AIM:To investigate the relationship between bulbocavernous reflex(BTR),patellar reflex(PTR) and rehabilitation during acute stage of cervical spinal injury.METHODS: 73 cases of a class frankel cervical spinal injury p...AIM:To investigate the relationship between bulbocavernous reflex(BTR),patellar reflex(PTR) and rehabilitation during acute stage of cervical spinal injury.METHODS: 73 cases of a class frankel cervical spinal injury patients were examined with BTR and PTR and recorded the time of the two reflexes,then follow up after 6 months to monitor recovery situation. RESULTS:There were 28 cases of positive BCR within the first 72 h (38%),7 cases of improved conditions(25%); there were 13 cases of PTR positive (17%),13 cases of improved status(100%). CONCLUSION:BCR and PTR are the sign of improved status and better rehabilitation during the acute stage.展开更多
A simple ballistic movement and two of its attributes (namely, reversal in time and synchronization with external events) are formulated. A three-dimensional, three-link musculoskeletal arm is subjected to a fast ball...A simple ballistic movement and two of its attributes (namely, reversal in time and synchronization with external events) are formulated. A three-dimensional, three-link musculoskeletal arm is subjected to a fast ballistic type movement. The central components of the movement from hippocampal, cerebellar, basal ganglia and reticular formation structures that may be involved in timing are identified. The role of agonist muscles and spinal reflexes in the execution of ballistic movements (namely, in fast starts and fast stops) is discussed. The needed three time intervals are constructed in real time and can be coordinated with external events. Delaying or advancing in time, synchronization, time scaling and inverting events in time relative to the movement is formulated. Digital computer simulations are presented to test the behavior of the formulated neural and spinal processing and demonstrate the behavior of the arm under such control.展开更多
AIM To investigate the effect of clonidine on the cutaneous silent period(CSP) during spinal anesthesia. METHODS A total of 67 adult patients were included in this randomized, prospective, single-center, double-blind ...AIM To investigate the effect of clonidine on the cutaneous silent period(CSP) during spinal anesthesia. METHODS A total of 67 adult patients were included in this randomized, prospective, single-center, double-blind trial. They did not have neurological disorders and were scheduled for inguinal hernia repair surgery. This trial was registered on ClinicalTrials.gov(NTC03121261). The patients were randomized into two groups with regards to the intrathecally administered solution:(1) 15 mg of 0.5% levobupivacaine with 50 μg of 0.015% clonidine, or(2) 15 mg of 0.5% levobupivacaine alone. There were 34 patients in the levobupivacaine-clonidine(LC) group and 33 patients in the levobupivacaine(L) group. CSP and its latency were measured four times: prior to the subarachnoid block(SAB), after motor block regression to the 0 level of the Bromage scale, with ongoing sensory blockade, and both 6 and 24 h after SAB.RESULTS Only data from 30 patients in each group were analyzed. There were no significant differences between the groups investigated preoperatively and after 24 h. The CSP of the L group at the time point when the Bromage scale was 0 was 44.8 ± 8.1 ms, while in the LC group it measured 40.2 ± 3.8 ms(P = 0.007). The latency in the L group at the time point when the Bromage scale was 0 was 130.3 ± 10.2 ms, and in the LC group it was 144.7 ± 8.3 ms(P < 0.001). The CSP of the L group after 6 h was 59.6 ± 9.8 ms, while in the LC group it was 44.5 ± 5.0 ms(P < 0.001). The latency in the L group after 6 h was 110.4 ± 10.6 ms, while in LC group it was 132.3 ± 9.7 ms(P < 0.001).CONCLUSION Intrathecal addition of clonidine to levobupivacaine for SAB in comparison with levobupivacaine alone resultsin a diminished inhibitory tonus and shortened CSP.展开更多
Pudendal nerve plays an important role in urine storage and voiding.Our hypothesis is that a neuroprosthetic device placed in the pudendal nerve trunk can modulate bladder function after suprasacral spinal cord injury...Pudendal nerve plays an important role in urine storage and voiding.Our hypothesis is that a neuroprosthetic device placed in the pudendal nerve trunk can modulate bladder function after suprasacral spinal cord injury.We had confirmed the inhibitory pudendal-to-bladder reflex by stimulating either the branch or the trunk of the pudendal nerve.This study explored the excitatory pudendal-to-bladder reflex in beagle dogs,with intact or injured spinal cord,by electrical stimulation of the pudendal nerve trunk.The optimal stimulation frequency was approximately 15–25 Hz.This excitatory effect was dependent to some extent on the bladder volume.We conclude that stimulation of the pudendal nerve trunk is a promising method to modulate bladder function.展开更多
文摘AIM:To investigate the relationship between bulbocavernous reflex(BTR),patellar reflex(PTR) and rehabilitation during acute stage of cervical spinal injury.METHODS: 73 cases of a class frankel cervical spinal injury patients were examined with BTR and PTR and recorded the time of the two reflexes,then follow up after 6 months to monitor recovery situation. RESULTS:There were 28 cases of positive BCR within the first 72 h (38%),7 cases of improved conditions(25%); there were 13 cases of PTR positive (17%),13 cases of improved status(100%). CONCLUSION:BCR and PTR are the sign of improved status and better rehabilitation during the acute stage.
