This paper presents plasma-induced blood coagulation and its pilot application in rat hepatectomy by using a home-made pulsed cold plasma jet. Experiments were conducted on blood coagulation in vitro, the influence of...This paper presents plasma-induced blood coagulation and its pilot application in rat hepatectomy by using a home-made pulsed cold plasma jet. Experiments were conducted on blood coagulation in vitro, the influence of plasma on tissue in vivo, and the pilot application of rat hepatectomy. Experimental results show that the cold plasma can lead to rapid blood coagulation. Compared with the control sample, the plasma-induced agglomerated layer of blood is thicker and denser, and is mostly composed of broken platelets. When the surface of the liver was treated by plasma, the influence of the plasma can penetrate into the liver to a depth of about 500 μm. During the rat hepatectomy, cold plasma was proved to be effective for stanching bleeding on incision. No obvious bleeding was found in the abdominal cavities of all six rats 48 h after the hepatectomy. This implies that cold plasma can be an effective modality to control bleeding during surgical operation.展开更多
The toxicity of the new hemostatic material S-100 absorbable stanching satin was studied by embedding it in the body of rats. The staching satin embedded in the abdominal cavity of rats could be absorbed rapidly witho...The toxicity of the new hemostatic material S-100 absorbable stanching satin was studied by embedding it in the body of rats. The staching satin embedded in the abdominal cavity of rats could be absorbed rapidly without any macroscopic residue or organic abnormality in one week. After being embedded outside the dura mater of rats for a week, some stanching satin was found to remain in the form of unadherent small soft balls which disappeared in one more week. In the pathological examination no residue in cells was found in the major organs, and no degeneration, necrosis, hemorrhage or thrombosis in these organs and the vessels was observed. All the biochemical parameters in blood and routine urine examination were in the normal ranges. The results of the three behavior function tests were negative. It showed S-100 stanching satin, embedded in the body of rats for 12 weeks, had neither general toxicity nor adverse effect on the higher nervous activity, general behavior and equilibrium function of rats.展开更多
基金supported by National Natural Science Foundation of China (51377145)the Science and Technology Program of Zhejiang Province (2015F10011 and 2014C33022), China
文摘This paper presents plasma-induced blood coagulation and its pilot application in rat hepatectomy by using a home-made pulsed cold plasma jet. Experiments were conducted on blood coagulation in vitro, the influence of plasma on tissue in vivo, and the pilot application of rat hepatectomy. Experimental results show that the cold plasma can lead to rapid blood coagulation. Compared with the control sample, the plasma-induced agglomerated layer of blood is thicker and denser, and is mostly composed of broken platelets. When the surface of the liver was treated by plasma, the influence of the plasma can penetrate into the liver to a depth of about 500 μm. During the rat hepatectomy, cold plasma was proved to be effective for stanching bleeding on incision. No obvious bleeding was found in the abdominal cavities of all six rats 48 h after the hepatectomy. This implies that cold plasma can be an effective modality to control bleeding during surgical operation.
文摘The toxicity of the new hemostatic material S-100 absorbable stanching satin was studied by embedding it in the body of rats. The staching satin embedded in the abdominal cavity of rats could be absorbed rapidly without any macroscopic residue or organic abnormality in one week. After being embedded outside the dura mater of rats for a week, some stanching satin was found to remain in the form of unadherent small soft balls which disappeared in one more week. In the pathological examination no residue in cells was found in the major organs, and no degeneration, necrosis, hemorrhage or thrombosis in these organs and the vessels was observed. All the biochemical parameters in blood and routine urine examination were in the normal ranges. The results of the three behavior function tests were negative. It showed S-100 stanching satin, embedded in the body of rats for 12 weeks, had neither general toxicity nor adverse effect on the higher nervous activity, general behavior and equilibrium function of rats.
