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Rare primary gastric peripheral T-cell lymphoma not otherwise specified:A case report
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作者 Hee Ryeong Jang Kyungyul Lee Kyu-Hyoung Lim 《World Journal of Clinical Cases》 SCIE 2024年第35期6834-6839,共6页
BACKGROUND Gastrointestinal lymphoma typically arises in the stomach,small bowel,or colorectum and is usually a B-cell lymphoma.However,primary T-cell lymp-homas originating in the stomach are particularly rare.Gastri... BACKGROUND Gastrointestinal lymphoma typically arises in the stomach,small bowel,or colorectum and is usually a B-cell lymphoma.However,primary T-cell lymp-homas originating in the stomach are particularly rare.Gastric peripheral T-cell lymphoma-not otherwise specified(PTCL-NOS)is an extremely rare subtype.CASE SUMMARY We report a 63-year-old male presenting with epigastric pain.Esophagogastro-duodenoscopy revealed a large ulcerative lesion in the gastric cardia.Biopsy and immunohistochemical profiling confirmed PTCL-NOS.Imaging indicated stage II disease involving the stomach and intra-abdominal lymph nodes.The patient is planned to undergo cyclophosphamide,doxorubicin,vincristine,and prednisone or cyclophosphamide,doxorubicin,vincristine,prednisone,and etoposide chemo-therapy.CONCLUSION This case highlights the necessity of considering PTCL-NOS in differential diag-noses of gastric lesions.Comprehensive histopathological and immunohistoche-mical analysis is crucial for accurate diagnosis and guiding treatment. 展开更多
关键词 Gastrointestinal lymphoma STOMACH Peripheral T-cell lymphoma-not otherwise specified Extranodal lymphoma Case report
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Autoimmune pancreatitis not otherwise specified(NOS): Clinical features and outcomes of the forgotten type 被引量:2
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作者 Nicolò de Pretis Filippo Vieceli +3 位作者 Alessandro Brandolese Lorenzo Brozzi Antonio Amodio Luca Frulloni 《Hepatobiliary & Pancreatic Diseases International》 SCIE CAS CSCD 2019年第6期576-579,共4页
Background:Autoimmune pancreatitis(AIP)is a well-recognized fibroinflammatory disease of the pancreas.Despite the significant number of studies published on AIP type 1 and 2,no studies have been focused on AIP type no... Background:Autoimmune pancreatitis(AIP)is a well-recognized fibroinflammatory disease of the pancreas.Despite the significant number of studies published on AIP type 1 and 2,no studies have been focused on AIP type not otherwise specified(NOS)and therefore very little is known about clinical features and long-term outcomes of these patients.The aim of this study was to investigate clinical and radiological features of AIP type NOS-patients.Methods:Patients classified as AIP type NOS at clinical onset included in our database prospectively maintained since 1995 were evaluated.Epidemiological,clinical data were collected and analyzed.Results:Forty-six patients were included in the study.The clinical onset was mainly characterized by weight loss,jaundice and acute pancreatitis.Eight patients(17.4%)were reclassified as AIP type 2 during follow-up because of the development of ulcerative colitis.Seven patients(15.2%)experienced relapse after steroid treatment but only one(2.2%)needed immunosuppressive drugs because of recurrent relapses.Conclusions:AIP type NOS shares clinical features similar to AIP type 2 and a relevant proportion of patients was reclassified as AIP type 2 during follow-up because of the development of ulcerative colitis.The risk of relapse is low but not irrelevant. 展开更多
关键词 AUTOIMMUNE PANCREATITIS Not otherwise specified OUTCOME FOLLOW-UP Therapy
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Function of pioneer neurons specified by the basic helix-loop-helix transcription factor atonal in neural development
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作者 Misako Okumura Takahiro Chihara 《Neural Regeneration Research》 SCIE CAS CSCD 2016年第9期1394-1395,共2页
Basic helix-loop-helix (bHLH) transcription factors regulate the differentiation of various tissues in a vast diversity of species. The bHLH protein Atonal was first identified as a proneural gene involved in the fo... Basic helix-loop-helix (bHLH) transcription factors regulate the differentiation of various tissues in a vast diversity of species. The bHLH protein Atonal was first identified as a proneural gene involved in the formation of mechanosensory cells and photoreceptor cells in Drosophila (larman et al., 1993, 1994). Atonal is expressed in sensory organ precursors and is required and sufficient for the development of chordotonal organs (Jar- man et al., 1993). Moreover, Atonal expression is observed in the developing eye and is essential for the differentiation of R8 photoreceptors, which are the first photoreceptors that appear during development. Atonal is not involved in the formation of other photoreceptors (R1-R7) directly. However, R8 photore- ceptors recruit other photoreceptors from the surrounding cells (Jarman et al., 1994). 展开更多
