Spectral Domain Optical Coherence Tomography of Vogt-Koyanagi-Harada Disease: Novel Findings and New Insights into the Pathogenesis

Objective To provide novel spectral domain optical coherence tomography (SD OCT) findings of Vogt-Koyanagi-Harada (VKH) disease as well as new insights into the pathogenesis of this disease. Methods Detailed SD OCT and fluorescein angiography (FA) findings of 18 consecutive VKH patients (11 women and 7 men) from December 2007 to April 2009 who were in acute uveitic stage at presentation were reviewed. All the patients had been followed up for at least 6 months with reevaluation(s) of SD OCT performed in 10 patients. Results Intraretinal cysts were found to be located in various layers of the outer retina. In addition to the photoreceptor layer, they could also be found between the outer plexiform layer and the outer nuclear layer, or spanning the external limiting membrane. On FA, intraretinal cysts could be hypofluorescent, normofluorescent, or hyperfluorescent. Some intraretinal cysts had a characteristic FA pattern, in which a small round hypofluorescent area was surrounded by a ring of hyperfluorescence (donut-shaped dye pooling). Subretinal fibrinoid deposit appeared in acute uveitic stage in two severe VKH patients and seemed to develop from subretinal exudates and evolved into typical subretinal fibrosis. Gradual transfiguration/migration and progressive proliferation/pigmentation of the subretinal fibrinoid deposit/subretinal fibrosis was observed in one patient. Conclusions Intraretinal cysts could form in various layers of the outer retina and may result from extension of choroidal inflammation. Subretinal fibrosis may develop from subretinal exudates in VKH patients and may cause substantial visual impairment.

Light-scattering model for aerosol particles with irregular shapes and inhomogeneous compositions using a parallelized pseudo-spectral time-domain technique

To improve the modeling accuracy of radiative transfer, the scattering properties of aerosol particles with irregular shapes and inhomogeneous compositions should be simulated accurately. To this end, a light-scattering model for nonspherical particles is established based on the pseudo-spectral time domain（PSTD） technique. In this model, the perfectly matched layer with auxiliary differential equation（ADE-PML）, an excellent absorption boundary condition（ABC） in the finite difference time domain generalized for the PSTD, and the weighted total field/scattered field（TF/SF） technique is employed to introduce the incident light into 3 D computational domain. To improve computational efficiency, the model is further parallelized using the Open MP technique. The modeling accuracy of the PSTD scheme is validated against Lorenz–Mie, Aden–Kerker, T-matrix theory and DDA for spheres, inhomogeneous particles and nonspherical particles, and the influence of the spatial resolution and thickness of ADE-PML on the modeling accuracy is discussed as well. Finally, the parallel computational efficiency of the model is also analyzed. The results show that an excellent agreement is achieved between the results of PSTD and well-tested scattering models, where the simulation errors of extinction efficiencies are generally smaller than 1%, indicating the high accuracy of our model. Despite its low spatial resolution, reliable modeling precision can still be achieved by using the PSTD technique, especially for large particles. To suppress the electromagnetic wave reflected by the absorption layers, a six-layer ADE-PML should be set in the computational domain at least.

Parallel Spectral-Domain Optical Coherence Tomography for Non-Scattering Object Imaging

The parallel spectral-domain optical coherence tomography(PSDOCT) is described for high-speed optical coherence tomography(OCT) without lateral scanning. In this setup, the self-elimination of auto-correlation(AC) interference algorithm was used for eradicating the AC interference and ghost images. However, when performed in free space OCT, this algorithm still generated a weak DC component. The algorithm was improved by adding the background intensity part to compensate for the mutual interference between object and reference arms. The results demonstrate that the DC component can be eradicated. Compared with conventional OCT and complex Fourier-domain optical coherence tomography, the advantages of PSDOCT with the improved algorithm in free space are that it has no moving parts to generate consecutive phase shift, the structure of the object can be reconstructed immediately and automatically, and the speed is approximately 16 times faster than those of the other two in the same case.

