The purpose of this study was to study the role of neurofilament （NF） mRNA and calpain in NF reduction of acrylamide （ACR） neuropathy. Male Wistar adult rats were injected i.p. every other day with AER （20 mg/kg....The purpose of this study was to study the role of neurofilament （NF） mRNA and calpain in NF reduction of acrylamide （ACR） neuropathy. Male Wistar adult rats were injected i.p. every other day with AER （20 mg/kg.bW or 40 mg/kg.bW） for 8 weeks. NF mRNA expression was detected using RT-PCR and the calpain concentration was determined using western blot analysis. The NF mRNA expression significantly decreased while the level of m-calpain and μ-calpain significantly increased in two ACR-treated rats groups regardless of the ACR dose. The light NF （NF-L） protein expression was significantly correlated with NF-L mRNA expression. Combined with previous data, the concentrations of three NF subunits were negatively correlated with the calpain levels. These findings suggest that NF-L mRNA and calpain mediated the reduction in NF of AER neuropathy.展开更多
The Kulu\|Rampur and Larji windows in the western Himalaya make a window in window structure in the Lesser Himalaya between the Main Boundary Thrust (MBT) and Main Central Thrust (MCT). The former constituted of late ...The Kulu\|Rampur and Larji windows in the western Himalaya make a window in window structure in the Lesser Himalaya between the Main Boundary Thrust (MBT) and Main Central Thrust (MCT). The former constituted of late Archean Rampur Group with middle Proterozoic intrusive Bandal Granite Complex has been thrusted on to the younger Larji Group (Riphean) along a splay thrust making the latter a window in window structure. Both the sequences have recorded multiple deformation during the Himalayan orogeny. Five sets of Himalayan structures have been recognised. The first deformation event (D 1) was responsible for large isoclinal, (recumbent) folds (F 1) which are older than the onset of Himalayan thrusting. Presently, the Rampur Group constitutes the antiform and the Larji Group occupies a synformal position of F 1 folds. The parautochthons of the window zone has been covered by the Chail and Jutogh nappes along the Chail and Jutogh thrusts during D 2. Thrusting was followed by F 3 folding during D 3 deformation. This fold can be recognised in form of Rampur Antiform and corresponding Nirath\|Pandoh Synform with NW—SE axial trend. The Chail and Jutogh nappes are folded along with the parautochthonous rocks of window zone by this folding event. The out\|of\|sequence imbrication and the splay thrusts in the hanging wall of the MBT were initiated during D 3. The F 3 are overprinted by cross folding (F 4) of D 4 deformation, which is responsible for the doubly plunging character of the window zones. Cross folding was followed by D 5 extensional faulting and collapse of the hanging wall in out\|of\|sequence shear zones. The D 5 extensional fabrics are attributed to gravity collapse in the hanging wall of the MBT.展开更多
Seafloor irregularities influence rupture behavior along the subducting slab and in the overriding plate,thus affecting earthquake cycles.Whether seafloor irregularities increase the likelihood of large earthquakes in...Seafloor irregularities influence rupture behavior along the subducting slab and in the overriding plate,thus affecting earthquake cycles.Whether seafloor irregularities increase the likelihood of large earthquakes in a subduction zone remains contested,partially due to focus put either on fault development or on rupture pattern.Here,we simulate a subducting slab with a seafloor irregularity and the resulting deformation pattern of the overriding plate using the discrete element method.Our simulations illustrate the rupture along three major fault systems:megathrust,splay and backthrust faults.Our results show different rupture dimensions of earthquake events varying from tens to ca.140 km.Our results suggest that the recurrence interval of megathrust events with rupture length of ca.100 km is ca.140 years,which is overall comparable to the paleoseismic records at the Mentawai area of the Sumatran zone.We further propose the coseismic slip amounts decrease and interseismic slip amounts increase from the surface downwards gradually.We conclude that the presence of seafloor irregularities significantly affects rupture events along the slab as well as fault patterns in the overriding plate.展开更多
There are various faults in northern and southern margins of Torbat-e-Jam-Fariman plain which show the probability of enormous earthquake in the future.In present study the geomorphic indices contain Asymmetry Functio...There are various faults in northern and southern margins of Torbat-e-Jam-Fariman plain which show the probability of enormous earthquake in the future.In present study the geomorphic indices contain Asymmetry Function(Af),Sinuosity of mountain front(Smf),Valley floor index(Vf),Hypsometric index(Hi),Mean Axial slope of channel index(MASC)and Drainage Basin Shape(Bs),have been utilized to determine the relative tectonic activity index(IAT)to recognize,eventually,the geo-structural model of the study area.Faults and folds control the geo-structural activities of the study area,and the geomorphic indices are being affected in consequence of their activities.The intensity of these activities is different throughout the plain.There are many geomorphic evidences,related to active transform fault which are detectable all over the study area such as deviated rivers,quaternary sediments transformation,fault traces.Therefore,recognition of geo-structural model of the study area is extremely vital.Field study,then,approved the results of geomorphic indices calculation in determining the geo-structural model of the study area.Results depicted that the geostructural model of the study area is a kind of Horsetail splay form which is in accordance to the relative tectonic activity of the study area.Based on the above mentioned results it can be predicted that the splays are the trail of Neyshabour fault.展开更多
