In order to meet the clinical requirements of spine surgery,this paper proposed the exploratory research of computer-aided design and selective laser melting(SLM)fabrication of a bionic porous titanium spine implant.T...In order to meet the clinical requirements of spine surgery,this paper proposed the exploratory research of computer-aided design and selective laser melting(SLM)fabrication of a bionic porous titanium spine implant.The structural design of the spinal implant is based on CT scanning data to ensure correct matching,and the mechanical properties of the implant are verified by simulation analysis and laser selective melting experiment.The surface roughness of the spinal implant manufactured by SLM without post-processing is Ra 15μm,and the implant is precisely jointed with the photosensitive resin model of the upper and lower spine.The surface micro-hardness of the implant is HV 373,tensile strengthσ_(b)=1238.7 MPa,yield strengthσ_(0.2)=1043.9 MPa,the elongation is 6.43%,and the compressive strength of porous structure under 84.60%porosity is 184.09 MPa,which can meet the requirements of the reconstruction of stable spines.Compared with the traditional implant and intervertebral fusion cage,the bionic porous spinal implant has the advantages of accurate fit,porous bionic structure and recovery of patients,and the ion release experiment proved that implants manufactured by SLM are more suitable for clinical application after certain treatments.The elastic modulus of the sample is improved after heat treatment,mainly because the microstructure of the sample changes fromα’phase toα+βdual-phase after heat treatment.In addition,the design of high-quality bionic porous spinal implants still needs to be optimized for the actual needs of doctors.展开更多
The introduction of compressive residual stress is an effective way to reduce fretting fatigue and fretting wear between a spinal implant rod and its holding fixture. The objective of this paper is to demonstrate that...The introduction of compressive residual stress is an effective way to reduce fretting fatigue and fretting wear between a spinal implant rod and its holding fixture. The objective of this paper is to demonstrate that cavitation peening can introduce compressive residual stress into the surface of a spinal implant rod manufactured from medical grade titanium alloy Ti-6Al-4V, which has already been processed by glass shot peening. In order to apply the cavitation peening for the small rod, whose diameter is only 5.5 mm, the cavitating region was concentrated by increasing the ambient pressure. The depth profiles of the resulting residual stress were evaluated by X-ray diffraction following layer removal by electropolishing. The results show that cavitation peening creates compressive residual stress deeper into the rod, even though the stress value at the near surface is saturated due to initial processing using glass shot peening. The depth of the compressive residual stress continuously increases from 44 μm to 230 μm with an increase in the cavitation peening processing time. In addition, the full width at half maximum value of the X-ray diffraction profile, which is closely related to the micro-strain, decreases by up to 32% following the application of cavitation peening.展开更多
Objective: To explore the effect of catgut implantation at Baliao and Xingfu One Acupuncture point for patients with urinary incontinence secondary to spinal cord injury (SCI). Methods: Three SCI patients received cat...Objective: To explore the effect of catgut implantation at Baliao and Xingfu One Acupuncture point for patients with urinary incontinence secondary to spinal cord injury (SCI). Methods: Three SCI patients received catgut embedding at Baliao and Xingfu One Acupuncture point. The data of intermittent catheterization (IC) volume, intermittent catheterization frequency and the amount of using urine pad (urethral condom) were corrected. Results: Compared to the baseline data, IC volume increased and the leakage volume decreased. Conclusions: Catgut Implantation at Baliao and Xingfu One Acupuncture point is effective for patients with urinary incontinence secondary to incomplete SCI.展开更多
Objective To approach the effect of microgene pSVPoMcat to modify genetically Schwann cells (SC) on central conduction function after spinal cord injury (SCI).Method Experimental animals were divided into three groups...Objective To approach the effect of microgene pSVPoMcat to modify genetically Schwann cells (SC) on central conduction function after spinal cord injury (SCI).Method Experimental animals were divided into three groups : the group of microgene pSVPoMcat implanted to genetically modify SC(group A), SC implanted group (group B), and the control group (group C). The cortical somatasensory evoked potentials (CESP) and combined behavioral score (CBS)were continuous monitored from operation second week to twelfth week. Result The result showed that the peak latency and peak amplitudes of group A,B have a recovery tendency and it was constant with CBS . Conclusion We concluded that the microgene pSVPoMcat to modify genetically Sc may play a promotion role in recovery of central conduction function after SCI.展开更多