Importance of 3-D image reconstruction of spectraldomain OCT on outcome of grid laser photocoagulation for diffuse diabetic macular edema

AIM:To present the outcome of modified grid laser photocoagulation(GLP)in diffuse diabetic macular edema(DDME)in eyes without extrafoveal and/or vitreofoveal traction.METHODS:Inclusion criteria for the retrospective study were DDME eyes of patients with typeⅡdiabetes mellitus that had≥4 months of follow-up following GLP.Only one eye per patient was analyzed.Using 3-D spectral-domain optical coherence tomography(3-D SDOCT),eyes that had either extrafoveal or vitreofoveal traction,or had been previously treated by an intravitreal medication(s)were excluded.Treated DDME eyes were divided into 4 groups:A)"Classic"DDME that involved the central macula;B)edema did not involve the macular center;C)eyes associated with central epiretinal membrane(ERM);D)DDME that was associated with macular capillary dropout≥2 disc-diameter(DD).RESULTS:GLP outcome in 35 DDME eyes after 4-24(mean,13.1±6.9)months was as follows:Group A)18eyes with"classic"DDME.Following one or 2(mean,1.2)GLP treatments,best-corrected visual acuity(BCVA)improved by 1-2 Snellen lines in 44.4%(8/18)of eyes,and worsened by 1 line in 11.1%(2/18).Central macular thickness(CMT)improved by 7%-49%(mean,26.6%)in77.8%(14/18)of eyes.Causes of CMT worsening(n=4)were commonly explainable,predominantly(n=3)associated with emergence of extrafoveal traction,5-9months post-GLP.Group B)GLP(s)in DDME that did not involve the macular center(n=6)resulted in improved BCVA by 1-2 lines in 2 eyes.However,the central macula became involved in the edema process after the GLP in 3(50%)eyes,associated with an emergence of extrafoveal traction in one of these eyes 4months following the GLP.Group C)GLP failed in all 5eyes associated with central ERM.Group D)GLP was of partial benefit in 2 of 6 treated eyes with macular capillary dropout≥2DD.CONCLUSION:Eyes with DDME that involved the macular center were found to achieve favourable outcomes after GLP(s)during mid-term follow-up,unless complicated pre-GLP or post-GLP by vltreoretinal interface abnormalities,often extrafoveal traction or ERM,or by capillary dropout≥2DD.Prospective studies with larger cohorts are required.

Predefined Exponential Basis Set for Half-Bounded Multi Domain Spectral Method

A non-orthogonal predefined exponential basis set is used to handle half-bounded domains in multi domain spectral method (MDSM). This approach works extremely well for real-valued semi-infinite differential problems. It spans simultaneously wide range of exponential decay rates with multi scaling and does not suffer from zero crossing. These two conditions are necessary for many physical problems. For comparison, the method is used to solve different problems and compared with analytical and published results. The comparison exhibits the strengths and accuracy of the presented basis set.

Single-Channel Speech Enhancement Based on Improved Frame-Iterative Spectral Subtraction in the Modulation Domain

Aiming at the problem of music noise introduced by classical spectral subtraction,a shorttime modulation domain(STM)spectral subtraction method has been successfully applied for singlechannel speech enhancement.However,due to the inaccurate voice activity detection(VAD),the residual music noise and enhanced performance still need to be further improved,especially in the low signal to noise ratio(SNR)scenarios.To address this issue,an improved frame iterative spectral subtraction in the STM domain(IMModSSub)is proposed.More specifically,with the inter-frame correlation,the noise subtraction is directly applied to handle the noisy signal for each frame in the STM domain.Then,the noisy signal is classified into speech or silence frames based on a predefined threshold of segmented SNR.With these classification results,a corresponding mask function is developed for noisy speech after noise subtraction.Finally,exploiting the increased sparsity of speech signal in the modulation domain,the orthogonal matching pursuit(OMP)technique is employed to the speech frames for improving the speech quality and intelligibility.The effectiveness of the proposed method is evaluated with three types of noise,including white noise,pink noise,and hfchannel noise.The obtained results show that the proposed method outperforms some established baselines at lower SNRs(-5 to +5 dB).

