The aim of this cross-sectional survey was to analyze the semen parameters of volunteers from the Human Sperm Bank of Fudan University,as well as the related factors influencing these parameters.From January 2019 to D...The aim of this cross-sectional survey was to analyze the semen parameters of volunteers from the Human Sperm Bank of Fudan University,as well as the related factors influencing these parameters.From January 2019 to December 2020,semen parameters from a total of 5214 men were included in this survey.The Kruskal-Wallis test was used to detect differences associated with several independent variables.A total of 5214 volunteers were included.The volunteers were registered in 33 provinces,autonomous regions,municipalities(including Macao and Taiwan)and 294 prefecture-level cities.The average age of volunteers was 27.40 years.Overall,76.50%of the volunteers had a college education or higher.Volunteers with BMI values of 18.5-23.9 kg/m2 accounted for 60.70%of participants.Semen parameters were significantly different according to season,education level,duration of abstinence,age group and BMI.The basic male fertility phenotypes(semen parameters)showed new trends in the study period,and accurate long-term tracking of male semen parameters will help researchers to better understand the changes in male fertility phenotypes(semen).展开更多
Beyond the scientific progress in assisted reproductive technologies （ART）, it is necessary to discuss the ethical considerations behind these advances. Ethical issues concerning sperm donation have been considered ...Beyond the scientific progress in assisted reproductive technologies （ART）, it is necessary to discuss the ethical considerations behind these advances. Ethical issues concerning sperm donation have been considered and discussed by government and non-governmental agencies, the public, media and academic institutions in many countries. Recommendations and guidelines concerning sperm donation issues vary from country to country and between professional groups within countries. This paper attempts to present an overview of findings and reports from various agencies concerning the ethics of sperm donation. The following topics are considered： limiting the number of donor offspring; minimizing risk of infection and genetics from sperm donors; age requirements for sperm donors; and anonymity versus non-anonymity of sperm donors. The diversity of policies shows that each country has its unique set of guidelines tailored toward its own specific needs. Similarly, countries designing their own procedures and guidelines concerning reproductive medicine must tailor them toward their own needs and practical considerations. In China's Mainland, the anonymous policy for sperm donation should still be carried out, and the number of donor offspring should be revaluated. ART procedures must be conducted in a way that is respectful of those involved. Ethical principles must respect the interests and welfare of persons who will be born as well as the health and psychosocial welfare of all participants, including sperm donors.展开更多
目的:为提高捐精志愿者回访率,改变传统纸质记录模式,优化工作流程,借助信息化手段设计一套人类精子库志愿者随访管理系统。方法:该系统基于三层B/S结构,采用SQL Server 2019数据库和Visual Studio 2013开发工具,并应用.NET MVC模式进...目的:为提高捐精志愿者回访率,改变传统纸质记录模式,优化工作流程,借助信息化手段设计一套人类精子库志愿者随访管理系统。方法:该系统基于三层B/S结构,采用SQL Server 2019数据库和Visual Studio 2013开发工具,并应用.NET MVC模式进行设计。系统包括志愿者管理、电话管理、系统管理3个功能模块。结果:基于精子库信息管理平台的业务数据,成功实现了捐精志愿者全流程的随访管理。通过将志愿者回访与工作人员绩效挂钩,回访率提升近60%。结论:该系统简化了工作流程,提高了随访效率,有效满足了精子库日常工作需求,展现出较高的实用价值。展开更多
Pericentric inversion of chromosome 9(inv[9])is a common chromosomal structural variant,but its impact on clinical outcomesremains debated.The screening criteria of sperm banks are rarely mentioned to individuals with...Pericentric inversion of chromosome 9(inv[9])is a common chromosomal structural variant,but its impact on clinical outcomesremains debated.The screening criteria of sperm banks are rarely mentioned to individuals with inv(9).In this study,we evaluatedthe fertility of sperm donors with inv(9)who met eligibility criteria for sperm banks(inv[9]-eligible donors).From March 2004 toMay 2022,chromosomal analysis of 16124 sperm donors at CITIC-Xiangya Human Sperm Bank in Hunan Province(Changsha,China)found that 251(1.6%)had chromosome variations,with inv(9)being the most prevalent at 1.1%.All 169 inv(9)-eligibledonors were contacted to collect fertility outcome data,along with 206 eligible donors without inv(9)as controls.In addition,semen samples from inv(9)-eligible donors and eligible donors underwent assessments of sperm fluorescence in situ hybridization(FISH),mitochondrial membrane potential,DNA fragmentation index,acrosome integrity,reactive oxygen species(ROS),andsperm morphology.Results showed that inv(9)did not significantly increase reproductive risks overall.Despite detecting ROSlevel differences,the clinical impact may be insignificant.This study provides new data on the inv(9)population that can serveas a valuable reference for decision-making by sperm banks as well as for genetic counseling and clinical guidance for individualscarrying inv(9)variant.展开更多
基金This work was supported by the Shanghai Municipal Science and Technology Major Project(2017SHZDZX01).