<strong>Objective:</strong> To probe into the effect of catgut implantation at Baliao and Xingfu One Acupuncture Point on dysdefecation in patients with incomplete spinal cord injury (SCI). <strong>M...<strong>Objective:</strong> To probe into the effect of catgut implantation at Baliao and Xingfu One Acupuncture Point on dysdefecation in patients with incomplete spinal cord injury (SCI). <strong>Methods:</strong> Three SCI patients voluntarily accepted catgut embedding at Baliao and Xingfu One Acupuncture point. Before and after treatment, they were filled out the self-rating scale of defecation, including the data of defecation frequency, total defecation time, defecation effort, fecal texture, fecal characteristics and fecal incontinence, etc. <strong>Results:</strong> Compared with the baseline data, constipation was improved and fecal incontinence was disappeared. <strong>Conclusions:</strong> Catgut implantation at Baliao and Xingfu One Acupuncture Point is effectual for patients with neurogenic dysporia secondary to incomplete SCI.展开更多
In this study a lumbar spinal fusion animal model is established to assess the effect of spinal fusion cage,and explore theminimum area ratio of titanium cage section to vertebral section that ensures bone healing and...In this study a lumbar spinal fusion animal model is established to assess the effect of spinal fusion cage,and explore theminimum area ratio of titanium cage section to vertebral section that ensures bone healing and biomechanical property.Lumbarcorpectomy was conducted by posterolateral approach with titanium cage implantation combined with plate fixation.Titaniumcages with the same length but different diameters were used.After implantation of titanium cages,the progress of bone healingwas observed and the bone biomechanical properties were measured,including deformation and displacement in axial compression,flexion,extension,and lateral bending motion.The factors affecting the in vivo growth of spine supporting body wereanalyzed.The results show that the area ratio of titanium cage section to vertebral section should reach 1/2 to ensure the bonehealing,sufficient bone intensity and biomechanical properties.Some bone healing indicators,such as BMP,suggest that there isa relationship between the peak time and the peak value of bone formation and metabolism markers and the bone healing strength.展开更多
Back pain is a common chronic disorder that represents a large burden for the health care system. There is a broad spectrum of available treatment options for patients suffering from chronic lower back pain in the set...Back pain is a common chronic disorder that represents a large burden for the health care system. There is a broad spectrum of available treatment options for patients suffering from chronic lower back pain in the setting of degenerative disorders of the lumbar spine, including both conservative and operative approaches. Lumbar arthrodesis techniques can be divided into subcategories based on the part of the vertebral column that is addressed(anterior vs posterior). Furthermore, one has to differentiate between approaches aiming at a solid fusion in contrast to motion-sparing techniques with the proposed advantage of a reduced risk of developing adjacent disc disease. However, the field of application and long-term outcomes of these novel motion-preserving surgical techniques, including facet arthroplasty, nucleus replacement, and lumbar disc arthroplasty, need to be more precisely evaluated in long-term prospective studies. Innovative surgical treatment strategies involving minimally invasive techniques, such as lateral lumbar interbody fusion or transforaminal lumbar interbody fusion, as well as percutaneous implantation of transpedicular or trans-facet screws, have been established with the reported advantages of reduced tissue invasiveness, decreased collateral damage, reduced blood loss, and decreased risk of infection. The aim of this study was to review well-established procedures for lumbar spinal fusion with the main focus on current concepts on spinal arthrodesis and motion-sparing techniques in degenerative disorders of the lumbar spine.展开更多
基金The work presented in this paper was fully supported by the following projects:National Natural Science Foundation of China(51775196)Guangdong Province Science and Technology Project(2017B090912003)+3 种基金High-level Personnel Special Support Plan of Guangdong Province(2016TQ03X289)The Fundamental Research Funds for the Central Universities(Project No.2018ZD30)Guangdong Province Science and Technology Project(2017B090911014)Guangzhou Science and Technology Project(201704030097)。
文摘In order to meet the clinical requirements of spine surgery,this paper proposed the exploratory research of computer-aided design and selective laser melting(SLM)fabrication of a bionic porous titanium spine implant.The structural design of the spinal implant is based on CT scanning data to ensure correct matching,and the mechanical properties of the implant are verified by simulation analysis and laser selective melting experiment.The surface roughness of the spinal implant manufactured by SLM without post-processing is Ra 15μm,and the implant is precisely jointed with the photosensitive resin model of the upper and lower spine.The surface micro-hardness of the implant is HV 373,tensile strengthσ_(b)=1238.7 MPa,yield strengthσ_(0.2)=1043.9 MPa,the elongation is 6.43%,and the compressive strength of porous structure under 84.60%porosity is 184.09 MPa,which can meet the requirements of the reconstruction of stable spines.Compared with the traditional implant and intervertebral fusion cage,the bionic porous spinal implant has the advantages of accurate fit,porous bionic structure and recovery of patients,and the ion release experiment proved that implants manufactured by SLM are more suitable for clinical application after certain treatments.The elastic modulus of the sample is improved after heat treatment,mainly because the microstructure of the sample changes fromα’phase toα+βdual-phase after heat treatment.In addition,the design of high-quality bionic porous spinal implants still needs to be optimized for the actual needs of doctors.