考虑时变特性的车-桥耦合系统非平稳振动频域方法研究

当列车行驶经过桥梁时,由于车辆在桥上的位置随时间不断变化,车-桥耦合系统具有时变特性,即使假设轨道不平顺为平稳激励,车辆和桥梁的振动仍然是一种非平稳的随机过程。本研究旨在提出一种非平稳频域分析方法,以高效分析受轨道不平顺激励的车-桥耦合系统的非平稳随机振动问题。首先推导了单节列车通过单跨简支桥的耦合系统时变频响传递函数(FRF),据此描述线性时变系统的动力特性。该函数满足一组变系数微分方程,可采用摄动法求解该函数,从而提高计算效率。随后,结合PRIESTLEY的演化谱理论,推导非平稳随机响应的演化功率谱密度函数(EPSD)。基于非平稳频域分析方法,计算响应时变均值和方差,结合3σ准则来估计非平稳响应的极值。研究结果表明,由于轨道不平顺的影响,车辆振动表现出平稳随机过程的特性,但其方差较大,表现出更大的离散性;而桥梁的振动则呈现出明显的非平稳特性,但方差较小,响应具有较小的随机性。极值分析表明,轨道不平顺激励对车辆振动具有显著影响,其均方根对极值响应起主导作用。而轨道不平顺激励对桥梁振动的影响较小,桥梁振动则主要受移动质量影响,其响应的极值主要受均值的影响。此外,相较于系统位移响应,车速对加速度响应的影响更为显著,例如车身加速度响应最大值随车速的增加可增大至3倍左右。

Physics-based seismic analysis of ancient wood structure:fault-to-structure simulation

Based on the domain reduction method,this study employs an SEM-FEM hybrid workflow which integrates the advantages of the spectral element method(SEM)for flexible and highly efficient simulation of seismic wave propagation in a three-dimensional(3D)regional-scale geophysics model and the finite element method(FEM)for fine simulation of structural response including soil-structure interaction,and performs a physics-based simulation from initial fault rupture on an ancient wood structure.After verification of the hybrid workflow,a large-scale model of an ancient wood structure in the Beijing area,The Tower of Buddhist Incense,is established and its responses under the 1665 Tongxian earthquake and the 1730 Yiheyuan earthquake are simulated.The results from the simulated ground motion and seismic response of the wood structure under the two earthquakes demonstrate that this hybrid workflow can be employed to efficiently provide insight into the relationships between geophysical parameters and the structural response,and is of great significance toward accurate input for seismic simulation of structures under specific site and fault conditions.

A SPECTRAL-DOMAIN IMMITTANCE APPROACH FOR THE CHARACTERISTICS OF FINLINES LOADED WITH ANISOTROPIC MEDIUM

The equations of electrodynamics for a gyrotropic medium by using Maxwell’s equa-tions are deduced.Through Fourier transformation,the admittances of TM and TE modes inthe electrically gyrotropic substrate and magnetically gyrotropic substrate are given.Numericalresults of the dominant mode in magnetized ferrite-loaded double-layered finlines are presentedwhich could be used in designing finline ferrite devices.

Direct spectral domain decomposition method for 2D incompressible Navier-Stokes equations

An efficient direct spectral domain decomposition method is developed coupled with Chebyshev spectral approximation for the solution of 2D, unsteady and in- compressible Navier-Stokes equations in complex geometries. In this numerical approach, the spatial domains of interest are decomposed into several non-overlapping rectangu- lar sub-domains. In each sub-domain, an improved projection scheme with second-order accuracy is used to deal with the coupling of velocity and pressure, and the Chebyshev collocation spectral method （CSM） is adopted to execute the spatial discretization. The influence matrix technique is employed to enforce the continuities of both variables and their normal derivatives between the adjacent sub-domains. The imposing of the Neu- mann boundary conditions to the Poisson equations of pressure and intermediate variable will result in the indeterminate solution. A new strategy of assuming the Dirichlet bound- ary conditions on interface and using the first-order normal derivatives as transmission conditions to keep the continuities of variables is proposed to overcome this trouble. Three test cases are used to verify the accuracy and efficiency, and the detailed comparison be- tween the numerical results and the available solutions is done. The results indicate that the present method is efficiency, stability, and accuracy.

