Anthrax is an infection caused by bacteria and it affects both human and animal populations. The disease can be categorized under zoonotic diseases and humans can contract infections through contact with infected anim...Anthrax is an infection caused by bacteria and it affects both human and animal populations. The disease can be categorized under zoonotic diseases and humans can contract infections through contact with infected animals, ingest contaminated dairy and animal products. In this paper, we developed a mathematical model for anthrax transmission dynamics in both human and animal populations with optimal control. The qualitative solution of the model behaviour was analyzed by determining Rhv, equilibrium points and sensitivity analysis. A vaccination class was incorporated into the model with waning immunity. Local and global stability of the model’s equilibria was found to be locally asymptotically stable whenever Rhv Rhv. It was revealed that reducing animal and human interaction rate, would decrease Rhv. We extended the model to optimal control in order to find the best control strategy in reducing anthrax infections. It showed that the effective strategy in combating the anthrax epidemics is vaccination of animals and prevention of humans.展开更多
A dispersion model is developed to provide a generic tool for configuring plasmonic resonance spectral characteristics.The customized design of the resonance curve aiming at specific detection requirements can be achi...A dispersion model is developed to provide a generic tool for configuring plasmonic resonance spectral characteristics.The customized design of the resonance curve aiming at specific detection requirements can be achieved.According to the model,a probe-type nano-modified fiber optic configurable plasmonic resonance(NMF-CPR)sensor with tip hot spot enhancement is demonstrated for the measurement of the refractive index in the range of 1.3332-1.3432 corresponding to the low-concentration biomarker solution.The new-type sensing structure avoids excessive broadening and redshift of the resonance dip,which provides more possibilities for the surface modification of other functional nanomaterials.The tip hot spots in nanogaps between the Au layer and Au nanostars(AuNSs),the tip electric field enhancement of AuNSs,and the high carrier mobility of the WSe_(2)layer synergistically and significantly enhance the sensitivity of the sensor.Ex-perimental results show that the sensitivity and the figure of merit of the tip hot spot enhanced fiber NMF-CPR sensor can achieve up to 2995.70 nm/RIU and 25.04 RIU^(−1),respectively,which are 1.68 times and 1.29 times higher than those of the conventional fiber plasmonic resonance sensor.The results achieve good agreements with numerical simulations,demonstrate a better level compared to similar reported studies,and verify the correctness of the dispersion model.The detection resolution of the sensor reaches up to 2.00×10^(−5)RIU,which is obviously higher than that of the conventional side-polished fiber plasmonic resonance sensor.This indicates a high detection accuracy of the sensor.The dense Au layer effectively prevents the intermediate nanomaterials from shedding and chemical degradation,which enables the sensor with high stability.Furthermore,the terminal reflective sensing structure can be used as a practical probe and can allow a more convenient operation.展开更多
The structure of the extended gate ion sensitive field effect transistor (EGISFET) is similar to the structure of the ion sensitive field effect transistor (ISFET).Moreover,the non-ideal effect of EGISFET is the mai...The structure of the extended gate ion sensitive field effect transistor (EGISFET) is similar to the structure of the ion sensitive field effect transistor (ISFET).Moreover,the non-ideal effect of EGISFET is the main impediment to development of commercial processes for sensitive devices.It is necessary to promote the stability and reliability of the devices by employing calibration circuits and the better fabrication conditions.The temporal drift exists in the entire measurement experiment. Furthermore,in this study we can reduce the temporal drift effect which influences the stability of the TiN sensitive electrode with the differential front-end offset circuit.The measurement system combines with shifting circuit,differential and instrument amplifiers.We employ the calibration circuit to compare with the variations of the output voltage,and expectably improve the stability and reliability of the TiN sensitive electrode by the novel calibration circuit.展开更多
The hydrological system of a watershed is intricately influenced by both underlying characteristics and climate conditions.Understanding the variability in water yield is essential for effective water resources manage...The hydrological system of a watershed is intricately influenced by both underlying characteristics and climate conditions.Understanding the variability in water yield is essential for effective water resources management and water security in the context of changing environments.In this study,we adopted the Budyko framework and leveraged simulations from the CMIP6 model to investigate the compensation effects of climate and underlying characteristics on watershed water yield.Based on Taylor expansion and Budyko framework,we estimated the sensitivity of watershed water yield to climate and underlying characteristics(the first-and second-order partial derivatives).By combining external watershed characteristics(e.g.,water yield ratios and underlying characteristics)with internal sensitivity coefficients,this study further used vine copula and principal component analysis to quantify the stability of watershed water yield.Our findings show:(1)Water-yield changes related to underlying characteristics could be offset by climate-related water-yield changes across all climate zones,maintaining the water yield ratio steady(i.e.,the compensation effects).(2)However,global watersheds will turn more sensitive to underlying characteristics and less sensitive to climate variation in the future.Both climate-and underlying-related sensitivities increase in watersheds with arid climates.(3)The stability of watershed water yield will gradually diminish in the future.From 1901–1950to 2051–2100,the global stability of 280 watersheds drops from 0.054 to 0.021(i.e.,stability index identified by the joint probability).Particularly,the largest change in stability of water yield reaches-0.347±0.18 in arid regions.In semi-arid,semihumid,and humid regions,the changes are-0.039±0.010,-0.028±0.005,and-0.005±0.002,respectively.The findings provide a reference for the future sustainable water resources development under climate change,highlighting the vulnerability of the water resources in arid and semi-arid watersheds.展开更多
文摘Anthrax is an infection caused by bacteria and it affects both human and animal populations. The disease can be categorized under zoonotic diseases and humans can contract infections through contact with infected animals, ingest contaminated dairy and animal products. In this paper, we developed a mathematical model for anthrax transmission dynamics in both human and animal populations with optimal control. The qualitative solution of the model behaviour was analyzed by determining Rhv, equilibrium points and sensitivity analysis. A vaccination class was incorporated into the model with waning immunity. Local and global stability of the model’s equilibria was found to be locally asymptotically stable whenever Rhv Rhv. It was revealed that reducing animal and human interaction rate, would decrease Rhv. We extended the model to optimal control in order to find the best control strategy in reducing anthrax infections. It showed that the effective strategy in combating the anthrax epidemics is vaccination of animals and prevention of humans.
