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Research on Practical Education of Speciality Teachers in Vocational Colleges to Promote Curriculum-based Ideological and Political Education
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作者 Yue Shen 《教育研究前沿(中英文版)》 2022年第2期20-25,共6页
Curriculum-based ideological and political education is the inevitable requirement of constructing the pattern of ideological and political education in the new era.As the main leader and implementer of curriculum-bas... Curriculum-based ideological and political education is the inevitable requirement of constructing the pattern of ideological and political education in the new era.As the main leader and implementer of curriculum-based ideological and political education in vocational colleges,speciality teachers should take the fundamental task of moral education as the guidance,focus on it through curriculum,promote the organic unity of knowledge teaching,skill improvement and value guidance in the teaching process,and finally form a new ideological and political work mode in line with the requirements of“high-level vocational college and speciality”construction.At present,speciality teachers in vocational colleges have some problems in curriculum-based ideological and political education,which is mainly reflected in some speciality teachers’weak self-consciousness,poor understanding and integration ability.In order to effectively solve the problem,they have to establish the curriculum-based ideological and political education promotion mechanism led by the college Party committee,consolidate the institutional guarantee for speciality teachers in moral education,strengthen their consciousness and awareness,innovate and improve the assessment and evaluation mechanism of their dedicated education. 展开更多
关键词 Vocational Colleges Curriculum-Based Ideological and Political Education speciality Teachers Practical Research
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Attributes of Specialized Households'Resilience and Its Impact on Rural Industrial Advancement:A Case Study of National Musical Instrument Production Specialized Households in Lankao County,Henan,China
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作者 WU Nalin WEI Yike +4 位作者 FAN Sizhe LI Li SUN Yufan ZHANG Yan SHU Yan 《Chinese Geographical Science》 SCIE CSCD 2024年第3期383-400,共18页
Specialized households serve as the primary units within specialized villages in China,and their capacity to withstand risks and external influences significantly shapes the future trajectory of specialized villages a... Specialized households serve as the primary units within specialized villages in China,and their capacity to withstand risks and external influences significantly shapes the future trajectory of specialized villages and the overall vitality of the rural economy.In this study,we established a measurement indicator system based on the definition of specialized households’resilience,elucidating the logical connection between specialized households’resilience and rural industrial development in China.The musical instrument industry in Lankao County,Henan Province of China,was employed as a case;survey data,the entropy method,and an obstacle diagnosis model were used to examine how instrument production specialized households responded to the challenges posed by Corona Virus Disease 2019(COVID-19)and the tightening of national environmental protection policies,yielding the following key findings:1)there exists substantial variation in the comprehensive resilience levels among different specialized households;2)the ability to learn and adapt is the most significant contributor to the overall resilience level of specialized households;3)technological proficiency and access to skilled talent emerge as pivotal factors influencing specialized households’resilience;4)the positioning of specialized households within the industrial supply chain and the stability of their income have a direct bearing on their resilience level.The influence of specialized households’resilience on industrial development primarily manifests in the following ways:stronger resilience correlates with increased stability in production and sales,fostering a more proactive approach to future actions.However,heightened exposure to the external macroeconomic environment can lead to a higher rate of export reduction.To enhance the development resilience of entities like specialized households and family farms,and to invigorate rural economic development,escalating investments in rural science and technology and prioritizing the training of technical talent become imperative. 展开更多