A Service-Based Intelligent Time-Domain and Spectral-Domain Flow Aggregation in IP-over-EON Based on SDON

The rapid growth of IP traffic has contributed to wide deployment of optical devices in elastic optical network.However,the passband shape of wavelength selective switches(WSSs)that are used in reconfigurable optical add-drop multiplexer(ROADM)/optical cross connect(OXC)is not ideal,causing the narrowing of spectrum.Spectral narrowing will lead to signal impairment.Therefore,guard-bands need to be inserted between adjacent paths which will cause the waste of resources.In this paper,we propose a service-based intelligent aggregation node selection and area division(ANS-AD)algorithm.For the rationality of the aggregation node selection,the ANS-AD algorithm chooses the aggregation nodes according to historical traffic information based on big data analysis.Then the ANS-AD algorithm divides the topology into areas according to the result of the aggregation node selection.Based on the ANS-AD algorithm,we propose a time-domain and spectral-domain flow aggregation(TS-FA)algorithm.For the purpose of reducing resources'waste,the TS-FA algorithm attempts to reduce the insertion of guard-bands by time-domain and spectral-domain flow aggregation.Moreover,we design a time-domain and spectral-domain flow aggregation module on software defined optical network(SDON)architecture.Finally,a simulation is designed to evaluate the performance of the proposed algorithms and the results show that our proposed algorithms can effectively reduce the resource waste.

Comparison of central macular thickness between two spectral-domain optical coherence tomography in elderly non-mydriatic eyes

AIM: To compare central macular thickness (CMT) measurements obtained by two spectral-domain optical coherence tomography (SD-OCT) exams, and to evaluate measurement reproducibility and agreement between these two exams, and to investigate the relationship between CMT and possible influencing factors such as age, sex, eye (OD/OS), and operators in elderly non-mydriatic eyes. METHODS: Seventy-two normal subjects were included. Every subject underwent CMT measurement twice using one of two SD-OCT (OSE-2000, Moptim, Shenzhen, China & 3-D OCT-1000, Topcon, Tokyo, Japan) instruments respectively where we randomly chose one eye in each patient for the test; these exams were performed by two operators over an hour period with a brief rest between sessions. Comparison of the OSE-2000 and 3-D OCT-1000 CMT measurements was based on paired- t test The mean difference between the CMT measurements was calculated. General linear model analyzed the relationships among eye (OD/OS), operator, sex, and CMT values using age as co-variant. All tests were considered statistically significant at P <0.05. The main outcome measures included CMT. RESULTS: When evaluated with general linear model analysis, CMT measurements were found to have high reproducibility across the two instruments between the two operators for the OSE-2000 single line scan and 3-D OCT-1000 macular scans (P=0.731; P=0.443). There was statistically significant difference in CMT values between the two instruments (P<0.001) and the mean difference was -46.83 mu m at 95% confidence limits (-49.15,-44.51). Age was positively correlated with CMT (beta coefficient =0.516, P=0.001; beta coefficient=0.453, P =0.009) and sex was correlated with CMT from the OSE-2000 (P=0.021) but not with the 3-D OCT-1000 (P=0.056). According to the actual thickness measurements, the CMT of the male was thicker than the female's but there was no statistical difference. There was interaction between sex and eye in OSE-2000 and not in 3-D OCT-1000 (P=0.02; P =0.374). No significant correlation was found between CMT and the influencing factor of eye in both of the instruments (P=0.884; P=0.492). CONCLUSION: Reproducibility of CMT measurement using the two SD-OCTs is excellent in normal eyes according to the operator factor analysis. OSE-2000 has a different posterior retinal boundary of CMT measurement, which results in the CMT value differences, compared with the 3-D OCT-1000. Age is positively correlated with CMT measurement while sex is correlated with CMT in the OSE-2000 but not in the 3-D OCT-1000 and eye (OD/OS) had no correlation with CMT values. Mydriatic drops may not be necessary for CMT measurement using high scan rate SD-OCT in normal eyes in dark room.

