Spirobisnaphthalenes comprise a relatively rare family of natural products that are normally isolated from fungi and occasionally from plants.Here we reported the discovery of seven new preussomerintype spirobisnaphth...Spirobisnaphthalenes comprise a relatively rare family of natural products that are normally isolated from fungi and occasionally from plants.Here we reported the discovery of seven new preussomerintype spirobisnaphthalenes,preussomerins YT1-YT7(1-7),and seven known ones(8-14),from the endophytic fungus Edenia gomezpompae,enriching the structural diversity of this family of natural products.Their structures were established by 1 D and 2 D NMR spectroscopy,HRESIMS analysis and comparison with previously reported compounds,with the absolute configurations of compounds 1 and2 being further confirmed by single-crystal X-ray diffraction using Cu Ka radiation.The antiinflammatory activities of all isolates were assessed by measuring the production of NO in LPS-induced RAW264.7 macrophage cells.Among them,compounds 8 and 13 exhibited potent inhibitory activities on the production of NO,with IC50 values of 2.61 and 1.32μmol/L,respectively.展开更多
基金financially supported by MOST(Nos.2018YFA0902000 and 2018YFC1706200)National Natural Science Foundation of China(Nos.81925033,21861142005,81773591,21761142001,81673333 and 21661140001)+1 种基金the Central Public-interest Scientific Institution Basal Research Fund for CATAS-ITBB(Nos.1630052020032,19CXTD-32 and 1630052019011)the Hainan Provincial Basic and Applied Basic Research Fund for High-Level Talents in Natural Science(No.2019RC306)。
文摘Spirobisnaphthalenes comprise a relatively rare family of natural products that are normally isolated from fungi and occasionally from plants.Here we reported the discovery of seven new preussomerintype spirobisnaphthalenes,preussomerins YT1-YT7(1-7),and seven known ones(8-14),from the endophytic fungus Edenia gomezpompae,enriching the structural diversity of this family of natural products.Their structures were established by 1 D and 2 D NMR spectroscopy,HRESIMS analysis and comparison with previously reported compounds,with the absolute configurations of compounds 1 and2 being further confirmed by single-crystal X-ray diffraction using Cu Ka radiation.The antiinflammatory activities of all isolates were assessed by measuring the production of NO in LPS-induced RAW264.7 macrophage cells.Among them,compounds 8 and 13 exhibited potent inhibitory activities on the production of NO,with IC50 values of 2.61 and 1.32μmol/L,respectively.