关键词 ORN Function of pioneer neurons specified by the basic helix-loop-helix transcription factor atonal in neural development
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Backward Dijkstra Algorithms for Finding the Departure Time Based on the Specified Arrival Time for Real-Life Time-Dependent Networks
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作者 Gelareh Bakhtyar Vi Nguyen +1 位作者 Mecit Cetin Duc Nguyen 《Journal of Applied Mathematics and Physics》 2016年第1期1-7,共7页
A practical transportation problem for finding the “departure” time at “all source nodes” in order to arrive at “some destination nodes” at specified time for both FIFO (i.e., First In First Out) and Non-FIFO “... A practical transportation problem for finding the “departure” time at “all source nodes” in order to arrive at “some destination nodes” at specified time for both FIFO (i.e., First In First Out) and Non-FIFO “Dynamic ” Networks is considered in this study. Although shortest path (SP) for dynamic networks have been studied/documented by various researchers, contributions from this present work consists of a sparse matrix storage scheme for efficiently storing large scale sparse network’s connectivity, a concept of Time Delay Factor (TDF) combining with a “general piece- wise linear function” to describe the link cost as a function of time for Non-FIFO links’ costs, and Backward Dijkstra SP Algorithm with simple heuristic rules for rejecting unwanted solutions during the backward search algorithm. Both small-scale (academic) networks as well as large- scale (real-life) networks are investigated in this work to explain and validate the proposed dynamic algorithms. Numerical results obtained from this research work have indicated that the newly proposed dynamic algorithm is reliable, and efficient. Based on the numerical results, the calculated departure time at the source node(s), for a given/specified arrival time at the destination node(s), can be non-unique, for some Non-FIFO networks’ connectivity. 展开更多
关键词 Backward Dijkstra Dynamic Networks Piece-Wise Linear Function specified Arrival Time
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A Fatal Case of Chronic Eosinophilic Leukemia Not Otherwise Specified (CEL-NOS) in a 19-Year-Old Male with Acute Transformation into Blast Crisis
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作者 Basheer Al-Sanouri Basheer Al-Sanouri +1 位作者 Yahya Maslamani Ibrahim Al-Sanouri 《Case Reports in Clinical Medicine》 2016年第12期528-540,共14页
Chronic eosinophilic leukemia (CEL) is a rare disorder that is characterized by hypereosinophilia with increased number of blood or marrow blasts (>5% and <20%). CEL is distinguished from hypereosinophilic syndr... Chronic eosinophilic leukemia (CEL) is a rare disorder that is characterized by hypereosinophilia with increased number of blood or marrow blasts (>5% and <20%). CEL is distinguished from hypereosinophilic syndrome (HES) by the presence of eosinophilic clonality. Chronic eosinophilic leukemia not otherwise specified (CEL-NOS) diagnosis is made when no fusion genes are detected by most modern molecular testing, particularly the most common fusion gene FIP1L-1/PDGFRA (Factor Interacting with PAP like-1/Platelet-Derived Growth Factor Receptor Alpha). This disease is very rare, and its description in the literature is not well characterized. We report a fetal case of severe CEL-NOS in a 19-year-old male who presented with a plethora of clinical features consists of constitutional symptoms, pancytopenia, intravascular thrombosis, acute stroke and endomyocardial infiltrates. The course of his disease was aggressive and resistant to conventional treatment. After a short period of improvement, an acute transformation into blast crisis (BC) had occurred. The diagnosis was confirmed by morphology and immunophenotyping of bone marrow biopsy. The patient eventually died of heart failure and sepsis. To our knowledge this is the first case report of fatal CEL-NOS transforming into severe blast crisis. 展开更多
关键词 Hypereosinophilic Syndrome (HES) Eosinophils Degranulation WHO World Health Organization Classification Chronic Eosinophilic Leukemia Not Other-wise specified (CEL-NOS) Fluorescent In Situ Hybridization (FISH) Tyrosine Kinase Inhibitor Imatinib Acute Transformation into Blast Crisis
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A general Boolean semantic modelling approach for complex and intelligent industrial systems in the framework of DES
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作者 XU Changyi WANG Yun +1 位作者 DUAN Yiman ZHANG Chao 《Journal of Systems Engineering and Electronics》 SCIE CSCD 2024年第5期1219-1230,共12页
