The perfect hybrid vector vortex beam(PHVVB)with helical phase wavefront structure has aroused significant concern in recent years,as its beam waist does not expand with the topological charge(TC).In this work,we inve...The perfect hybrid vector vortex beam(PHVVB)with helical phase wavefront structure has aroused significant concern in recent years,as its beam waist does not expand with the topological charge(TC).In this work,we investigate the spatial quantum coherent modulation effect with PHVVB based on the atomic medium,and we observe the absorption characteristic of the PHVVB with different TCs under variant magnetic fields.We find that the transmission spectrum linewidth of PHVVB can be effectively maintained regardless of the TC.Still,the width of transmission peaks increases slightly as the beam size expands in hot atomic vapor.This distinctive quantum coherence phenomenon,demonstrated by the interaction of an atomic medium with a hybrid vector-structured beam,might be anticipated to open up new opportunities for quantum coherence modulation and accurate magnetic field measurement.展开更多
Elucidating the complex dynamic cellular organization in the hypothalamus is critical for understanding its role in coordinating fundamental body functions. Over the past decade, single-cell and spatial omics technolo...Elucidating the complex dynamic cellular organization in the hypothalamus is critical for understanding its role in coordinating fundamental body functions. Over the past decade, single-cell and spatial omics technologies have significantly evolved, overcoming initial technical challenges in capturing and analyzing individual cells. These high-throughput omics technologies now offer a remarkable opportunity to comprehend the complex spatiotemporal patterns of transcriptional diversity and cell-type characteristics across the entire hypothalamus. Current single-cell and single-nucleus RNA sequencing methods comprehensively quantify gene expression by exploring distinct phenotypes across various subregions of the hypothalamus. However, single-cell/single-nucleus RNA sequencing requires isolating the cell/nuclei from the tissue, potentially resulting in the loss of spatial information concerning neuronal networks. Spatial transcriptomics methods, by bypassing the cell dissociation, can elucidate the intricate spatial organization of neural networks through their imaging and sequencing technologies. In this review, we highlight the applicative value of single-cell and spatial transcriptomics in exploring the complex molecular-genetic diversity of hypothalamic cell types, driven by recent high-throughput achievements.展开更多
Glial cells play crucial roles in regulating physiological and pathological functions,including sensation,the response to infection and acute injury,and chronic neurodegenerative disorders.Glial cells include astrocyt...Glial cells play crucial roles in regulating physiological and pathological functions,including sensation,the response to infection and acute injury,and chronic neurodegenerative disorders.Glial cells include astrocytes,microglia,and oligodendrocytes in the central nervous system,and satellite glial cells and Schwann cells in the peripheral nervous system.Despite the greater understanding of glial cell types and functional heterogeneity achieved through single-cell and single-nucleus RNA sequencing in animal models,few studies have investigated the transcriptomic profiles of glial cells in the human spinal cord.Here,we used high-throughput single-nucleus RNA sequencing and spatial transcriptomics to map the cellular and molecular heterogeneity of astrocytes,microglia,and oligodendrocytes in the human spinal cord.To explore the conservation and divergence across species,we compared these findings with those from mice.In the human spinal cord,astrocytes,microglia,and oligodendrocytes were each divided into six distinct transcriptomic subclusters.In the mouse spinal cord,astrocytes,microglia,and oligodendrocytes were divided into five,four,and five distinct transcriptomic subclusters,respectively.The comparative results revealed substantial heterogeneity in all glial cell types between humans and mice.Additionally,we detected sex differences in gene expression in human spinal cord glial cells.Specifically,in all astrocyte subtypes,the levels of NEAT1 and CHI3L1 were higher in males than in females,whereas the levels of CST3 were lower in males than in females.In all microglial subtypes,all differentially expressed genes were located on the sex chromosomes.In addition to sex-specific gene differences,the levels of MT-ND4,MT2A,MT-ATP6,MT-CO3,MT-ND2,MT-ND3,and MT-CO_(2) in all spinal cord oligodendrocyte subtypes were higher in females than in males.Collectively,the present dataset extensively characterizes glial cell heterogeneity and offers a valuable resource for exploring the cellular basis of spinal cordrelated illnesses,including chronic pain,amyotrophic lateral sclerosis,and multiple sclerosis.展开更多
In this study,we developed multiple hybrid machine-learning models to address parameter optimization limitations and enhance the spatial prediction of landslide susceptibility models.We created a geographic informatio...In this study,we developed multiple hybrid machine-learning models to address parameter optimization limitations and enhance the spatial prediction of landslide susceptibility models.We created a geographic information system database,and our analysis results were used to prepare a landslide inventory map containing 359 landslide events identified from Google Earth,aerial photographs,and other validated sources.A support vector regression(SVR)machine-learning model was used to divide the landslide inventory into training(70%)and testing(30%)datasets.The landslide susceptibility map was produced using 14 causative factors.We applied the established gray wolf optimization(GWO)algorithm,bat algorithm(BA),and cuckoo optimization algorithm(COA)to fine-tune the parameters of the SVR model to improve its predictive accuracy.The resultant hybrid models,SVR-GWO,SVR-BA,and SVR-COA,were validated in terms of the area under curve(AUC)and root mean square error(RMSE).The AUC values for the SVR-GWO(0.733),SVR-BA(0.724),and SVR-COA(0.738)models indicate their good prediction rates for landslide susceptibility modeling.SVR-COA had the greatest accuracy,with an RMSE of 0.21687,and SVR-BA had the least accuracy,with an RMSE of 0.23046.The three optimized hybrid models outperformed the SVR model(AUC=0.704,RMSE=0.26689),confirming the ability of metaheuristic algorithms to improve model performance.展开更多
In this paper,a sparse nonuniform rectangular array based on spatially spread electromagnetic vector sensor(SNRASSEMVS)is introduced,and a method for estimating 2D-direction of arrival(DOA)and polarization is devised....In this paper,a sparse nonuniform rectangular array based on spatially spread electromagnetic vector sensor(SNRASSEMVS)is introduced,and a method for estimating 2D-direction of arrival(DOA)and polarization is devised.Firstly,according to the special structure of the sparse nonuniform rectangular array(SNRA),a set of accurate but ambiguous direction-cosine estimates can be obtained.Then the steering vector of spatially spread electromagnetic vector sensor(SSEMVS)can be extracted from the array manifold to obtain the coarse but unambiguous direction-cosine estimates.Finally,the disambiguation approach can be used to get the final accurate estimates of 2DDOA and polarization.Compared with some existing methods,the SNRA configuration extends the spatial aperture and refines the parameters estimation accuracy without adding any redundant antennas,as well as reduces the mutual coupling effect.Moreover,the proposed algorithm resolves multiple sources without the priori knowledge of signal information,suffers no ambiguity in the estimation of the Poynting vector,and pairs the x-axis direction cosine with the y-axis direction cosine automatically.Simulation results are given to verify the effectiveness and superiority of the proposed algorithm.展开更多