基金financial supports from in part by National Natural Science Foundation of China under Grants 61922061, 61775161 and 61735011in part by the Tianjin Science Fund for Distinguished Young Scholars under Grant 19JCJQJC61400
文摘A dispersion model is developed to provide a generic tool for configuring plasmonic resonance spectral characteristics.The customized design of the resonance curve aiming at specific detection requirements can be achieved.According to the model,a probe-type nano-modified fiber optic configurable plasmonic resonance(NMF-CPR)sensor with tip hot spot enhancement is demonstrated for the measurement of the refractive index in the range of 1.3332-1.3432 corresponding to the low-concentration biomarker solution.The new-type sensing structure avoids excessive broadening and redshift of the resonance dip,which provides more possibilities for the surface modification of other functional nanomaterials.The tip hot spots in nanogaps between the Au layer and Au nanostars(AuNSs),the tip electric field enhancement of AuNSs,and the high carrier mobility of the WSe_(2)layer synergistically and significantly enhance the sensitivity of the sensor.Ex-perimental results show that the sensitivity and the figure of merit of the tip hot spot enhanced fiber NMF-CPR sensor can achieve up to 2995.70 nm/RIU and 25.04 RIU^(−1),respectively,which are 1.68 times and 1.29 times higher than those of the conventional fiber plasmonic resonance sensor.The results achieve good agreements with numerical simulations,demonstrate a better level compared to similar reported studies,and verify the correctness of the dispersion model.The detection resolution of the sensor reaches up to 2.00×10^(−5)RIU,which is obviously higher than that of the conventional side-polished fiber plasmonic resonance sensor.This indicates a high detection accuracy of the sensor.The dense Au layer effectively prevents the intermediate nanomaterials from shedding and chemical degradation,which enables the sensor with high stability.Furthermore,the terminal reflective sensing structure can be used as a practical probe and can allow a more convenient operation.
文摘The structure of the extended gate ion sensitive field effect transistor (EGISFET) is similar to the structure of the ion sensitive field effect transistor (ISFET).Moreover,the non-ideal effect of EGISFET is the main impediment to development of commercial processes for sensitive devices.It is necessary to promote the stability and reliability of the devices by employing calibration circuits and the better fabrication conditions.The temporal drift exists in the entire measurement experiment. Furthermore,in this study we can reduce the temporal drift effect which influences the stability of the TiN sensitive electrode with the differential front-end offset circuit.The measurement system combines with shifting circuit,differential and instrument amplifiers.We employ the calibration circuit to compare with the variations of the output voltage,and expectably improve the stability and reliability of the TiN sensitive electrode by the novel calibration circuit.
基金supported by the National Natural Science Foundation of China(Grant No.52179031)the National Key Research and Development Program of China(Grant No.2021YFC3001000)+1 种基金the Outstanding Youth Fund of Guangdong Province(Grant No.2023B1515020116)the Team Project of Pearl River Talent Program(Grant No.2019ZT08G090)。
文摘The hydrological system of a watershed is intricately influenced by both underlying characteristics and climate conditions.Understanding the variability in water yield is essential for effective water resources management and water security in the context of changing environments.In this study,we adopted the Budyko framework and leveraged simulations from the CMIP6 model to investigate the compensation effects of climate and underlying characteristics on watershed water yield.Based on Taylor expansion and Budyko framework,we estimated the sensitivity of watershed water yield to climate and underlying characteristics(the first-and second-order partial derivatives).By combining external watershed characteristics(e.g.,water yield ratios and underlying characteristics)with internal sensitivity coefficients,this study further used vine copula and principal component analysis to quantify the stability of watershed water yield.Our findings show:(1)Water-yield changes related to underlying characteristics could be offset by climate-related water-yield changes across all climate zones,maintaining the water yield ratio steady(i.e.,the compensation effects).(2)However,global watersheds will turn more sensitive to underlying characteristics and less sensitive to climate variation in the future.Both climate-and underlying-related sensitivities increase in watersheds with arid climates.(3)The stability of watershed water yield will gradually diminish in the future.From 1901–1950to 2051–2100,the global stability of 280 watersheds drops from 0.054 to 0.021(i.e.,stability index identified by the joint probability).Particularly,the largest change in stability of water yield reaches-0.347±0.18 in arid regions.In semi-arid,semihumid,and humid regions,the changes are-0.039±0.010,-0.028±0.005,and-0.005±0.002,respectively.The findings provide a reference for the future sustainable water resources development under climate change,highlighting the vulnerability of the water resources in arid and semi-arid watersheds.
