A Cross-Sectional Study on the Impact of Operation Triple Zero (OTZ) Program on Viral Load Suppression amongst Members of the Adolescent Club in 68 Nigerian Army Reference Hospital Yaba Lagos, Nigeria

Background: In Nigeria, adolescents and young people (AYP) aged 10 - 24, comprise 22.3% of the population and with HIV prevalence of 3.5%. The AYP living with HIV enrolled at the 68 NARHY, Lagos reflects the national challenges with poor viral suppression. The OTZ program aligns with the UNAIDS 95-95-95 goals. It seeks to empower AYPLHIV to be in charge of their treatment and commit to triple zero outcomeszero missed appointments, zero missed drugs, and zero viral loads. The purpose of the study was to assess the impact of the OTZ program on viral load suppression among members of the adolescent club in 68 NARHY, Lagos. Method: A cross-sectional retrospective study to evaluate the impact of the OTZ program on the viral load of 53 AYP enrolled in the OTZ program between March 2019 to December 2019 was analyzed. The Percentage of viral load suppression before enrollment compared with 6 and 12 months after enrollment into the OTZ program. The AYP is grouped into 10 - 14, 15 - 19, and 20 - 24 years. Activities conducted were peer driven monthly meetings with the AYP during which the adolescents interacted on issues relating to improving their treatment outcomes, healthcare workers reviewed their clinical status, viral load result, provider peer counseling, and caregivers engagement to support adherence to medication and ARV refills. Results: Before OTZ, 81% aged 10 - 14 years, 75% aged 15 - 19 years, and 25% aged 20 - 24 years were virally suppressed (VL less than 1000 copies/ml). Six months after enrollment, 94% were virally suppressed95% aged 10 - 14 years, 96% aged 15 - 19 years, and 66% aged 20-24 years. Twelve months after enrollment, 96% of AYP were virally suppressed100% aged 10-14 years, 93% aged 15 - 19 years, and 100% aged 20 - 24 years. Males viral load (VL) suppression improved from 79% to 96% and 92%, while females VL suppression improved from 69% to 93% and 100% at 6 and 12 months respectively. Conclusion: The OTZ activities contributed to improved viral load suppression in the AYP of the facility.

A Three-Stage Operational Amplifier for a Wide Range of Capacitive Loads

This paper presents a three-stage CMOS operational amplifier （opamp） that combines accuracy with stability for a wide range of capacitive loads. A so-called quenching capacitor is added to a multipath nested Miller compensation （MNMC） topology to obtain stability for a wide range of capacitive loads. Theoretical analysis and mathematical formulas are provided to prove the improvement in stability. A prototype of this frequency compen- sation scheme is implemented in a 0.7μm CMOS process. Measurement′s show that the amplifier can drive capaci- tive loads ranging from 100pF to 100/μF with a gain of 90dB and a minimum phase margin of 26°. The amplifier has a unity-gain bandwidth of 1MHz for a 100pF capacitive load. It employs a quenching capacitance of 18pF.

Energy-Efficient Operation of Water Systems through Optimization of Load Power Reduction in Electricity Markets

Demand response(DR) is gaining more and more importance in the architecture of power systems in a context of flexible loads and high share of intermittent generation. Changes in electricity markets regulation in several countries have recently enabled an effective integration of DR mechanisms in power systems. Through its flexible components(pumps, tanks), drinking water systems are suitable candidates for energy-efficient DR mechanisms. However, these systems are often managed independently of power system operation for both economic and operational reasons. Indeed, a sufficient level of economic viability and water demands risk management are necessary for water utilities to integrate their flexibilities to power system operation. In this paper,we proposed a mathematical model for optimizing pump schedules in water systems while trading DR blocs in a spot power market during peak times. Uncertainties about water demands were considered in the mathematical model allowing to propose power reductions covering the potential risk of real-time water demand forecasting inaccuracy.Numerical results were discussed on a real water system in France, demonstrating both economic and ecological benefits.

