[Objectives]To observe the clinical efficacy of Shenling Baizhu Powder in the treatment of primary nephrotic syndrome(PNS)featuring damp abundance due to splenic asthenia.[Methods]40 patients with PNS were randomly di...[Objectives]To observe the clinical efficacy of Shenling Baizhu Powder in the treatment of primary nephrotic syndrome(PNS)featuring damp abundance due to splenic asthenia.[Methods]40 patients with PNS were randomly divided into treatment group(n=19)and control group(n=21).In the treatment group and the control group,methylprednisolone tablets were taken orally and cytoxan(CTX)was given intravenously for treatment;in the treatment group,based on oral administration of methylprednisolone tablets and intravenous drip of cytoxan(CTX),oral administration of traditional Chinese medicine(addition and subtraction of Shenling Baizhu Powder)was added.Urine routine,24-hour urinary protein,renal function and serum albumin were re-examined after 4 weeks of treatment.[Results]The total effective rate of the treatment group was significantly higher than that of the control group(89.47%vs 61.90%,P<0.05).After treatment,both groups could effectively reduce the levels of 24-hour urinary protein(P<0.05),serum creatinine(P<0.05)and urea nitrogen(P<0.05),and increase the level of serum albumin(P<0.05),but the degree of improvement in the treatment group was significantly higher than that in the control group(P<0.05),and the difference was statistically significant(P<0.05).[Conclusions]Methylprednisolone combined with addition and subtraction of Shenling Baizhu Powder could effectively reduce urinary protein,improve edema symptoms,shorten the course of hormone use and reduce adverse reactions in the treatment of PNS featuring damp abundance due to splenic asthenia.展开更多
血清高密度脂蛋白(High density lipoprotein,HDL)具有抗As的作用,HDL水平与冠心病发病率呈明显的负相关,低HDL-C是冠心病的独立的危险因素。HDL通过多种机制发挥其抗动脉粥样硬化作用,其中最重要的是参与胆固醇的逆向转运(reverse chol...血清高密度脂蛋白(High density lipoprotein,HDL)具有抗As的作用,HDL水平与冠心病发病率呈明显的负相关,低HDL-C是冠心病的独立的危险因素。HDL通过多种机制发挥其抗动脉粥样硬化作用,其中最重要的是参与胆固醇的逆向转运(reverse cholesterol transport,RCT),阻止巨噬细胞转化为泡沫细胞,防止胆固醇在动脉壁沉积,并将胆固醇从血管壁运送至肝脏被清除,从动态平衡的思路认识HDL的代谢及其功能,认为中医脾的运化和传输功能可能与HDL代谢及RCT密切相关,提出健脾益气中药可能有促进RCT的作用,进一步研究可望为研发调节RCT的中药新药和防治冠心病提供线索。展开更多
目的通过观测补中益气颗粒对实验大鼠血清IL-5水平及鼻黏膜IL-5 m RNA表达水平的影响,探讨其治疗脾气虚型变应性鼻炎的作用机制。方法 (1)采用病症结合造模原理,在采用游泳力竭法、大黄法、饥饿法等多因素复合伤脾的方法造成大鼠脾气虚...目的通过观测补中益气颗粒对实验大鼠血清IL-5水平及鼻黏膜IL-5 m RNA表达水平的影响,探讨其治疗脾气虚型变应性鼻炎的作用机制。方法 (1)采用病症结合造模原理,在采用游泳力竭法、大黄法、饥饿法等多因素复合伤脾的方法造成大鼠脾气虚模型的基础上,用卵清蛋白为过敏原使大鼠致敏,建立脾气虚型变应性鼻炎大鼠模型。(2)以补气升阳,甘温除热的代表方药补中益气颗粒灌胃,创立脾气虚型变应性鼻炎大鼠中药组模型。(3)观察各模型组大鼠接受治疗后症状改变情况,用酶联免疫吸附法(ELISA)对各组血清中IL-5水平进行检测;用聚合酶链式反应(PCR)对各组鼻黏膜中IL-5 m RNA表达水平进行检测。结果与变应性鼻炎组及脾气虚型变应性鼻炎组相比,脾气虚型变应性鼻炎药物组症状改善明显,且血清IL-5水平及鼻黏膜IL-5 m RNA表达水平均明显降低(P<0.01)。结论补中益气颗粒治疗脾气虚型变应性鼻炎的作用机制之一是通过调节Th2细胞因子IL-5的表达,从而纠正Th2细胞因子的失衡状态,最终对脾气虚型变应性鼻炎产生治疗效果。展开更多
基金Natural Science Research Project of Guangxi University of Chinese Medicine(2015LX037).
