Understanding the interaction between biological structures and nanoscale technologies,dubbed the nano-bio interface,is required for successful development of safe and efficient nanomedicine products.The lack of a uni...Understanding the interaction between biological structures and nanoscale technologies,dubbed the nano-bio interface,is required for successful development of safe and efficient nanomedicine products.The lack of a universal reporting system and decentralized methodologies for nanomaterial characterization have resulted in a low degree of reliability and reproducibility in the nanomedicine literature.As such,there is a strong need to establish a characterization system to support the reproducibility of nanoscience data particularly for studies seeking clinical translation.Here,we discuss the existing key standards for addressing robust characterization of nanomaterials based on their intended use in medical devices or as pharmaceuticals.We also discuss the challenges surrounding implementation of such standard protocols and their implication for translation of nanotechnology into clinical practice.We,however,emphasize that practical implementation of standard protocols in experimental laboratories requires long-term planning through integration of stakeholders including institutions and funding agencies.展开更多
This research paper describes the design and implementation of the Consultative Committee for Space Data Systems (CCSDS) standards REF _Ref401069962 \r \h \* MERGEFORMAT [1] for Space Data Link Layer Protocol (SDLP). ...This research paper describes the design and implementation of the Consultative Committee for Space Data Systems (CCSDS) standards REF _Ref401069962 \r \h \* MERGEFORMAT [1] for Space Data Link Layer Protocol (SDLP). The primer focus is the telecommand (TC) part of the standard. The implementation of the standard was in the form of DLL functions using C++ programming language. The second objective of this paper was to use the DLL functions with OMNeT++ simulating environment to create a simulator in order to analyze the mean end-to-end Packet Delay, maximum achievable application layer throughput for a given fixed link capacity and normalized protocol overhead, defined as the total number of bytes transmitted on the link in a given period of time (e.g. per second) divided by the number of bytes of application data received at the application layer model data sink. In addition, the DLL was also integrated with Ground Support Equipment Operating System (GSEOS), a software system for space instruments and small spacecrafts especially suited for low budget missions. The SDLP is designed for rapid test system design and high flexibility for changing telemetry and command requirements. GSEOS can be seamlessly moved from EM/FM development (bench testing) to flight operations. It features the Python programming language as a configuration/scripting tool and can easily be extended to accommodate custom hardware interfaces. This paper also shows the results of the simulations and its analysis.展开更多
随着航空电子全双工交换式以太网(Avionics Full Duplex Switched Ethernet,AFDX)网络在航电通信网络设备中的广泛使用,给出一种基于ARINC6I5A-3标准协议的数据加载客户端软件的实现方式,详细描述了ARINC6I5A协议中Find操作、信息操作...随着航空电子全双工交换式以太网(Avionics Full Duplex Switched Ethernet,AFDX)网络在航电通信网络设备中的广泛使用,给出一种基于ARINC6I5A-3标准协议的数据加载客户端软件的实现方式,详细描述了ARINC6I5A协议中Find操作、信息操作、上传操作、介质自定义下载以及操作者自定义下载的具体实现过程,保证了航空电子设备和软件加载客户端交换数据的安全可靠性。该数据加载客户端的设计架构对航电系统数据传输类工具的开发具有一定的参考价值。展开更多
基金support from the U.S. National Institute of Diabetes and Digestive and Kidney Diseases (Grant DK131417) (MM)support of a Burroughs Wellcome Fund Career Award at the Scientific Interface (CASI) (MPL)+11 种基金a Dreyfus foundation award (MPL)the Philomathia foundation (MPL)an NIH MIRA award R35GM128922 (MPL)an NIH R21 NIDA award 1R03DA052810 (MPL)an NSF CAREER award 2046159 (MPL)an NSF CBET award 1733575 (to MPL)a CZI imaging award (MPL)a Sloan Foundation Award (MPL)a USDA BBT EAGER award (MPL)a Moore Foundation Award (MPL)a DOE office of Science grant DE-SC0020366 (MPL)support from a Fulbright fellowship (NNM)。
文摘Understanding the interaction between biological structures and nanoscale technologies,dubbed the nano-bio interface,is required for successful development of safe and efficient nanomedicine products.The lack of a universal reporting system and decentralized methodologies for nanomaterial characterization have resulted in a low degree of reliability and reproducibility in the nanomedicine literature.As such,there is a strong need to establish a characterization system to support the reproducibility of nanoscience data particularly for studies seeking clinical translation.Here,we discuss the existing key standards for addressing robust characterization of nanomaterials based on their intended use in medical devices or as pharmaceuticals.We also discuss the challenges surrounding implementation of such standard protocols and their implication for translation of nanotechnology into clinical practice.We,however,emphasize that practical implementation of standard protocols in experimental laboratories requires long-term planning through integration of stakeholders including institutions and funding agencies.
文摘This research paper describes the design and implementation of the Consultative Committee for Space Data Systems (CCSDS) standards REF _Ref401069962 \r \h \* MERGEFORMAT [1] for Space Data Link Layer Protocol (SDLP). The primer focus is the telecommand (TC) part of the standard. The implementation of the standard was in the form of DLL functions using C++ programming language. The second objective of this paper was to use the DLL functions with OMNeT++ simulating environment to create a simulator in order to analyze the mean end-to-end Packet Delay, maximum achievable application layer throughput for a given fixed link capacity and normalized protocol overhead, defined as the total number of bytes transmitted on the link in a given period of time (e.g. per second) divided by the number of bytes of application data received at the application layer model data sink. In addition, the DLL was also integrated with Ground Support Equipment Operating System (GSEOS), a software system for space instruments and small spacecrafts especially suited for low budget missions. The SDLP is designed for rapid test system design and high flexibility for changing telemetry and command requirements. GSEOS can be seamlessly moved from EM/FM development (bench testing) to flight operations. It features the Python programming language as a configuration/scripting tool and can easily be extended to accommodate custom hardware interfaces. This paper also shows the results of the simulations and its analysis.
文摘随着航空电子全双工交换式以太网(Avionics Full Duplex Switched Ethernet,AFDX)网络在航电通信网络设备中的广泛使用,给出一种基于ARINC6I5A-3标准协议的数据加载客户端软件的实现方式,详细描述了ARINC6I5A协议中Find操作、信息操作、上传操作、介质自定义下载以及操作者自定义下载的具体实现过程,保证了航空电子设备和软件加载客户端交换数据的安全可靠性。该数据加载客户端的设计架构对航电系统数据传输类工具的开发具有一定的参考价值。
