Effects of gradient high-field static magnetic fields on diabetic mice

Although 9.4 T magnetic resonance imaging(MRI) has been tested in healthy volunteers,its safety in diabetic patients is unclear.Furthermore,the effects of high static magnetic fields(SMFs),especially gradient vs.uniform fields,have not been investigated in diabetics.Here,we investigated the consequences of exposure to 1.0-9.4 T high SMFs of different gradients(>10 T/m vs.0-10 T/m)on type 1 diabetic(T1D) and type 2 diabetic(T2D) mice.We found that 14 h of prolonged treatment of gradient(as high as 55.5 T/m) high SMFs(1.0-8.6 T) had negative effects on T1D and T2D mice,including spleen,hepatic,and renal tissue impairment and elevated glycosylated serum protein,blood glucose,inflammation,and anxiety,while 9.4 T quasi-uniform SMFs at 0-10 T/m did not induce the same effects.In regular T1D mice(blood glucose>16.7 mmol/L),the>10 T/m gradient high SMFs increased malondialdehyde(P<0.01) and decreased superoxide dismutase(P<0.05).However,in the severe T1D mice(blood glucose≥30.0 mmol/L),the>10 T/m gradient high SMFs significantly increased tissue damage and reduced survival rate.In vitro cellular studies showed that gradient high SMFs increased cellular reactive oxygen species and apoptosis and reduced MS-1 cell number and proliferation.Therefore,this study showed that prolonged exposure to high-field(1.0-8.6 T)>10 T/m gradient SMFs(35-1 380 times higher than that of current clinical MRI)can have negative effects on diabetic mice,especially mice with severe T1D,whereas 9.4 T high SMFs at 0-10T/m did not produce the same effects,providing important information for the future development and clinical application of SMFs,especially high-field MRI.

Design Optimization for Generating a High Static Magnetic Field

This paper details the creation of a device capable of generating a powerful and consistent static magnetic field. This apparatus serves the purpose of quantifying the magnetostrictive strain found in materials like annealed cobalt ferrite and Terfenol-D, specifically those shaped as cylindrical rods. In our investigation, the use of static magnetic fields proves most advantageous. This choice is made to mitigate the generation of eddy currents, which would inevitably occur if the magnetic field intensity were varied. The fundamental idea behind this design involves employing a C-shaped iron core constructed from low-carbon mild steel. On this core, three coils are mounted, each capable of producing one-third of the required 9000 Oersted (Oe) magnetic field strength. The test specimen is situated within the “jaws” of the C-shaped core, thus completing the magnetic circuit. To manage the heat generated by each coil, a cooling system consisting of copper tubes is employed. These tubes facilitate the flow of air to dissipate the heat. To model and predict the magnetic field strength produced by the coils, finite element analysis (FEMM) software is utilized, and the results align closely with the anticipated outcomes. This design effectively generates a robust and unchanging magnetic field measuring a stable 9000 Oe in total. Consequently, this equipment finds utility in characterizing the magnetic properties of specific materials.

Direct Generation of Intense Compression Waves in Molten Metals by Using a High Static Magnetic Field and Their Application

Compression waves propagating through molten metals are contributed to degassing, accelerating reaction rate,removing exclusions from molten metals and refining solidification structures during metallurgical processing of materials. In the present study, two electromagnetic methods are proposed to generate intense compression wavesdirectly in liquid metals. One is the simultaneous imposition of a high frequency electrical current field and a staticmagnetic field; the other is that of a high frequency magnetic field and a static magnetic field. A mathematical modelbased on compressible fluid dynamics and electromagnetic fields theory has been developed to derive pressure distributions of the generated waves in a metal. It shows that the intensity of compression waves is proportional to thatof the high frequency electromagnetic force. And the frequency is the same as that of the imposed electromagneticforce. On the basis of theoretical analyses, pressure change in liquid gallium was examined by a pressure transducerunder various conditions. The observed results approximately agreed with the predictions derived from the theoreticalanalyses and calculations. Moreover, the effect of the generated waves on improvement of solidification structureswas also examined. It shows that the generated compression waves can refine solidification structures when they wereapplied to solidification process of Sn-Pb alloy. This study indicates a new method to generate compression wavesby imposing high frequency electromagnetic force locally on molten metals and this kind of compression waves canprobably overcome the difficulties when waves are excited by mechanical vibration in high temperature environments.