关键词 RESILIENCE specialized households rural industry Lankao County China
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AGGREGATE SPECIAL FUNCTIONS TO APPROXIMATE PERMUTING TRI-HOMOMORPHISMS AND PERMUTING TRI-DERIVATIONS ASSOCIATED WITH A TRI-ADDITIVEψ-FUNCTIONAL INEQUALITY IN BANACH ALGEBRAS
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作者 Safoura Rezaei ADERYANI Azam AHADI +1 位作者 Reza SAADATI Hari M.SRIVASTAVA 《Acta Mathematica Scientia》 SCIE CSCD 2024年第1期311-338,共28页
In this paper,we define a new class of control functions through aggregate special functions.These class of control functions help us to stabilize and approximate a tri-additiveψ-functional inequality to get a better... In this paper,we define a new class of control functions through aggregate special functions.These class of control functions help us to stabilize and approximate a tri-additiveψ-functional inequality to get a better estimation for permuting tri-homomorphisms and permuting tri-derivations in unital C*-algebras and Banach algebras by the vector-valued alternative fixed point theorem. 展开更多
关键词 permuting tri-homomorphism in Banach algebra permuting tri-derivation on C*-algebra fixed point theorem Ulam-Hyers-Rassias stability aggregate special functions tri-additiveψ-functional inequality
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Effect of special types of bread with select herbal components on postprandial glucose levels in diabetic patients
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作者 Drasko M Gostiljac Srdjan S Popovic +4 位作者 Vesna Dimitrijevic-Sreckovic Sasa M Ilic Jelena A Jevtovic Dragan M Nikolic Ivan A Soldatovic 《World Journal of Diabetes》 SCIE 2024年第4期664-674,共11页
BACKGROUND Nutrition recommendations in patients with type 2 diabetes mellitus(T2DM)are to consume rye or integral bread instead of white bread.A positive effect on glucoregulation has been achieved by enriching food ... BACKGROUND Nutrition recommendations in patients with type 2 diabetes mellitus(T2DM)are to consume rye or integral bread instead of white bread.A positive effect on glucoregulation has been achieved by enriching food with various biologically active substances of herbal origin,so we formulated an herbal mixture that can be used as a supplement for a special type of bread(STB)to achieve better effects on postprandial glucose and insulin levels in patients with T2DM.AIM To compare organoleptic characteristics and effects of two types of bread on postprandial glucose and insulin levels in T2DM patients.METHODS This trial included 97 patients with T2DM.A parallel group of 16 healthy subjects was also investigated.All participants were given 50 g of rye bread and the same amount of a STB with an herbal mixture on 2 consecutive days.Postprandial blood glucose and insulin levels were compared at the 30^(th),60^(th),90^(th) and 120th min.A questionnaire was used for subjective estimation of the organoleptic and satiety features of the two types of bread.RESULTS Compared to patients who consumed rye bread,significantly lower postprandial blood glucose and insulin concentrations were found in T2DM patients who consumed STB.No relevant differences were found among the healthy subjects.Subjectively estimated organoleptic and satiety characteristics are better for STB than for rye bread.CONCLUSION STB have better effects than rye bread on postprandial glucoregulation in T2DM patients.Subjectively estimated organoleptic and satiety characteristics are better for STB than for rye bread.Therefore,STB can be recommended for nutrition in T2DM patients. 展开更多
关键词 Special types of bread Postprandial glucoregulation INSULIN NUTRITION Type 2 diabetes mellitus
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The Oral Health Status of Person with Special Needs in Kumasi
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作者 Ama Agyeibea Amuasi Alexander Oti-Acheampong +1 位作者 Victoria N. A. Boadu Lord J. J. Gowans 《Open Journal of Stomatology》 2024年第1期14-31,共18页
