3D MERGE与3D SPACE STIR序列在腰椎间盘突出症检查中的应用比较

目的:对比三维多回波恢复梯度回波(3D MERGE)、三维可变反转角快速自旋回波(3D SPACE STIR)序列在腰椎间盘突出症(LDH)检查中的应用效果。方法:选择2020年1月~2022年11月收治的135例LDH患者,回顾性分析患者临床和磁共振成像(MRI)资料,所有患者均接受常规MRI扫描及3D MERGE、3D SPACE STIR序列扫描,对比3D MERGE、3D SPACE STIR序列测量神经根直径的一致性,评价两种序列的图像质量参数[信噪比(SNR)、对比噪声比(CNR)]、图像清晰度评分。结果:3D MERGE和3D SPACE STIR序列测量的L3~S1神经根直径比较差异无统计学意义(P>0.05),且两组序列测量的L3、L4、L5和S1直径均显示出较高相关性(r=0.957,0.986,0.975,0.972,P<0.05);3D MERGE序列的SNR及CNR均高于3D SPACE STIR序列,神经根显示分级、图像清晰度评分优于3D SPACE STIR序列,差异有统计学意义(P<0.05)。结论:3D MERGE、3D SPACE STIR序列在LDH神经根直径测量中具有极高一致性,3D MERGE序列较3D SPACE STIR序列能够更清晰显示神经跟的解剖形态,图像质量更好。

中国人才政策研究的现状与趋势——基于Cite Space的可视化分析

科学的人才政策是实现人才强国和科教兴国战略的重要保障。借助Cite Space量化分析软件,分别从发文作者、发文机构、高被引文献、关键词等方面对人才政策研究情况进行可视化分析,在整合既有研究基础上展望未来。研究表明:我国人才政策研究主要聚焦于人才政策本身、实施存在的问题、可行性路径三个维度。当前的研究热点主题为人才战略、人才开发、人才培养,已有关键词之间关联性不强,机构合作密度不高,缺少系统研究框架和强大理论支持。据此,今后人才政策的研究应该加强跨学科融合思考,建构具有中国特色的本土化研究架构,注重人才培养的硬环境和软环境建设。

Energy conversion materials for the space solar power station

Since it was first proposed,the space solar power station(SSPS)has attracted great attention all over the world;it is a huge space system and provides energy for Earth.Although several schemes and abundant studies on the SSPS have been proposed and conducted,it is still not realized.The reason why SSPS is still an idea is not only because it is a giant and complex project,but also due to the requirement for various excellent space materials.Among the diverse required materials,we believe energy materials are the most important.Herein,we review the space energy conversion materials for the SSPS.

基于Cite Space对螺旋藻藻蓝蛋白的研究进展与热点分析

螺旋藻(Spirulina)藻蓝蛋白具有独特的理化特性及生理功能,是药物、食品和化妆品的天然原料,具有较大的开发潜力。为探讨螺旋藻藻蓝蛋白的研究现状与发展前景,对中国知网和Web of Science数据库中1990—2023年发表的文献进行检索并筛选,使用Cite Space软件对文章发文量、研究团队及研究热点进行图谱分析。综合分析可知,国内年发文量偏少,呈平稳趋势;国外年发文量持续上升,尤其近几年发文量迅速增长,且发文量超过了100篇;国外研究热点集中于藻蓝蛋白在食品、医药行业的应用方面,而国内研究热点集中在提取纯化、稳定性、功能活性的研究与应用,下一步应结合研究现状开发适合规模化生产的提取纯化工艺,进一步加强藻蓝蛋白研究的广度与深度;国内外研究群体主要是高校的相关生物技术学院或研究机构等,总体来讲,学者间存在较为密切的合作,但研究机构间尚未形成紧密的合作关系,在地域上比较分散,各大高校和研究机构应突破地区或机构间的各种限制,促进该研究领域的深度融合和快速发展,深入挖掘藻蓝蛋白在各个领域的潜在应用。