Effects of 13 T Static Magnetic Fields (SMF) in the Cell Cycle Distribution and Cell Viability in Immortalized Hamster Cells and Human Primary Fibroblasts Cells

Magnetic resonance image （MRI） systems with a much higher magnetic flux density were developed and applied for potential use in medical diagnostic. Recently, much attention has been paid to the biological effects of static, strong magnetic fields （SMF）. With the 13 T SMF facility in the Institute of Plasma Physics, Chinese Academy of Sciences, the present study focused on the cellular effects of the SMF with 13 T on the cell viability and the cell cycle distribution in immortalized hamster cells, such as human-hamster hybrid （AL） cells, Chinese hamster ovary （CHO） cells, DNA double-strand break repair deficient mutant （XRS-5） cells, and human primary skin fibroblasts （AG1522） cells. It was found that the exposure of 13 T SMF had less effect on the colony formation in either nonsynchronized or synchronized AL cells. Moreover, as compared to non-exposed groups, there were slight differences in the cell cycle distribution no matter in either synchronized or nonsynchronized immortalized hamster ceils after exposure to 13 T SMF. However, it should be noted that the percentage of exposed AG1522 cells at G0/G1 phase was decreased by 10% as compared to the controls. Our data indicated that although 13 T SMF had minimal effects in immortalized hamster cells, the cell cycle distribution was slightly modified by SMF in human primary fibroblasts.

The effects of a static magnetic field on the microwave absorption of hydrogen plasma in carbon nanotubes: a numerical study

We theoretically investigate the microwave absorption properties of hydrogen plasma in iron-catalyzed high- pressure disproportionation-grown carbon nanotubes under an external static magnetic field in the frequency range 0.3 GHz to 30 GHz, using the Maxwell equations in conjunction with a general expression for the effective complex permittivity of magnetized plasma known as the Appleton Hartree formula. The effects of the external static magnetic field intensity and the incident microwave propagation direction on the microwave absorption of hydrogen plasma in CNTs are studied in detail. The numerical results indicate that the microwave absorption properties of hydrogen plasma in iron-catalyzed high-pressure disproportionation-grown carbon nanotubes can be obviously improved when the exter- nal static magnetic field is applied to the material. It is found that the specified frequency microwave can be strongly absorbed by the hydrogen plasma in iron-catalyzed high-pressure disproportionation-grown carbon nanotubes over a wide range of incidence angles by adjusting the external magnetic field intensity and the parameters of the hydrogen plasma.

Rapid air film continuous casting of aluminum alloy using static magnetic field

The influences of the cooling style and static magnetic field on the air film casting process were investigated. Ingots of 6063 aluminum alloy were produced by AIRSOL VEIL casting with double-layer cooling water and static magnetic field. Surface segregation, hot crack and variation of solute content along the radius direction of ingot were examined. The results showed that double-layer cooling water can improve the surface quality and avoid of hot crack, which created conditions to increase the casting speed. The electromagnetic casting process can effectively improve the surface quality in high speed casting process, and static magnetic field has a great influence on solute distribution along the radius direction of ingot.

Genotoxic Effects of Superconducting Static Magnetic Fields(SMFs)on Wheat(Triticum aestivum)Pollen Mother Cells(PMCs)

The effects of superconducting static magnetic fields （SMFs） on the pollen mother cells （PMCs） of wheat were investigated in order to evaluate the possible genotoxic effect of such non-ionizing radiation. The seeds of wheat were exposed to static magnetic fields with either different magnetic flux densities （0, 1, 3, 5 and 7 Tesla） for 5 h or different durations （1, 3 and 5 h） at a magnetic flux density of 7 Tesla. The seeds were germinated at 23℃ after exposure and the seedlings were transplanted into the field. The PMCs from young wheat ears were taken and slides were made following the conventional method. The genotoxic effect was evaluated in terms of micronucleus （MN）, chromosomal bridge, lagging chromosome and fragments in PMCs. Although the exposed groups of a low field intensity （below 5 Tesla） showed no statistically significant difference in the aberration frequency compared with the unexposed control groups and sham exposed groups, a significant increase in the chromosomal bridge, lagging chromosome, triple-polar segregation or micronucleus was observed at a field strength of 5 Tesla or 7 Tesla, respectively. The analysis of dose-effect relationships indicated that the increased frequency of meiotic abnormal cells correlated with the flux density of the magnetic field and duration, but no linear relationship was observed. Such statistically significant differences indicated a potential genotoxic effect of high static magnetic fields above 5 T.