Analysis of spatial patterns to describe the spatial correlation between a tree location and marks(i.e.,structural variables),can reveal stand history,population dynamics,competition and symbiosis.However,most studies...Analysis of spatial patterns to describe the spatial correlation between a tree location and marks(i.e.,structural variables),can reveal stand history,population dynamics,competition and symbiosis.However,most studies of spatial patterns have concentrated on tree location and tree sizes rather than on crown asymmetry especially with direct analysis among marks characterizing facilitation and competition among of trees,and thus cannot reveal the cause of the distributions of tree locations and quantitative marks.To explore the spatial correlation among quantitative and vectorial marks and their implication on population dynamics,we extracted vertical and horizontal marks(tree height and crown projection area)characterizing tree size,and a vectorial mark(crown displacement vector characterizing the crown asymmetry)using an airborne laser scanning point cloud obtained from two forest stands in Oxfordshire,UK.Quantitatively and vectorially marked spatial patterns were developed,with corresponding null models established for a significance test.We analyzed eight types of univariate and bivariate spatial patterns,after first proposing four types.The accuracy of the pattern analysis based on an algorithm-segmented point cloud was compared with that of a truly segmented point cloud.The algorithm-segmented point cloud managed to detect 70–86%of patterns correctly.The eight types of spatial patterns analyzed the spatial distribution of trees,the spatial correlation between tree size and facilitated or competitive interactions of sycamore and other species.These four types of univariate patterns jointly showed that,at smaller scales,the trees tend to be clustered,and taller,with larger crowns due to the detected facilitations among trees in the study area.The four types of bivariate patterns found that at smaller scales there are taller trees and more facilitation among sycamore and other species,while crown size is mostly homogeneous across scales.These results indicate that interspecific facilitation and competition mainly affect tree height in the study area.This work further confirms the connection of tree size with individual facilitation and competition,revealing the potential spatial structure that previously was hard to detect.展开更多
Firewalls use packet filtering to either accept or deny packets on the basis of a set of predefined rules called filters. The firewall forms the initial layer of defense and protects the network from unauthorized acce...Firewalls use packet filtering to either accept or deny packets on the basis of a set of predefined rules called filters. The firewall forms the initial layer of defense and protects the network from unauthorized access. However, maintaining firewall policies is always an error prone task, because the policies are highly complex. Conflict is a misconfiguration that occurs when a packet matches two or more filters. The occurrence of conflicts in a firewall policy makes the filters either redundant or shadowed, and as a result, the network does not reflect the actual configuration of the firewall policy. Hence, it is necessary to detect conflicts to keep the filters meaningful. Even though geometry-based conflict detection provides an exhaustive method for error classification, when the number of filters and headers increases, the demands on memory and computation time increase. To solve these two issues, we make two main contributions. First, we propose a topology-based conflict detection system that computes the topological relationship of the filters to detect the conflicts. Second, we propose a systematic implementation method called BISCAL (a bit-vector-based spatial calculus) to implement the proposed system and remove irrelevant data from the conflict detection computation. We perform a mathematical analysis as well as experimental evaluations and find that the amount of data needed for topology is only one-fourth of that needed for geometry.展开更多
Parallel vector buffer analysis approaches can be classified into 2 types:algorithm-oriented parallel strategy and the data-oriented parallel strategy.These methods do not take its applicability on the existing geogra...Parallel vector buffer analysis approaches can be classified into 2 types:algorithm-oriented parallel strategy and the data-oriented parallel strategy.These methods do not take its applicability on the existing geographic information systems(GIS)platforms into consideration.In order to address the problem,a spatial decomposition approach for accelerating buffer analysis of vector data is proposed.The relationship between the number of vertices of each feature and the buffer analysis computing time is analyzed to generate computational intensity transformation functions(CITFs).Then,computational intensity grids(CIGs)of polyline and polygon are constructed based on the relative CITFs.Using the corresponding CIGs,a spatial decomposition method for parallel buffer analysis is developed.Based on the computational intensity of the features and the sub-domains generated in the decomposition,the features are averagely assigned within the sub-domains into parallel buffer analysis tasks for load balance.Compared with typical regular domain decomposition methods,the new approach accomplishes greater balanced decomposition of computational intensity for parallel buffer analysis and achieves near-linear speedups.展开更多
Geospatial objects detection within complex environment is a challenging problem in remote sensing area. In this paper, we derive an extension of the Relevance Vector Machine (RVM) technique to multiple kernel version...Geospatial objects detection within complex environment is a challenging problem in remote sensing area. In this paper, we derive an extension of the Relevance Vector Machine (RVM) technique to multiple kernel version. The proposed method learns an optimal kernel combination and the associated classifier simultaneously. Two feature types are extracted from images, forming basis kernels. Then these basis kernels are weighted combined and resulted the composite kernel exploits interesting points and appearance information of objects simultaneously. Weights and the detection model are finally learnt by a new algorithm. Experimental results show that the proposed method improve detection accuracy to above 88%, yields good interpretation for the selected subset of features and appears sparser than traditional single-kernel RVMs.展开更多
The increase in China’s skilled labor force has drawn much attention from policymakers,national and international firms and media.Understanding how educated talent locates and re-locates across the country can guide ...The increase in China’s skilled labor force has drawn much attention from policymakers,national and international firms and media.Understanding how educated talent locates and re-locates across the country can guide future policy discussions of equality,firm localization and service allocation.Prior studies have tended to adopt a static cross-national approach providing valuable insights into the relative importance of economic and amenity differentials driving the distribution of talent in China.Yet,few adopt longitudinal analysis to examine the temporal dynamics in the stregnth of existing associations.Recently released official statistical data now enables space-time analysis of the geographic distribution of talent and its determinants in China.Using four-year city-level data from national population censuses and 1%population sample surveys conducted every five years between 2000 and 2015,we examine the spatial patterns of talent across Chinese cities and their underpinning drivers evolve over time.Results reveal that the spatial distribution of talent in China is persistently unequal and spatially concentrated between 2000 and 2015.It also shows gradually strengthened and significantly positive spatial autocorrelation in the distribution of talent.An eigenvector spatial filtering negative binomial panel is employed to model the spatial determinants of talent distribution.Results indicate the influences of both economic opportunities and urban amenities,particularly urban public services and greening rate,on the distribution of talent.These results highlight that urban economic-and amenity-related factors have simultaneously driven China’s talent’s settlement patterns over the first fifteen years of the 21st century.展开更多
