristic roots. By applying iteration and induction we present an explicit formula of general solution for a class of ho...In practice, it is very difficult to find the solution of recurrence relation by using the characteristic roots. By applying iteration and induction we present an explicit formula of general solution for a class of homogeneous trinomial recurrence of variable coefficients with two indices. It provides a concrete and applicable model to solve the relevant problem with computer.展开更多
It is very difficult, sometimes impossible, to get a formula solution of recurrence relation, even for the case of homogeneous recurrence with one indite. In this paper, according to the principle of soluting algebrai...It is very difficult, sometimes impossible, to get a formula solution of recurrence relation, even for the case of homogeneous recurrence with one indite. In this paper, according to the principle of soluting algebraic equation, we present the formula of solution for a class of recurrnce relations with two indices by appling iteration and induction. It provides a concrete model to solve the concerning problems with modern computing tools.展开更多
This work studies the asymptotic formulas for the solutions of the Sturm-Liouville equation with the polynomial dependence in the spectral parameter. Using these asymptotic formulas it is proved some trace formulas fo...This work studies the asymptotic formulas for the solutions of the Sturm-Liouville equation with the polynomial dependence in the spectral parameter. Using these asymptotic formulas it is proved some trace formulas for the eigenvalues of a simple boundary problem generated in a finite interval by the considered Sturm-Liouville equation.展开更多
A simple method for solving Cauchy’s problem of wave equations in higher space dimensions with initial condition of separated variables, has been given by using D’Alembert’s formula and some examples have been shown.
This paper discusses the regularization solution of ill posed equation with the help of its spectral decomposition formula. It shows that regularization can filter the influence of the high frequency errors which are ...This paper discusses the regularization solution of ill posed equation with the help of its spectral decomposition formula. It shows that regularization can filter the influence of the high frequency errors which are very sensitive to the parameters to be estimated, and gives a complete derivation of the spectral decomposition formulae of least squares adjustment, rank deficient adjustment and the regularization solution of ill posed equation. It also shows the equivalence between the trace of the mean squares error and the expectation of the secondnorm of estimated parameter’s total error.展开更多
We discuss the fundamental solution for m-th powers of the sub-Laplacian on the Heisenberg group. We use the representation theory of the Heisenberg group to analyze the associated m-th powers of the sub-Laplacian and...We discuss the fundamental solution for m-th powers of the sub-Laplacian on the Heisenberg group. We use the representation theory of the Heisenberg group to analyze the associated m-th powers of the sub-Laplacian and to construct its fundamental solution. Besides, the series representation of the fundamental solution for square of the sub-Laplacian on the Heisenberg group is given and we also get the closed form of the fundamental solution for square of the sub-Laplacian on the Heisenberg group with dimension n = 2, 3, 4.展开更多
Hirota's bilinear direct method is applied to constructing soliton solutions to a special coupled modified Korteweg- de Vries (mKdV) system. Some physical properties such as the spatiotemporal evolution, waveform s...Hirota's bilinear direct method is applied to constructing soliton solutions to a special coupled modified Korteweg- de Vries (mKdV) system. Some physical properties such as the spatiotemporal evolution, waveform structure, interactive phenomena of solitons are discussed, especially in the two-soliton case. It is found that different interactive behaviours of solitary waves take place under different parameter conditions of overtaking collision in this system. It is verified that the elastic interaction phenomena exist in this (1+1)-dimensional integrable coupled model.展开更多
By means of an extension of Mawhin's continuation theorem and some analysis methods, the existence of a set with 2kT-periodic solutions for a class of second order neutral functional differential systems is studied, ...By means of an extension of Mawhin's continuation theorem and some analysis methods, the existence of a set with 2kT-periodic solutions for a class of second order neutral functional differential systems is studied, and then the homoclinic solutions are obtained as the limit points of a certain subsequence of the above set.展开更多