Time-Spectral Solution of Initial-Value Problems—Subdomain Approach

Temporal and spatial subdomain techniques are proposed for a time-spectral method for solution of initial-value problems. The spectral method, called the generalised weighted residual method (GWRM), is a generalisation of weighted residual methods to the time and parameter domains [1]. A semi-analytical Chebyshev polynomial ansatz is employed, and the problem reduces to determine the coefficients of the ansatz from linear or nonlinear algebraic systems of equations. In order to avoid large memory storage and computational cost, it is preferable to subdivide the temporal and spatial domains into subdomains. Methods and examples of this article demonstrate how this can be achieved.

1310 nm Source Spectral-Domain Optical Coherence Tomography for Chinese Pigment and Jadeite Research

Optical Coherence Tomography (OCT) technique is a nondestructive optical detection technology based on low-coherence interferometer and it has become an attractive cultural heritage research method. A 1310 nm source spectral-domain optical coherence tomography (SD-OCT) system based on optical fiber Michelson interferometer and optical spectrum analyzer is proposed and demonstrated for Chinese cultural heritage research. The cross-section OCT images of Chinese pigment samples and jadeite samples can provide a lot of valuable microstructure information for the Chinese cultural heritage research and identification works.

关于紧连续L-domain的一个刻画定理

本文从函数空间的Isbell拓扑以及ω-连续性两方面给出了紧连续L-domain的刻画定理。其主要结果是:连续L-domain是Lawson紧的当且仅当函数空间[L→L]的Scott拓扑与Isbell拓扑一致。

SD-OCT检测Nd∶YAG激光周边虹膜切除术后黄斑区视网膜厚度变化

目的:探讨Nd∶YAG激光周边虹膜切除术(LPI)对原发性闭角型青光眼(PACG)患者黄斑区视网膜厚度的影响。方法:前瞻性研究。选取2019-10/2021-10我院PACG患者30例30眼为PACG组,同期健康体检者20名20眼为正常对照组(随机选取一眼)。PACG组患者接受LPI治疗,术后随访1mo。两组受试者均行最佳矫正视力(BCVA)、眼压、角膜内皮细胞、IOL Master 500光学测量仪测量前房深度(ACD)及眼轴长度(AL)、频域光学相干断层扫描(SD-OCT)检查黄斑区视网膜厚度。比较两组受试者及PACG组患者LPI前后ACD、眼压、AL和黄斑区视网膜厚度,并行相关性分析。结果:PACG组患者术后1wk, 1mo ACD较术前变深(均P<0.05)。PACG组患者手术前后眼压和AL均无差异(均P>0.05)。PACG组患者术前黄斑中心区,内外环上方、颞侧、下方、鼻侧,共9个区域视网膜厚度分别为243.50±13.24、324.50±13.46、308.83±15.94、310.00±14.24、314.50±16.29、300.67±19.95、290.17±12.58、302.40±16.37、307.33±14.84μm,正常对照组相应部位分别为266.14±16.16、342.67±15.86、327.95±16.41、337.85±13.03、341.24±15.58、313.76±17.59、290.24±16.29、303.81±13.91、323.01±14.80μm,两组间中心区、内环上方、颞侧、下方、鼻侧比较均有差异(均P<0.05)。PACG组术后1wk黄斑区9个区域视网膜厚度分别与术前相比均增加,术后1mo接近术前水平,但手术前后各分区比较均无差异(均P>0.05)。结论:与正常受试者比较,PACG患者黄斑区视网膜厚度较薄。PACG患者LPI术后早期黄斑区视网膜可变厚。