Spatial correlation of sound pressure and particle velocity of the surface noise in horizontally stratified media was demonstrated, with directional noise sources uniformly distributed on the ocean surface. In the eva...Spatial correlation of sound pressure and particle velocity of the surface noise in horizontally stratified media was demonstrated, with directional noise sources uniformly distributed on the ocean surface. In the evaluation of particle velocity, plane wave approximation was applied to each incident ray. Due to the equivalence of the sound source correlation property and its directivity, solutions for the spatial correlation of the field were transformed into the integration of the coherent function generated by a single directional source. As a typical horizontally stratified media, surface noise in a perfect waveguide was investigated. Correlation coefficients given by normal mode and geometric models show satisfactory agreement. Also, the normalized covariance between sound pressure and the vertical component of particle velocity is proportional to acoustic absorption coefficient, while that of the surface noise in semi-infinitely homogeneous space is zero.展开更多
Snow water equivalent(SWE)is an important factor reflecting the variability of snow.It is important to estimate SWE based on remote sensing data while taking spatial autocorrelation into account.Based on the segmentat...Snow water equivalent(SWE)is an important factor reflecting the variability of snow.It is important to estimate SWE based on remote sensing data while taking spatial autocorrelation into account.Based on the segmentation method,the relationship between SWE and environmental factors in the central part of the Tibetan Plateau was explored using the eigenvector spatial filtering(ESF)regression model,and the influence of different factors on the SWE was explored.Three sizes of 16×16,24×24 and 32×32 were selected to segment raster datasets into blocks.The eigenvectors of the spatial adjacency matrix of the segmented size were selected to be added into the model as spatial factors,and the ESF regression model was constructed for each block in parallel.Results show that precipitation has a great influence on SWE,while surface temperature and NDVI have little influence.Air temperature,elevation and surface temperature have completely different effects in different areas.Compared with the ordinary least square(OLS)linear regression model,geographically weighted regression(GWR)model,spatial lag model(SLM)and spatial error model(SEM),ESF model can eliminate spatial autocorrelation with the highest accuracy.As the segmentation size increases,the complexity of ESF model increases,but the accuracy is improved.展开更多
Osteoarthritis(OA)is a debilitating degenerative disease affecting multiple joint tissues,including cartilage,bone,synovium,and adipose tissues.OA presents diverse clinical phenotypes and distinct molecular endotypes,...Osteoarthritis(OA)is a debilitating degenerative disease affecting multiple joint tissues,including cartilage,bone,synovium,and adipose tissues.OA presents diverse clinical phenotypes and distinct molecular endotypes,including inflammatory,metabolic,mechanical,genetic,and synovial variants.Consequently,innovative technologies are needed to support the development of effective diagnostic and precision therapeutic approaches.Traditional analysis of bulk OA tissue extracts has limitations due to technical constraints,causing challenges in the differentiation between various physiological and pathological phenotypes in joint tissues.This issue has led to standardization difficulties and hindered the success of clinical trials.Gaining insights into the spatial variations of the cellular and molecular structures in OA tissues,encompassing DNA,RNA,metabolites,and proteins,as well as their chemical properties,elemental composition,and mechanical attributes,can contribute to a more comprehensive understanding of the disease subtypes.Spatially resolved biology enables biologists to investigate cells within the context of their tissue microenvironment,providing a more holistic view of cellular function.Recent advances in innovative spatial biology techniques now allow intact tissue sections to be examined using various-omics lenses,such as genomics,transcriptomics,proteomics,and metabolomics,with spatial data.This fusion of approaches provides researchers with critical insights into the molecular composition and functions of the cells and tissues at precise spatial coordinates.Furthermore,advanced imaging techniques,including high-resolution microscopy,hyperspectral imaging,and mass spectrometry imaging,enable the visualization and analysis of the spatial distribution of biomolecules,cells,and tissues.Linking these molecular imaging outputs to conventional tissue histology can facilitate a more comprehensive characterization of disease phenotypes.This review summarizes the recent advancements in the molecular imaging modalities and methodologies for in-depth spatial analysis.It explores their applications,challenges,and potential opportunities in the field of OA.Additionally,this review provides a perspective on the potential research directions for these contemporary approaches that can meet the requirements of clinical diagnoses and the establishment of therapeutic targets for OA.展开更多
For a n-dimensional vector fields preserving some n-form, the following conclusion is reached by the method of Lie group. That is, if it admits an one-parameter, n-form preserving symmetry group, a transformation inde...For a n-dimensional vector fields preserving some n-form, the following conclusion is reached by the method of Lie group. That is, if it admits an one-parameter, n-form preserving symmetry group, a transformation independent of the vector field is constructed explicitly, which can reduce not only dimesion of the vector field by one, but also make the reduced vector field preserve the corresponding ( n - 1)-form. In partic ular, while n = 3, an important result can be directly got which is given by Me,ie and Wiggins in 1994.展开更多
In recent years, the coastal region of Southeast China has witnessed a significant increase in the frequency and intensity of extreme rainfall events associated with landfalling typhoons. The hilly and mountainous ter...In recent years, the coastal region of Southeast China has witnessed a significant increase in the frequency and intensity of extreme rainfall events associated with landfalling typhoons. The hilly and mountainous terrain of this area, combined with rapid rainfall accumulation, has led to a surge in flash floods and severe geological hazards. On August 10, 2019, Typhoon Lekima made landfall in Zhejiang Province, China, and its torrential rainfall triggered extensive landslides, resulting in substantial damage and economic losses. Utilizing high-resolution satellite images, we compiled a landslide inventory of the affected area, which comprises a total of 2,774 rainfallinduced landslides over an area of 2965 km2. The majority of these landslides were small to mediumsized and exhibited elongated, clustered patterns. Some landslides displayed characteristics of high-level initiation, obstructing or partially blocking rivers, leading to the formation of debris dams. We used the inventory to analyze the distribution pattern of the landslides and their relationship with topographical, geological, and hydrological factors. The results showed that landslide abundance was closely related to elevation, slope angle, faults, and road density. The landslides were predominantly located in hilly and low mountainous areas, with elevations ranging from 150 to 300 m, slopes of 20 to 30 degrees, and a NE-SE aspect. Notably, we observed the highest Landslide Number Density(LND) and Landslide Area Percentage(LAP) in the rhyolite region. Landslides were concentrated within approximately 4 km on either side of fault zones, with their size and frequency negatively correlated with distances to faults, roads, and river systems. Furthermore, under the influence of typhoons, regions with denser vegetation cover exhibited higher landslide density, reaching maximum values in shrubland areas. In areas experiencing significantly increased concentrated rainfall, landslide density also showed a corresponding rise. In terms of spatial distribution, the rainfall-triggered landslides primarily occurred in the northeastern part of the study area, particularly in regions characterized by complex topography such as Shanzao Village in Yantan Town, Xixia Township, and Shangzhang Township. The research findings offer crucial data on the rainfallinduced landslides triggered by Typhoon Lekima, shedding light on their spatial distribution patterns. These findings provide valuable references for mitigating risks and planning reconstruction in typhoon-affected area.展开更多