Background: The most prevalent non-communicable disease worldwide is oral health-related disease, with dental caries and periodontal conditions being common. Oral health status significantly impacts overall health and... Background: The most prevalent non-communicable disease worldwide is oral health-related disease, with dental caries and periodontal conditions being common. Oral health status significantly impacts overall health and quality of life. Barriers to dental care affect children with special needs. This study evaluates the oral health status and treatment requirements of people with special needs. Methodology: This descriptive cross-sectional study in Kumasi, Ghana examined oral health status among people, 121 children with special needs over two months, in June-July 2022. Dental caries, periodontal changes, malocclusion, and trauma were assessed. The data was analyzed using SPSS 20.0. Results: The oral health status among people with special needs in this study was generally moderate, with a range from very good to very poor. The prevalence of dental caries was 37%, with a mean DMFT score of 2.82. Periodontal health showed unsatisfactory indicators such as mobile teeth, poor gingival health, high plaque scores, and the presence of halitosis. Conclusion: This descriptive study aimed to provide baseline data on the oral health status of special needs students in Kumasi, addressing the lack of knowledge in this area. It highlighted the importance of dental care in maintaining good oral health and overall well-being in individuals with special needs. Coordinated efforts by dental professionals are needed to provide dental health education and preventive interventions for these children. 展开更多
关键词 Special Needs Oral Health Dental Caries Periodontal Diseases MALOCCLUSION
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College English Curriculum Reform in the Context of New Engineering Education:Taking Wuhan University of Technology as an Example
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作者 WANG Hai-yan SHE Ran-ran 《Journal of Literature and Art Studies》 2024年第4期302-305,共4页
With the introduction of“new engineering,new medical science,new agricultural science,and new liberal arts”construction,the reform of college English teaching is also imperative.Scholars nationwide have conducted at... With the introduction of“new engineering,new medical science,new agricultural science,and new liberal arts”construction,the reform of college English teaching is also imperative.Scholars nationwide have conducted attempts in different aspects of college English teaching and produced fruitful results.Yet,more efforts should be made.This paper discusses the reforms made by Wuhan University of Technology,focusing on the reformation of curriculum. 展开更多
关键词 new engineering construction CURRICULUM specialized purpose courses
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Empowering Rice Farmers in Nueva Ecija, Philippines: A Strategic Approach to Boosting Income through Special Purpose Rice Production
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作者 Armando C. Lagasca Eugenia G. Baltazar +3 位作者 Johnah Jefferson S. Mercado Randy L. Kwan Erwin M. Valiente Jerski Jarzen C. Duria 《Open Journal of Ecology》 2024年第3期199-214,共16页
Low income is the main problem of millions of farmers who are cultivating 4.81 million hectares in the Philippines. This problem is attributed to challenges specifically low yield, low quality of produce, and signific... Low income is the main problem of millions of farmers who are cultivating 4.81 million hectares in the Philippines. This problem is attributed to challenges specifically low yield, low quality of produce, and significant post-harvest losses, particularly in a resource-scarce setting. This study aimed to help increase the farmers’ income in selected towns of Nueva Ecija through the promotion and use of special purpose rice production technology. Twenty (20) farmer-cooperators in three towns of Nueva Ecija were selected to demonstrate the production technology covering a total area of 4.75 hectares during the dry season, and 3.3 hectares during the wet season, both in 2023. Extension modalities such as training, techno-demo establishment, information material and technical assistance provision, and market linkage were undertaken to enhance their knowledge, attitude, and skills on special rice production and enterprise. The study utilized the descriptive quantitative method wherein the data were gathered through surveys, specifically personal interviews. Results showed that 70% of the farmer-cooperators were male and 60% were living below the poverty threshold. The farmers were 53 years old on average and engaged in farming as their primary source of income. The average yield of special purpose rice particularly the CLS-2 variety was higher (6.46 MT/ha and 6.22 MT/ha during dry and wet seasons, respectively) than that of inbred or non-special rice. The income per hectare from special purpose rice production per hectare was Php 75,420.00, which is higher than that of regular rice at Php 29,389.00, giving a higher benefit of Php 46,031.00. The technology adopters and area planted increased (from 6 to 9 and from 1.4 hectares to 2.75 hectares, respectively) in Licab, Nueva Ecija. The opposite was true in Sto. Domingo and Guimba, Nueva Ecija where farmers were discouraged by the marketing issues that arose. 展开更多