Discrete event system(DES)models promote system engineering,including system design,verification,and assessment.The advancement in manufacturing technology has endowed us to fabricate complex industrial systems.Conseq... Discrete event system(DES)models promote system engineering,including system design,verification,and assessment.The advancement in manufacturing technology has endowed us to fabricate complex industrial systems.Consequently,the adoption of advanced modeling methodologies adept at handling complexity and scalability is imperative.Moreover,industrial systems are no longer quiescent,thus the intelligent operations of the systems should be dynamically specified in the model.In this paper,the composition of the subsystem behaviors is studied to generate the complexity and scalability of the global system model,and a Boolean semantic specifying algorithm is proposed for generating dynamic intelligent operations in the model.In traditional modeling approaches,the change or addition of specifications always necessitates the complete resubmission of the system model,a resource-consuming and error-prone process.Compared with traditional approaches,our approach has three remarkable advantages:(i)an established Boolean semantic can be fitful for all kinds of systems;(ii)there is no need to resubmit the system model whenever there is a change or addition of the operations;(iii)multiple specifying tasks can be easily achieved by continuously adding a new semantic.Thus,this general modeling approach has wide potential for future complex and intelligent industrial systems. 展开更多
关键词 industrial complex system operation specifying Boolean semantic discrete event system(DES)theory intelligent operation
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Overall Survival with Adjuvant Pembrolizumab in Renal-Cell Carcinoma
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作者 Toni K Choueiri 《四川生理科学杂志》 2024年第4期872-872,共1页
Background:Adjuvant pembrolizumab therapy after surgery for renal-cell carcinoma was approved on the basis of a significant improvement in disease-free survival in the KEYNOTE-564 trial.Whether the results regarding o... Background:Adjuvant pembrolizumab therapy after surgery for renal-cell carcinoma was approved on the basis of a significant improvement in disease-free survival in the KEYNOTE-564 trial.Whether the results regarding overall survival from the third prespecified interim analysis of the trial would also favor pembrolizumab was uncertain.Methods:In this phase 3,double-blind,placebo-controlled trial,we randomly assigned(in a 1:1 ratio)participants with clear-cell renal-cell carcinoma who had an increased risk of recurrence after surgery to receive pembrolizumab(at a dose of 200 mg)or placebo every 3 weeks for up to 17 cycles(approximately 1 year)or until recurrence,the occurrence of unacceptable toxic effects,or withdrawal of consent.A significant improvement in disease-free survival according to investigator assessment(the primary end point)was shown previously.Overall survival was the key secondary end point.Safety was a secondary end point. 展开更多
关键词 CARCINOMA SURVIVAL specified
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Usefulness of CT angiography in diagnosing acute gastrointestinal bleeding:A meta-analysis 被引量:20
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作者 Lian-Ming Wu Jian-Rong Xu +1 位作者 Yan Yin Xin-Hua Qu 《World Journal of Gastroenterology》 SCIE CAS CSCD 2010年第31期3957-3963,共7页
AIM: To analyze the accuracy of computed tomography (CT) angiography in the diagnosis of acute gastrointestinal (GI) bleeding. METHODS: The MEDLINE, EMBASE, Cancerlit, Cochrane Library database, Sciencedirect, Springe... AIM: To analyze the accuracy of computed tomography (CT) angiography in the diagnosis of acute gastrointestinal (GI) bleeding. METHODS: The MEDLINE, EMBASE, Cancerlit, Cochrane Library database, Sciencedirect, Springerlink and Scopus, from January 1995 to December 2009, were searched for studies evaluating the accuracy of CT angiography in diagnosing acute GI bleeding. Studies were included if the ycompared CT angiography to a reference standard of upper GI endoscopy, colonoscopy, angiography or surgery in the diagnosis of acute GI bleeding. Meta-analysis methods were used to pool sensitivity and specificity and to construct summary receiver-operating characteristic. RESULTS: A total of 9 studies with 198 patients were included in this meta-analysis. Data were used to form 2 × 2 tables. CT angiography showed pooled sensi-tivity of 89% (95% CI: 82%-94%) and specificity of 85% (95% CI: 74%-92%), without showing significant heterogeneity (χ2 = 12.5, P = 0.13) and (χ2 = 22.95, P = 0.003), respectively. Summary receiver operating characteristic analysis showed an area under the curve of 0.9297. CONCLUSION: CT angiography is an accurate, costeffective tool in the diagnosis of acute GI bleeding and can show the precise location of bleeding, thereby directing further management. 展开更多