The geological data are constructed in vector format in geographical information system (GIS) while other data such as remote sensing images, geographical data and geochemical data are saved in raster ones. This paper...The geological data are constructed in vector format in geographical information system (GIS) while other data such as remote sensing images, geographical data and geochemical data are saved in raster ones. This paper converts the vector data into 8 bit images according to their importance to mineralization each by programming. We can communicate the geological meaning with the raster images by this method. The paper also fuses geographical data and geochemical data with the programmed strata data. The result shows that image fusion can express different intensities effectively and visualize the structure characters in 2 dimensions. Furthermore, it also can produce optimized information from multi-source data and express them more directly.展开更多
We extract the 3 D phase△and the Stokes parameter S3 of a transmissive anisotropic object spatially using an interferometric Polar Cam.Four parallel interferograms with a phase shift ofπ/2 between the images are cap...We extract the 3 D phase△and the Stokes parameter S3 of a transmissive anisotropic object spatially using an interferometric Polar Cam.Four parallel interferograms with a phase shift ofπ/2 between the images are captured in a single snapshot and then reconstructed by the four-bucket algorithm to extract the 3 D phase of the object.The S3 is then calculated directly from the obtained 3 D phase△.The extracted results of△and S3 were compared with those extracted from the non-interferometric Polar Cam and the Thorlabs polarimeter,and the results match quite well.The merit of using the interferometric Polar Cam is that no mechanical movement mechanisms are included,and hence the△and S3 of the object can be extracted,with high accuracy and within a part of a second(three times faster than non-interferometric Polar Cam and Thorlabs polarimeter methods).Moreover,this method can be applied in the field of the dynamic spectro–interferometric Polar Cam and can be implemented using swept-wavelength approaches.展开更多
Historically,landslides have been the primary type of geological disaster worldwide.Generally,the stability of reservoir banks is primarily affected by rainfall and reservoir water level fluctuations.Moreover,the stab...Historically,landslides have been the primary type of geological disaster worldwide.Generally,the stability of reservoir banks is primarily affected by rainfall and reservoir water level fluctuations.Moreover,the stability of reservoir banks changes with the long-term dynamics of external disastercausing factors.Thus,assessing the time-varying reliability of reservoir landslides remains a challenge.In this paper,a machine learning(ML)based approach is proposed to analyze the long-term reliability of reservoir bank landslides in spatially variable soils through time series prediction.This study systematically investigated the prediction performances of three ML algorithms,i.e.multilayer perceptron(MLP),convolutional neural network(CNN),and long short-term memory(LSTM).Additionally,the effects of the data quantity and data ratio on the predictive power of deep learning models are considered.The results show that all three ML models can accurately depict the changes in the time-varying failure probability of reservoir landslides.The CNN model outperforms both the MLP and LSTM models in predicting the failure probability.Furthermore,selecting the right data ratio can improve the prediction accuracy of the failure probability obtained by ML models.展开更多
A new measurement method for the spatial distribution of neutron beam flux in boron neutron capture therapy(BNCT)is being developed based on the two-dimensional Micromegas detector.To address the issue of long process...A new measurement method for the spatial distribution of neutron beam flux in boron neutron capture therapy(BNCT)is being developed based on the two-dimensional Micromegas detector.To address the issue of long processing times in traditional offline position reconstruction methods,this paper proposes a field programmable gate array based online position reconstruction method utilizing the micro-time projection chamber principle.This method encapsulates key technical aspects:a self-adaptive serial link technique built upon the dynamical adjustment of the delay chain length,fast sorting,a coordinate-matching technique based on the mapping between signal timestamps and random access memory(RAM)addresses,and a precise start point-merging technique utilizing a circular combined RAM.The performance test of the selfadaptive serial link shows that the bit error rate of the link is better than 10-12 at a confidence level of 99%,ensuring reliable data transmission.The experiment utilizing the readout electronics and Micromegas detector shows a spatial resolution of approximately 1.4 mm,surpassing the current method’s resolution level of 5 mm.The beam experiment confirms that the readout electronics system can obtain the flux spatial distribution of neutron beams online,thus validating the feasibility of the position reconstruction method.The online position reconstruction method avoids traditional methods,such as bubble sorting and traversal searching,simplifies the design of the logic firmware,and reduces the time complexity from O(n2)to O(n).This study contributes to the advancement in measuring neutron beam flux for BNCT.展开更多
As a set of supervised pattern recognition methods, support vector machines (SVMs) have been successfully applied to functional magnetic resonance imaging (fMRI) field, but few studies have focused on visualizing disc...As a set of supervised pattern recognition methods, support vector machines (SVMs) have been successfully applied to functional magnetic resonance imaging (fMRI) field, but few studies have focused on visualizing discriminative regions of whole brain between different cognitive tasks dynamically. This paper presents a SVM-based method for visualizing dynamically discriminative activation of whole-brain voxels between two kinds of tasks without any contrast. Our method provides a series of dynamic spatial discrimination maps (DSDMs), representing the temporal evolution of discriminative brain activation during a duty cycle and describing how the discriminating information changes over the duty cycle. The proposed method was applied to investigate discriminative brain functional activations of whole brain voxels dynamically based on a hand-motor task experiment. A set of DSDMs between left hand movement and right hand movement were reached. Our results demonstrated not only where but also when the discriminative activations of whole brain voxels occurred between left hand movement and right hand movement during one duty cycle.展开更多
基金Project supported by the Youth Innovation Promotion Association CASState Key Laboratory of Transient Optics and Photonics Open Topics (Grant No. SKLST202222)
文摘The perfect hybrid vector vortex beam(PHVVB)with helical phase wavefront structure has aroused significant concern in recent years,as its beam waist does not expand with the topological charge(TC).In this work,we investigate the spatial quantum coherent modulation effect with PHVVB based on the atomic medium,and we observe the absorption characteristic of the PHVVB with different TCs under variant magnetic fields.We find that the transmission spectrum linewidth of PHVVB can be effectively maintained regardless of the TC.Still,the width of transmission peaks increases slightly as the beam size expands in hot atomic vapor.This distinctive quantum coherence phenomenon,demonstrated by the interaction of an atomic medium with a hybrid vector-structured beam,might be anticipated to open up new opportunities for quantum coherence modulation and accurate magnetic field measurement.