Optimal Operation Strategies for a Large Multi-Chiller System Based on Cooling Load Forecast

In semiconductor and electronics factories, large multi-chiller systems are needed to satisfy strict cooling load requirements. In order to save energy, it is worthwhile to design the chilled water system operation. In this paper, an optimal flexible operation scheme is developed based on a two-dimensional time-series model to forecast the cooling load of multi-chiller systems with chiller units of different cooling capacities running in parallel. The optimal integrity scheme can be obtained using the Mixed Integer Nonlinear Programming method, which minimizes the energy consumption of the system within a future time period. In order to better adapt the change of cooling load, the operation strategy of regulating the chilled water flowrates is employed. The chilled water flowrates are set as a design variable. When the chillers are running, their chilled water flowrates can vary within limits, whereas the flowrates are zero when the chillers are unloaded. This forecasting method provides integral optimization within a future time period and offers the operating reference for operators. The power and advantages of the proposed method are presented using an industrial case to help readers delve into this matter.

Load Shedding Application within a Microgrid to Assure Its Dynamic Performance during Its Transition to the Islanded Mode of Operation

This article presents the simulation results and analysis related to the response of the generators within a microgrid towards an accidental overload condition that will require some load shedding action. A microgrid overload can occur due to various reasons ranging from poor load schedule, inadequate switching of circuits within the microgrid, outage of one or more generators inside the microgrid, illegal load connections by some low voltage consumers, etc. It was observed that among the main factors that determine the survival of the microgrid during its transition from the grid connected mode to the islanded mode of operation are the size and type of the load connected (passive or dynamic load) as well as the length of time during which the unexpected load is connected. Models of a speed and voltage regulators of a diesel generator, and important for coping with the overload conditions are provided in the paper. The novelty of the work lies in the load shedding simulation and analysis of the specific generators studied herein, regarding that in many countries the microgrid technology is seen as an important alternative towards the ever increasing load demand and also to assist the system during periods of blackout.

Step-Loading Characteristics of Gas Engine Cogeneration System Using Doubly-Fed Induction Generator in Stand-Alone Operation

Application of a DFIG （doubly-fed induction generator）, which is one of adjustable speed generators, to a gas engine cogeneration system has been investigated. To operate during a blackout as an emergency power supply is one of important roles for the gas engine eogeneration system. In the case of conventional constant speed of synchronous generator, the amount of the allowed step load is limited to around 30% of the rated power. On the other hand, DFIG is expected to increase the amount of step load during the stand-alone operation. In this paper, it has been demonstrated that an increase in the gas engine speed resulted in an increase in the maximum amount of step load using experimental equipment with a real gas engine. It has been concluded that the proposed system can improve the performance of an emergency power supply at step-loading.

Nonlinear uncertainty impact of geometric variations on aerodynamic performance of low-pressure turbine blades with ultra-high loading under extreme operational conditions

Uncertainty impact of random geometric variations on the aerodynamic performance of low-pressure turbine blades is considerable,which is further amplified by the current ultra-high-lift design trend for weight reduction.Therefore,this uncertainty impact on ultra-highly loaded blades under extreme operational conditions near the margins with potential large-scale open separation is focused on in this study.It is demonstrated that this impact is significant,unfavourable,and nonlinear,which is clearly severer under extreme conditions.In addition to the overall attenuation and notable scattering of specific performance,the operational margins with open separation are also notably scattered with great risk of significant reduction.This scattering and nonlinearity are dominated by the variations in leading-edge thickness.The thinning of leading edge triggers local transition,enhancing downstream friction and reducing resistance to open separation,which is further exacerbated by operational deterioration.However,the opposite thickening yields less benefit,implying nonlinearity.This unfavourable impact highlights the need for robust aerodynamic design,where both a safer operational condition and a more robust blade are indispensable,i.e.,a compromise among performance,weight,and robustness.Besides the necessary limitation of loading levels,a mid-loaded design is recommended to reduce adverse pressure gradients in both the leading edge and rear region of the suction side,which helps to decrease the susceptibility of the transition and open separation to random perturbations.Similar improvements can also be achieved by appropriately thickening the leading edge.