关键词 ANGIOGRAPHY Gastrointestinal hemorrhage META-ANALYSIS Sensitivity and specifi city TOMOGRAPHY
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Shakedown Criterion Employing Actual Residual Stress Field and Its Application in Numerical Shakedown Analysis 被引量:4
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作者 ZOU Zongyuan GUO Baofeng +2 位作者 LI Yinxiao JIN Miao ZHAO Shiyan 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2015年第5期919-927,共9页
Construction of the static admissible residual stress field and searching the optimal field are key tasks in the shakedown analysis methods applying the static theorem. These methods always meet dimension obstacles wh... Construction of the static admissible residual stress field and searching the optimal field are key tasks in the shakedown analysis methods applying the static theorem. These methods always meet dimension obstacles when dealing with complex problems. In this paper, a novel shakedown criterion is proposed employing actual residual stress field based on the static shakedown theorem. The actual residual stress field used here is produced under a specified load path, which is a sequence of proportional loading and unloading from zero to all the vertices of the given load domain. This ensures that the shakedown behavior in the whole load domain can be determined based on the theorem proposed by K6nig. The shakedown criterion is then implemented in numerical shakedown analysis, The actual residual stress fields are calculated by incremental finite element elastic-plastic analysis technique for finite deformation under the specified load path with different load levels. The shakedown behavior and the shakedown limit load are determined according to the proposed criterion. The validation of the criterion is performed by a benchmark shakedown example, which is a square plate with a central hole under biaxial loading. The results are consistent with existing results in the literatures and are validated by full cyclic elastic-plastic finite element analysis. The numerical shakedown analysis applying the proposed criterion avoids processing dimension obstacles and performing full cyclic elastic-plastic analysis under arbitrary load paths which should be accounted for appearing. The effect of material model and geometric changes on shakedown behavior can he considered conveniently. 展开更多
关键词 ELASTOPLASTIC finite element shakedown criterion specified load path actual residual stress field
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Modified Static Floor Field and Exit Choice for Pedestrian Evacuation 被引量:5
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作者 XU Yan HUANG Hai-Jun YONG Gui 《Chinese Physics Letters》 SCIE CAS CSCD 2012年第8期48-51,共4页
An improved floor field model is proposed to simulate the pedestrian evacuation behavior in a room with multiple exits by modifying the static floor field.The modified static floor field is determined additionally by ... An improved floor field model is proposed to simulate the pedestrian evacuation behavior in a room with multiple exits by modifying the static floor field.The modified static floor field is determined additionally by two cognitive coefficients of exit width and congestion degree around the exits.The logit-based discrete choice principle is used to govern the initial exit selection strategy based on the modified static floor field in such a scenario that pedestrians are distributed in the room's specified zone.Simulation results show that the proposed model can better perform the evacuation process.Sensitivity analyses of the model parameters are also presented. 展开更多
关键词 FLOOR PROCESS specified
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Comparison of plasma microRNA-1 and cardiac troponin T in early diagnosis of patients with acute myocardial infarction 被引量:20
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作者 Li-ming Li Wen-bo Cai +3 位作者 Qin Ye Jian-min Liu Xin Li Xiao-xing Liao 《World Journal of Emergency Medicine》 CAS 2014年第3期182-186,共5页
BACKGROUND:Early reperfusion can effectively treat acute myocardial infarction(AMI) and reduce the mortality signif icantly. This study aimed to compare the role of plasma microRNA-1(miR-1) and cardiac troponin T(cTnT... BACKGROUND:Early reperfusion can effectively treat acute myocardial infarction(AMI) and reduce the mortality signif icantly. This study aimed to compare the role of plasma microRNA-1(miR-1) and cardiac troponin T(cTnT) in early diagnosis of AMI patients.METHODS:From May 2011 to May 2012,plasma samples were collected from 56 AMI patients and 28 non-AMI controls. The expression of plasma miR-1 was measured by quantitative reverse transcription-polymerase chain reaction(qRT-PCR),and the level of plasma cTnT was measured using electrochemiluminescence-based methods on an Elecsys 2010 Immunoassay Analyzer. SPSS 16.0 was used for the statistical analysis of the