基于CiteSpace的红色文创设计可视化分析与方法研究

目的基于CiteSpace概述国内红色文创设计的发展状况,梳理关于红色文创设计的相关方法与理论模型,探讨未来红色文创设计发展的趋势,为研究者提供相关设计思路与发展动向。方法通过对国内相关文献的研究,梳理了红色文创设计的概念与发展现状,归纳了当前红色文创设计中包括文化转译维度、文化层次理论、叙事性设计的三种主要方法与理论模型。结论目前红色文创设计方法较为单一,很难满足用户的不同需求,且缺乏具体针对性的完整理论体系与设计方法。在今后的红色文创设计中,可以综合运用叙事性及文化转译维度等设计理论和手段,对红色文创设计和方法加以探究和创新,打造具有中国特色的红色文创产品,使红色文化得到更好的普及和弘扬。

Enabling heterogeneous catalysis to achieve carbon neutrality: Directional catalytic conversion of CO_(2) into carboxylic acids

The increase in anthropogenic carbon dioxide(CO_(2))emissions has exacerbated the deterioration of the global environment,which should be controlled to achieve carbon neutrality.Central to the core goal of achieving carbon neutrality is the utilization of CO_(2) under economic and sustainable conditions.Recently,the strong need for carbon neutrality has led to a proliferation of studies on the direct conversion of CO_(2) into carboxylic acids,which can effectively alleviate CO_(2) emissions and create high-value chemicals.The purpose of this review is to present the application prospects of carboxylic acids and the basic principles of CO_(2) conversion into carboxylic acids through photo-,electric-,and thermal catalysis.Special attention is focused on the regulation strategy of the activity of abundant catalysts at the molecular level,inspiring the preparation of high-performance catalysts.In addition,theoretical calculations,advanced technologies,and numerous typical examples are introduced to elaborate on the corresponding process and influencing factors of catalytic activity.Finally,challenges and prospects are provided for the future development of this field.It is hoped that this review will contribute to a deeper understanding of the conversion of CO_(2) into carboxylic acids and inspire more innovative breakthroughs.

基于Cite Space可视化分析我国多发伤急救研究热点及趋势

目的梳理国内多发伤急救相关研究文献,分析研究现状、热点和趋势,为我国多发伤急救研究提供借鉴和指导。方法检索中国知网数据库中2011—2021年关于多发伤急救的相关文献,使用Cite Space 6.1.R3可视化软件对该领域的年发文量、机构、作者、关键词进行分析。结果最终纳入多发伤急救研究文献2519篇,整体发文数量较平稳,以2016年为小高峰;发文量最高的机构是华中科技大学附属同济医院。多发伤急救研究热点包括院前急救、并发症护理、风险因素分析和预后效果评估,研究前沿包括不同多发伤人群的诊断、治疗、手术和护理体会等方面。结论本文通过可视化分析国内多发伤急救研究的热点及趋势,指明了多发伤目前研究存在的问题和未来研究发展的方向,为进一步完善多发伤急救卫生服务和管理体系提供指导。

Two-photon live imaging of direct glia-to-neuron conversion in the mouse cortex

Over the past decade,a growing number of studies have reported transcription factor-based in situ reprogramming that can directly conve rt endogenous glial cells into functional neurons as an alternative approach for n euro regeneration in the adult mammalian central ne rvous system.Howeve r,many questions remain regarding how a terminally differentiated glial cell can transform into a delicate neuron that forms part of the intricate brain circuitry.In addition,concerns have recently been raised around the absence of astrocyte-to-neuron conversion in astrocytic lineage-tra cing mice.In this study,we employed repetitive two-photon imaging to continuously capture the in situ astrocyte-to-neuron conversion process following ecto pic expression of the neural transcription factor NeuroD1 in both prolife rating reactive astrocytes and lineage-tra ced astrocytes in the mouse cortex.Time-lapse imaging over several wee ks revealed the ste p-by-step transition from a typical astrocyte with numero us short,tapered branches to a typical neuro n with a few long neurites and dynamic growth cones that actively explored the local environment.In addition,these lineage-converting cells were able to migrate ra dially or to ngentially to relocate to suitable positions.Furthermore,two-photon Ca2+imaging and patch-clamp recordings confirmed that the newly generated neuro ns exhibited synchronous calcium signals,repetitive action potentials,and spontaneous synaptic responses,suggesting that they had made functional synaptic connections within local neural circuits.In conclusion,we directly visualized the step-by-step lineage conversion process from astrocytes to functional neurons in vivo and unambiguously demonstrated that adult mammalian brains are highly plastic with respect to their potential for neuro regeneration and neural circuit reconstruction.