Application of subsurface wastewater infiltration system to on-site treatment of domestic sewage under high hydraulic loading rate

In order to enhance the hydraulic loading rate （HLR） of a subsurface wastewater infiltration system （SWIS） used in treating domestic sewage, the intermittent operation mode was employed in the SWIS. The results show that the intermittent operation mode contributes to the improvement of the HLR and the pollutant removal rate. When the wetting-drying ratio （RwD） was 1.0, the pollutant removal rate increased by （13.6 ± 0.3）% for NH3-N, （20.7 ± 1.1）% for TN, （18.6± 0.4）% for TP, （12.2 ± 0.5）% for BOD, （10.1 ± 0.3）% for COD, and （36.2 ± 1.2）% for SS, compared with pollutant removal rates under the continuous operation mode. The pollutant removal rate declined with the increase of the HLR. The effluent quality met The Reuse of Urban Recycling Water - Water Quality Standard for Scenic Environment Use （GB/T 18921-2002） even when the HLR was as high as 10 cm/d. Hydraulic conductivity, oxidation reduction potential （ORP）, the quantity of nitrifying bacteria, and the pollutant removal rate of NH3-N increased with the decrease of the RWD. For the pollutant removal rates of TP, BOD, and COD, there were no significant difference （p 〈 0.05） under different RwDS. The suggested RWD was 1.0. Relative contribution of the pretreatment and SWlS to the pollutant removal was examined, and more than 80% removal of NH3-N, TN, TP, COD, and BOD occurred in the SWIS.

Operational Safety Assessment of a High-Speed Train Exposed to the Strong Gust Wind

The operational safety characteristics of trains exposed to a strong wind have caused great concern in recent years.In the present paper,the effect of the strong gust wind on a high-speed train is investigated.A typical gust wind model for any wind angle,named“Chinese hat gust wind model”,was first constructed,and an algorithm for computing the aerodynamic loads was elaborated accordingly.A vehicle system dynamic model was then set up in order to investigate the vehicle system dynamic characteristics.The assessment of the operational safety has been conducted by means of characteristic wind curves(CWC).As some of the parameters of the wind-train system were difficult to measure,we also investigated the impact of the uncertain system parameters on the CWC.Results indicate that,the descending order of the operational safety index of the vehicle for each wind angle is 90°-60°-120°-30°-150°,and the worst condition for the operational safety occurs when the wind angle reaches around 90°.According to our findings,the gust factor and aerodynamic side force coefficient have great impact on the critical wind speed.Thus,these two parameters require special attention when considering the operational safety of a railway vehicle subjected to strong gust wind.

Parallel Operation Characteristics Analysis of Sewage Source Heat Pump Units in Winter

Sewage source heat pump unit operates under partial load most of the time, and study on the law of coefficient of performance (COP) of the unit varying with load ratio can provide basis for the heat pump units running in high efficiency. A mathematical model determining COP, evaporation temperature and condensation temperature of a single unit was proposed. Under the condition of uniform load distribution, the model was established according to different ways of bearing partial load with the same type multi...

Mikusinski算符演算及其在梁的静力学中的应用

基于王建午翻译的《算符演算》,对Mikusinski算符理论系统进行简单介绍。在实际应用中对比算符演算理论和Laplace变换理论,说明算符理论更加有效。通过两个实例将Mikusinski算符理论应用到梁的静力学。

Operator health risk evaluation of off-highway dump truck under shovel loading condition

To evaluate the operator health risk exposed to whole-body vibration(WBV) while the electric-shovel loads the ore on the truck body, the semi-truck mathematical model and 3-D virtual prototype were built to simulate the high shockwave of truck cab under the shovel loading. Discrete element method was utilized to accurately estimate the impacting force on the truck body. Based on the ISO 2631-5 criteria, the Sed is about 0.56 MPa in both models, which means that the dump operators have a high probability of adverse health effects over long-term exposure to these vibrations. The 4-DOF operator model was built to investigate the biodynamic response of seated-human body exposed to WBV in terms of the transmission of vibrations through the body. The results show that the response peak is in the frequency range of 4-6 Hz corresponding to the primary body resonant frequency.