Deduplication technology has been increasingly used to reduce storage costs. Though it has been successfully applied to backup and archival systems, existing techniques can hardly be deployed in primary storage system...Deduplication technology has been increasingly used to reduce storage costs. Though it has been successfully applied to backup and archival systems, existing techniques can hardly be deployed in primary storage systems due to the associated latency cost of detecting duplicated data, where every unit has to be checked against a substantially large fin- gerprint index before it is written. In this paper we introduce Leach, for inline primary storage, a self-learning in-memory fingerprints cache to reduce the writing cost in deduplica- tion system. Leach is motivated by the characteristics of real- world I/O workloads： highly data skew exist in the access patterns of duplicated data. Leach adopts a splay tree to or- ganize the on-disk fingerprint index, automatically learns the access patterns and maintains hot working sets in cache mem- ory, with a goal to service a majority of duplicated data de- tection. Leveraging the working set property, Leach provides optimization to reduce the cost of splay operations on the fin- gerprint index and cache updates. In comprehensive experi- ments on several real-world datasets, Leach outperforms con- ventional LRU （least recently used） cache policy by reducing the number of cache misses, and significantly improves write performance without great impact to cache hits.展开更多
You've seen Li,or-at least-men like him.Street-side,splayed across the bed of a rusted trike,napping in the afternoon sun with hiked-up pant legs reveal・ing tan skin as an unlit cigarette hangs from a bottom lip.T...You've seen Li,or-at least-men like him.Street-side,splayed across the bed of a rusted trike,napping in the afternoon sun with hiked-up pant legs reveal・ing tan skin as an unlit cigarette hangs from a bottom lip.Those guys.展开更多
基金the National Natural Science Funding of China(No.30872088,81372969)
文摘The purpose of this study was to study the role of neurofilament （NF） mRNA and calpain in NF reduction of acrylamide （ACR） neuropathy. Male Wistar adult rats were injected i.p. every other day with AER （20 mg/kg.bW or 40 mg/kg.bW） for 8 weeks. NF mRNA expression was detected using RT-PCR and the calpain concentration was determined using western blot analysis. The NF mRNA expression significantly decreased while the level of m-calpain and μ-calpain significantly increased in two ACR-treated rats groups regardless of the ACR dose. The light NF （NF-L） protein expression was significantly correlated with NF-L mRNA expression. Combined with previous data, the concentrations of three NF subunits were negatively correlated with the calpain levels. These findings suggest that NF-L mRNA and calpain mediated the reduction in NF of AER neuropathy.
文摘The Kulu\|Rampur and Larji windows in the western Himalaya make a window in window structure in the Lesser Himalaya between the Main Boundary Thrust (MBT) and Main Central Thrust (MCT). The former constituted of late Archean Rampur Group with middle Proterozoic intrusive Bandal Granite Complex has been thrusted on to the younger Larji Group (Riphean) along a splay thrust making the latter a window in window structure. Both the sequences have recorded multiple deformation during the Himalayan orogeny. Five sets of Himalayan structures have been recognised. The first deformation event (D 1) was responsible for large isoclinal, (recumbent) folds (F 1) which are older than the onset of Himalayan thrusting. Presently, the Rampur Group constitutes the antiform and the Larji Group occupies a synformal position of F 1 folds. The parautochthons of the window zone has been covered by the Chail and Jutogh nappes along the Chail and Jutogh thrusts during D 2. Thrusting was followed by F 3 folding during D 3 deformation. This fold can be recognised in form of Rampur Antiform and corresponding Nirath\|Pandoh Synform with NW—SE axial trend. The Chail and Jutogh nappes are folded along with the parautochthonous rocks of window zone by this folding event. The out\|of\|sequence imbrication and the splay thrusts in the hanging wall of the MBT were initiated during D 3. The F 3 are overprinted by cross folding (F 4) of D 4 deformation, which is responsible for the doubly plunging character of the window zones. Cross folding was followed by D 5 extensional faulting and collapse of the hanging wall in out\|of\|sequence shear zones. The D 5 extensional fabrics are attributed to gravity collapse in the hanging wall of the MBT.