While the Bushen Yizhi Formula can treat Alzheimer’s disease(AD),the yet to be ascertained specific mechanism of action was explored in this work.Methods:Different concentrations of the Bushen Yizhi Formula and amylo...While the Bushen Yizhi Formula can treat Alzheimer’s disease(AD),the yet to be ascertained specific mechanism of action was explored in this work.Methods:Different concentrations of the Bushen Yizhi Formula and amyloid-beta peptide(Aβ)were used to treat rat pheochromocytoma cells(P12)and human neuroblastoma cells(SH-SY5Y).Cell morphological changes were observed to determine the in vitro cell damage.Cell Counting Kit(CCK)-8 assay and flow cytometry were employed to identify cell viability and apoptosis/cell cycle,respectively.Western blotting and immunohistochemistry were employed to measure the expressions of endoplasmic reticulum stress(ERS)-related proteins(GRP78 and CHOP),p-IRE1α,IRE1α,ASK1,p-JNK,JNK,Bax,Bcl-2,XBP-1,and Bim.Fura 2-acetoxymethyl ester(Fura-2/AM)was used to determine the intracellular calcium(Ca^(2+))concentration.Also,an AD model was constructed by injecting Aβinto the CA1 area of the hippocampus in Sprague Dawley rats.AD model rats were gavaged with different concentrations of Bushen Yizhi Formula for 14 consecutive days.The Morris water maze experiment was conducted to test the learning and memory of rats.Hematoxylin&Eosin(H&E)and Terminal-deoxynucleotidyl Transferase(TdT)-mediated dUTP Nick-End Labeling(TUNEL)staining were done to determine histopathological changes in the brain.Results:Bushen Yizhi Formula relieved the Aβ-induced effects including cell injury,decreased viability,increased apoptosis,G0/G1 phase cell cycle arrest,upregulation of GRP78,CHOP,p-IRE1α,p-JNK,Bax,XBP-1 and Bim,as well as down-regulation of Bcl-2.These results were also seen with IRE1αsilencing.While Aβsuppressed the learning and memory abilities of rats,the Bushen Yizhi Formula alleviated these effects of Aβ.Brain nerve cell injury induced by Aβcould also be treated with Bushen Yizhi Formula.Conclusion:Bushen Yizhi Formula could influence ERS through the IRE1αsignaling pathway to achieve its therapeutic effects on AD.展开更多
文摘BACKGROUND Tumoral calcinosis is a condition characterized by deposits of calcium phosphate crystals in extra-articular soft tissues,occurring in hemodialysis patients.Calcium phosphate crystals are mainly composed of hydroxyapatite,which is highly infilt-rative to tissues,thus making complete resection difficult.An adjuvant method to remove or resolve the residual crystals during the operation is necessary.CASE SUMMARY A bicarbonate Ringer’s solution with bicarbonate ions(28 mEq/L)was used as the adjuvant.After resecting calcium phosphate deposits of tumoral calcinosis as much as possible,while filling with the solution,residual calcium phosphate deposits at the pseudocyst wall can be gently scraped by fingers or gauze in the operative field.A 49-year-old female undergoing hemodialysis for 15 years had swelling with calcium deposition for 2 years in the shoulders,bilateral hip joints,and the right foot.A shoulder lesion was resected,but the calcification remained and early re-deposition was observed.Considering the difficulty of a complete rection,we devised a bicarbonate dissolution method and excised the foot lesion.After resection of the calcified material,the residual calcified material was washed away with bicarbonate Ringer’s solution.CONCLUSION The bicarbonate dissolution method is a new,simple,and effective treatment for tumoral calcinosis in hemodialysis patients.
文摘This paper is concerned with the following fourth-order three-point boundary value problem , where , we discuss the existence of positive solutions to the above problem by applying to the fixed point theory in cones and iterative technique.
基金the National Natural Science Foundation of China(Grant No.12061054)Program for Young Talents of Science and Technology in Universities of Inner Mongolia Autonomous Region of China(Grant No.NJYT-20A06)。
文摘We gave the localized solutions,the interaction solutions and the mixed solutions to a reduced(3+1)-dimensional nonlinear evolution equation.These solutions were characterized by superposition formulas of positive quadratic functions,the exponential and hyperbolic functions.According to the known lump solution in the outset,we obtained the superposition formulas of positive quadratic functions by plausible reasoning.Next,we constructed the interaction solutions between the localized solutions and the exponential function solutions with the similar theory.These two kinds of solutions contained superposition formulas of positive quadratic functions,which were turned into general ternary quadratic functions,the coefficients of which were all rational operation of vector inner product.Then we obtained linear superposition formulas of exponential and hyperbolic function solutions.Finally,for aforementioned various solutions,their dynamic properties were showed by choosing specific values for parameters.From concrete plots,we observed wave characteristics of three kinds of solutions.Especially,we could observe distinct generation and separation situations when the localized wave and the stripe wave interacted at different time points.