results. Data were expressed as mean±standard deviation unless otherwise described. The differences about clinical characteristics between the AMI patients and controls were tested using Student's t test or Fisher's exact test. The Mann-Whitney U test was conducted to compare the expression of microRNAs between the AMI patients and controls. MicroRNAs expression between different intervals of the AMI patients was compared using Wilcoxon's signed-rank test. The receiver operating characteristic(ROC) curve was established to discriminate the AMI patients from the controls.RESULTS:In the present study,the expression of plasma miR-1 was signifi cantly increased in the AMI patients compared with the healthy controls(P<0.01). The plasma miR-1 in the AMI patients decreased to the normal level at 14 days(P>0.05). The expression of plasma miR-1 was not related to the clinical characteristics of the study population(P>0.05). ROC curve analyses demonstrated that miR-1 was specifi c and sensitive for the early diagnosis of AMI,but not superior to cTnT.CONCLUSION:Plasma miR-1 could be used in the early diagnosis of AMI,but it is similar to cTnT. 展开更多
关键词 MICRORNA-1 High sensitive cardiac troponin T Acute myocardial infarction BIOMARKER Early diagnosis Specifi city Sensitivity
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Disordered eating behaviors in type 1 diabetic patients 被引量:2
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作者 Alejandra Larraaga Ricardo V García-Mayor María F Docet 《World Journal of Diabetes》 SCIE CAS 2011年第11期189-195,共7页
Patients with type 1 diabetes mellitus are at high risk for disordered eating behaviors (DEB). Due to the fact that type 1 diabetes mellitus is one of the most common chronic illnesses of childhood and adolescence, th... Patients with type 1 diabetes mellitus are at high risk for disordered eating behaviors (DEB). Due to the fact that type 1 diabetes mellitus is one of the most common chronic illnesses of childhood and adolescence, the coexistence of eating disorders (ED) and diabetes often affects adolescents and young adults. Since weight management during this state of development can be especially diff icult for those with type 1 diabetes, some diabetics may restrict or omit insulin, a condition known as diabulimia, as a form of weight control. It has been clearly shown that ED in type 1 diabetics are associated with impaired metabolic control, more frequent episodes of ketoacidosis and an earlier than expected onset of diabetes-related microvascular complications, particularly retinopathy. The management of these conditions requires a multidisciplinary team formed by an endocrinologist/diabetologist, a nurse educator, a nutritionist, a psychologist and, frequently, a psychiatrist. The treatment of type 1 diabetes patients with DEB and ED should have the following compo- nents: diabetes treatment, nutritional management and psychological therapy. A high index of suspicion of the presence of an eating disturbance, particularly among those patients with persistent poor metabolic control, repeated episodes of ketoacidosis and/or weight andshape concerns are recommended in the initial stage of diabetes treatment, especially in young women. Given the extent of the problem and the severe medical risk associated with it, more clinical and technological research aimed to improve its treatment is critical to the future health of this at-risk population. 展开更多
关键词 ANOREXIA nervosa BULIMIA nervosa EATING DISORDERS not otherwise specified DISORDERED EATING behaviors TYPE 1 diabetes
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Functional food products in Japan:A review 被引量:4
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作者 Shun Iwatani Naoyuki Yamamoto 《Food Science and Human Wellness》 SCIE 2019年第2期96-101,共6页
Japan has a long history of using foods with health benefits and Japanese people are well-known for their longevity.In 1991,the Ministry of Health,Labor and Welfare introduced a functional food regulation called“food... Japan has a long history of using foods with health benefits and Japanese people are well-known for their longevity.In 1991,the Ministry of Health,Labor and Welfare introduced a functional food regulation called“foods for specified health uses”(FOSHU)in Japan.After the introduction of the functional food system,many clinically proven FOSHU products with health benefits have been developed and launched in the market.As a result,the net sales of FOSHU products reached 6.2 billion dollars in 2007.Most of the health claims relate to improving gastro-intestinal health using probiotics.Triglycerides,high blood pressure,high LDL-cholesterol,and high blood glucose are mainly associated with the related health claims.After 2007,the market for FOSHU products was almost saturated.However,a novel functional regulatory system\called“Foods with Function Claims”was established in 2015 based on the Dietary Supplement Health and Education Act system established in the USA.Major health claims in the new regulation system are associated with fatigue,eyes,memory,stress,sleep,joints,blood flow,body temperature,muscles,and Body Mass Index.After the introduction of the new system,the total sales for functional foods including FOSHU products reached 8 billion dollars in 2018.The new functional regulatory system is more flexible in terms of health claims,the protocol for clinical studies,and the required results.Therefore,the market for new regulatory products is still growing.In the present paper,the potential of both regulatory systems and some related issues will be discussed. 展开更多
