Amyotrophic lateral sclerosis is a rare neurodegenerative disease characterized by the involvement of both upper and lower motor neurons.Early bilateral limb involvement significantly affects patients'daily lives ...Amyotrophic lateral sclerosis is a rare neurodegenerative disease characterized by the involvement of both upper and lower motor neurons.Early bilateral limb involvement significantly affects patients'daily lives and may lead them to be confined to bed.However,the effect of upper and lower motor neuron impairment and other risk factors on bilateral limb involvement is unclear.To address this issue,we retrospectively collected data from 586 amyotrophic lateral sclerosis patients with limb onset diagnosed at Peking University Third Hospital between January 2020 and May 2022.A univariate analysis revealed no significant differences in the time intervals of spread in different directions between individuals with upper motor neuron-dominant amyotrophic lateral sclerosis and those with classic amyotrophic lateral sclerosis.We used causal directed acyclic graphs for risk factor determination and Cox proportional hazards models to investigate the association between the duration of bilateral limb involvement and clinical baseline characteristics in amyotrophic lateral sclerosis patients.Multiple factor analyses revealed that higher upper motor neuron scores(hazard ratio[HR]=1.05,95%confidence interval[CI]=1.01–1.09,P=0.018),onset in the left limb(HR=0.72,95%CI=0.58–0.89,P=0.002),and a horizontal pattern of progression(HR=0.46,95%CI=0.37–0.58,P<0.001)were risk factors for a shorter interval until bilateral limb involvement.The results demonstrated that a greater degree of upper motor neuron involvement might cause contralateral limb involvement to progress more quickly in limb-onset amyotrophic lateral sclerosis patients.These findings may improve the management of amyotrophic lateral sclerosis patients with limb onset and the prediction of patient prognosis.展开更多
Stimulus-Response Compatibility (SRC) refers to the fact that some tasks are performed easier and better than others because of the way stimuli and responses are paired with each other. To assess the brain responses t...Stimulus-Response Compatibility (SRC) refers to the fact that some tasks are performed easier and better than others because of the way stimuli and responses are paired with each other. To assess the brain responses to stimulus-response conflicts, we investigated the behavioral (accuracy and Reaction Times: RTs) as well as the physiological response (Lateralized Readiness Potentials: LRP) modulations in a positional blocked and a conditional mixed design in twelve university students. Results revealed that the performance was less accurate and the RTs, as well as the LRP onset, were delayed under the mixed conditional design. A greater compatibility effect was also noted on accuracy, RTs and LRP onset latency in the mixed design. Consistent with these findings, smaller peak activation at fronto-central areas suggests that more selective inhibition is needed in a mixed design context. Despite a smaller activation, the topographical distribution is similar in both designs. These results indicate that the translation time between stimulus- and response codes are greater under the mixed instruction, while the similar LRP topography suggests that common neural structures underlie LRPs in response to both type of designs.展开更多
介绍了中国《建筑隔震设计标准》(GB/T 51408—2021)(以下简称《隔标》)和美国Minimum design loads and associated criteria for buildings and other structures(ASCE 7-16)隔震设计的相关要求,并针对基于《建筑抗震设计规范》(GB 50...介绍了中国《建筑隔震设计标准》(GB/T 51408—2021)(以下简称《隔标》)和美国Minimum design loads and associated criteria for buildings and other structures(ASCE 7-16)隔震设计的相关要求,并针对基于《建筑抗震设计规范》(GB 50011—2010)(2016年版)(以下简称《抗规》)设计的某9度区近场隔震结构,进行了两国规范的设计对比。按《抗规》设计的隔震结构,仍然能满足《隔标》的设计要求。ASCE 7-16对于隔震支座考虑了老化和环境、测试、制造等因素引起的性能参数变化,并按隔震支座的上限及下限属性进行了结构设计。基于相同地震概率水准(50年超越概率2%)的设计对比研究表明,ASCE 7-16的等效侧力法计算值高于《隔标》,按ASCE 7-16要求选择的地震波反应谱明显高于《隔标》,其时程分析结果也大于中国规范,对隔震支座的性能要求更高。展开更多
The seismic capacity curves of three types of buildings including frame,frame-shear wall and shear wall ob- tained by pushover analysis under different lateral load patterns are compared with those from nonlinear time...The seismic capacity curves of three types of buildings including frame,frame-shear wall and shear wall ob- tained by pushover analysis under different lateral load patterns are compared with those from nonlinear time history analy- sis.Based on the numerical results obtained a two-phase load pattern:an inverted triangle(first mode)load pattern until the base shear force reaches β times its maximum value,V_(max)followed by a(x/H)~α form,here β and α being some coeffi- cients depending on the type of the structures considered,is proposed in the paper,which can provide excellent approxima- tion of the seismic capacity curve for low-to-mid-rise shear type buildings.Furthermore,it is shown both the two-phase load pattern proposed and the invariant uniform pattern can be used for low-to-mid-rise shear-bending type and low-rise bending type of buildings.No suitable load patterns have been found for high-rise buildings.展开更多