Dealuminated Hβ zeolite for selective conversion of fructose to furfural and formic acid

The fructose-to-furfural transformation is facing major challenges in the selectivity and high efficiency. Herein, we have developed a simple and effective approach for the selective conversion of fructose to furfural using Hβ zeolite modified by organic acids for dealuminization to regulate its textural and acidic properties. It was found that citric acid-dealuminized Hβ zeolite possessed high specific surface areas, wide channels and high Brønsted acid amount, which facilitated the selective conversion of fructose to furfural with a maximum yield of 76.2% at433 K for 1 h in the γ-butyrolactone(GBL)-H_(2)O system, as well as the concomitant formation of 83.0% formic acid. The^(13)C-isotope labelling experiments and the mechanism revealed that the selective cleavage of C1–C2 or C5–C6 bond on fructose was firstly occurred to form pentose or C5 intermediate by weak Brønsted acid, which was then dehydrated to furfural by strong Brønsted acid. Also this dealuminized Hβ catalyst showed the great recycling performance and was active for the conversion of glucose and mannose.

基于CiteSpace的我国高校公共空间研究热点及趋势分析

文章基于CiteSpace软件对CNKI数据库中相关609篇文献进行可视化分析,发现当前我国关于高校公共空间的研究具有阶段性、各地域间相互独立的特点;研究热点分布于空间扩充、功能拓展、设计优化多个角度,并朝着精细化、人性化、多学科交叉等趋势探索。总结现有研究提出加强地域间机构合作、融合多学科研究视角、引入创新性研究方法等发展方向,以期为新时代我国高校公共空间的研究提供思路和参考。

Oxygen functionalization-assisted anionic exchange toward unique construction of flower-like transition metal chalcogenide embedded carbon fabric for ultra-long life flexible energy storage and conversion

The metal-organic framework(MOF)derived Ni–Co–C–N composite alloys(NiCCZ)were“embedded”inside the carbon cloth(CC)strands as opposed to the popular idea of growing them upward to realize ultrastable energy storage and conversion application.The NiCCZ was then oxygen functionalized,facilitating the next step of stoichiometric sulfur anion diffusion during hydrothermal sulfurization,generating a flower-like metal hydroxysulfide structure(NiCCZOS)with strong partial implantation inside CC.Thus obtained NiCCZOS shows an excellent capacity when tested as a supercapacitor electrode in a three-electrode configuration.Moreover,when paired with the biomass-derived nitrogen-rich activated carbon,the asymmetric supercapacitor device shows almost 100%capacity retention even after 45,000 charge–discharge cycles with remarkable energy density(59.4 Wh kg^(-1)/263.8μWh cm^(–2))owing to a uniquely designed cathode.Furthermore,the same electrode performed as an excellent bifunctional water-splitting electrocatalyst with an overpotential of 271 mV for oxygen evolution reaction(OER)and 168.4 mV for hydrogen evolution reaction(HER)at 10 mA cm−2 current density along with 30 h of unhinged chronopotentiometric stability performance for both HER and OER.Hence,a unique metal chalcogenide composite electrode/substrate configuration has been proposed as a highly stable electrode material for flexible energy storage and conversion applications.

基于CiteSpace知识图谱的智慧养老领域研究文献综述

“十四五”规划将发展智慧养老产业上升为国家战略高度。文章借助Cite Space和Vosviewer绘图软件对2012-2022年国内外智慧养老领域研究的发文量、突现词等进行可视化分析。发现国内外研究都经历了三个发展阶段,国外研究起步早,研究成果丰富;国内研究虽然起步较晚,但进展快速。总结出“智慧养老内涵”“智慧养老模式”“智慧养老产业”“智慧养老平台”“智慧养老产品”“智慧养老用户”六大国内外都重点关注的研究议题,发现技术赋能智慧养老发展是近年来国内外共同关注的研究热点,大数据、物联网、养老金融、数字技术、区块链等成为围绕智慧养老文献的关键词。