文摘[Objectives]To observe the clinical efficacy of Shenling Baizhu Powder in the treatment of primary nephrotic syndrome(PNS)featuring damp abundance due to splenic asthenia.[Methods]40 patients with PNS were randomly divided into treatment group(n=19)and control group(n=21).In the treatment group and the control group,methylprednisolone tablets were taken orally and cytoxan(CTX)was given intravenously for treatment;in the treatment group,based on oral administration of methylprednisolone tablets and intravenous drip of cytoxan(CTX),oral administration of traditional Chinese medicine(addition and subtraction of Shenling Baizhu Powder)was added.Urine routine,24-hour urinary protein,renal function and serum albumin were re-examined after 4 weeks of treatment.[Results]The total effective rate of the treatment group was significantly higher than that of the control group(89.47%vs 61.90%,P<0.05).After treatment,both groups could effectively reduce the levels of 24-hour urinary protein(P<0.05),serum creatinine(P<0.05)and urea nitrogen(P<0.05),and increase the level of serum albumin(P<0.05),but the degree of improvement in the treatment group was significantly higher than that in the control group(P<0.05),and the difference was statistically significant(P<0.05).[Conclusions]Methylprednisolone combined with addition and subtraction of Shenling Baizhu Powder could effectively reduce urinary protein,improve edema symptoms,shorten the course of hormone use and reduce adverse reactions in the treatment of PNS featuring damp abundance due to splenic asthenia.
文摘血清高密度脂蛋白(High density lipoprotein,HDL)具有抗As的作用,HDL水平与冠心病发病率呈明显的负相关,低HDL-C是冠心病的独立的危险因素。HDL通过多种机制发挥其抗动脉粥样硬化作用,其中最重要的是参与胆固醇的逆向转运(reverse cholesterol transport,RCT),阻止巨噬细胞转化为泡沫细胞,防止胆固醇在动脉壁沉积,并将胆固醇从血管壁运送至肝脏被清除,从动态平衡的思路认识HDL的代谢及其功能,认为中医脾的运化和传输功能可能与HDL代谢及RCT密切相关,提出健脾益气中药可能有促进RCT的作用,进一步研究可望为研发调节RCT的中药新药和防治冠心病提供线索。
文摘目的通过观测补中益气颗粒对实验大鼠血清IL-5水平及鼻黏膜IL-5 m RNA表达水平的影响,探讨其治疗脾气虚型变应性鼻炎的作用机制。方法 (1)采用病症结合造模原理,在采用游泳力竭法、大黄法、饥饿法等多因素复合伤脾的方法造成大鼠脾气虚模型的基础上,用卵清蛋白为过敏原使大鼠致敏,建立脾气虚型变应性鼻炎大鼠模型。(2)以补气升阳,甘温除热的代表方药补中益气颗粒灌胃,创立脾气虚型变应性鼻炎大鼠中药组模型。(3)观察各模型组大鼠接受治疗后症状改变情况,用酶联免疫吸附法(ELISA)对各组血清中IL-5水平进行检测;用聚合酶链式反应(PCR)对各组鼻黏膜中IL-5 m RNA表达水平进行检测。结果与变应性鼻炎组及脾气虚型变应性鼻炎组相比,脾气虚型变应性鼻炎药物组症状改善明显,且血清IL-5水平及鼻黏膜IL-5 m RNA表达水平均明显降低(P<0.01)。结论补中益气颗粒治疗脾气虚型变应性鼻炎的作用机制之一是通过调节Th2细胞因子IL-5的表达,从而纠正Th2细胞因子的失衡状态,最终对脾气虚型变应性鼻炎产生治疗效果。