关键词 Food for specified health uses FOSHU New Functional Foods Foods with function claims Consumer Affairs Agency Approval
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Prevalence of functional dyspepsia and its subgroups in patients with eating disorders 被引量:6
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作者 Antonella Santonicola Monica Siniscalchi +3 位作者 Pietro Capone Serena Gallotta Carolina Ciacci Paola Iovino 《World Journal of Gastroenterology》 SCIE CAS CSCD 2012年第32期4379-4385,共7页
AIM:To study the prevalence of functional dyspepsia(FD)(Rome Ⅲ criteria) across eating disorders(ED),obese patients,constitutional thinner and healthy volunteers.METHODS:Twenty patients affected by anorexia nervosa,6... AIM:To study the prevalence of functional dyspepsia(FD)(Rome Ⅲ criteria) across eating disorders(ED),obese patients,constitutional thinner and healthy volunteers.METHODS:Twenty patients affected by anorexia nervosa,6 affected by bulimia nervosa,10 affected by ED not otherwise specified according to diagnostic and statistical manual of mental disorders,4th edition,nine constitutional thinner subjects and,thirtytwo obese patients were recruited from an outpatients clinic devoted to eating behavior disorders.Twentytwo healthy volunteers matched for age and gender were enrolled as healthy controls.All participants underwent a careful clinical examination.Demographic and anthropometric characteristics were obtained from a structured questionnaires.The presence of FD and,its subgroups,epigastric pain syndrome and postprandial distress syndrome(PDS) were diagnosed according to Rome Ⅲ criteria.The intensity-frequency score of broader dyspeptic symptoms such as early satiety,epigastric fullness,epigastric pain,epigastric burning,epigastric pressure,belching,nausea and vomiting were studied by a standardized questionnaire(0-6).Analysis of variance and post-hoc Sheffè tests were used for comparisons.RESULTS:90% of patients affected by anorexia nervosa,83.3% of patients affected by bulimia nervosa,90% of patients affected by ED not otherwise specified,55.6% of constitutionally thin subjects and 18.2% healthy volunteers met the Postprandial Distress Syndrome Criteria(χ 2,P < 0.001).Only one bulimic patient met the epigastric pain syndrome diagnosis.Postprandial fullness intensity-frequency score was significantly higher in anorexia nervosa,bulimia nervosa and ED not otherwise specified groups compared to the score calculated in the constitutional thinner group(4.15 ± 2.08 vs 1.44 ± 2.35,P = 0.003;5.00 ± 2.45vs 1.44 ± 2.35,P = 0.003;4.10 ± 2.23vs 1.44 ± 2.35,P = 0.002,respectively),the obese group(4.15 ± 2.08vs 0.00 ± 0.00,P < 0.001;5.00 ± 2.45vs 0.00 ± 0.00,P < 0.001;4.10 ± 2.23 vs 0.00 ± 0.00,P < 0.001,respectively) and healthy volunteers(4.15 ± 2.08 vs 0.36 ± 0.79,P < 0.001;5.00 ± 2.45 vs 0.36 ± 0.79,P < 0.001;4.10 ± 2.23 vs 0.36 ± 0.79,P < 0.001,respectively).Early satiety intensity-frequency score was prominent in anorectic patients compared to bulimic patients(3.85 ± 2.23 vs 1.17 ± 1.83,P = 0.015),obese patients(3.85 ± 2.23 vs 0.00 ± 0.00,P < 0.001) and healthy volunteers(3.85 ± 2.23 vs 0.05 ± 0.21,P < 0.001).Nausea and epigastric pressure were increased in bulimic and ED not otherwise specified patients.Specifically,nausea intensity-frequencyscore was significantly higher in bulimia nervosa and ED not otherwise specified patients compared to anorectic patients(3.17 ± 2.56 vs 0.89 ± 1.66,P = 0.04;2.70 ± 2.91 vs 0.89 ± 1.66,P = 0.05,respectively),constitutional thinner subjects(3.17 ± 2.56 vs 0.00 ± 0.00,P = 0.004;2.70 ± 2.91 vs 0.00 ± 0.00,P = 0.005,respectively),obese patients(3.17 ± 2.56 vs 0.00 ± 0.00,P < 0.001;3.17 ± 2.56 vs 0.00 ± 0.00,P < 0.001 respectively) and,healthy volunteers(3.17 ± 2.56 vs 0.17 ± 0.71,P = 0.002;3.17 ± 2.56 vs 0.17 ± 0.71,P = 0.001,respectively).Epigastric pressure intensityfrequency score was significantly higher in bulimic and ED not otherwise specified patients compared to constitutional thin subjects(4.67 ± 2.42 vs 1.22 ± 1.72,P = 0.03;4.20 ± 2.21 vs 1.22 ± 1.72,P = 0.03,respectively),obese patients(4.67 ± 2.42 vs 0.75 ± 1.32,P = 0.001;4.20 ± 2.21vs 0.75 ± 1.32,P < 0.001,respectively) and,healthy volunteers(4.67 ± 2.42 vs 0.67 ± 1.46,P = 0.001;4.20 ± 2.21vs 0.67 ± 1.46,P = 0.001,respectively).Vomiting was referred in 100% of bulimia nervosa patients,in 20% of ED not otherwise specified patients,in 15% of anorexia nervosa patients,in 22% of constitutional thinner subjects,and,in 5.6% healthy volunteers(χ 2,P < 0.001).CONCLUSION:PDS is common in eating disorders.Is it mandatory in outpatient gastroenterological clinics to investigate eating disorders in patients with PDS? 展开更多