基金supported by the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI)the Ministry of Health&Welfare,Republic of Korea (HR22C1734)+2 种基金the National Research Foundation (NRF) of Korea (2020R1A6A1A03043539,2020M3A9D8037604,2022R1C1C1004756)(to SBL)the NRF of Korea (2022R1C1C1005741 and RS-2023-00217595)the new faculty research fund of Ajou University School of Medicine (to EJL)。
文摘Elucidating the complex dynamic cellular organization in the hypothalamus is critical for understanding its role in coordinating fundamental body functions. Over the past decade, single-cell and spatial omics technologies have significantly evolved, overcoming initial technical challenges in capturing and analyzing individual cells. These high-throughput omics technologies now offer a remarkable opportunity to comprehend the complex spatiotemporal patterns of transcriptional diversity and cell-type characteristics across the entire hypothalamus. Current single-cell and single-nucleus RNA sequencing methods comprehensively quantify gene expression by exploring distinct phenotypes across various subregions of the hypothalamus. However, single-cell/single-nucleus RNA sequencing requires isolating the cell/nuclei from the tissue, potentially resulting in the loss of spatial information concerning neuronal networks. Spatial transcriptomics methods, by bypassing the cell dissociation, can elucidate the intricate spatial organization of neural networks through their imaging and sequencing technologies. In this review, we highlight the applicative value of single-cell and spatial transcriptomics in exploring the complex molecular-genetic diversity of hypothalamic cell types, driven by recent high-throughput achievements.
基金supported by the National Natural Science Foundation of China,No.82301403(to DZ)。
文摘Glial cells play crucial roles in regulating physiological and pathological functions,including sensation,the response to infection and acute injury,and chronic neurodegenerative disorders.Glial cells include astrocytes,microglia,and oligodendrocytes in the central nervous system,and satellite glial cells and Schwann cells in the peripheral nervous system.Despite the greater understanding of glial cell types and functional heterogeneity achieved through single-cell and single-nucleus RNA sequencing in animal models,few studies have investigated the transcriptomic profiles of glial cells in the human spinal cord.Here,we used high-throughput single-nucleus RNA sequencing and spatial transcriptomics to map the cellular and molecular heterogeneity of astrocytes,microglia,and oligodendrocytes in the human spinal cord.To explore the conservation and divergence across species,we compared these findings with those from mice.In the human spinal cord,astrocytes,microglia,and oligodendrocytes were each divided into six distinct transcriptomic subclusters.In the mouse spinal cord,astrocytes,microglia,and oligodendrocytes were divided into five,four,and five distinct transcriptomic subclusters,respectively.The comparative results revealed substantial heterogeneity in all glial cell types between humans and mice.Additionally,we detected sex differences in gene expression in human spinal cord glial cells.Specifically,in all astrocyte subtypes,the levels of NEAT1 and CHI3L1 were higher in males than in females,whereas the levels of CST3 were lower in males than in females.In all microglial subtypes,all differentially expressed genes were located on the sex chromosomes.In addition to sex-specific gene differences,the levels of MT-ND4,MT2A,MT-ATP6,MT-CO3,MT-ND2,MT-ND3,and MT-CO_(2) in all spinal cord oligodendrocyte subtypes were higher in females than in males.Collectively,the present dataset extensively characterizes glial cell heterogeneity and offers a valuable resource for exploring the cellular basis of spinal cordrelated illnesses,including chronic pain,amyotrophic lateral sclerosis,and multiple sclerosis.
基金supported by the Basic Research Project of the Korea Institute of Geoscience and Mineral Resources(KIGAM)Project of Environmental Business Big Data Platform and Center Construction funded by the Ministry of Science and ICT。
文摘In this study,we developed multiple hybrid machine-learning models to address parameter optimization limitations and enhance the spatial prediction of landslide susceptibility models.We created a geographic information system database,and our analysis results were used to prepare a landslide inventory map containing 359 landslide events identified from Google Earth,aerial photographs,and other validated sources.A support vector regression(SVR)machine-learning model was used to divide the landslide inventory into training(70%)and testing(30%)datasets.The landslide susceptibility map was produced using 14 causative factors.We applied the established gray wolf optimization(GWO)algorithm,bat algorithm(BA),and cuckoo optimization algorithm(COA)to fine-tune the parameters of the SVR model to improve its predictive accuracy.The resultant hybrid models,SVR-GWO,SVR-BA,and SVR-COA,were validated in terms of the area under curve(AUC)and root mean square error(RMSE).The AUC values for the SVR-GWO(0.733),SVR-BA(0.724),and SVR-COA(0.738)models indicate their good prediction rates for landslide susceptibility modeling.SVR-COA had the greatest accuracy,with an RMSE of 0.21687,and SVR-BA had the least accuracy,with an RMSE of 0.23046.The three optimized hybrid models outperformed the SVR model(AUC=0.704,RMSE=0.26689),confirming the ability of metaheuristic algorithms to improve model performance.