关键词 Special Purpose Rice Technology Promotion Extension Modality
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Exploration and Practice of“Four Integration and Four Innovation”Specialized and Creative Integration Talent Cultivation Mode:Taking Chongqing Energy Vocational College as an Example
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作者 Liyan Zhang Qingying Zhou +2 位作者 Yueming Zhan Yu Xiao Mingli Chen 《Journal of Contemporary Educational Research》 2024年第4期296-303,共8页
With the release of China Education Modernization 2035,education modernization has become a national strategic goal.In this context,Chongqing Energy Vocational College is actively exploring the“four integration and f... With the release of China Education Modernization 2035,education modernization has become a national strategic goal.In this context,Chongqing Energy Vocational College is actively exploring the“four integration and four innovation”specialized and creative integration talent cultivation mode,aiming at cultivating high-quality talents with innovative spirit and practical skills.This paper analyzes the status quo and challenges of talent cultivation in higher vocational education,puts forward the main practices of innovation-driven,creation and research,cross-border integration,and innovative practice,and has achieved remarkable results.Additionally,it summarizes the experience revelation and provides a reference for other higher vocational colleges and universities. 展开更多
关键词 Specialized and creative integration Talent cultivation Higher vocational education Innovation-driven Cross-border integration
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Application of Specialized Group Management in the Quality Control of Perioperative Nursing
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作者 Cong Fu Xuefei Li +4 位作者 Li Wang Yuanyuan Jiang Xinrong Qi Chen Ding Shanshan Tang 《Journal of Clinical and Nursing Research》 2024年第2期70-75,共6页
Objective:To explore the role of specialized group management in the quality control of perioperative nursing.Methods:45 surgical nurses from our hospital were selected as the research subjects.Traditional operating r... Objective:To explore the role of specialized group management in the quality control of perioperative nursing.Methods:45 surgical nurses from our hospital were selected as the research subjects.Traditional operating room management was adopted from July 2019 to June 2020,and specialized group management was adopted from July 2020 to June 2021.The surgeon’s satisfaction,surgical nurses’core professional competence,and surgical patients’satisfaction were obtained through surveys and the results were analyzed.Results:Surgeon satisfaction before the implementation of specialized group management was significantly lower than after its implementation(P<0.05).Besides,surgical nurses’core professional competency scores before the implementation of specialized group management were significantly lower than after its implementation(P<0.05).Lastly,surgical patients’satisfaction before the implementation of specialized group management was significantly lower than after its implementation(P<0.05).Conclusion:Specialized group management helps to improve the quality of perioperative care and should be applied in clinical practice. 展开更多
关键词 Specialized group management Operating room Quality of care CONTROL
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Physical Space Is Finite
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作者 Youqi Wang 《Journal of Modern Physics》 2024年第5期550-595,共46页
Metrological analysis shows that any clock in inertial motion in infinite space shall not have time dilation, due to relativity of such motion in such space. On the other hand, atomic clock in inertial motion in finit... Metrological analysis shows that any clock in inertial motion in infinite space shall not have time dilation, due to relativity of such motion in such space. On the other hand, atomic clock in inertial motion in finite space shall exhibit time dilation, due to alteration of momentum of clock-defining particle caused by nonzero curvature of trajectory of such motion in such space. Therefore, time dilation experiment of atomic clock in inertial motion in physical space provides a direct and decisive way of determining geometry of physical space in real-time. Phenomenon of time dilation of atomic clock in inertial motion in physical space has long been observed and confirmed experimentally. Therefore, extent of physical space has to be finite, consistent with result of high precision experiment of free particle in high-speed motion conducted a decade ago.Keywords Geometry of Physical Space, Time Dilation, Atomic Clock, Special Relativity Theory. 展开更多