Discussion on the Operation of Urban Domestic Sewage Treatment Facilities: A Case Study of Guangdong Province

Urban sewage treatment facility is an important ways to control polluted domestic water. The operation of urban sewage treatment facilities is good or not, and whether the effectiveness of pollutant emission reduction can be exerted play a significant role in reducing the pollution of living sources. Nowadays the operation of urban sewage treatment facilities is mainly evaluated by the load rate. However, due to the failure to fully implement the reformation of the rainwater and polluted water in Guangdong Province, the domestic sewage is mixed with rainwater during the rainy season and is included in the treatment of urban sewage treatment facilities. Therefore, it is not objective to evaluate the operation of sewage treatment facilities using only the load rate of sewage treatment. According to the situation of Guangdong Province, the load rates of COD, ammonia nitrogen and total phosphorus in domestic sewage and load rate of sewage treatment were included in the evaluation, and 20 urban sewage treatment facilities were selected as research objects. The operation situations and emission reduction benefits of urban sewage treatment facilities in different regions of Guangdong Province were roughly evaluated.

Process Adaption of a Small WWTP Operated at Low Loading Conditions for Substantial Energy Savings

The very long tradition of the activated sludge treatment model within the water industry has demonstrated very versatile possibilities to adopt the operation mode for different enhancements. By looking into other treatment models within the activated sludge family it is possible to find alternatives for the operation. This paper concentrates on the possibilities to improve even small WWTP with respect to energy savings. The small plant in Northern Sweden, called Rosvik WWTP, is given as an example. Some important findings related to the intermittent aeration mode may be summarized as follows: 1) An energy savings for the operation of the small WWTP with respect to aeration needs that resulted in a decrease of the energy power supply by more than 35%, as compared with the previous operation based on continuous aeration;2) The up to date effluent levels with respect to the main pollutants have remained at very good levels in 2020, P-level averages 0.16 mg P/l versus consent level < 0.5 mg P/l;COD-level 40 versus < 70 mg/l and BOD7 9 versus < 15 mg/l;3) Sometimes, also improved sludge settling characteristics have been observed, thus providing improved discharge figures;4) The potential to develop an enhanced biological phosphorus removal. There are however some needed conditions to accomplish these improvements: 1) Reliable on-line probes for both oxygen control, SS-concentration control and optionally also for nitrogen control;2) A flexible automation system that allows the needed process modifications to take place;3) And finally, very important dedicated and competent plant operators, with the needed curiosity for operation improvements.

Multi-level Evaluation of Load Supply Adequacy for Transmission Network

Considering sharp increase of central integration scale of intermittent energy generation, power system couldn’t rely on the determined model based operation schedule to assure its reliable load supply. Then, this article presents a new load supply adequacy evaluation method, which based on continuous security constrained generation optimization, and provides the functional architecture design of online multi-level short term load supply adequacy evaluation system.

Real-Time Operation of Microgrids

Microgrid (MG) systems effectively integrate a generation mix of solar, wind, and other renewable energy resources. The intermittent nature of renewable resources and the unpredictable weather conditions contribute largely to the unreliability of microgrid real-time operation. This paper investigates the behavior of microgrid for different intermittent scenarios of photovoltaic generation in real-time. Reactive power coordination control and load shedding mechanisms are used for reliable operation and are implemented using OPAL-RT simulator integrated with Matlab. In an islanded MG, load shedding can be an effective mechanism to maintain generation-load balance. The microgrid of the German Jordanian University (GJU) is used for illustration. The results show that reactive power coordination control not only stabilizes the MG operation in real-time but also reduces power losses on transmission lines. The results also show that the power losses at some substations are reduced by a range of 6% - 9.8%.

Off-Design Performance of Gas Turbine Power Units with Alternative Load-Control Strategies

