Multiple sclerosis(MS) is a chronic inflammatory condition of the central nervous system determined by a presumed autoimmune process mainly directed against myelin components but also involving axons and neurons. Acut...Multiple sclerosis(MS) is a chronic inflammatory condition of the central nervous system determined by a presumed autoimmune process mainly directed against myelin components but also involving axons and neurons. Acute demyelination shows as clinical relapses that may fully or partially resolve, while chronic demyelination and neuroaxonal injury lead to persistent and irreversible neurological symptoms, often progressing over time. Currently approved disease-modifying therapies are immunomodulatory or immunosuppressive drugs that significantly although variably reduce the frequency of attacks of the relapsing forms of the disease. However, they have limited efficacy in preventing the transition to the progressive phase of MS and are of no benefit after it has started. It is therefore likely that the potential advantage of a given treatment is condensed in a relatively limited window of opportunity for each patient, depending on individual characteristics and disease stage, most frequently but not necessarily in the early phase of the disease. In addition, a sizable proportion of patients with MS may have a very mild clinical course not requiring a disease-modifying therapy. Finally, individual response to existing therapies for MS varies significantly across subjects and the risk of serious adverse events remains an issue, particularly for the newest agents. The present review is aimed at critically describing current treatment strategies for MS with a particular focus on the decision of starting, switching and stopping commercially available immunomodulatory and immunosuppressive therapies.展开更多
混合动力汽车(hybrid electric vehicle,HEV)发动机启停过程伴随的转矩脉动,易诱发车辆传动系扭振,导致车辆动力不平顺。为解决上述问题,提出并验证基于电磁阻尼自适应模糊控制的传动系扭振主动控制方法。建立行星混联式混合动力汽车发...混合动力汽车(hybrid electric vehicle,HEV)发动机启停过程伴随的转矩脉动,易诱发车辆传动系扭振,导致车辆动力不平顺。为解决上述问题,提出并验证基于电磁阻尼自适应模糊控制的传动系扭振主动控制方法。建立行星混联式混合动力汽车发动机启停工况动力学仿真模型和发动机启停控制逻辑,提出发动机启停扭振自适应模糊控制策略,开展2种运行状态下发动机启停工况仿真,对比分析无控制和自适应模糊控制下传动系扭转振动响应曲线。结果表明,自适应模糊控制相比无控制状态:定置停车时发动机启动和停机工况扭振平均衰减率分别为23.8%和30.1%,车辆行进间发动机启动和停机工况扭振平均衰减率分别为12.1%和23.6%。该方法可有效衰减发动机启停工况传动系扭转振动,提升混合动力汽车发动机启停工况NVH(noise,vibration,and harshness)性能。展开更多
文摘Multiple sclerosis(MS) is a chronic inflammatory condition of the central nervous system determined by a presumed autoimmune process mainly directed against myelin components but also involving axons and neurons. Acute demyelination shows as clinical relapses that may fully or partially resolve, while chronic demyelination and neuroaxonal injury lead to persistent and irreversible neurological symptoms, often progressing over time. Currently approved disease-modifying therapies are immunomodulatory or immunosuppressive drugs that significantly although variably reduce the frequency of attacks of the relapsing forms of the disease. However, they have limited efficacy in preventing the transition to the progressive phase of MS and are of no benefit after it has started. It is therefore likely that the potential advantage of a given treatment is condensed in a relatively limited window of opportunity for each patient, depending on individual characteristics and disease stage, most frequently but not necessarily in the early phase of the disease. In addition, a sizable proportion of patients with MS may have a very mild clinical course not requiring a disease-modifying therapy. Finally, individual response to existing therapies for MS varies significantly across subjects and the risk of serious adverse events remains an issue, particularly for the newest agents. The present review is aimed at critically describing current treatment strategies for MS with a particular focus on the decision of starting, switching and stopping commercially available immunomodulatory and immunosuppressive therapies.
文摘混合动力汽车(hybrid electric vehicle,HEV)发动机启停过程伴随的转矩脉动,易诱发车辆传动系扭振,导致车辆动力不平顺。为解决上述问题,提出并验证基于电磁阻尼自适应模糊控制的传动系扭振主动控制方法。建立行星混联式混合动力汽车发动机启停工况动力学仿真模型和发动机启停控制逻辑,提出发动机启停扭振自适应模糊控制策略,开展2种运行状态下发动机启停工况仿真,对比分析无控制和自适应模糊控制下传动系扭转振动响应曲线。结果表明,自适应模糊控制相比无控制状态:定置停车时发动机启动和停机工况扭振平均衰减率分别为23.8%和30.1%,车辆行进间发动机启动和停机工况扭振平均衰减率分别为12.1%和23.6%。该方法可有效衰减发动机启停工况传动系扭转振动,提升混合动力汽车发动机启停工况NVH(noise,vibration,and harshness)性能。