Graves眼病视网膜厚度改变的SD-OCT检测研究

目的观察Graves眼病(GO)患者黄斑区视网膜厚度(RT)的变化。方法横断面研究。采集Graves眼病患者及正常对照组的视力、眼压(IOP)、裂隙灯、眼底、眼轴、眼球突出度等检查,并根据临床活动性评分(CAS)评分将GO患者分为活动性和非活动性两组。视网膜厚度检查使用频域相干光层析成像术(SD-OCT)设备检测。采用单因素方差分析以及非配对t检验对各组患者视网膜厚度、眼压、眼球突出度、眼轴等进行比较。结果本研究最终纳入66例(132只眼),其中非活动性GO 22例(44只眼),活动性GO 22例(44只眼),对照组22例(44只眼)。活动性GO与对照组、非活动性GO组相比较,眼球突出度增加,差异均有统计学意义(均P<0.001)。各组比较,眼压差异无统计学意义(P=0.142)。活动性GO的患者的颞侧1 mm,3 mm处视网膜厚度较对照组薄,差异均有统计学意义(P值分别为0.016、0.013)。结论活动性GO患者的颞侧视网膜厚度明显低于正常对照,视网膜厚度可作为评估GO患者早期视网膜病变以及疾病活动性的一种潜在的生物学指标。

Time-and Frequency-Domain Analysis of Ice-Induced Displacement Responses Offshore Fixed Platforms

On the basis of ice- induced forced vibration model, ice- induced displacement responses of offshore fixed platforms are investigated in both time domain and frequency domain. The relationships of ice-induced displacement responses with ice breaking modes, ice acting directions and platform structures are analyzed and determined. The results lead to an important conclusion obtained for the first time that ice breaking frequency and the natural frequency of the first mode of the platform are the two main factors that dominate the degree of vibration. The present work provides a firm basis for both design and operation of fixed platforms against ice loading.

基于CEEMD-PSD算法的变电站控制电缆故障定位方法

频域反射法(frequency domain reflection,FDR)是电力电缆故障定位的有效办法,但尚未应用于控制电缆,且现有FDR法存在频域泄露严重、灵敏度低等问题,导致故障定位误差较大。该文提出了采用补充集合经验模态分解(complementary ensemble empirical mode decomposition,CEEMD)与功率谱密度(power spectral density,PSD)联合算法,实现了变电站控制电缆精准定位。首先通过CEEMD对首端反射系数谱实部进行分解,然后对模态分量进行加努塔尔-布莱克曼混合卷积窗(nutall-blackman window)处理;最后对加窗后的模态分量进行PSD分析,获得故障电缆的定位曲线。该文搭建了控制电缆模型进行仿真研究,并选取总长为100 m,在50 m存在故障的ZR-KVVP2-22 4×4型控缆进行实验验证。仿真及实验结果表明:与传统FDR定位方法相比,该文所提方法可以有效抑制频谱泄露,提升故障识别的灵敏度。

Comparison of ultrasound biomicroscopy and spectraldomain anterior segment optical coherence tomography in evaluation of anterior segment after laser peripheral iridotomy

AIM：To quantitatively assess narrow anterior chamber angle using spectral-domain anterior segment optical coherence tomography（SD-AS-OCT） and ultrasound biomicroscopy（UBM）,and to evaluate the correlations and consistency between SD-AS-OCT and UBM.· METHODS：Fifty-five eyes from 40 patients were examined.Patients were diagnosed with primary angleclosure glaucoma（PACG） remission（11 eyes from 8patients）,primary angle closure（PAC,20 eyes from 20patients） and PAC suspect（24 eyes from 12 patients）.Each eye was examined by SD-AS-OCT and UBM after laser peripheral iridotomy（LPI）.The measurements of SD-AS-OCT were angle open distance（AOD）,anterior chamber angle（ACA）,trabecular iris angle（TIA）,and trabecular iris space area（TISA）.UBM measurements were AOD and TIA.Correlations of AOD500 and TIA500 between UBM and AS-OCT were assessed.All parameters were analysed by SPSS 16.0 and MedCalc.· RESULTS：ACA,TIA and AOD measured by SD-ASOCT reached a maximum at the temporal quadrant and minimum at the nasal quadrant.Group parameters of AOD500 and AOD750 showed a linear positive correlation,and AOD750 had less variability.UBM outcomes of AOD500 and TIA500 were significantly smaller than those of SD-AS-OCT.The results of the two techniques were correlated at the superior,nasal and inferior quadrants.CONCLUSION：Both UBM and SD-AS-OCT are efficient tools for follow-up during the course of PACG.We recommended using parameters at 750 μm anterior to the sclera spur for the screening and follow-up of PACG and PAC.The two methods might be alternatives to each other.