基金This work was supported by the innovation project of Science and Technology Commission of the Central Military Commission。
文摘In this paper,a sparse nonuniform rectangular array based on spatially spread electromagnetic vector sensor(SNRASSEMVS)is introduced,and a method for estimating 2D-direction of arrival(DOA)and polarization is devised.Firstly,according to the special structure of the sparse nonuniform rectangular array(SNRA),a set of accurate but ambiguous direction-cosine estimates can be obtained.Then the steering vector of spatially spread electromagnetic vector sensor(SSEMVS)can be extracted from the array manifold to obtain the coarse but unambiguous direction-cosine estimates.Finally,the disambiguation approach can be used to get the final accurate estimates of 2DDOA and polarization.Compared with some existing methods,the SNRA configuration extends the spatial aperture and refines the parameters estimation accuracy without adding any redundant antennas,as well as reduces the mutual coupling effect.Moreover,the proposed algorithm resolves multiple sources without the priori knowledge of signal information,suffers no ambiguity in the estimation of the Poynting vector,and pairs the x-axis direction cosine with the y-axis direction cosine automatically.Simulation results are given to verify the effectiveness and superiority of the proposed algorithm.
基金supported by the China Scholarship Council(Grant No.201906010036)。
文摘Analysis of spatial patterns to describe the spatial correlation between a tree location and marks(i.e.,structural variables),can reveal stand history,population dynamics,competition and symbiosis.However,most studies of spatial patterns have concentrated on tree location and tree sizes rather than on crown asymmetry especially with direct analysis among marks characterizing facilitation and competition among of trees,and thus cannot reveal the cause of the distributions of tree locations and quantitative marks.To explore the spatial correlation among quantitative and vectorial marks and their implication on population dynamics,we extracted vertical and horizontal marks(tree height and crown projection area)characterizing tree size,and a vectorial mark(crown displacement vector characterizing the crown asymmetry)using an airborne laser scanning point cloud obtained from two forest stands in Oxfordshire,UK.Quantitatively and vectorially marked spatial patterns were developed,with corresponding null models established for a significance test.We analyzed eight types of univariate and bivariate spatial patterns,after first proposing four types.The accuracy of the pattern analysis based on an algorithm-segmented point cloud was compared with that of a truly segmented point cloud.The algorithm-segmented point cloud managed to detect 70–86%of patterns correctly.The eight types of spatial patterns analyzed the spatial distribution of trees,the spatial correlation between tree size and facilitated or competitive interactions of sycamore and other species.These four types of univariate patterns jointly showed that,at smaller scales,the trees tend to be clustered,and taller,with larger crowns due to the detected facilitations among trees in the study area.The four types of bivariate patterns found that at smaller scales there are taller trees and more facilitation among sycamore and other species,while crown size is mostly homogeneous across scales.These results indicate that interspecific facilitation and competition mainly affect tree height in the study area.This work further confirms the connection of tree size with individual facilitation and competition,revealing the potential spatial structure that previously was hard to detect.
文摘Firewalls use packet filtering to either accept or deny packets on the basis of a set of predefined rules called filters. The firewall forms the initial layer of defense and protects the network from unauthorized access. However, maintaining firewall policies is always an error prone task, because the policies are highly complex. Conflict is a misconfiguration that occurs when a packet matches two or more filters. The occurrence of conflicts in a firewall policy makes the filters either redundant or shadowed, and as a result, the network does not reflect the actual configuration of the firewall policy. Hence, it is necessary to detect conflicts to keep the filters meaningful. Even though geometry-based conflict detection provides an exhaustive method for error classification, when the number of filters and headers increases, the demands on memory and computation time increase. To solve these two issues, we make two main contributions. First, we propose a topology-based conflict detection system that computes the topological relationship of the filters to detect the conflicts. Second, we propose a systematic implementation method called BISCAL (a bit-vector-based spatial calculus) to implement the proposed system and remove irrelevant data from the conflict detection computation. We perform a mathematical analysis as well as experimental evaluations and find that the amount of data needed for topology is only one-fourth of that needed for geometry.
基金the National Natural Science Foundation of China(No.41971356,41701446)National Key Research and Development Program of China(No.2017YFB0503600,2018YFB0505500,2017YFC0602204).
文摘Parallel vector buffer analysis approaches can be classified into 2 types:algorithm-oriented parallel strategy and the data-oriented parallel strategy.These methods do not take its applicability on the existing geographic information systems(GIS)platforms into consideration.In order to address the problem,a spatial decomposition approach for accelerating buffer analysis of vector data is proposed.The relationship between the number of vertices of each feature and the buffer analysis computing time is analyzed to generate computational intensity transformation functions(CITFs).Then,computational intensity grids(CIGs)of polyline and polygon are constructed based on the relative CITFs.Using the corresponding CIGs,a spatial decomposition method for parallel buffer analysis is developed.Based on the computational intensity of the features and the sub-domains generated in the decomposition,the features are averagely assigned within the sub-domains into parallel buffer analysis tasks for load balance.Compared with typical regular domain decomposition methods,the new approach accomplishes greater balanced decomposition of computational intensity for parallel buffer analysis and achieves near-linear speedups.
基金Supported by the National Natural Science Foundation of China (No.41001285)
文摘Geospatial objects detection within complex environment is a challenging problem in remote sensing area. In this paper, we derive an extension of the Relevance Vector Machine (RVM) technique to multiple kernel version. The proposed method learns an optimal kernel combination and the associated classifier simultaneously. Two feature types are extracted from images, forming basis kernels. Then these basis kernels are weighted combined and resulted the composite kernel exploits interesting points and appearance information of objects simultaneously. Weights and the detection model are finally learnt by a new algorithm. Experimental results show that the proposed method improve detection accuracy to above 88%, yields good interpretation for the selected subset of features and appears sparser than traditional single-kernel RVMs.
基金Under the auspices of the National Social Science Foundation of China(No.17ZDA055).
