[Objective] This study aimed to explore the histological effects of Guchangcuzhang powder on intestine and spleen in experiment piglets with spleen weakness.[Method] The 12 piglets with diarrhea were divided into two ...[Objective] This study aimed to explore the histological effects of Guchangcuzhang powder on intestine and spleen in experiment piglets with spleen weakness.[Method] The 12 piglets with diarrhea were divided into two groups,namely the Guchangcuzhang powder group and the control group,six in each.On two and eight days after the drug discontinuance respectively,three piglets were selected from each of the group and killed by bloodletting from the jugular vein.Afterwards,paraffin sections of intestine and spleen were made and stained by HE staining solution,followed by observation of the histological changes.[Result] The structures of intestine and spleen in piglets drenched with Guchangcuzhang powder restored or approachedto normal.[Conlusion] Guchangcuzhang powder has the function of healing piglet diarrhea.展开更多
Objective:To explore the therapeutic effect of Shengyang Yiwei Decoction in patients with diarrhea-predominant irritable bowel syndrome(IBS)due to spleen and stomach weakness.Methods:40 patients with diarrhea-predomin...Objective:To explore the therapeutic effect of Shengyang Yiwei Decoction in patients with diarrhea-predominant irritable bowel syndrome(IBS)due to spleen and stomach weakness.Methods:40 patients with diarrhea-predominant IBS who were treated from April 2018 to April 2020 were taken as samples.TCM(traditional Chinese medicine)syndrome differentiation found that they were all due to spleen and stomach weakness.They were randomly divided into two groups.Group A was treated with modified prescriptions of Shengyang Yiwei Decoction,while Group B was treated with Western medicine.The therapeutic effects in the two groups were compared.Results:The treatment efficacy in Group A was higher than that in Group B(P<0.05);the symptom scores of Group A such as loose stools,chills,physical weakness,poor appetite,and abdominal distension after meals were all lower than those in Group B(P<0.05);the SF-36(36-Item Short Form Health Survey)scores of patients with diarrhea-predominant IBS in Group A were higher than those in Group B(P<0.05);the treatment satisfaction of Group A was higher than that of Group B(P<0.05).Conclusion:Treatment of diarrhea-predominant IBS patients with spleen and stomach weakness by Shengyang Yiwei Decoction can promote the disappearance of gastrointestinal discomfort symptoms,improve the quality of life,and enhance treatment efficacy.Hence,it is an efficient and feasible treatment for diarrhea-predominant IBS due to spleen and stomach weakness.展开更多
Dyspepsia is a clinical syndrome caused by gastric motility disorder,including gastroparesis and esophageal reflux disease.Dyspepsia of spleen stomach weakness type is the most common TCM syndrome type in clinic.TCM h...Dyspepsia is a clinical syndrome caused by gastric motility disorder,including gastroparesis and esophageal reflux disease.Dyspepsia of spleen stomach weakness type is the most common TCM syndrome type in clinic.TCM has unique advantages in the prevention and treatment of spleen stomach weakness dyspepsia.This paper summarizes the research progress of TCM in the prevention and treatment of spleen stomach weakness dyspepsia in recent years,discusses its mechanism and advantages,and analyzes the existing problems,so as to provide research ideas and directions for TCM to further prevent and treat the disease and improve human quality of life.展开更多
Objective: To study the mechanism of Sijunzi decoction treating limb weakness in spleen Qi deficiency (SQD) based on the myonuclear domain (MND) theory. Methods: 40 male Sprague-Dawley rats were randomly divided into ...Objective: To study the mechanism of Sijunzi decoction treating limb weakness in spleen Qi deficiency (SQD) based on the myonuclear domain (MND) theory. Methods: 40 male Sprague-Dawley rats were randomly divided into the normal group, SQD model group (model group), SQD+ still water group (SW group) and SQD+ Sijunzi decoction group (CM group), 10 rats each group;Grip-Strength Meter was used to measure limb grip strength;transmission electron microscope was employed to observe the ultrastructural changes of the myofibers, Image