文摘A simple ballistic movement and two of its attributes (namely, reversal in time and synchronization with external events) are formulated. A three-dimensional, three-link musculoskeletal arm is subjected to a fast ballistic type movement. The central components of the movement from hippocampal, cerebellar, basal ganglia and reticular formation structures that may be involved in timing are identified. The role of agonist muscles and spinal reflexes in the execution of ballistic movements (namely, in fast starts and fast stops) is discussed. The needed three time intervals are constructed in real time and can be coordinated with external events. Delaying or advancing in time, synchronization, time scaling and inverting events in time relative to the movement is formulated. Digital computer simulations are presented to test the behavior of the formulated neural and spinal processing and demonstrate the behavior of the arm under such control.
文摘AIM To investigate the effect of clonidine on the cutaneous silent period(CSP) during spinal anesthesia. METHODS A total of 67 adult patients were included in this randomized, prospective, single-center, double-blind trial. They did not have neurological disorders and were scheduled for inguinal hernia repair surgery. This trial was registered on ClinicalTrials.gov(NTC03121261). The patients were randomized into two groups with regards to the intrathecally administered solution:(1) 15 mg of 0.5% levobupivacaine with 50 μg of 0.015% clonidine, or(2) 15 mg of 0.5% levobupivacaine alone. There were 34 patients in the levobupivacaine-clonidine(LC) group and 33 patients in the levobupivacaine(L) group. CSP and its latency were measured four times: prior to the subarachnoid block(SAB), after motor block regression to the 0 level of the Bromage scale, with ongoing sensory blockade, and both 6 and 24 h after SAB.RESULTS Only data from 30 patients in each group were analyzed. There were no significant differences between the groups investigated preoperatively and after 24 h. The CSP of the L group at the time point when the Bromage scale was 0 was 44.8 ± 8.1 ms, while in the LC group it measured 40.2 ± 3.8 ms(P = 0.007). The latency in the L group at the time point when the Bromage scale was 0 was 130.3 ± 10.2 ms, and in the LC group it was 144.7 ± 8.3 ms(P < 0.001). The CSP of the L group after 6 h was 59.6 ± 9.8 ms, while in the LC group it was 44.5 ± 5.0 ms(P < 0.001). The latency in the L group after 6 h was 110.4 ± 10.6 ms, while in LC group it was 132.3 ± 9.7 ms(P < 0.001).CONCLUSION Intrathecal addition of clonidine to levobupivacaine for SAB in comparison with levobupivacaine alone resultsin a diminished inhibitory tonus and shortened CSP.
基金supported by the Capital Medical Development Research Fund of China,No.2014-2-4141
文摘Pudendal nerve plays an important role in urine storage and voiding.Our hypothesis is that a neuroprosthetic device placed in the pudendal nerve trunk can modulate bladder function after suprasacral spinal cord injury.We had confirmed the inhibitory pudendal-to-bladder reflex by stimulating either the branch or the trunk of the pudendal nerve.This study explored the excitatory pudendal-to-bladder reflex in beagle dogs,with intact or injured spinal cord,by electrical stimulation of the pudendal nerve trunk.The optimal stimulation frequency was approximately 15–25 Hz.This excitatory effect was dependent to some extent on the bladder volume.We conclude that stimulation of the pudendal nerve trunk is a promising method to modulate bladder function.