This work studies the stabilization of a class of control systems that use communication networks as signal transmission medium. The lateral motion of independently actuated four-wheel vehicle is modeled as an uncerta...This work studies the stabilization of a class of control systems that use communication networks as signal transmission medium. The lateral motion of independently actuated four-wheel vehicle is modeled as an uncertain-linear system. Time delay and quantization density are modeled as Markov chains.The networked control systems(NCSs) with plants being lateral motion are first transformed to switched linear systems with uncertain parameters. Sufficient and necessary conditions for the stochastic stability of closed-loop networked control systems are then established. By solving the matrix inequalities, this work presents an output-feedback controller that depends on the modes of time delay and quantization density. The controller performance is illustrated via a vehicular lateral motion system.展开更多
BACKGROUND：Amyotrophic lateral sclerosis （ALS） is the most common of all the motor neuron diseases and the absence of a biologic marker has made both diagnosis and tracking evolution of the disease difficult, Elect...BACKGROUND：Amyotrophic lateral sclerosis （ALS） is the most common of all the motor neuron diseases and the absence of a biologic marker has made both diagnosis and tracking evolution of the disease difficult, Electrodiagnostic tests play a fundamental role in quantifying pathological changes in the motor unit pool.OBJECTIVE：We assessed distal-proximal Motor Unit （MU） loss and changes using the method of motor unit number estimation （MUNE）.DESIGN, TIME AND SETTING：A case-control study was performed at the Department of Neuroscience, Pisa University Medical School, Italy from December 1999 to November 2009. PARTICIPANTS：A total of 50 ALS patients were recruited, 30 males：mean age （59.6 ± 13.3） years; 20 females：mean age （63.9 ± 11.7） years; range （30-82） years; all patients had probable or definite ALS. Thirty healthy volunteers were recruited from department staffs, including 20 males and 10 females; mean age （57.7 ± 13.8） years served as controls.METHODS：MUNE was performed for both the biceps brachii and abductor digiti minimi muscles of the same side. The technique used relayed substantially on manual incremental stimulation of the motor nerve, known as the McComas technique （50 ms sweep duration, a gain of 2 mV/Div for M wave, 0.5 mV/Div for each step; filters 10-20 kHz）.MAIN OUTCOME MEASURES：MUNE results were measured.RESULTS：Functioning MU numbers, measured by MUNE, decreased in the biceps brachii and abductor digiti minimi muscles over the entire one-year follow-up period （one assessment every three months） compared with baseline determination, the rate of MU decrease was similar in both muscles, but steeper distally.CONCLUSION：MUNE is a feasible method for ALS patients both proximally and distally to track changes over time in muscle MUs during the disease＇s evolution.展开更多
This study observed the changes in somatosensory evoked potentials between patients with amyotrophic lateral sclerosis （ALS） and healthy controls to evaluate the function of the central deep somatosensory pathway. I...This study observed the changes in somatosensory evoked potentials between patients with amyotrophic lateral sclerosis （ALS） and healthy controls to evaluate the function of the central deep somatosensory pathway. In patients with ALS, 28 patients （54%） showed an abnormality in somatosensory evoked potentials. All had abnormal lower limb somatosensory evoked potentials. Compared with healthy controls, the abnormality in somatosensory evoked potential was characterized by prolonged N20, P2, N2 latency and central conduction time, with or without a decrease in wave amplitude or disappearance of waveform. Results showed marked alterations in the somatosensory evoked potential in cortical components of the upper and lower limb in 54% of patients with ALS, and confirmed that patients with ALS may also have a defective deep somatosensory pathway, particularly an abnormal central deep somatosensory pathway.展开更多