体育教师信念的国际研究现状与趋势——基于CiteSpace的文献计量分析

高质量教师是高质量教育发展的中坚力量。教师信念作为教师专业素养构成的关键要素,对促进教师专业发展、提升教师质量具有重要作用与影响。为借鉴国际体育教师信念研究的成果与经验,促进国内对体育教师信念的研究,研究利用CiteSpace软件,对Web of Science核心合集数据库中1960—2022年的英文文献进行可视化研究。发现:体育教师信念研究高潮出现于2021年,载文数量最多的期刊是Journal of Teaching in Physical Education;研究中心度最高的国家是美国,核心圈层的代表学者是Richards KAR、Kulinna PH和Curtner-smith MD等人;研究热点趋势集中于体力活动促进、职业社会化、批判性教学法、职前体育教师、专业发展等方面。启示:国内未来研究应重点关注体育教师信念对课程改革的影响以及促进职前、职后阶段体育教师信念的发展。

Reversible solid-liquid conversion enabled by self-capture effect for stable non-flow zinc-bromine batteries

Non-flow aqueous zinc-bromine batteries without auxiliary components(e.g.,pumps,pipes,storage tanks)and ion-selective membranes represent a cost-effective and promising technology for large-scale energy storage.Unfortunately,they generally suffer from serious diffusion and shuttle of polybromide(Br^(-),Br^(3-))due to the weak physical adsorption between soluble polybromide and host carbon materials,which results in low energy efficiency and poor cycling stability.Here,we develop a novel self-capture organic bromine material(1,10-bis[3-(trimethylammonio)propyl]-4,4'-bipyridinium bromine,NVBr4)to successfully realize reversible solid complexation of bromide components for stable non-flow zinc-bromine battery applications.The quaternary ammonium groups(NV^(4+)ions)can effectively capture the soluble polybromide species based on strong chemical interaction and realize reversible solid complexation confined within the porous electrodes,which transforms the conventional“liquid-liquid”conversion of soluble bromide components into“liquid-solid”model and effectively suppresses the shuttle effect.Thereby,the developed non-flow zinc-bromide battery provides an outstanding voltage platform at 1.7 V with a notable specific capacity of 325 mAh g^(-1)NVBr4(1 A g^(-1)),excellent rate capability(200 mAh g^(-1)NVBr4 at 20 A g^(-1)),outstanding energy density of 469.6 Wh kg^(-1)and super-stable cycle life(20,000 cycles with 100%Coulombic efficiency),which outperforms most of reported zinc-halogen batteries.Further mechanism analysis and DFT calculations demonstrate that the chemical interaction of quaternary ammonium groups and bromide species is the main reason for suppressing the shuttle effect.The developed strategy can be extended to other halogen batteries to obtain stable charge storage.

Conversion therapy of a giant hepatocellular carcinoma with portal vein thrombus and inferior vena cava thrombus:A case report and review of literature

BACKGROUND The prognosis of hepatocellular carcinoma(HCC)combined with portal and hepatic vein cancerous thrombosis is poor,for unresectable patients the combination of targeted therapy and immune therapy was the first-line recommended treatment for advanced HCC,with a median survival time of only about 2.7-6 months.In this case report,we present the case of a patient with portal and hepatic vein cancerous thrombosis who achieved pathologic complete response after conversion therapy.CASE SUMMARY In our center,a patient with giant HCC combined with portal vein tumor thrombus and hepatic vein tumor thrombus was treated with transcatheter arterial chemoembolization(TACE),radiotherapy,targeted therapy and immunotherapy,and was continuously given icaritin soft capsules for oral regulation.After 7 months of conversion therapy,the patient's tumor shrank and the tumor thrombus subsided significantly.The pathology of surgical resection was in complete remission,and there was no progression in the postoperative follow-up for 7 months,which provided a basis for the future strategy of combined conversion therapy.CONCLUSION In this case,atezolizumab,bevacizumab,icaritin soft capsules combined with radiotherapy and TACE had a good effect.For patients with hepatocellular carcinoma combined with hepatic vein/inferior vena cava tumor thrombus,adopting a high-intensity,multimodal proactive strategy under the guidance of multidisciplinary team(MDT)is an important attempt to break through the current treatment dilemma.