Experimental study of repair effects of moderate-intensity static magnetic fields on type 2 diabetic soft tissue wound healing

Objective: To systematically explore the effects of moderate-intensity static magnetic fields (SMF) on type 2 diabetic wound healing and preliminarily explore the possible mechanism, and hence to lay a foundation for its scientific and extensive clinical application. Methods:Round-shape wound of soft tissues with 1-cm diameter was constructed on the dorsum of thirty-two 3-month-old male type 2 diabetic db/db mice and sixteen wild-type mice with the same gene background, followed by covered with transparent film wound dressing. The experiment was divided into the control group (control), db/db mice group (db/db), and db/db mice exposed to SMF group (db/db+SMF) with sixteen mice in each group. Four mice in each group were killed post 5, 12 and 19 days of the wound model establishment, respectively. The mice in the db/db+SMF group were subjected to systemic SMF exposure (4 mT peak intensity) with 2 h per day. The wound closure rate, overall wound healing period, tensile strength, and histopathological morphology in each group were determined and analyzed. The interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF) gene expression were also measured and analyzed. Results: SMF significantly increased the wound closure rate (P<0.05), decreased the overall healing period (P<0.05), increased the tensile strength of wound tissues (P<0.05), decreased the number of inflammatory cells, and inhibited the expression of inflammatory cytokines (IL-1β, TNF-αand IL-6) in db/db mice at 5, 12 and 19 days post-surgery (P<0.05), whereas SMF had no significant effect on the VEGF expression. Conclusion: Moderate-intensity systemic SMF exposure exhibits positive therapeutic effects on accelerating type 2 diabetic soft tissue wound repair, and the positive effects are closely related to its significant anti-inflammatory response.

A Simulation Study on the Specific Loss Power in Magnetic Hyperthermia in the Presence of a Static Magnetic Field

Our purpose in this study was to present a method for estimating the specific loss power (SLP) in magnetic hyperthermia in the presence of an external static magnetic field (SMF) and to investigate the SLP values estimated by this method under various diameters (D) of magnetic nanoparticles (MNPs) and amplitudes (H0) and frequencies (f) of an alternating magnetic field (AMF). In our method, the SLP was calculated by solving the magnetization relaxation equation of Shliomis numerically, in which the magnetic field strength at time t (H(t)) was assumed to be given by , with Hs being the strength of the SMF. We also investigated the SLP values in the case when the SMF with a field-free point (FFP) generated by two solenoid coils was used. The SLP value in the quasi steady state (SLPqss) decreased with increasing Hs. The plot of the SLPqss values against the position from the FFP became narrow as the gradient strength of the SMF (Gs) increased. Conversely, it became broad as Gs decreased. These results suggest that the temperature rise and the area of local heating in magnetic hyperthermia can be controlled by varying the Hs and Gs values, respectively. In conclusion, our method will be useful for estimating the SLP in the presence of both the AMF and SMF and for designing an effective local heating system for magnetic hyperthermia in order to reduce the risk of overheating surrounding healthy tissues.

Acetaminophen overdose-induced acute liver injury can be alleviated by static magnetic field

Acetaminophen(APAP),the most frequently used mild analgesic and antipyretic drug worldwide,is implicated in causing 46%of all acute liver failures in the USA and between 40%and 70%in Europe.The predominant pharmacological intervention approved for mitigating such overdose is the antioxidant N-acetylcysteine(NAC);however,its efficacy is limited in cases of advanced liver injury or when administered at a late stage.In the current study,we discovered that treatment with a moderate intensity static magnetic field(SMF)notably reduced the mortality rate in mice subjected to high-dose APAP from 40%to 0%,proving effective at both the initial liver injury stage and the subsequent recovery stage.During the early phase of liver injury,SMF markedly reduced APAPinduced oxidative stress,free radicals,and liver damage,resulting in a reduction in multiple oxidative stress markers and an increase in the antioxidant glutathione(GSH).During the later stage of liver recovery,application of vertically downward SMF increased DNA synthesis and hepatocyte proliferation.Moreover,the combination of NAC and SMF significantly mitigated liver damage induced by high-dose APAP and increased liver recovery,even 24 h post overdose,when the effectiveness of NAC alone substantially declines.Overall,this study provides a noninvasive non-pharmaceutical tool that offers dual benefits in the injury and repair stages following APAP overdose.Of note,this tool can work as an alternative to or in combination with NAC to prevent or minimize liver damage induced by APAP,and potentially other toxic overdoses.