关键词 Geometry of Physical Space Time Dilation Atomic Clock Special Relativity Theory
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Motion and Special Relativity in Complex Spaces
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作者 Jerzy K. Filus 《Journal of Applied Mathematics and Physics》 2024年第1期330-361,共32页
A natural extension of the Lorentz transformation to its complex version was constructed together with a parallel extension of the Minkowski M<sup>4</sup> model for special relativity (SR) to complex C<... A natural extension of the Lorentz transformation to its complex version was constructed together with a parallel extension of the Minkowski M<sup>4</sup> model for special relativity (SR) to complex C<sup>4</sup> space-time. As the [signed] absolute values of complex coordinates of the underlying motion’s characterization in C<sup>4</sup> one obtains a Newtonian-like type of motion whereas as the real parts of the complex motion’s description and of the complex Lorentz transformation, all the SR theory as modeled by M<sup>4</sup> real space-time can be recovered. This means all the SR theory is preserved in the real subspace M<sup>4</sup> of the space-time C<sup>4</sup> while becoming simpler and clearer in the new complex model’s framework. Since velocities in the complex model can be determined geometrically, with no primary use of time, time turns out to be definable within the equivalent theory of the reduced complex C<sup>4</sup> model to the C<sup>3</sup> “para-space” model. That procedure allows us to separate time from the (para)space and consider all the SR theory as a theory of C<sup>3</sup> alone. On the other hand, the complex time defined within the C<sup>3</sup> theory is interpreted and modeled by the single separate C<sup>1</sup> complex plane. The possibility for application of the C<sup>3</sup> model to quantum mechanics is suggested. As such, the model C<sup>3</sup> seems to have unifying abilities for application to different physical theories. 展开更多
关键词 Special Relativity Complex Space and Time Models and Dramatic SR Simplification Complex Time and Space Separation Complex Time Interpretation
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某三级甲等专科医院互联网医院发展的实践与思考 被引量:1
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作者 谢诗蓉 叶卿云 叶正强 《中国卫生资源》 CSCD 北大核心 2023年第3期293-297,共5页
介绍复旦大学附属眼耳鼻喉科医院互联网医院建设历程和运营管理模式。该院互联网医院通过手机即可在线预约、挂号、支付,查看电子病历、检查检验结果、电子发票和药品配送情况等,实现就诊服务全流程移动化,大幅提升患者在线就诊体验。运... 介绍复旦大学附属眼耳鼻喉科医院互联网医院建设历程和运营管理模式。该院互联网医院通过手机即可在线预约、挂号、支付,查看电子病历、检查检验结果、电子发票和药品配送情况等,实现就诊服务全流程移动化,大幅提升患者在线就诊体验。运营3年来,该院互联网医疗数据始终领先于上海各类医院,单科接诊量、周互联网服务量、年互联网服务量、周互联网处方量均保持全市第一。并从患者、医生和医院层面提出未来公立医院互联网医院持续稳定发展的建议和思考。 展开更多
关键词 专科医院specialized hospital 互联网医院Internet hospital 发展模式development model 实践practice
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Analysis of the management and therapeutic performance of diabetes mellitus employing special target 被引量:1
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作者 Hong-Yan Sun Xiao-Yan Lin 《World Journal of Diabetes》 SCIE 2023年第12期1721-1737,共17页
Diabetes mellitus (DM) is a chronic metabolic condition characterized predominantlyby hyperglycemia. The most common causes contributing to the pathophysiologyof diabetes are insufficient insulin secretion, resistance... Diabetes mellitus (DM) is a chronic metabolic condition characterized predominantlyby hyperglycemia. The most common causes contributing to the pathophysiologyof diabetes are insufficient insulin secretion, resistance to insulin’stissue-acting effects, or a combination of both. Over the last 30 years, the globalprevalence of diabetes increased from 4% to 6.4%. If no better treatment or cure isfound, this amount might climb to 430 million in the coming years. The major fact-ors of the disease’s deterioration include age, obesity, and a sedentary lifestyle.Finding new therapies to manage diabetes safely and effectively without jeopardizingpatient compliance has always been essential. Among the medicationsavailable to manage DM on this journey are glucagon-like peptide-1 agonists,thiazolidinediones, sulphonyl urease, glinides, biguanides, and insulin-targetingreceptors discovered more than 10 years ago. Despite the extensive preliminarystudies, a few clinical observations suggest this process is still in its early stages.The present review focuses on targets that contribute to insulin regulation andmay be employed as targets in treating diabetes since they may be more efficientand secure than current and traditional treatments. 展开更多