AIM:To investigate the impact of lag time to metastasis and survival rates among patients with retinoblastoma.METHODS:This retrospective study was conducted with 52 patients from the Department of Ophthalmology and th...AIM:To investigate the impact of lag time to metastasis and survival rates among patients with retinoblastoma.METHODS:This retrospective study was conducted with 52 patients from the Department of Ophthalmology and the Department of Pediatrics of Dr.Sardjito General Hospital,between 1^(st) January 2014 and 31^(st) December 2020.Lag time was defined as the time delay between the first sign of retinoblastoma to the diagnosis of retinoblastoma.The subjects with lag time>one year were included in the case group,while the subjects with lag time<one year were included in the control group.RESULTS:The lag time was significantly correlated with American Joint Committee on Cancer and Intraocular Classification of Retinoblastoma staging of retinoblastoma(P=0.005 and P=0.006,respectively).The lag time was also significantly correlated with both metastasis event[odds ratio(OR):5.06,95%Cl:1.56-16.44,P=0.006]and mortality(OR:4.54,95%Cl:1.37-15.07,P=0.011).The follow-up was continued for 32 subjects for 3y after initial diagnoses.Survival analysis revealed a significant difference among these two groups(P=0.021).Furthermore,lag time was significantly correlated with survival of retinoblastoma(r=-0.53,P=0.046).CONCLUSION:The study highlights the importance of lag time between the onset of first symptoms and the time of retinoblastoma diagnosis which significantly contribute to metastasis and mortality of patients with retinoblastoma.Examinations for the early detection of retinoblastoma should be performed for individuals at-risk to minimize lag time and improve the outcomes.展开更多
The properties of phase time taken for particles to pass through a quantum potential well are investigated. It is found in a 1 dimensional quantum mechanical problem that the phase time is negative when the incident e...The properties of phase time taken for particles to pass through a quantum potential well are investigated. It is found in a 1 dimensional quantum mechanical problem that the phase time is negative when the incident energy and the thickness of potential well satisfy certain conditions. Similar results are also found in a 2 dimensional fully relativistic optical analog. It is shown that the expression of the la teral shift of transmitted optical waves is similar to that of the phase time in the 1 dimensional quantum mechanical problem. The phase time in the 2 dimensional optical problem is also shown to be negative under certain conditions.展开更多
Pulsed signal experiment was carried out to determine the hydrodynamic behaviours of lateral flow biological aerated filter(LBAF). With the analysis of experimental results, LBAF is viewed as an approximate plug flow ...Pulsed signal experiment was carried out to determine the hydrodynamic behaviours of lateral flow biological aerated filter(LBAF). With the analysis of experimental results, LBAF is viewed as an approximate plug flow reactor, and hydraulic retention time distribution function was derived based on LBAF. The results show that flow rate and aeration strength are two critical factors which influence flow patterns in LBAF reactor. The hydrodynamic behaviour analysis of LBAF is the theoretical basis of future research on improving capacity factor and developing kinetic model for the reactor.展开更多
To evaluate the lateral sealing mechanism of extensional fault based on the pressure difference between fault and reservoir, an integral mathematical-geological model of diagenetic time on diagenetic pressure consider...To evaluate the lateral sealing mechanism of extensional fault based on the pressure difference between fault and reservoir, an integral mathematical-geological model of diagenetic time on diagenetic pressure considering the influence of diagenetic time on the diagenetic pressure and diagenetic degree of fault rock has been established to quantitatively calculate the lateral sealing ability of extensional fault. By calculating the time integral of the vertical stress and horizontal in-situ stress on the fault rock and surrounding rock, the burial depth of the surrounding rock with the same clay content and diagenesis degree as the target fault rock was worked out. In combination with the statistical correlation of clay content, burial depth and displacement pressure of rock in the study area, the displacement pressure of target fault rock was calculated quantitatively. The calculated displacement pressure was compared with that of the target reservoir to quantitatively evaluate lateral sealing state and ability of the extensional fault. The method presented in this work was used to evaluate the sealing of F_(1), F_(2) and F_(3) faults in No.1 structure of Nanpu Sag, and the results were compared with those from fault-reservoir displacement pressure differential methods without considering the diagenetic time and simple considering the diagenetic time. It is found that the results calculated by the integral mathematical-geological model are the closest to the actual underground situation, the errors between the hydrocarbon column height predicted by this method and the actual column height were 0–8 m only, proving that this model is more feasible and credible.展开更多