文摘Implementing machine learning algorithms in the non-conducive environment of the vehicular network requires some adaptations due to the high computational complexity of these algorithms.K-clustering algorithms are simplistic,with fast performance and relative accuracy.However,their implementation depends on the initial selection of clusters number(K),the initial clusters’centers,and the clustering metric.This paper investigated using Scott’s histogram formula to estimate the K number and the Link Expiration Time(LET)as a clustering metric.Realistic traffic flows were considered for three maps,namely Highway,Traffic Light junction,and Roundabout junction,to study the effect of road layout on estimating the K number.A fast version of the PAM algorithm was used for clustering with a modification to reduce time complexity.The Affinity propagation algorithm sets the baseline for the estimated K number,and the Medoid Silhouette method is used to quantify the clustering.OMNET++,Veins,and SUMO were used to simulate the traffic,while the related algorithms were implemented in Python.The Scott’s formula estimation of the K number only matched the baseline when the road layout was simple.Moreover,the clustering algorithm required one iteration on average to converge when used with LET.
文摘We compare Newton’s force law of universal gravitation with a corrected simple approach based on Bhandari’s recently presented work, where the gravitation constant G is maintained. A reciprocity relation exists between both alternative gravity formulas with respect to the distances between mass centers. We conclude a one-to-one mapping of the two gravitational formulas. We don’t need Einstein’s construct of spacetime bending by matter.
文摘The current study examines the important class of Chebyshev’s differential equations via the application of the efficient Adomian Decomposition Method (ADM) and its modifications. We have proved the effectiveness of the employed methods by acquiring exact analytical solutions for the governing equations in most cases;while minimal noisy error terms have been observed in a particular method modification. Above all, the presented approaches have rightly affirmed the exactitude of the available literature. More to the point, the application of this methodology could be extended to examine various forms of high-order differential equations, as approximate exact solutions are rapidly attained with less computation stress.
基金partly supported by Natural Science Foundation of China(11471332 and 11071246)
文摘In this article, we prove the existence and obtain the expression of its solution formula of global smooth solution for non-homogeneous multi-dimensional(m-D) conservation law with unbounded initial value; our methods are new and essentially different with the situation of bounded initial value.
文摘This paper develops Euler ’loadlng formula of large deflection to be easy to measure in-situ and puts forward the differeuce quick iterative solution ror large deflection of beam and column, whick can solve the uon-linear equation like a kind of θ"+K(s)f(θ) =0.
文摘Starting from the step-by-step iterative method, the analytical formulas of solutions of the geometrically nonlinear equations of the axisymmetric plates and shallow shells, have been obtained. The uniform convergence of the iterative method, is used to prove the convergence of the analytical formulas of the exact solutions of the equa- tions.
文摘In this paper, we obtain an explicit formula of general solution for a class of the homogeneous recurrence of variable coefficients with two indices.
文摘In practice, it is very difficult to find the solution of recurrence relation by using the characteristic roots. By applying iteration and induction we present an explicit formula of general solution for a class of homogeneous trinomial recurrence of variable coefficients with two indices. It provides a concrete and applicable model to solve the relevant problem with computer.
基金Supported by the National Natural Science Foun-dation of China (10071059)
文摘It is very difficult, sometimes impossible, to get a formula solution of recurrence relation, even for the case of homogeneous recurrence with one indite. In this paper, according to the principle of soluting algebraic equation, we present the formula of solution for a class of recurrnce relations with two indices by appling iteration and induction. It provides a concrete model to solve the concerning problems with modern computing tools.
文摘This work studies the asymptotic formulas for the solutions of the Sturm-Liouville equation with the polynomial dependence in the spectral parameter. Using these asymptotic formulas it is proved some trace formulas for the eigenvalues of a simple boundary problem generated in a finite interval by the considered Sturm-Liouville equation.
基金Supported by the Natural Science Foundation of Hubei Province!(992P0 30 7) the National Natural Science Foun-dation of Chi
文摘A simple method for solving Cauchy’s problem of wave equations in higher space dimensions with initial condition of separated variables, has been given by using D’Alembert’s formula and some examples have been shown.