关键词 Diabetes mellitus HYPERGLYCEMIA Therapeutic performance MANAGEMENT Special target Literature review
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Teaching Practice of Integrating Labor Education into Specialized Courses:A Case Study of Plant Cultivation and Maintenance 被引量:1
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作者 Chuanlei LI Nianhua SHEN 《Asian Agricultural Research》 2023年第4期61-64,共4页
Vocational colleges attach great importance to labor education.Specialized courses are an effective way to cultivate students labor quality,and the integration of labor education in specialized courses plays an import... Vocational colleges attach great importance to labor education.Specialized courses are an effective way to cultivate students labor quality,and the integration of labor education in specialized courses plays an important role in the overall cultivation of students moral quality and practical ability.Combined with the teaching practice of landscape technology specialty,labor education is integrated into the teaching of Plant Cultivation and Maintenance,and certain results have been achieved.In this paper,the course content"grafting propagation"was analyzed from the aspects of overall teaching design,teaching implementation process,teaching effect and reflection improvement,so as to provide reference for other contents of this major or other majors to carry out integrated teaching. 展开更多
关键词 Labor education Specialized courses Plant cultivation Plant conservation
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Transcriptional profiling of dental sensory and proprioceptive trigeminal neurons using single-cell RNA sequencing
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作者 Pa Reum Lee Jihoon Kim +4 位作者 Heather Lynn Rossi Sena Chung Seung Yub Han Junhyong Kim Seog Bae Oh 《International Journal of Oral Science》 SCIE CAS CSCD 2023年第3期513-526,共14页
Dental primary afferent(DPA)neurons and proprioceptive mesencephalic trigeminal nucleus(MTN)neurons,located in the trigeminal ganglion and the brainstem,respectively,are essential for controlling masticatory functions... Dental primary afferent(DPA)neurons and proprioceptive mesencephalic trigeminal nucleus(MTN)neurons,located in the trigeminal ganglion and the brainstem,respectively,are essential for controlling masticatory functions.Despite extensive transcriptomic studies on various somatosensory neurons,there is still a lack of knowledge about the molecular identities of these populations due to technical challenges in their circuit-validated isolation.Here,we employed high-depth single-cell RNA sequencing(scRNA-seq)in combination with retrograde tracing in mice to identify intrinsic transcriptional features of DPA and MTN neurons.Our transcriptome analysis revealed five major types of DPA neurons with cell type-specific gene enrichment,some of which exhibit unique mechano-nociceptive properties capable of transmitting nociception in response to innocuous mechanical stimuli in the teeth.Furthermore,we discovered cellular heterogeneity within MTN neurons that potentially contribute to their responsiveness to mechanical stretch in the masseter muscle spindles.Additionally,DPA and MTN neurons represented sensory compartments with distinct molecular profiles characterized by various ion channels,receptors,neuropeptides,and mechanoreceptors.Together,our study provides new biological insights regarding the highly specialized mechanosensory functions of DPA and MTN neurons in pain and proprioception. 展开更多
关键词 TRIGEMINAL specialized TOGETHER
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Neuroplastin in Ca^(2+)signal regulation and plasticity of glutamatergic synapses
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作者 Ayse Malci Xiao Lin +1 位作者 Yun Stone Shi Rodrigo Herrera-Molina 《Neural Regeneration Research》 SCIE CAS CSCD 2023年第8期1705-1706,共2页