文摘The increase in China’s skilled labor force has drawn much attention from policymakers,national and international firms and media.Understanding how educated talent locates and re-locates across the country can guide future policy discussions of equality,firm localization and service allocation.Prior studies have tended to adopt a static cross-national approach providing valuable insights into the relative importance of economic and amenity differentials driving the distribution of talent in China.Yet,few adopt longitudinal analysis to examine the temporal dynamics in the stregnth of existing associations.Recently released official statistical data now enables space-time analysis of the geographic distribution of talent and its determinants in China.Using four-year city-level data from national population censuses and 1%population sample surveys conducted every five years between 2000 and 2015,we examine the spatial patterns of talent across Chinese cities and their underpinning drivers evolve over time.Results reveal that the spatial distribution of talent in China is persistently unequal and spatially concentrated between 2000 and 2015.It also shows gradually strengthened and significantly positive spatial autocorrelation in the distribution of talent.An eigenvector spatial filtering negative binomial panel is employed to model the spatial determinants of talent distribution.Results indicate the influences of both economic opportunities and urban amenities,particularly urban public services and greening rate,on the distribution of talent.These results highlight that urban economic-and amenity-related factors have simultaneously driven China’s talent’s settlement patterns over the first fifteen years of the 21st century.
基金Supported by the National Natural Science Foundation of China under Grant No.(50909028).
文摘Spatial correlation of sound pressure and particle velocity of the surface noise in horizontally stratified media was demonstrated, with directional noise sources uniformly distributed on the ocean surface. In the evaluation of particle velocity, plane wave approximation was applied to each incident ray. Due to the equivalence of the sound source correlation property and its directivity, solutions for the spatial correlation of the field were transformed into the integration of the coherent function generated by a single directional source. As a typical horizontally stratified media, surface noise in a perfect waveguide was investigated. Correlation coefficients given by normal mode and geometric models show satisfactory agreement. Also, the normalized covariance between sound pressure and the vertical component of particle velocity is proportional to acoustic absorption coefficient, while that of the surface noise in semi-infinitely homogeneous space is zero.
基金funded by the National Key S&T Special Projects of China(grant number:2018YFB0505302)the National Nature Science Foundation of China(grant number:41671380)。
文摘Snow water equivalent(SWE)is an important factor reflecting the variability of snow.It is important to estimate SWE based on remote sensing data while taking spatial autocorrelation into account.Based on the segmentation method,the relationship between SWE and environmental factors in the central part of the Tibetan Plateau was explored using the eigenvector spatial filtering(ESF)regression model,and the influence of different factors on the SWE was explored.Three sizes of 16×16,24×24 and 32×32 were selected to segment raster datasets into blocks.The eigenvectors of the spatial adjacency matrix of the segmented size were selected to be added into the model as spatial factors,and the ESF regression model was constructed for each block in parallel.Results show that precipitation has a great influence on SWE,while surface temperature and NDVI have little influence.Air temperature,elevation and surface temperature have completely different effects in different areas.Compared with the ordinary least square(OLS)linear regression model,geographically weighted regression(GWR)model,spatial lag model(SLM)and spatial error model(SEM),ESF model can eliminate spatial autocorrelation with the highest accuracy.As the segmentation size increases,the complexity of ESF model increases,but the accuracy is improved.
基金the NHMRC Investigator grant fellowship (APP1176298)the EMCR grant from the Centre for Biomedical Technologies (QUT)+4 种基金the QUT Postgraduate Research Award (QUTPRA)QUT HDR TOP-UP scholarshipQUT HDR Tuition Fee Sponsorshipfunding support from the Academy of Finland (315820)the Jane and Aatos Erkko Foundation (190001).
文摘Osteoarthritis(OA)is a debilitating degenerative disease affecting multiple joint tissues,including cartilage,bone,synovium,and adipose tissues.OA presents diverse clinical phenotypes and distinct molecular endotypes,including inflammatory,metabolic,mechanical,genetic,and synovial variants.Consequently,innovative technologies are needed to support the development of effective diagnostic and precision therapeutic approaches.Traditional analysis of bulk OA tissue extracts has limitations due to technical constraints,causing challenges in the differentiation between various physiological and pathological phenotypes in joint tissues.This issue has led to standardization difficulties and hindered the success of clinical trials.Gaining insights into the spatial variations of the cellular and molecular structures in OA tissues,encompassing DNA,RNA,metabolites,and proteins,as well as their chemical properties,elemental composition,and mechanical attributes,can contribute to a more comprehensive understanding of the disease subtypes.Spatially resolved biology enables biologists to investigate cells within the context of their tissue microenvironment,providing a more holistic view of cellular function.Recent advances in innovative spatial biology techniques now allow intact tissue sections to be examined using various-omics lenses,such as genomics,transcriptomics,proteomics,and metabolomics,with spatial data.This fusion of approaches provides researchers with critical insights into the molecular composition and functions of the cells and tissues at precise spatial coordinates.Furthermore,advanced imaging techniques,including high-resolution microscopy,hyperspectral imaging,and mass spectrometry imaging,enable the visualization and analysis of the spatial distribution of biomolecules,cells,and tissues.Linking these molecular imaging outputs to conventional tissue histology can facilitate a more comprehensive characterization of disease phenotypes.This review summarizes the recent advancements in the molecular imaging modalities and methodologies for in-depth spatial analysis.It explores their applications,challenges,and potential opportunities in the field of OA.Additionally,this review provides a perspective on the potential research directions for these contemporary approaches that can meet the requirements of clinical diagnoses and the establishment of therapeutic targets for OA.
文摘For a n-dimensional vector fields preserving some n-form, the following conclusion is reached by the method of Lie group. That is, if it admits an one-parameter, n-form preserving symmetry group, a transformation independent of the vector field is constructed explicitly, which can reduce not only dimesion of the vector field by one, but also make the reduced vector field preserve the corresponding ( n - 1)-form. In partic ular, while n = 3, an important result can be directly got which is given by Me,ie and Wiggins in 1994.