Gas turbine power units,as an effective way to cope with the severe challenge of renewable energy accommodation in power grids,arouse the interest of power enterprises in the deep peak-load regulation performance.Two common alternative load-control strategies including constant turbine inlet temperature(TIT)and constant turbine exhaust temperature(TET)regulations were taken into consideration.To comparatively investigate the part-load performance under these strategies,both mathematical and physical models were set up successively to serve as a validation and complementary to each other.For the mathematical model of compressor with inlet guide vane(IGV),combustor and turbine,stage-stacking method based on blade average geometric parameter,energy conservation and turbine stage model were adopted respectively.For the physical model,design and off-design analysis were carried out based on GT PRO and THERMOFLEX respectively.The simulation result of mathematical model validated the reliability of the physical model.Based on this,the influence of ambient temperature and different load-regulating strategies on the off-design performance of gas turbine power units was studied in THERMOFLEX.The results in the case of a PG 9351FA gas turbine show that the ambient temperature has a great impact on system performance,i.e.,every 5℃ increase in the ambient temperature produces a reduction of 3.7%in the relative full-load output and 1.1%in the relative efficiency respectively;when the gas turbine operates under constant TIT strategy,TET starts to rise till it reaches the maximum allowable value with the load rate decreasing,and IGV keeps at the minimum angle with both TIT and TET decreasing when the load rate is lower than 65%;when the gas turbine operates under constant TET strategy,TIT drops slightly at load rate of above 60%while both TIT and TET evidently decrease below 60%load rate operating along the constant corrected speed line at the minimum allowable IGV opening;gas turbine effi-ciency is greatly affected by load rate and the performance degradation is more obvious especially in lower load rate regions;constant TET strategy is superior in the operating efficiency to constant TIT strategy under part-load conditions.

Process Adaption and Modifications of a Nutrient Removing Wastewater Treatment Plant in Sri Lanka Operated at Low Loading Conditions

The Sri Lankan national water authority, that is The National Water Supply and Drainage Board (NWS&DB) has taken a new wastewater treatment plant into operation at Ja Ela, North of Colombo. The plant has been in operation since September 2011. In April 2012, it was concluded how a test of the aeration efficiency and a performance test should be carried out. The tests have been based on the actual loading of the plant and the analysis results from the daily process control. The evaluation of the aeration efficiency is not reported in this paper. The paper presents the overall performance of the water treatment part of the plant during start-up conditions, from fall 2011 through the first five months of 2012. The results from the operation are found in Table 1. An important circumstance at the plant is the current very low loading in comparison with the design load. This fact has resulted in an introduction of an intermittent mode of the aeration (nitrification) reactor. Based on operation figures, during more than a month (May 2012), it has been possible to give a realistic assessment of the overall performance. The most striking results are summarized as follows: 1) The intermittent operation has enabled an energy efficient operation of the plant. By the introduction of the intermittent aeration, the energy consumption has been reduced by around 75%, compared with the continuous operation mode;2) The plant performance during the intermittent operation has been improved with respect to virtually all important pollution variables. The most striking improvement is the discharge total P level, reflecting that a substantial enhanced biological phosphorus removal takes. The typical discharge levels found during May 2012, were compared with the earlier obtained values. It is important to underline that the loading on the plant has slightly increased during May as compared with the previous operation period.

基于VS-IRL的继电保护装置测试研究

在动态应力情况下,继电保护装置很容易发生三区误动作,导致电力系统级联跳闸,甚至使得用户端停电。对此,提出了增强型广域距离继电保护算法,利用实时脆弱性研究(VS)和故障检测方法(IRL)对常规三区备用继电保护装置进行测试,以在各种应力条件下识别故障。在继电保护装置发生意外跳闸之前,计算适当的装置脆弱性指数,并利用该指数对任意运行条件下的关键装置进行排序,来估计继电保护装置脆弱性的强度,一旦识别出一组高度易受攻击的继电保护装置(RPE),智能继电保护装置将监控测试这些RPE。最后通过在DDRTS平台上实现数字动态实时仿真验证该方案的有效性。结果表明该算法在不影响系统可靠性的前提下可以对继电保护装置进行测试,有效地增强了电力设备的全站保护运行,显著提高了远距离中继的安全性。

基于UPI-GA的台区三相不平衡的治理方法

在低压配电网中,单相负荷在系统负荷中占据较大的比重,配电变压器的三相不平衡度的超标情况严重。为解决这个问题,本文提出运用泛在电力物联网(UPI),通过信息终端调节各个负荷的启动、停止时间及开关档位等状态,在保证用电需求的情况下,降低台区三相不平衡度;并运用遗传算法(GA)选取台区平均三相不平衡度为目标函数,优化调整每台智能电器的启动、终止时刻,以某X台区用电侧数据为案例进行仿真实验。仿真实验表明:该方法可以迅速寻找到目标调整时间,实现配电网精细化管理和经济性运行,通过电网侧和用户侧信息联通的方式解决三相不平衡的问题。