关键词 Eating disorders Functional dyspepsia Post prandial distress syndrome Epigastric pain sindrome Rome criteria Upper abdominal symptoms Anorexia nervosa Bulimia nervosa Eating disorders not otherwise specified Constitutional thinness
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Modulation of lysophosphatidic acid (LPA) receptor activity: the key to successful neural regeneration? 被引量:1
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作者 Isabel Gross Anja U.Brauer 《Neural Regeneration Research》 SCIE CAS CSCD 2020年第1期53-54,共2页
The central nervous system(CNS)is characterized by a remarkably elaborate cellular architecture comprising large numbers of glial and neuronal cells with enormous functional diversity,organized into highly complex and... The central nervous system(CNS)is characterized by a remarkably elaborate cellular architecture comprising large numbers of glial and neuronal cells with enormous functional diversity,organized into highly complex and specific networks.During development,the various neural cell types must first be correctly specified,then assume their appropriate positions through carefully choreographed cellular migration,and finally establish and refine their functional connections,often over long distances.The end result of all these processes is an extraordinarily intricate anatomical structure,able to receive,integrate,and store information and orchestrate appropriate responses. 展开更多
关键词 NEURAL specified finally
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Design of adaptive intuitionistic fuzzy controller for synchronisation of uncertain chaotic systems 被引量:1
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作者 Mohamed Hamdy Salah Helmy Mohamed Magdy 《CAAI Transactions on Intelligence Technology》 EI 2020年第4期237-246,共10页
This study presents the synchronisation between two non-linear Lorenz chaotic systems using an adaptive intuitionistic fuzzy controller(AIFC).This problem is solved in the presence of external disturbances and uncerta... This study presents the synchronisation between two non-linear Lorenz chaotic systems using an adaptive intuitionistic fuzzy controller(AIFC).This problem is solved in the presence of external disturbances and uncertainties.Two classes of Lorenz systems have been formulated one as the master and the other as the slave.The master and slave systems have different initial conditions.Under different initial conditions,both systems diverge.This is called the butterfly effect that rules the behaviour of chaotic systems.AIFC is chosen as a different method that has not been used before to synchronise the chaotic systems.The scaling factors of the inputs and the output of the intuitionistic fuzzy controller(IFC)are tuned using the artificial bee colony(ABC)algorithm depending on a specified objective function.Then IFC stability is studied when it is applied to synchronise the Lorenz system.The simulation results achieved to assess the adequacy of the proposed control and to exhibit its dependability to synchronise the Lorenz system. 展开更多
关键词 function. CHAOTIC specified
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Design of a DSLM-based cerebral palsy action rehabilitation training system 被引量:1
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作者 Lu Zhenli Ma Zhipeng +8 位作者 Shen Xuanlin Borovac Branislav Liu Yan Shan Changkao Wang Hong Zhao Yu Koumiana ilieva Bojan Nemec Maijan Memik 《High Technology Letters》 EI CAS 2020年第3期342-348,共7页
Based on domain specified language mechanism(DSLM),the architecture of the robotic training system for the rehabilitation of children with cerebral palsy(CP)is designed.Application of human-computer interaction(HCI)mo... Based on domain specified language mechanism(DSLM),the architecture of the robotic training system for the rehabilitation of children with cerebral palsy(CP)is designed.Application of human-computer interaction(HCI)motion recognition technology is combined with Kinect to improve the effect of cerebral palsy rehabilitation training.In this system,Kinect's bone recognition method is used to judge the patient's training movements,and the collected bone movement information is judged.The human-computer interaction function is based on the Microsoft foundation classes function of Visual Studio based on DSLM development,which can realize real-time interactive training and evaluation of people and actions,and record the training information of patients.The system combines the designed small game to train the upper limb movement ability and reaction ability of the cerebral palsy patient,and provides key technology for improving the cerebral palsy rehabilitation training system. 展开更多