基金supported by the National Natural Science Foundation of China,Nos.82071426,81873784Clinical Cohort Construction Program of Peking University Third Hospital,No.BYSYDL2019002(all to DF)。
文摘Amyotrophic lateral sclerosis is a rare neurodegenerative disease characterized by the involvement of both upper and lower motor neurons.Early bilateral limb involvement significantly affects patients'daily lives and may lead them to be confined to bed.However,the effect of upper and lower motor neuron impairment and other risk factors on bilateral limb involvement is unclear.To address this issue,we retrospectively collected data from 586 amyotrophic lateral sclerosis patients with limb onset diagnosed at Peking University Third Hospital between January 2020 and May 2022.A univariate analysis revealed no significant differences in the time intervals of spread in different directions between individuals with upper motor neuron-dominant amyotrophic lateral sclerosis and those with classic amyotrophic lateral sclerosis.We used causal directed acyclic graphs for risk factor determination and Cox proportional hazards models to investigate the association between the duration of bilateral limb involvement and clinical baseline characteristics in amyotrophic lateral sclerosis patients.Multiple factor analyses revealed that higher upper motor neuron scores(hazard ratio[HR]=1.05,95%confidence interval[CI]=1.01–1.09,P=0.018),onset in the left limb(HR=0.72,95%CI=0.58–0.89,P=0.002),and a horizontal pattern of progression(HR=0.46,95%CI=0.37–0.58,P<0.001)were risk factors for a shorter interval until bilateral limb involvement.The results demonstrated that a greater degree of upper motor neuron involvement might cause contralateral limb involvement to progress more quickly in limb-onset amyotrophic lateral sclerosis patients.These findings may improve the management of amyotrophic lateral sclerosis patients with limb onset and the prediction of patient prognosis.
文摘Stimulus-Response Compatibility (SRC) refers to the fact that some tasks are performed easier and better than others because of the way stimuli and responses are paired with each other. To assess the brain responses to stimulus-response conflicts, we investigated the behavioral (accuracy and Reaction Times: RTs) as well as the physiological response (Lateralized Readiness Potentials: LRP) modulations in a positional blocked and a conditional mixed design in twelve university students. Results revealed that the performance was less accurate and the RTs, as well as the LRP onset, were delayed under the mixed conditional design. A greater compatibility effect was also noted on accuracy, RTs and LRP onset latency in the mixed design. Consistent with these findings, smaller peak activation at fronto-central areas suggests that more selective inhibition is needed in a mixed design context. Despite a smaller activation, the topographical distribution is similar in both designs. These results indicate that the translation time between stimulus- and response codes are greater under the mixed instruction, while the similar LRP topography suggests that common neural structures underlie LRPs in response to both type of designs.
文摘介绍了中国《建筑隔震设计标准》(GB/T 51408—2021)(以下简称《隔标》)和美国Minimum design loads and associated criteria for buildings and other structures(ASCE 7-16)隔震设计的相关要求,并针对基于《建筑抗震设计规范》(GB 50011—2010)(2016年版)(以下简称《抗规》)设计的某9度区近场隔震结构,进行了两国规范的设计对比。按《抗规》设计的隔震结构,仍然能满足《隔标》的设计要求。ASCE 7-16对于隔震支座考虑了老化和环境、测试、制造等因素引起的性能参数变化,并按隔震支座的上限及下限属性进行了结构设计。基于相同地震概率水准(50年超越概率2%)的设计对比研究表明,ASCE 7-16的等效侧力法计算值高于《隔标》,按ASCE 7-16要求选择的地震波反应谱明显高于《隔标》,其时程分析结果也大于中国规范,对隔震支座的性能要求更高。
文摘The seismic capacity curves of three types of buildings including frame,frame-shear wall and shear wall ob- tained by pushover analysis under different lateral load patterns are compared with those from nonlinear time history analy- sis.Based on the numerical results obtained a two-phase load pattern:an inverted triangle(first mode)load pattern until the base shear force reaches β times its maximum value,V_(max)followed by a(x/H)~α form,here β and α being some coeffi- cients depending on the type of the structures considered,is proposed in the paper,which can provide excellent approxima- tion of the seismic capacity curve for low-to-mid-rise shear type buildings.Furthermore,it is shown both the two-phase load pattern proposed and the invariant uniform pattern can be used for low-to-mid-rise shear-bending type and low-rise bending type of buildings.No suitable load patterns have been found for high-rise buildings.