Pro 6.0 was used to measure the myonuclear numbers, cross-section area (CSA) and then their ratios (the MND sizes) were calculated, immunofluorescence assay was chosen to test the expressions of paired box gene 7 (Pax7) and myogenic differentiation antigen (MyoD). Results: Compared with those in the normal group, limb grip strength was decreased, sarcomeres were abnormal, and all the myonuclear numbers, CSA and MND sizes were reduced, but the Pax7+ cell numbers were increased, significantly, in the model and SW groups;Compared with those in the model and SW groups, limb grip strength was increased, sarcomeres were basically normal, the myonuclear number and CSA were both greater, and the Pax7+ and MyoD+ cell numbers were both increased, significantly, in the CM group. Conclusion: Sijunzi decoction might increase the myonuclear number by activating the MSCs to treat limb weakness in SQD.展开更多
肠道从正常黏膜至癌变病程较为漫长,始于炎性状态,进展至癌前病变和癌前状态,终于结肠癌,简称结肠炎-癌转化类疾病。在肠道炎-癌转化类疾病进程中,所呈现“虚、郁、滞、瘀”核心病机与机体的神经、免疫状态以及平衡失调诱发的炎症反应...肠道从正常黏膜至癌变病程较为漫长,始于炎性状态,进展至癌前病变和癌前状态,终于结肠癌,简称结肠炎-癌转化类疾病。在肠道炎-癌转化类疾病进程中,所呈现“虚、郁、滞、瘀”核心病机与机体的神经、免疫状态以及平衡失调诱发的炎症反应密切相关。脾胃虚弱,炎症始生,郁化促炎,脑肠互损,气血运行不畅,肠腑痰浊内生,气滞痰凝血瘀,初未能成积聚,留滞不去,乃成积聚。从现代生物学角度而言,辅助性T细胞(T helper cell,Th)17/调节性T细胞(regulatory T cell,Treg)介导的促炎因子与抗炎因子释放,影响肠道微环境内肠道菌群结构的动态平衡,通过神经免疫等上传至大脑中枢,脑肠相互作用,在内外因的刺激下,其中某一环境平衡失调,就会造成局部和整体的失衡,诱发炎症逐步发展至不可控状态,驱动基因突变形成癌症。围绕“虚、郁、滞、瘀”核心病机,从健运脾胃入手,缓解炎症,行滞化瘀,未癌先治炎,阻断炎-癌转化,能为肠道炎-癌转化疾病的临床防治提供思路借鉴。展开更多
目的分析穴位贴敷与隔姜灸联合应用于脾胃虚寒型胃脘痛患者中的效果。方法方便选取2022年1—12月东台市中医院收治的102例脾胃虚寒型胃脘痛患者为研究对象,参照随机数表法分为两组。对照组(n=51)患者接受穴位贴敷干预,研究组(n=51)患者...目的分析穴位贴敷与隔姜灸联合应用于脾胃虚寒型胃脘痛患者中的效果。方法方便选取2022年1—12月东台市中医院收治的102例脾胃虚寒型胃脘痛患者为研究对象,参照随机数表法分为两组。对照组(n=51)患者接受穴位贴敷干预,研究组(n=51)患者联用隔姜灸干预。比较干预前后两组患者的视觉模拟评分法(Visual Analogue Scale,VAS)评分、慢性病患者生命质量测定量表(Quality of Life Instruments for Chronic Diseases,QLICD)-慢性胃炎(Chronic Gastritis,CG)评分以及护理满意度。结果研究组干预后VAS评分较对照组低,差异有统计学意义(P<0.05)。与对照组相比,研究组QLICD-CG评分更高,差异有统计学意义(P<0.05)。与对照组护理总满意率(84.31%)相比,研究组护理总满意率(98.04%)更高,差异有统计学意义(χ^(2)=4.287,P<0.05)。结论胃脘痛脾胃虚寒型患者采用穴位贴敷与隔姜灸联合干预可以缓解疼痛症状,保障生活质量,提高护理满意度。展开更多
文摘[Objective] This study aimed to explore the histological effects of Guchangcuzhang powder on intestine and spleen in experiment piglets with spleen weakness.[Method] The 12 piglets with diarrhea were divided into two groups,namely the Guchangcuzhang powder group and the control group,six in each.On two and eight days after the drug discontinuance respectively,three piglets were selected from each of the group and killed by bloodletting from the jugular vein.Afterwards,paraffin sections of intestine and spleen were made and stained by HE staining solution,followed by observation of the histological changes.[Result] The structures of intestine and spleen in piglets drenched with Guchangcuzhang powder restored or approachedto normal.[Conlusion] Guchangcuzhang powder has the function of healing piglet diarrhea.
文摘Objective:To explore the therapeutic effect of Shengyang Yiwei Decoction in patients with diarrhea-predominant irritable bowel syndrome(IBS)due to spleen and stomach weakness.Methods:40 patients with diarrhea-predominant IBS who were treated from April 2018 to April 2020 were taken as samples.TCM(traditional Chinese medicine)syndrome differentiation found that they were all due to spleen and stomach weakness.They were randomly divided into two groups.Group A was treated with modified prescriptions of Shengyang Yiwei Decoction,while Group B was treated with Western medicine.The therapeutic effects in the two groups were compared.Results:The treatment efficacy in Group A was higher than that in Group B(P<0.05);the symptom scores of Group A such as loose stools,chills,physical weakness,poor appetite,and abdominal distension after meals were all lower than those in Group B(P<0.05);the SF-36(36-Item Short Form Health Survey)scores of patients with diarrhea-predominant IBS in Group A were higher than those in Group B(P<0.05);the treatment satisfaction of Group A was higher than that of Group B(P<0.05).Conclusion:Treatment of diarrhea-predominant IBS patients with spleen and stomach weakness by Shengyang Yiwei Decoction can promote the disappearance of gastrointestinal discomfort symptoms,improve the quality of life,and enhance treatment efficacy.Hence,it is an efficient and feasible treatment for diarrhea-predominant IBS due to spleen and stomach weakness.