基金supported by National Natural Science Foundation of China (42277136)Natural Science Research Project of Anhui Educational Committee (2023AH030041)National Key Research and Development Program of China (2021YFB3901205)。
文摘In recent years, the coastal region of Southeast China has witnessed a significant increase in the frequency and intensity of extreme rainfall events associated with landfalling typhoons. The hilly and mountainous terrain of this area, combined with rapid rainfall accumulation, has led to a surge in flash floods and severe geological hazards. On August 10, 2019, Typhoon Lekima made landfall in Zhejiang Province, China, and its torrential rainfall triggered extensive landslides, resulting in substantial damage and economic losses. Utilizing high-resolution satellite images, we compiled a landslide inventory of the affected area, which comprises a total of 2,774 rainfallinduced landslides over an area of 2965 km2. The majority of these landslides were small to mediumsized and exhibited elongated, clustered patterns. Some landslides displayed characteristics of high-level initiation, obstructing or partially blocking rivers, leading to the formation of debris dams. We used the inventory to analyze the distribution pattern of the landslides and their relationship with topographical, geological, and hydrological factors. The results showed that landslide abundance was closely related to elevation, slope angle, faults, and road density. The landslides were predominantly located in hilly and low mountainous areas, with elevations ranging from 150 to 300 m, slopes of 20 to 30 degrees, and a NE-SE aspect. Notably, we observed the highest Landslide Number Density(LND) and Landslide Area Percentage(LAP) in the rhyolite region. Landslides were concentrated within approximately 4 km on either side of fault zones, with their size and frequency negatively correlated with distances to faults, roads, and river systems. Furthermore, under the influence of typhoons, regions with denser vegetation cover exhibited higher landslide density, reaching maximum values in shrubland areas. In areas experiencing significantly increased concentrated rainfall, landslide density also showed a corresponding rise. In terms of spatial distribution, the rainfall-triggered landslides primarily occurred in the northeastern part of the study area, particularly in regions characterized by complex topography such as Shanzao Village in Yantan Town, Xixia Township, and Shangzhang Township. The research findings offer crucial data on the rainfallinduced landslides triggered by Typhoon Lekima, shedding light on their spatial distribution patterns. These findings provide valuable references for mitigating risks and planning reconstruction in typhoon-affected area.
文摘The geological data are constructed in vector format in geographical information system (GIS) while other data such as remote sensing images, geographical data and geochemical data are saved in raster ones. This paper converts the vector data into 8 bit images according to their importance to mineralization each by programming. We can communicate the geological meaning with the raster images by this method. The paper also fuses geographical data and geochemical data with the programmed strata data. The result shows that image fusion can express different intensities effectively and visualize the structure characters in 2 dimensions. Furthermore, it also can produce optimized information from multi-source data and express them more directly.
基金Supported by Samsung Research Funding&Incubation Center of Samsung Electronics under Grant No.SRFC-TA1703-11。
文摘We extract the 3 D phase△and the Stokes parameter S3 of a transmissive anisotropic object spatially using an interferometric Polar Cam.Four parallel interferograms with a phase shift ofπ/2 between the images are captured in a single snapshot and then reconstructed by the four-bucket algorithm to extract the 3 D phase of the object.The S3 is then calculated directly from the obtained 3 D phase△.The extracted results of△and S3 were compared with those extracted from the non-interferometric Polar Cam and the Thorlabs polarimeter,and the results match quite well.The merit of using the interferometric Polar Cam is that no mechanical movement mechanisms are included,and hence the△and S3 of the object can be extracted,with high accuracy and within a part of a second(three times faster than non-interferometric Polar Cam and Thorlabs polarimeter methods).Moreover,this method can be applied in the field of the dynamic spectro–interferometric Polar Cam and can be implemented using swept-wavelength approaches.
基金supported by the National Natural Science Foundation of China(Grant No.52308340)the Innovative Projects of Universities in Guangdong(Grant No.2022KTSCX208)Sichuan Transportation Science and Technology Project(Grant No.2018-ZL-01).
文摘Historically,landslides have been the primary type of geological disaster worldwide.Generally,the stability of reservoir banks is primarily affected by rainfall and reservoir water level fluctuations.Moreover,the stability of reservoir banks changes with the long-term dynamics of external disastercausing factors.Thus,assessing the time-varying reliability of reservoir landslides remains a challenge.In this paper,a machine learning(ML)based approach is proposed to analyze the long-term reliability of reservoir bank landslides in spatially variable soils through time series prediction.This study systematically investigated the prediction performances of three ML algorithms,i.e.multilayer perceptron(MLP),convolutional neural network(CNN),and long short-term memory(LSTM).Additionally,the effects of the data quantity and data ratio on the predictive power of deep learning models are considered.The results show that all three ML models can accurately depict the changes in the time-varying failure probability of reservoir landslides.The CNN model outperforms both the MLP and LSTM models in predicting the failure probability.Furthermore,selecting the right data ratio can improve the prediction accuracy of the failure probability obtained by ML models.
基金supported by the National Natural Science Foundation of China(No.12075237)。
文摘A new measurement method for the spatial distribution of neutron beam flux in boron neutron capture therapy(BNCT)is being developed based on the two-dimensional Micromegas detector.To address the issue of long processing times in traditional offline position reconstruction methods,this paper proposes a field programmable gate array based online position reconstruction method utilizing the micro-time projection chamber principle.This method encapsulates key technical aspects:a self-adaptive serial link technique built upon the dynamical adjustment of the delay chain length,fast sorting,a coordinate-matching technique based on the mapping between signal timestamps and random access memory(RAM)addresses,and a precise start point-merging technique utilizing a circular combined RAM.The performance test of the selfadaptive serial link shows that the bit error rate of the link is better than 10-12 at a confidence level of 99%,ensuring reliable data transmission.The experiment utilizing the readout electronics and Micromegas detector shows a spatial resolution of approximately 1.4 mm,surpassing the current method’s resolution level of 5 mm.The beam experiment confirms that the readout electronics system can obtain the flux spatial distribution of neutron beams online,thus validating the feasibility of the position reconstruction method.The online position reconstruction method avoids traditional methods,such as bubble sorting and traversal searching,simplifies the design of the logic firmware,and reduces the time complexity from O(n2)to O(n).This study contributes to the advancement in measuring neutron beam flux for BNCT.
文摘As a set of supervised pattern recognition methods, support vector machines (SVMs) have been successfully applied to functional magnetic resonance imaging (fMRI) field, but few studies have focused on visualizing discriminative regions of whole brain between different cognitive tasks dynamically. This paper presents a SVM-based method for visualizing dynamically discriminative activation of whole-brain voxels between two kinds of tasks without any contrast. Our method provides a series of dynamic spatial discrimination maps (DSDMs), representing the temporal evolution of discriminative brain activation during a duty cycle and describing how the discriminating information changes over the duty cycle. The proposed method was applied to investigate discriminative brain functional activations of whole brain voxels dynamically based on a hand-motor task experiment. A set of DSDMs between left hand movement and right hand movement were reached. Our results demonstrated not only where but also when the discriminative activations of whole brain voxels occurred between left hand movement and right hand movement during one duty cycle.