Inhibition of the NLRP3 inflammasome attenuates spiral ganglion neuron degeneration in aminoglycoside-induced hearing loss

Aminoglycosides are a widely used class of antibacterials renowned for their effectiveness and broad antimicrobial spectrum.However,their use leads to irreversible hearing damage by causing apoptosis of hair cells as their direct target.In addition,the hearing damage caused by aminoglycosides involves damage of spiral ganglion neurons upon exposure.To investigate the mechanisms underlying spiral ganglion neuron degeneration induced by aminoglycosides,we used a C57BL/6J mouse model treated with kanamycin.We found that the mice exhibited auditory deficits following the acute loss of outer hair cells.Spiral ganglion neurons displayed hallmarks of pyroptosis and exhibited progressive degeneration over time.Transcriptomic profiling of these neurons showed significant upregulation of genes associated with inflammation and immune response,particularly those related to the NLRP3 inflammasome.Activation of the canonical pyroptotic pathway in spiral ganglion neurons was observed,accompanied by infiltration of macrophages and the release of proinflammatory cytokines.Pharmacological intervention targeting NLRP3 using Mcc950 and genetic intervention using NLRP3 knockout ameliorated spiral ganglion neuron degeneration in the injury model.These findings suggest that NLRP3 inflammasome-mediated pyroptosis plays a role in aminoglycoside-induced spiral ganglion neuron degeneration.Inhibition of this pathway may offer a potential therapeutic strategy for treating sensorineural hearing loss by reducing spiral ganglion neuron degeneration.

Influence of spiral crystal selector on crystal orientation of single crystal superalloy

To increase efficiency and improve performance, reducing cost and emissions, advanced single crystal Ni-based superalloys are required in aerospace propulsion and power generating gas turbines. With the development of alloy, significant improvements in casting techniques have been achieved by introducing the directionally solidified （DS） casting process followed by single crystal （SX） technique. The deviation of preferred orientation of single crystal superalloys is one of the most important defects in casting. In directional solidification equipment with high temperature gradient, single crystal specimens of DZ417G alloy were prepared successfully by the modified Bridgeman method with spiral grain selector. The orientation was investigated by means of X-ray diffraction （XRD） and electron backscattered diffraction （EBSD）.The results show that the crystal selector with a smaller angle can effectively reduce the deviation of preferred orientation.

Three-dimensional Imaging of Multi-slice Spiral CT in Bronchial Artery Correlative Study on Blood Supply of Central Lung Cancer and Its Clinical Significance

Objective: To evaluate three-dimensional bronchial artery imaging charactersin central lung cancer and applied values with multi-slice spiral CT (MSCT) to provide theoreticalevidence on blood supply and intervention therapy. Methods: Eighteen patients with central lungcancer underwent MSCT with real time helical thin-slice CT scanning. Three-dimensional bronchialartery reconstruction was done at the console work-station. The space anatomical characters ofbronchial artery were observed through different rotations. Results: For 6 cases, thethree-dimensional images of bronchial artery (33.33%) could exactly show the origins, the routes(lung inner segment and mediatism segment) and the diameters of bronchial arteries. Vision rate ofbronchial arteries was the highest in pulmonary artery stricture and truncation groups, and thevessels' diameter became larger apparently. These characters demonstrated blood supply of this kindof central lung cancer come from bronchial artery. Volume rendering images were the best ones amongthree-dimensional images. Conclusion: Three-dimensional imaging with MSCT in bronchial artery canreveal the anatomical characters of bronchial artery and provide theoretical evidence on bloodsupply and intervention therapy of central lung cancer.

Tooth surface geometry optimization of spiral bevel and hypoid gears generated by duplex helical method with circular profile blade

In order to effectively improve meshing performance of spiral bevel and hypoid gears generated by the duplex helical method, the effects of straight lined and circular cutting edges profile on meshing and contact of spiral bevel and hypoid gears were investigated analytically. Firstly, a mathematical model of spiral bevel and hypoid gears with circular blade profile was established according to the cutting characteristics of the duplex helical method. Based on a hypoid gear drive, the tooth bearings and the functions of transmission errors of four design cases were analyzed respectively by the use of the tooth contact analysis(TCA), and the contact stresses of the four design cases were analyzed and compared using simulation software. Finally, the curvature radius of the circular profile blade was optimized. The results show that the contact stresses are availably reduced, and the areas of edge contact and severe contact stresses can be avoided by selecting appropriate circular blade profile. In addition, the convex and concave sides are separately modified by the use of different curvature radii of inside and outside blades, which can increase the flexibility of the duplex helical method.