文摘Dyspepsia is a clinical syndrome caused by gastric motility disorder,including gastroparesis and esophageal reflux disease.Dyspepsia of spleen stomach weakness type is the most common TCM syndrome type in clinic.TCM has unique advantages in the prevention and treatment of spleen stomach weakness dyspepsia.This paper summarizes the research progress of TCM in the prevention and treatment of spleen stomach weakness dyspepsia in recent years,discusses its mechanism and advantages,and analyzes the existing problems,so as to provide research ideas and directions for TCM to further prevent and treat the disease and improve human quality of life.
文摘Objective: To study the mechanism of Sijunzi decoction treating limb weakness in spleen Qi deficiency (SQD) based on the myonuclear domain (MND) theory. Methods: 40 male Sprague-Dawley rats were randomly divided into the normal group, SQD model group (model group), SQD+ still water group (SW group) and SQD+ Sijunzi decoction group (CM group), 10 rats each group;Grip-Strength Meter was used to measure limb grip strength;transmission electron microscope was employed to observe the ultrastructural changes of the myofibers, Image Pro 6.0 was used to measure the myonuclear numbers, cross-section area (CSA) and then their ratios (the MND sizes) were calculated, immunofluorescence assay was chosen to test the expressions of paired box gene 7 (Pax7) and myogenic differentiation antigen (MyoD). Results: Compared with those in the normal group, limb grip strength was decreased, sarcomeres were abnormal, and all the myonuclear numbers, CSA and MND sizes were reduced, but the Pax7+ cell numbers were increased, significantly, in the model and SW groups;Compared with those in the model and SW groups, limb grip strength was increased, sarcomeres were basically normal, the myonuclear number and CSA were both greater, and the Pax7+ and MyoD+ cell numbers were both increased, significantly, in the CM group. Conclusion: Sijunzi decoction might increase the myonuclear number by activating the MSCs to treat limb weakness in SQD.
文摘肠道从正常黏膜至癌变病程较为漫长,始于炎性状态,进展至癌前病变和癌前状态,终于结肠癌,简称结肠炎-癌转化类疾病。在肠道炎-癌转化类疾病进程中,所呈现“虚、郁、滞、瘀”核心病机与机体的神经、免疫状态以及平衡失调诱发的炎症反应密切相关。脾胃虚弱,炎症始生,郁化促炎,脑肠互损,气血运行不畅,肠腑痰浊内生,气滞痰凝血瘀,初未能成积聚,留滞不去,乃成积聚。从现代生物学角度而言,辅助性T细胞(T helper cell,Th)17/调节性T细胞(regulatory T cell,Treg)介导的促炎因子与抗炎因子释放,影响肠道微环境内肠道菌群结构的动态平衡,通过神经免疫等上传至大脑中枢,脑肠相互作用,在内外因的刺激下,其中某一环境平衡失调,就会造成局部和整体的失衡,诱发炎症逐步发展至不可控状态,驱动基因突变形成癌症。围绕“虚、郁、滞、瘀”核心病机,从健运脾胃入手,缓解炎症,行滞化瘀,未癌先治炎,阻断炎-癌转化,能为肠道炎-癌转化疾病的临床防治提供思路借鉴。
文摘目的分析穴位贴敷与隔姜灸联合应用于脾胃虚寒型胃脘痛患者中的效果。方法方便选取2022年1—12月东台市中医院收治的102例脾胃虚寒型胃脘痛患者为研究对象,参照随机数表法分为两组。对照组(n=51)患者接受穴位贴敷干预,研究组(n=51)患者联用隔姜灸干预。比较干预前后两组患者的视觉模拟评分法(Visual Analogue Scale,VAS)评分、慢性病患者生命质量测定量表(Quality of Life Instruments for Chronic Diseases,QLICD)-慢性胃炎(Chronic Gastritis,CG)评分以及护理满意度。结果研究组干预后VAS评分较对照组低,差异有统计学意义(P<0.05)。与对照组相比,研究组QLICD-CG评分更高,差异有统计学意义(P<0.05)。与对照组护理总满意率(84.31%)相比,研究组护理总满意率(98.04%)更高,差异有统计学意义(χ^(2)=4.287,P<0.05)。结论胃脘痛脾胃虚寒型患者采用穴位贴敷与隔姜灸联合干预可以缓解疼痛症状,保障生活质量,提高护理满意度。