The main function of neurons is information transmission in the form of action potentials.To fulfill this duty,neurons are connected functionally with each other via synapses,the microscopic structures where specializ... The main function of neurons is information transmission in the form of action potentials.To fulfill this duty,neurons are connected functionally with each other via synapses,the microscopic structures where specialized molecular machinery is strategically placed to release and receive neurotransmitters and to generate and extinguish calcium(Ca^(2+))signals.These synaptic molecular components are highly dynamic and they influence each other to confer structural and functional adaptability(plasticity)to neuronal communication(Biederer et al.,2017). 展开更多
关键词 PLASTICITY specialized STRUCTURAL
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Spatial niche segregation between bird species in the Białowieża primeval forest(NE Poland)
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作者 Oliwia Karpińska Katarzyna Kamionka-Kanclerska +2 位作者 Patryk Czortek Marcin K.Dyderski Dorota Czeszczewik 《Forest Ecosystems》 SCIE CSCD 2023年第4期483-493,共11页
Drivers of bird niche separation in temperate primeval forests have not yet been determined,due to the low number of intact forest sites.Here,we analyzed the general patterns of niche usage on trees by birds’assembla... Drivers of bird niche separation in temperate primeval forests have not yet been determined,due to the low number of intact forest sites.Here,we analyzed the general patterns of niche usage on trees by birds’assemblages.We tested how tree species affect the sharing of space in an assemblage of birds and their level of specialization.We conducted our study in the Białowieża primeval forest(NE Poland).During two breeding seasons,we observed bird positions on trees,divided into three vertical and six horizontal zones in 768 observation points.Based on the interaction networks framework we calculated the Kullback-Leibler distance d′as a metric of species specialization and the resource range RR index,which estimates the species’specificity based on the fraction of space utilized with a non-zero performance.The d′index was the highest in the lower understory for all parts of the tree on the basis of the position from the trunk.The RR index was the highest in the lower understory for all parts based on the position from the trunk.Regarding the tree species,the lowest d′index was observed in all tree species together,and hornbeam,whereas the highest in oak.At the tree species level,the RR index was the lowest for hornbeam.We show tree species importance in forest space sharing in the case of bird assemblages.Hornbeam,alder,and spruce are universal species that were used by birds almost entirely.In contrast,oak,lime,and maple were only partially used.Tree species with less complex structures could shape bird assemblages,as they could offer birds much fewer niches to realize.Therefore,we showed that high specialization and niche separation are drivers of high bird diversity.Consequently maintaining a diverse stand structure is crucial for biodiversity conservation. 展开更多
关键词 Tree use Niche partitioning Foraging guild SPECIALIZATION Habitat filtering Foundation species Tree species effect
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Adult dental epithelial stem cell-derived organoids deposit hydroxylapatite biomineral
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作者 Hyun-Yi Kim Victoria Cooley +7 位作者 Eun-Jung Kim Shujin Li Jong-Min Lee Dina Sheyfer Wenjun Liu Ophir D.Klein Derk Joester Han-Sung Jung 《International Journal of Oral Science》 SCIE CAS CSCD 2023年第4期676-690,共15页
Ameloblasts are specialized cells derived from the dental epithelium that produce enamel,a hierarchically structured tissue comprised of highly elongated hydroxylapatite(OHAp)crystallites.The unique function of the ep... Ameloblasts are specialized cells derived from the dental epithelium that produce enamel,a hierarchically structured tissue comprised of highly elongated hydroxylapatite(OHAp)crystallites.The unique function of the epithelial cells synthesizing crystallites and assembling them in a mechanically robust structure is not fully elucidated yet,partly due to limitations with in vitro experimental models.Herein,we demonstrate the ability to generate mineralizing dental epithelial organoids(DEOs)from adult dental epithelial stem cells(aDESCs)isolated from mouse incisor tissues.DEOs expressed ameloblast markers,could be maintained for more than five months(11 passages)in vitro in media containing modulators of Wnt,Egf,Bmp,Fgf and Notch signaling pathways,and were amenable to cryostorage.When transplanted underneath murine kidney capsules,organoids produced OHAp crystallites similar in composition,size,and shape to mineralized dental tissues,including some enamel-like elongated crystals.DEOs are thus a powerful in vitro model to study mineralization process by dental epithelium,which can pave the way to understanding amelogenesis and developing regenerative therapy of enamel. 展开更多