基金supported by Humanities and Social Sciences Youth Foundation of the Ministry of Education(17YJC630093)
文摘This work studies the stabilization of a class of control systems that use communication networks as signal transmission medium. The lateral motion of independently actuated four-wheel vehicle is modeled as an uncertain-linear system. Time delay and quantization density are modeled as Markov chains.The networked control systems(NCSs) with plants being lateral motion are first transformed to switched linear systems with uncertain parameters. Sufficient and necessary conditions for the stochastic stability of closed-loop networked control systems are then established. By solving the matrix inequalities, this work presents an output-feedback controller that depends on the modes of time delay and quantization density. The controller performance is illustrated via a vehicular lateral motion system.
基金Supported by the Italian MIUR PRIN Grant year 2006,# 2006062332_002
文摘BACKGROUND：Amyotrophic lateral sclerosis （ALS） is the most common of all the motor neuron diseases and the absence of a biologic marker has made both diagnosis and tracking evolution of the disease difficult, Electrodiagnostic tests play a fundamental role in quantifying pathological changes in the motor unit pool.OBJECTIVE：We assessed distal-proximal Motor Unit （MU） loss and changes using the method of motor unit number estimation （MUNE）.DESIGN, TIME AND SETTING：A case-control study was performed at the Department of Neuroscience, Pisa University Medical School, Italy from December 1999 to November 2009. PARTICIPANTS：A total of 50 ALS patients were recruited, 30 males：mean age （59.6 ± 13.3） years; 20 females：mean age （63.9 ± 11.7） years; range （30-82） years; all patients had probable or definite ALS. Thirty healthy volunteers were recruited from department staffs, including 20 males and 10 females; mean age （57.7 ± 13.8） years served as controls.METHODS：MUNE was performed for both the biceps brachii and abductor digiti minimi muscles of the same side. The technique used relayed substantially on manual incremental stimulation of the motor nerve, known as the McComas technique （50 ms sweep duration, a gain of 2 mV/Div for M wave, 0.5 mV/Div for each step; filters 10-20 kHz）.MAIN OUTCOME MEASURES：MUNE results were measured.RESULTS：Functioning MU numbers, measured by MUNE, decreased in the biceps brachii and abductor digiti minimi muscles over the entire one-year follow-up period （one assessment every three months） compared with baseline determination, the rate of MU decrease was similar in both muscles, but steeper distally.CONCLUSION：MUNE is a feasible method for ALS patients both proximally and distally to track changes over time in muscle MUs during the disease＇s evolution.
基金the National Natural Science Youth Foundation of China, No. 81000524
文摘This study observed the changes in somatosensory evoked potentials between patients with amyotrophic lateral sclerosis （ALS） and healthy controls to evaluate the function of the central deep somatosensory pathway. In patients with ALS, 28 patients （54%） showed an abnormality in somatosensory evoked potentials. All had abnormal lower limb somatosensory evoked potentials. Compared with healthy controls, the abnormality in somatosensory evoked potential was characterized by prolonged N20, P2, N2 latency and central conduction time, with or without a decrease in wave amplitude or disappearance of waveform. Results showed marked alterations in the somatosensory evoked potential in cortical components of the upper and lower limb in 54% of patients with ALS, and confirmed that patients with ALS may also have a defective deep somatosensory pathway, particularly an abnormal central deep somatosensory pathway.