Suppression of spiral waves using intermittent local electric shock

In this paper, an intermittent local electric shock scheme is proposed to suppress stable spiral waves in the Barkley model by a weak electric shock （about 0.4 to 0.7） imposed on a random selected n × n grids （n =1 - 5, compared with the original 256×256 lattice） and monitored synchronically the evolutions of the activator on the grids as the sampled signal of the activator steps out a given threshold （i.e., the electric shock works on the n ~ n grids if the activator u ≤ 0.4 or u ≥ 0.8）. The numerical simulations show that a breakup of spiral is observed in the media state evolution to finally obtain homogeneous states if the electric shock with appropriate intensity is imposed.

Development and transition of spiral wave in the coupled Hindmarsh-Rose neurons in two-dimensional space

The dynamics and the transition of spiral waves in the coupled Hindmarsh-Rose （H-R） neurons in two-dimensional space are investigated in the paper. It is found that the spiral wave can be induced and developed in the coupled HR neurons in two-dimensional space, with appropriate initial values and a parameter region given. However, the spiral wave could encounter instability when the intensity of the external current reaches a threshold value of 1.945. The transition of spiral wave is found to be affected by coupling intensity D and bifurcation parameter r. The spiral wave becomes sparse as the coupling intensity increases, while the spiral wave is eliminated and the whole neuronal system becomes homogeneous as the bifurcation parameter increases to a certain threshold value. Then the coupling action of the four sub-adjacent neurons, which is described by coupling coefficient D＇, is also considered, and it is found that the spiral wave begins to breakup due to the introduced coupling action from the sub-adjacent neurons （or sites） and together with the coupling action of the nearest-neighbour neurons, which is described by the coupling intensity D.

Theoretical and Experimental Study on Ground Coupled Heat Pump with Vertical Spiral Coil

The numeric al simulation study on the temperature distribution of underground field for the ground coupled heat pump (GCHP) with vertical spira l coil was carried out by using finite element. The distribution and recovery of undergroun d field temperature under different operation ratio and the optimal operation ratio were simulated.The performance parameters, i.e. inlet and outlet temperature of the ground spiral coil in heating and cooling modes were tested, the heat extracted or emitted by the heat pump to the ground was calculated, and the coefficients of performance (COP) of GCHP at heat ing and cooling modes were analyzed.

Segmented Spiral Waves and Anti-phase Synchronization in a Model System with Two Identical Time-Delayed Coupled Layers

In this paper, we consider a model system with two identical time-delayed coupled layers. Synchronization and anti-phase synchronization are exhibited in the reactive system without diffusion term. New segmented spiral waves, which are constituted by many thin trips, are found in each layer of two identical time-delayed coupled layers, and are different from the segmented spiral waves in a water-in-oil aerosol sodium bis（2-ethylhexyl） sulfosuccinate （AOT） microemulsion （ME） （BZ-AOT system）, which consists of many small segments. ＂Anti-phase spiral wave synchronization＂ can be realized between the first layer and the second one. For different excitable parameters, we also give the minimum values of the coupling strength to generate segmented spiral waves and the tip orbits of spiral waves in the whole bilayer.

Synchronization of spiral waves in a two-layer coupled inhomogeneous excitable system

We studied synchronization behaviours of spiral waves in a two-layer coupled inhomogeneous excitable system. It was found that phase synchronization can be observed under weak coupling strength. By increasing the coupling strength, the synchronization is broken down. With the further increase of the coupling strength, complete synchronization and phase synchronization occur again. We also found that the inhomogeneity in excitable systems is helpful to the synchronization.

Dynamic Coupling Correlation of Gas Film in Dry Gas Seal with Spiral Groove

In working state, the dynamic performance of dry gas seal, generated by the rotating end face with spiral grooves, is determined by the open force of gas film and leakage flow rate. Generally, the open force and the leakage flow rate can be obtained by finite element method, computational fluid dynamics method and experimental measurement method. However, it will take much time to carry out the above measurements and calculations. In this paper, the approximate model of parallel grooves based on the narrow groove theory is used to establish the dynamic equations of the gas film for the purpose of obtaining the dynamic parameters of gas film. The nonlinear differential equations of gas film model are solved by Runge-Kutta method and shooting method. The numerical values of the pressure profiles, leakage flux and opening force on the seal surface are integrated, and then compared to experimental data for the reliability of the numerical simulation. The results show that the numerical simulation curves are in good agreement with experimental values. Furthermore, the opening force and the leakage flux are proved to be strongly correlated with the operating parameters. Then, the function-coupling method is introduced to analyze the numerical results to obtain the correlation formulae of the opening force and leakage flux respectively with the operating parameters, i.e., the inlet pressure and the rotating speed. This study intends to provide an effective way to predict the aerodynamic performance for designing and optimizing the groove styles in dry gas seal rapidly and accurately.