文摘The aim of this cross-sectional survey was to analyze the semen parameters of volunteers from the Human Sperm Bank of Fudan University,as well as the related factors influencing these parameters.From January 2019 to December 2020,semen parameters from a total of 5214 men were included in this survey.The Kruskal-Wallis test was used to detect differences associated with several independent variables.A total of 5214 volunteers were included.The volunteers were registered in 33 provinces,autonomous regions,municipalities(including Macao and Taiwan)and 294 prefecture-level cities.The average age of volunteers was 27.40 years.Overall,76.50%of the volunteers had a college education or higher.Volunteers with BMI values of 18.5-23.9 kg/m2 accounted for 60.70%of participants.Semen parameters were significantly different according to season,education level,duration of abstinence,age group and BMI.The basic male fertility phenotypes(semen parameters)showed new trends in the study period,and accurate long-term tracking of male semen parameters will help researchers to better understand the changes in male fertility phenotypes(semen).
文摘Beyond the scientific progress in assisted reproductive technologies （ART）, it is necessary to discuss the ethical considerations behind these advances. Ethical issues concerning sperm donation have been considered and discussed by government and non-governmental agencies, the public, media and academic institutions in many countries. Recommendations and guidelines concerning sperm donation issues vary from country to country and between professional groups within countries. This paper attempts to present an overview of findings and reports from various agencies concerning the ethics of sperm donation. The following topics are considered： limiting the number of donor offspring; minimizing risk of infection and genetics from sperm donors; age requirements for sperm donors; and anonymity versus non-anonymity of sperm donors. The diversity of policies shows that each country has its unique set of guidelines tailored toward its own specific needs. Similarly, countries designing their own procedures and guidelines concerning reproductive medicine must tailor them toward their own needs and practical considerations. In China's Mainland, the anonymous policy for sperm donation should still be carried out, and the number of donor offspring should be revaluated. ART procedures must be conducted in a way that is respectful of those involved. Ethical principles must respect the interests and welfare of persons who will be born as well as the health and psychosocial welfare of all participants, including sperm donors.
文摘目的:为提高捐精志愿者回访率,改变传统纸质记录模式,优化工作流程,借助信息化手段设计一套人类精子库志愿者随访管理系统。方法:该系统基于三层B/S结构,采用SQL Server 2019数据库和Visual Studio 2013开发工具,并应用.NET MVC模式进行设计。系统包括志愿者管理、电话管理、系统管理3个功能模块。结果:基于精子库信息管理平台的业务数据,成功实现了捐精志愿者全流程的随访管理。通过将志愿者回访与工作人员绩效挂钩,回访率提升近60%。结论:该系统简化了工作流程,提高了随访效率,有效满足了精子库日常工作需求,展现出较高的实用价值。
基金financial supported by National Natural Science Foundationof China(No.82001634)the China Postdoctoral Science Foundation(No.2019M661521).
文摘Pericentric inversion of chromosome 9(inv[9])is a common chromosomal structural variant,but its impact on clinical outcomesremains debated.The screening criteria of sperm banks are rarely mentioned to individuals with inv(9).In this study,we evaluatedthe fertility of sperm donors with inv(9)who met eligibility criteria for sperm banks(inv[9]-eligible donors).From March 2004 toMay 2022,chromosomal analysis of 16124 sperm donors at CITIC-Xiangya Human Sperm Bank in Hunan Province(Changsha,China)found that 251(1.6%)had chromosome variations,with inv(9)being the most prevalent at 1.1%.All 169 inv(9)-eligibledonors were contacted to collect fertility outcome data,along with 206 eligible donors without inv(9)as controls.In addition,semen samples from inv(9)-eligible donors and eligible donors underwent assessments of sperm fluorescence in situ hybridization(FISH),mitochondrial membrane potential,DNA fragmentation index,acrosome integrity,reactive oxygen species(ROS),andsperm morphology.Results showed that inv(9)did not significantly increase reproductive risks overall.Despite detecting ROSlevel differences,the clinical impact may be insignificant.This study provides new data on the inv(9)population that can serveas a valuable reference for decision-making by sperm banks as well as for genetic counseling and clinical guidance for individualscarrying inv(9)variant.