基金This work is Earth Observatory of Singapore contribution(No.M4430217.B50.706022)the Ministry of Science and Technology(Grant Nos.MOST 109-2116-M-008-029-MY3,MOST 110-2124-M-002-008,and MOST 110-2634-F-008-008)。
文摘Seafloor irregularities influence rupture behavior along the subducting slab and in the overriding plate,thus affecting earthquake cycles.Whether seafloor irregularities increase the likelihood of large earthquakes in a subduction zone remains contested,partially due to focus put either on fault development or on rupture pattern.Here,we simulate a subducting slab with a seafloor irregularity and the resulting deformation pattern of the overriding plate using the discrete element method.Our simulations illustrate the rupture along three major fault systems:megathrust,splay and backthrust faults.Our results show different rupture dimensions of earthquake events varying from tens to ca.140 km.Our results suggest that the recurrence interval of megathrust events with rupture length of ca.100 km is ca.140 years,which is overall comparable to the paleoseismic records at the Mentawai area of the Sumatran zone.We further propose the coseismic slip amounts decrease and interseismic slip amounts increase from the surface downwards gradually.We conclude that the presence of seafloor irregularities significantly affects rupture events along the slab as well as fault patterns in the overriding plate.
文摘There are various faults in northern and southern margins of Torbat-e-Jam-Fariman plain which show the probability of enormous earthquake in the future.In present study the geomorphic indices contain Asymmetry Function(Af),Sinuosity of mountain front(Smf),Valley floor index(Vf),Hypsometric index(Hi),Mean Axial slope of channel index(MASC)and Drainage Basin Shape(Bs),have been utilized to determine the relative tectonic activity index(IAT)to recognize,eventually,the geo-structural model of the study area.Faults and folds control the geo-structural activities of the study area,and the geomorphic indices are being affected in consequence of their activities.The intensity of these activities is different throughout the plain.There are many geomorphic evidences,related to active transform fault which are detectable all over the study area such as deviated rivers,quaternary sediments transformation,fault traces.Therefore,recognition of geo-structural model of the study area is extremely vital.Field study,then,approved the results of geomorphic indices calculation in determining the geo-structural model of the study area.Results depicted that the geostructural model of the study area is a kind of Horsetail splay form which is in accordance to the relative tectonic activity of the study area.Based on the above mentioned results it can be predicted that the splays are the trail of Neyshabour fault.
文摘Deduplication technology has been increasingly used to reduce storage costs. Though it has been successfully applied to backup and archival systems, existing techniques can hardly be deployed in primary storage systems due to the associated latency cost of detecting duplicated data, where every unit has to be checked against a substantially large fin- gerprint index before it is written. In this paper we introduce Leach, for inline primary storage, a self-learning in-memory fingerprints cache to reduce the writing cost in deduplica- tion system. Leach is motivated by the characteristics of real- world I/O workloads： highly data skew exist in the access patterns of duplicated data. Leach adopts a splay tree to or- ganize the on-disk fingerprint index, automatically learns the access patterns and maintains hot working sets in cache mem- ory, with a goal to service a majority of duplicated data de- tection. Leveraging the working set property, Leach provides optimization to reduce the cost of splay operations on the fin- gerprint index and cache updates. In comprehensive experi- ments on several real-world datasets, Leach outperforms con- ventional LRU （least recently used） cache policy by reducing the number of cache misses, and significantly improves write performance without great impact to cache hits.
文摘You've seen Li,or-at least-men like him.Street-side,splayed across the bed of a rusted trike,napping in the afternoon sun with hiked-up pant legs reveal・ing tan skin as an unlit cigarette hangs from a bottom lip.Those guys.