Suppression of Spiral Wave in Modified Orengonator Model

In this paper, a spatial perturbation scheme is proposed to suppress the spiral wave in the modified Orengonator model, which is used to describe the chemical reaction in the light-sensitive media. The controllable external illumination Ф is perturbed with a spatial linear function. In our numerical simulation, the scheme is investigated by imposing the external controllable illumination on the space continuously and/or intermittently. The numerical simulation results confirm that the stable rotating spiral wave still can be removed with the scheme proposed in this paper even if the controllable Ф changed vs. time and space synchronously. Then the scheme is also used to control the spiral wave and turbulence in the modified Fitzhugh-Nagumo model. It is found that the scheme is effective to remove the sable rotating and meandering spiral wave but it costs long transient period and intensity of the gradient parameter to eliminate the soiral turbulence.

Superposing the Magnetic Spiral Structure of the Milky Way, on the Stellar Spiral Arms—Matching the Unique Galactic Magnetic Field Reversal Zone with Two Galactic Spiral Arm Segments

To pinpoint the peak location of the synchrotron total intensity emission in a spiral arm, we use a map of the spiralarm locations (from the observed arm tangent). Thus in a typical spiral arm in Galactic Quadrant I, we find the peak of the synchrotron radiation to be located about 220 ± 40 pc away from the inner arm edge (hot dust lane) inside the spiral arm. While most of the galactic disk has a clockwise large-scale magnetic field, we make a statistical analysis to delimitate more precisely the smaller reverse annulus with a counterclockwise galactic magnetic field. We find an annulus width of 2.1 ± 0.3 kpc (measured along the Galactic radius), located from 5.5 to 7.6 kpc from the Galactic Center). The annulus does not overlay with a single spiral arm—it encompasses segments of two different spiral arms. Using a recent delineation of the position of spiral arms, the field-reversed annulus is seen to encompass the Crux-Centaurus arm (in Galactic Quadrant IV) and the Sagittarius arm (in Galactic Quadrant I). Thus the full Sagittarius-Carina arm is composed of: 1) a Sagittarius arm (in Galactic quadrant I) with a counterclockwise magnetic field, and 2) a Carina arm (in Galactic Quadrant IV) with a clockwise magnetic field. Also the full Scutum-Crux-Centaurus arm is composed of: 1) a Scutum arm (in Galactic Quadrant I) with a clockwise magnetic field, and 2) a Crux-Centaurus arm (in Galactic Quadrant IV) with a counterclockwise magnetic field. Arm segments do not all have the same magnetic field direction. For completeness, we display 6 known magnetised advancing supershells around the Sun (within 400 pc), pushing out the interstellar magnetic field.

Breakup of spiral wave under different boundary conditions

In this paper, we investigate the breakup of spiral wave under no-flux, periodic and Dirichlet boundary conditions respectively. When the parameter ε is close to a critical value for Doppler-induced wave breakup, the instability of the system caused by the boundary effect occurs in the last two cases, resulting in the breakup of spiral wave near the boundary. With our defined average order measure of spiral wave （AOMSW）, we quantify the degree of order of the system when the boundary-induced breakup of spiral wave happens. By analysing the AOMSW and outer diameter R of the spiral tip orbit, it is easy to find that this boundary effect is correlated with large values of R, especially under the Dirichlet boundary condition. This correlation is nonlinear, so the AOMSW sometimes oscillates with the variation of ε.

The coupling effect of air-bridges on broadband spiral inductors in SiC-based MMIC technology

The coupling effect of air-bridges on broadband spiral inductors in SiC-based MMIC technology has been investigated deeply. The fabricated 1-nH spiral inductor on SiC substrate demonstrates a self-resonant frequency of 51.6 GHz, with a peak Q-fact of 12.14 at 22.1 GHz. From the S-parameters measurements, the exponential decay phenomenon is observed for L, Q-factor, and SRF with the air-bridge height decreasing, and an analytic expression is concluded to exactly fit the measured data which can be used to predict the performance of the spiral inductor. All the coefficients in the formula have specific meaning. By means of establishing the lumped model, the parasitic coupling capacitance of the air-bridge has been extracted and presents the exponential decay with the air-bridge heights decreasing which indicates that this capacitor is directly related to the coupling effect of the air-bridge. Through the electromagnetic field distribution simulation, the details of the electric field around the air-bridge have been presented which demonstrate the formation and the variation principles of the coupling effect.