文摘The introduction of compressive residual stress is an effective way to reduce fretting fatigue and fretting wear between a spinal implant rod and its holding fixture. The objective of this paper is to demonstrate that cavitation peening can introduce compressive residual stress into the surface of a spinal implant rod manufactured from medical grade titanium alloy Ti-6Al-4V, which has already been processed by glass shot peening. In order to apply the cavitation peening for the small rod, whose diameter is only 5.5 mm, the cavitating region was concentrated by increasing the ambient pressure. The depth profiles of the resulting residual stress were evaluated by X-ray diffraction following layer removal by electropolishing. The results show that cavitation peening creates compressive residual stress deeper into the rod, even though the stress value at the near surface is saturated due to initial processing using glass shot peening. The depth of the compressive residual stress continuously increases from 44 μm to 230 μm with an increase in the cavitation peening processing time. In addition, the full width at half maximum value of the X-ray diffraction profile, which is closely related to the micro-strain, decreases by up to 32% following the application of cavitation peening.
文摘Objective: To explore the effect of catgut implantation at Baliao and Xingfu One Acupuncture point for patients with urinary incontinence secondary to spinal cord injury (SCI). Methods: Three SCI patients received catgut embedding at Baliao and Xingfu One Acupuncture point. The data of intermittent catheterization (IC) volume, intermittent catheterization frequency and the amount of using urine pad (urethral condom) were corrected. Results: Compared to the baseline data, IC volume increased and the leakage volume decreased. Conclusions: Catgut Implantation at Baliao and Xingfu One Acupuncture point is effective for patients with urinary incontinence secondary to incomplete SCI.
文摘Objective To approach the effect of microgene pSVPoMcat to modify genetically Schwann cells (SC) on central conduction function after spinal cord injury (SCI).Method Experimental animals were divided into three groups : the group of microgene pSVPoMcat implanted to genetically modify SC(group A), SC implanted group (group B), and the control group (group C). The cortical somatasensory evoked potentials (CESP) and combined behavioral score (CBS)were continuous monitored from operation second week to twelfth week. Result The result showed that the peak latency and peak amplitudes of group A,B have a recovery tendency and it was constant with CBS . Conclusion We concluded that the microgene pSVPoMcat to modify genetically Sc may play a promotion role in recovery of central conduction function after SCI.
文摘<strong>Objective:</strong> To probe into the effect of catgut implantation at Baliao and Xingfu One Acupuncture Point on dysdefecation in patients with incomplete spinal cord injury (SCI). <strong>Methods:</strong> Three SCI patients voluntarily accepted catgut embedding at Baliao and Xingfu One Acupuncture point. Before and after treatment, they were filled out the self-rating scale of defecation, including the data of defecation frequency, total defecation time, defecation effort, fecal texture, fecal characteristics and fecal incontinence, etc. <strong>Results:</strong> Compared with the baseline data, constipation was improved and fecal incontinence was disappeared. <strong>Conclusions:</strong> Catgut implantation at Baliao and Xingfu One Acupuncture Point is effectual for patients with neurogenic dysporia secondary to incomplete SCI.
文摘In this study a lumbar spinal fusion animal model is established to assess the effect of spinal fusion cage,and explore theminimum area ratio of titanium cage section to vertebral section that ensures bone healing and biomechanical property.Lumbarcorpectomy was conducted by posterolateral approach with titanium cage implantation combined with plate fixation.Titaniumcages with the same length but different diameters were used.After implantation of titanium cages,the progress of bone healingwas observed and the bone biomechanical properties were measured,including deformation and displacement in axial compression,flexion,extension,and lateral bending motion.The factors affecting the in vivo growth of spine supporting body wereanalyzed.The results show that the area ratio of titanium cage section to vertebral section should reach 1/2 to ensure the bonehealing,sufficient bone intensity and biomechanical properties.Some bone healing indicators,such as BMP,suggest that there isa relationship between the peak time and the peak value of bone formation and metabolism markers and the bone healing strength.
文摘Back pain is a common chronic disorder that represents a large burden for the health care system. There is a broad spectrum of available treatment options for patients suffering from chronic lower back pain in the setting of degenerative disorders of the lumbar spine, including both conservative and operative approaches. Lumbar arthrodesis techniques can be divided into subcategories based on the part of the vertebral column that is addressed(anterior vs posterior). Furthermore, one has to differentiate between approaches aiming at a solid fusion in contrast to motion-sparing techniques with the proposed advantage of a reduced risk of developing adjacent disc disease. However, the field of application and long-term outcomes of these novel motion-preserving surgical techniques, including facet arthroplasty, nucleus replacement, and lumbar disc arthroplasty, need to be more precisely evaluated in long-term prospective studies. Innovative surgical treatment strategies involving minimally invasive techniques, such as lateral lumbar interbody fusion or transforaminal lumbar interbody fusion, as well as percutaneous implantation of transpedicular or trans-facet screws, have been established with the reported advantages of reduced tissue invasiveness, decreased collateral damage, reduced blood loss, and decreased risk of infection. The aim of this study was to review well-established procedures for lumbar spinal fusion with the main focus on current concepts on spinal arthrodesis and motion-sparing techniques in degenerative disorders of the lumbar spine.