基于Cite Space对近5年发酵领域的研究进展与热点分析

近年来,我国生物产业快速发展,且发酵对身体和胃肠道健康具有很多益处,有关微生物发酵的研究逐渐增多。为探讨发酵领域近5年的研究现状与发展前景,对中国知网和Web of Science数据库中2019—2023年发表的文献进行检索并筛选,使用Cite Space软件对文章发文量、研究团队、研究热点进行图谱分析。结果表明,近5年国内发酵领域发文量偏少,年发文量平稳上升;国外发文量较多,年发文量超过100篇,2023年发文量达到200篇;国内外研究群体主要是中医药高校和研究机构;国内外研究热点集中在抗氧化和肠道菌群,国内研究重点为发酵技术,而国外研究范围较广,重点为益生菌的研究;国内外学者间合作较为密切,但研究机构间尚未形成紧密的合作关系。高校和研究机构应突破地区间的限制,促进发酵研究领域的融合。肠道菌群是近5年发酵的研究热点,也是未来发酵研究深入的对象。

我国医教协同的研究现状与思考——基于Cite Space的可视化分析

随着医教协同深化临床医学人才培养改革的深入,医教协同已经成为我国医学人才改革与发展的主要方向。文章采用Cite Space可视化分析工具,围绕医教协同的研究现状和研究热点进行系统分析,以期为我国高等医学教育的理论研究和实践应用提供参考。研究发现,医教协同研究热点主要集中于教学改革、学科建设、人才培养和医学人文四个方面。为推动医学教育与医疗卫生协同融合发展,建议从宏观层面提升医教协同的认识高度,中观层面拓展医教协同的合作深度,微观层面强化医教协同的融合力度。

MR3D-STIR SPACE序列增强扫描在臂丛节后神经成像的效果分析

目的探讨在臂丛节后神经成像中施行MR3D-STIR SPACE序列增强扫描的临床价值及成像质量。方法选取50例、2021年1月-2022年8月臂丛神经患者,均行MR常规序列扫描、MR3D-SPACE-STIR序列平扫及增强扫描。对患者的损伤部位、形态、信号强度与近、远侧段臂丛神经的相关性,并对比平扫及增强图像质量。结果MRI平扫诊断节后神经损伤敏感性为89.47%、特异性为83.33%、准确性88.64%。增强MR3D-SPACE-STIR的组织对比显著提高,经处理后,可对臂丛神经节后的走行图像进行完整显示。且该技术增强序列图像的对比噪声比(CNR)为(0.57±0.09)、背景抑制评分(3.56±0.63)分及对臂丛神经显示评分(3.96±0.53)与平扫(0.35±0.06)、(1.58±0.51)分、(2.02±0.59)分均存在显著差异(t=12.231,12.214,10.170;P<0.05)。结论MR 3D-SPACE-STIR序列增强扫描的背景抑制效果较佳,可使臂丛神经损伤及走形得以清晰显示,其臂丛神经节后图像质量较平扫明显提升。

基于CiteSpace对近10年国内外护理不良事件的可视化分析

为了解国内外近10年护理不良事件的研究热点与前沿,为医院管理和临床护士提供参考,保障患者安全,通过检索中国期刊全文数据库(CNKI)和Web of Science(WOS)数据库,检索时限为2012年1月—2022年8月,导入CiteSpace进行可视化分析。研究显示,从发文量看,国内外学者对护理不良事件的关注度整体较高,可视化分析结果并未发现作者之间、机构之间的联系。未来减少护理不良事件的方法一定会越来越紧贴科学技术,越来越多的新型信息化平台、App等会用于医疗行业,降低护理不良事件预防的难度,但护理人员仍要重视护理安全。

基于Cite space的我国蔬菜制种产业研究热点与趋势分析

运用可视化工具Cite Space和文献计量方法,对刊载在中国知网数据库所有与蔬菜制种相关主题的1212篇相关文献进行分析,并总结了我国蔬菜制种产业的热点及发展趋势。研究发现,蔬菜制种产业的研究热点主要集中在制种技术、杂交制种、种子产量、杂交授粉、杂种纯度等方面。我们建议后续应加强核心技术攻关,加快生物技术在蔬菜制种上的应用、强化基地建设,提高蔬菜制种产业化水平、加强研究主体间的合作与交流,重视制种人才培养,打造智慧农业。本研究可为进一步完善我国蔬菜制种产业提供借鉴。