Synchronizing spiral waves in a coupled Rssler system

The synchronisation of spiral patterns in a drive-response R6ssler system is studied. The existence of three types of synchronisation is revealed by inspecting the coupling parameter space. Two transient stages of phase synchronisation and partial synchronisation are observed in a comparatively weak feedback coupling parameter regime, whilst complete synchronisation of spirals is found with strong negative couplings. Detailed observations of the synchronous process, such as oscillatory frequencies, parameters mismatches and amplitude variations, etc, are investigated via numerical simulations.

Multi-mode Spiral Wave in a Coupled Oscillatory Medium

Multi-mode spiral wave and its breakup in 1-d and 2-d coupled oscillatory media is studied here by theoretic analysis and numerical simulations. The analysis in 1-d system shows that the dispersion relation curve could be nonmonotonic depending on the coupling strength. It may also lead to the coexistence of different wave numbers within one system. Direct numerical observations in 1-d and 2-d systems conform to the prediction of dispersion relation analysis. Our findings indicate that the wave grouping can also be observed in oscillatory media without tip meandering and waves with negative group velocity can occur without inhomogeneity.

Numerical simulation of flow and heat transfer of n-decane in sub-millimeter spiral tube at supercritical pressure

The flow and heat transfer characteristics of n-decane in the sub-millimeter spiral tube(SMST) at supercritical pressure(p = 3 MPa) are studied by the RNG k-ε numerical model in this paper. The effects of various Reynolds numbers(Re) and structural parameters pitch(s) and spiral diameter(D) are analyzed.Results indicate that the average Nusselt numberNu and friction factorNu increase with an increase in Re, and decrease with an increase in D/d(tube diameter). In terms of the structural parameter s/d, it is found that as s/d increases, the Nu first increase, and then decrease. and the critical structural parameter is s/d = 4. Compared with the straight tube, the SMST can improve Nu by 34.8% at best, while it can improve Nu by 102.1% at most. In addition, a comprehensive heat transfer coefficient is applied to analyze the thermodynamic properties of SMST. With the optimal structural parameters of D/d = 6 and s/d = 4, the comprehensive heat transfer factor of supercritical pressure hydrocarbon fuel in the SMST can reach 1.074. At last, correlations of the average Nusselt number and friction factor are developed to predict the flow and heat transfer of n-decane at supercritical pressure.

Suppression of Spiral Waves and Spatiotemporal Chaos Under Local Self-adaptive Coupling Interactions

In this paper, a close-loop feedback control is imposed locally on the Fitzhugh-Nagumo （FHN） system to suppress the stable spirals and spatiotemporal chaos according to the principle of self-adaptive coupling interaction. The simulation results show that an expanding target wave is stimulated by the spiral waves under dynamic control period when a local area. of 5 × 5 grids is controlled, or the spiral tip is driven to the board of the system, It is also found that the spatiotemporal chaos can be suppressed to get a stable homogeneous state within 50 time units as two local grids are controlled mutually. The mechanism of the scheme is briefly discussed.

Derivation of the Spiral Motion of an Eruptive Prominence and Its Explanation

A 2D velocity field of the eruptive prominence （EP） of 1991 March 5 is obtained from its spectral data observed at the Yunnan Observatory and the velocity distributions along the entrance slit are derived for different observing frames. Under the assumption that matter in the EP undergoes axial, radial and possible rotational motions, we construct a theoretical velocity distribution of the EP along the entrance slit, to derive, by fitting, the angular velocity of rotation ω and the other three parameters （axial velocity v0, radial velocity vr and the angle between the EP plane and the line of sight Ф）. We found： an averaged angular velocity ω of 3.0 × 10^-3 arc s^-1 and the variation of ω with the height above the solar limb. As the EP rises, the matter within it in fact moves along a spiral path around its axis. The spiral motion may be explained by the theory of plasma ‘double pole diffusion＇ （DPD） caused by a sharp density gradient between the eruptive prominence and the surrounding corona. A theoretical angular velocity ω′ is estimated based on the DPD and basically coincides with ω obtained from the optimal velocity fitting.

UBVVI Surface Photometry of the Spiral Galaxy NGC 300 in the Sculptor Group

We present UBVI surface photometry over a 20.5' × 20.5' area of the late-type spiral galaxy NGC 300. We have derived isophotal maps, surface brightness profiles, ellipticity profiles, position angle profiles, and color profiles. By merging our I-band measurements with those of Boker et al. based on Hubble Space Telescope observations, we have obtained combined I-band surface brightness profiles for the region 0.02' < r < 500' and have decomposed the profiles into three components: a nucleus, a bulge, and an exponential disk.