文摘This paper discusses the regularization solution of ill posed equation with the help of its spectral decomposition formula. It shows that regularization can filter the influence of the high frequency errors which are very sensitive to the parameters to be estimated, and gives a complete derivation of the spectral decomposition formulae of least squares adjustment, rank deficient adjustment and the regularization solution of ill posed equation. It also shows the equivalence between the trace of the mean squares error and the expectation of the secondnorm of estimated parameter’s total error.
基金Supported by Doctor Special Foundation of Jiangsu Second Normal University(JSNU2015BZ07)
文摘We discuss the fundamental solution for m-th powers of the sub-Laplacian on the Heisenberg group. We use the representation theory of the Heisenberg group to analyze the associated m-th powers of the sub-Laplacian and to construct its fundamental solution. Besides, the series representation of the fundamental solution for square of the sub-Laplacian on the Heisenberg group is given and we also get the closed form of the fundamental solution for square of the sub-Laplacian on the Heisenberg group with dimension n = 2, 3, 4.
文摘Hirota's bilinear direct method is applied to constructing soliton solutions to a special coupled modified Korteweg- de Vries (mKdV) system. Some physical properties such as the spatiotemporal evolution, waveform structure, interactive phenomena of solitons are discussed, especially in the two-soliton case. It is found that different interactive behaviours of solitary waves take place under different parameter conditions of overtaking collision in this system. It is verified that the elastic interaction phenomena exist in this (1+1)-dimensional integrable coupled model.
基金sponsored by the National Natural Science Foundation of China(11271197)the Science and Technology Foundation in Ministry of Education of China(207047)the Science Foundation of NUIST of China(20090202 and 2012r101)
文摘By means of an extension of Mawhin's continuation theorem and some analysis methods, the existence of a set with 2kT-periodic solutions for a class of second order neutral functional differential systems is studied, and then the homoclinic solutions are obtained as the limit points of a certain subsequence of the above set.
基金supported by the National Natural Science Foundation of China[81904266,82004309].
文摘While the Bushen Yizhi Formula can treat Alzheimer’s disease(AD),the yet to be ascertained specific mechanism of action was explored in this work.Methods:Different concentrations of the Bushen Yizhi Formula and amyloid-beta peptide(Aβ)were used to treat rat pheochromocytoma cells(P12)and human neuroblastoma cells(SH-SY5Y).Cell morphological changes were observed to determine the in vitro cell damage.Cell Counting Kit(CCK)-8 assay and flow cytometry were employed to identify cell viability and apoptosis/cell cycle,respectively.Western blotting and immunohistochemistry were employed to measure the expressions of endoplasmic reticulum stress(ERS)-related proteins(GRP78 and CHOP),p-IRE1α,IRE1α,ASK1,p-JNK,JNK,Bax,Bcl-2,XBP-1,and Bim.Fura 2-acetoxymethyl ester(Fura-2/AM)was used to determine the intracellular calcium(Ca^(2+))concentration.Also,an AD model was constructed by injecting Aβinto the CA1 area of the hippocampus in Sprague Dawley rats.AD model rats were gavaged with different concentrations of Bushen Yizhi Formula for 14 consecutive days.The Morris water maze experiment was conducted to test the learning and memory of rats.Hematoxylin&Eosin(H&E)and Terminal-deoxynucleotidyl Transferase(TdT)-mediated dUTP Nick-End Labeling(TUNEL)staining were done to determine histopathological changes in the brain.Results:Bushen Yizhi Formula relieved the Aβ-induced effects including cell injury,decreased viability,increased apoptosis,G0/G1 phase cell cycle arrest,upregulation of GRP78,CHOP,p-IRE1α,p-JNK,Bax,XBP-1 and Bim,as well as down-regulation of Bcl-2.These results were also seen with IRE1αsilencing.While Aβsuppressed the learning and memory abilities of rats,the Bushen Yizhi Formula alleviated these effects of Aβ.Brain nerve cell injury induced by Aβcould also be treated with Bushen Yizhi Formula.Conclusion:Bushen Yizhi Formula could influence ERS through the IRE1αsignaling pathway to achieve its therapeutic effects on AD.