基金Supported in part by funding from the the Teuku Jacobs Foundation Research Fellowship Program(No.#312)。
文摘AIM:To investigate the impact of lag time to metastasis and survival rates among patients with retinoblastoma.METHODS:This retrospective study was conducted with 52 patients from the Department of Ophthalmology and the Department of Pediatrics of Dr.Sardjito General Hospital,between 1^(st) January 2014 and 31^(st) December 2020.Lag time was defined as the time delay between the first sign of retinoblastoma to the diagnosis of retinoblastoma.The subjects with lag time>one year were included in the case group,while the subjects with lag time<one year were included in the control group.RESULTS:The lag time was significantly correlated with American Joint Committee on Cancer and Intraocular Classification of Retinoblastoma staging of retinoblastoma(P=0.005 and P=0.006,respectively).The lag time was also significantly correlated with both metastasis event[odds ratio(OR):5.06,95%Cl:1.56-16.44,P=0.006]and mortality(OR:4.54,95%Cl:1.37-15.07,P=0.011).The follow-up was continued for 32 subjects for 3y after initial diagnoses.Survival analysis revealed a significant difference among these two groups(P=0.021).Furthermore,lag time was significantly correlated with survival of retinoblastoma(r=-0.53,P=0.046).CONCLUSION:The study highlights the importance of lag time between the onset of first symptoms and the time of retinoblastoma diagnosis which significantly contribute to metastasis and mortality of patients with retinoblastoma.Examinations for the early detection of retinoblastoma should be performed for individuals at-risk to minimize lag time and improve the outcomes.
基金Supported by the National Natural Science Foundation of China!( 6 9870 0 9)by the Science Foundation of Shanghai Municipal
文摘The properties of phase time taken for particles to pass through a quantum potential well are investigated. It is found in a 1 dimensional quantum mechanical problem that the phase time is negative when the incident energy and the thickness of potential well satisfy certain conditions. Similar results are also found in a 2 dimensional fully relativistic optical analog. It is shown that the expression of the la teral shift of transmitted optical waves is similar to that of the phase time in the 1 dimensional quantum mechanical problem. The phase time in the 2 dimensional optical problem is also shown to be negative under certain conditions.
基金Project(2001BA604A01) supported by the Key Project of National"Tenth Five Year"Science & Technology of China
文摘Pulsed signal experiment was carried out to determine the hydrodynamic behaviours of lateral flow biological aerated filter(LBAF). With the analysis of experimental results, LBAF is viewed as an approximate plug flow reactor, and hydraulic retention time distribution function was derived based on LBAF. The results show that flow rate and aeration strength are two critical factors which influence flow patterns in LBAF reactor. The hydrodynamic behaviour analysis of LBAF is the theoretical basis of future research on improving capacity factor and developing kinetic model for the reactor.
基金Supported by the China National Science and Technology Major Project(41872153)Northeast Petroleum University Research Startup Fund(1305021839)。
文摘To evaluate the lateral sealing mechanism of extensional fault based on the pressure difference between fault and reservoir, an integral mathematical-geological model of diagenetic time on diagenetic pressure considering the influence of diagenetic time on the diagenetic pressure and diagenetic degree of fault rock has been established to quantitatively calculate the lateral sealing ability of extensional fault. By calculating the time integral of the vertical stress and horizontal in-situ stress on the fault rock and surrounding rock, the burial depth of the surrounding rock with the same clay content and diagenesis degree as the target fault rock was worked out. In combination with the statistical correlation of clay content, burial depth and displacement pressure of rock in the study area, the displacement pressure of target fault rock was calculated quantitatively. The calculated displacement pressure was compared with that of the target reservoir to quantitatively evaluate lateral sealing state and ability of the extensional fault. The method presented in this work was used to evaluate the sealing of F_(1), F_(2) and F_(3) faults in No.1 structure of Nanpu Sag, and the results were compared with those from fault-reservoir displacement pressure differential methods without considering the diagenetic time and simple considering the diagenetic time. It is found that the results calculated by the integral mathematical-geological model are the closest to the actual underground situation, the errors between the hydrocarbon column height predicted by this method and the actual column height were 0–8 m only, proving that this model is more feasible and credible.