关键词 domain specified language mechanism(DSLM) robot-assistant system humancomputer interaction(HCI) cerebral palsy rehabilitation training
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Determination of the Fracture Toughness of Optomechanical Devices 被引量:1
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作者 George A. Kurilenko Valerik S. Ayrapetyan 《Optics and Photonics Journal》 2016年第11期298-304,共8页
Static fracture toughness characteristics are traditionally determined in tests of standard notched specimens using a P-V curve, where P is the load and V is the notch-opening displacement. This curve has a characteri... Static fracture toughness characteristics are traditionally determined in tests of standard notched specimens using a P-V curve, where P is the load and V is the notch-opening displacement. This curve has a characteristic point Q. At the load P<sub>Q</sub> corresponding to this point, the crack starts to propagate. For this load, the fracture toughness characteristics are then calculated. In brittle (elastic) fracture, the P-V curve at the onset of crack propagation has an extremum (or a local extremum), from whose ordinate PQ</sub> is determined with sufficient accuracy. In ductile and elastic-ductile fracture, P-V curves are monotonically increasing, and PQ</sub> is calculated using the 5% secant offset method without taking into account the characteristics of the material, so that the PQ</sub> is determined inaccurately. To improve the accuracy of PQ</sub> determination, we propose a thermographic method for determining the fracture toughness of metals. This method involves plotting the load P against the temperature change &Delta;Т over a relatively short period of time at the notch tip. This plot is then transformed to a P-ΔS curve, where ΔS is the specific entropy increment at the notch tip, which is calculated through &Delta;Т. This thermodynamic diagram has a characteristic step at the beginning of crack propagation, and from the ordinate of this step, PQ</sub> can be determined much more accurately. Furthermore, in the thermographic method, the preparation of test specimens can be simplified by replacing the process of growing a fatigue crack at the tip of a notch by making a sharp cut, which provides significant time savings. Statistical processing and comparison of test results of steel 20 specimens using the conventional and thermographic methods have shown the advantages of the thermographic method in accuracy and complexity. 展开更多
关键词 Crack Resistance Stress Intensity Factor Temperature ENTROPY specified Load INCISION CUT Crack Motion
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浅析HMPE缆绳对LNG船系泊件强度的潜在影响 被引量:1
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作者 宋锋 杨瑞玲 徐亮 《中国水运(下半月)》 2018年第3期93-95,共3页
LNG船由于货物传输时的高风险性,以及船对岸、船对船靠泊的多样性,对系泊稳定性的要求可谓是重中之重。为了不断完善系泊的设计标准,通过多年的系泊实践,以及对船员系泊经验的总结,OCIMF给出了系泊力计算时对风力,水流力,波浪等自然环... LNG船由于货物传输时的高风险性,以及船对岸、船对船靠泊的多样性,对系泊稳定性的要求可谓是重中之重。为了不断完善系泊的设计标准,通过多年的系泊实践,以及对船员系泊经验的总结,OCIMF给出了系泊力计算时对风力,水流力,波浪等自然环境条件的选取引导,对系泊缆绳的材质,强度及断裂伸长率做出了详细对比及选取推荐,对导缆孔等系泊件强度计算时的缆绳合力包角及安全系数给出了合理性的范围指导。而在实船设计中,发现超高分子系泊缆绳HMPE和系泊件强度之间产生了一种不可调和的矛盾,确实存在极端受力下系泊件先于HMPE缆绳破损的潜在风险,进而导致缆绳及系泊件碰坏甲板设备和管路。后面分别从系泊力计算,系泊缆绳的选取,缆绳工厂拉力试验,系泊件的选取,实际系泊工况出发,得出最终结论,此风险几乎不可能出现。 展开更多
关键词 OCIMF(国际海事石油论坛协会) HMPE(High MODULUS Polyethylene) MBL(Minimum Breaking Load) SWL(Safe Working Load) SMYS(specified Minimum Yield Stress)
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A Comparative Study of News Sources in Sino-English News Reports Related to Nobel Winner Mo Yan
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作者 徐莺 《海外英语》 2014年第3X期211-213,共3页
News,by no means a neutral vehicle,is in reality ideologically driven and controlled by news values to which the use of news sources is of great help.Geis once argued that the single most important power of the press ... News,by no means a neutral vehicle,is in reality ideologically driven and controlled by news values to which the use of news sources is of great help.Geis once argued that the single most important power of the press is its capacity to say what the important issues are at any particular time and to determine whose voices will be heard on any given issue(Geis,1987:10).News sources may tell readers something,but it may also mislead readers since people cannot think about and make sense out of news events without imposing a bias on the news.It is,therefore,worth our attention and effort to understand how news source works,how it affects readers'perceptions of news events,how it is produced,how it is shaped by values and ideology. 展开更多
关键词 MO Yan accessed VOICES newsworthiness specifiable
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