Spatial search weighting information contained in cell velocity distribution

Cell migration plays a significant role in physiological and pathological processes.Understanding the characteristics of cell movement is crucial for comprehending biological processes such as cell functionality,cell migration,and cell–cell interactions.One of the fundamental characteristics of cell movement is the specific distribution of cell speed,containing valuable information that still requires comprehensive understanding.This article investigates the distribution of mean velocities along cell trajectories,with a focus on optimizing the efficiency of cell food search in the context of the entire colony.We confirm that the specific velocity distribution in the experiments corresponds to an optimal search efficiency when spatial weighting is considered.The simulation results indicate that the distribution of average velocity does not align with the optimal search efficiency when employing average spatial weighting.However,when considering the distribution of central spatial weighting,the specific velocity distribution in the experiment is shown to correspond to the optimal search efficiency.Our simulations reveal that for any given distribution of average velocity,a specific central spatial weighting can be identified among the possible central spatial weighting that aligns with the optimal search strategy.Additionally,our work presents a method for determining the spatial weights embedded in the velocity distribution of cell movement.Our results have provided new avenues for further investigation of significant topics,such as relationship between cell behavior and environmental conditions throughout their evolutionary history,and how cells achieve collective cooperation through cell-cell communication.

Finding map regions with high density of query keywords

We consider the problem of finding map regions that best match query keywords. This region search problem can be applied in many practical scenarios such as shopping recommendation, searching for tourist attractions, and collision region detection for wireless sensor networks. While conventional map search retrieves isolate locations in a map, users frequently attempt to find regions of interest instead, e.g., detecting regions having too many wireless sensors to avoid collision, or finding shopping areas featuring various merchandise or tourist attractions of different styles. Finding regions of interest in a map is a non-trivial problem and retrieving regions of arbitrary shapes poses particular challenges. In this paper, we present a novel region search algorithm, dense region search(DRS), and its extensions, to find regions of interest by estimating the density of locations containing the query keywords in the region. Experiments on both synthetic and real-world datasets demonstrate the effectiveness of our algorithm.