关键词 EPITHELIUM maintained specialized
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Uncovering genetic and metabolite markers associated with resistance against anthracnose fruit rot in northern highbush blueberry
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作者 MacKenzie Jacobs Samantha Thompson +12 位作者 Adrian E.Platts Melanie J.A.Body Alexys Kelsey Amanda Saad Patrick Abeli Scott J.Teresi Anthony Schilmiller Randolph Beaudry Mitchell J.Feldmann Steven J.Knapp Guo-qing Song Timothy Miles Patrick P.Edger 《Horticulture Research》 SCIE CSCD 2023年第10期25-36,共12页
Anthracnose fruit rot(AFR),caused by the fungal pathogen Colletotrichum fioriniae,is among the most destructive and widespread fruit disease of blueberry,impacting both yield and overall fruit quality.Blueberry cultiv... Anthracnose fruit rot(AFR),caused by the fungal pathogen Colletotrichum fioriniae,is among the most destructive and widespread fruit disease of blueberry,impacting both yield and overall fruit quality.Blueberry cultivars have highly variable resistance against AFR.To date,this pathogen is largely controlled by applying various fungicides;thus,a more cost-effective and environmentally conscious solution for AFR is needed.Here we report three quantitative trait loci associated with AFR resistance in northern highbush blueberry(Vaccinium corymbosum).Candidate genes within these genomic regions are associated with the biosynthesis of flavonoids(e.g.anthocyanins)and resistance against pathogens.Furthermore,we examined gene expression changes in fruits following inoculation with Colletotrichum in a resistant cultivar,which revealed an enrichment of significantly differentially expressed genes associated with certain specialized metabolic pathways(e.g.flavonol biosynthesis)and pathogen resistance.Using non-targeted metabolite profiling,we identified a flavonol glycoside with properties consistent with a quercetin rhamnoside as a compound exhibiting significant abundance differences among the most resistant and susceptible individuals from the genetic mapping population.Further analysis revealed that this compound exhibits significant abundance differences among the most resistant and susceptible individuals when analyzed as two groups.However,individuals within each group displayed considerable overlapping variation in this compound,suggesting that its abundance may only be partially associated with resistance against C.fioriniae.These findings should serve as a powerful resource that will enable breeding programs to more easily develop new cultivars with superior resistance to AFR and as the basis of future research studies. 展开更多
关键词 applying RESISTANCE specialized
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Advances in understanding epigenetic regulation of plant trichome development: a comprehensive review
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作者 Yuming Dong Sen Li +7 位作者 Haoying Wu Yiming Gao Zhongxuan Feng Xi Zhao Li Shan Zhongren Zhang Huazhong Ren Xingwang Liu 《Horticulture Research》 SCIE CSCD 2023年第9期293-305,共13页
Plant growth and development are controlled by a complex gene regulatory network,which is currently a focal point of research.It has been established that epigenetic factors play a crucial role in plant growth.Trichom... Plant growth and development are controlled by a complex gene regulatory network,which is currently a focal point of research.It has been established that epigenetic factors play a crucial role in plant growth.Trichomes,specialized appendages that arise from epidermal cells,are of great significance in plant growth and development.As a model system for studying plant development,trichomes possess both commercial and research value.Epigenetic regulation has only recently been implicated in the development of trichomes in a limited number of studies,and microRNA-mediated post-transcriptional regulation appears to dominate in this context.In light of this,we have conducted a review that explores the interplay between epigenetic regulations and the formation of plant trichomes,building upon existing knowledge of hormones and transcription factors in trichome development.Through this review,we aim to deepen our understanding of the regulatory mechanisms underlying trichome formation and shed light on future avenues of research in the field of epigenetics as it pertains to epidermal hair growth. 展开更多
关键词 development. COMPREHENSIVE specialized
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