Reaction characteristics of carbon-bearing pellets of Bayan Obo lean iron ores in a static magnetic field

The use of low-grade,refractory and composite paragenetic mineral resources is necessary for overcoming the shortage of iron ore resources in China.As a solution to the treatment of such iron ores,the direct reduction of carbon-bearing pellets can ensure complete iron removal and the effective enrichment of other high-value elements.Thus,this technology enjoys a broad application prospect.However,there are several problems with low-temperature reduction,such as low iron ore reaction efficiency,long reaction time,and high energy consumption.To improve the low-temperature carbothermic reduction efficiency of iron ores,a static magnetic field with magnetic induction intensity of 1.0 T was introduced.An isothermal reduction experiment was conducted at 1223 K to study the low-temperature self-reduction characteristics of carbon-bearing pellets of Bayan Obo lean iron ores in the static magnetic field.Also,the acting mechanism of the magnetic field was explored from the perspective of the reduction process,reaction efficiency,phase composition,microstructure changes,and dynamic behavior of iron ores.The results showed that the magnetic field can increase the low-temperature reduction rate of carbon-bearing pellets of Bayan Obo lean iron ores.Under the conditions of reduction temperature of 1223 K,magnetic induction intensity of 1.0 T,and reduction time of 60 min,the reduction degree was 92.42%,1.65 times that without a magnetic field.The magnetic field promoted the replacement of Ca^(2+)and Fe^(2+),so that the hard-to-reduce iron-bearing silicates were reduced in the order of Fe2SiO_(4)→(Ca,Na)FeSiO_(4)→FeO→Fe.The magnetic field enabled loose minerals,more pores and cracks,and changes in the growth morphology and distribution position of metallic iron.Compared with the case under the non-magnetic condition,the metallic iron precipitated from the slag phase in a foliated shape,separated from the matrix iron oxides,and grew up at the junction of the slag phase and coke.The magnetic field significantly increased the interfacial chemical reaction rate of the carbothermic reduction of iron ores and reduced the internal diffusion resistance of gas in the product layer.Specifically,the interfacial chemical reaction rate increased by 138%and the internal diffusion coefficient increased by 309%.Therefore,the effect of the magnetic field on the internal diffusion resistance was the main cause for strengthening the low-temperature reduction of iron ores.

Effect of Transverse Static Magnetic Field on Droplets Transient and Inclusions Evolution During the Electroslag Remelting Process of GCr15 Ingots

The voltage was recorded to investigate the influence of the static magnetic field on droplet evolution during the mag-netically controlled electroslag remelting （MC-ESR） process. MC-ESR experiments were carried out under differentremelting current, and transverse static magnetic fields （TSMF） of 85 mT, 130 mT and 160 mT were superimposed.Statistical work was performed to obtain the quantitative data of the droplets. The ASPEX Explorer was utilized toinvestigate the inclusions evolution of GCr15 ingots. The number of the droplets was 31 in 20 s during the traditional ESRprocess and reached 50 and 51 under the MC-ESR process with the TSMF of 85 mT and 130 mT, respectively. Whencompared the traditional ESR process with the MC-ESR process, the inclusions amount reduced 67%.

Effect of transverse static magnetic field on radial microstructure of hypereutectic aluminum alloy during directional solidification

The effect of different scales thermoelectric magnetic convection(TEMC)on the radial solidification microstructure of hypereutectic Al alloy has been investigated under transverse static magnetic field during directional solidification,focusing on the formation of freckle.Our experimental and numerical simulation results indicate that the TEMC circulation at sample scale under transverse static magnetic field leads to the enrichment of solute Al on one side of the sample.The TEMC and the solute enrichment degree increase with the increase of magnetic field when the magnetic field increases to 0.5 T.The enrichment degree of solute elements under magnetic field is affected by temperature gradient and growth rate.The non-uniform distribution of solute Al in the radial direction of the sample results in the non-uniform distribution of primary dendrite arm spacing(PDAS).Moreover,the applied magnetic field can lead to freckle formation and its number increases with the increase of magnetic field.The change of freckle is consistent with the anisotropy TEMC caused by the anisotropy of primary dendrite or primary dendrite network under magnetic field.Finally,the mechanism of synergism effect of the anisotropy TEMC,the distribution of solute Al and the PDAS on freckle formation and evolution is studied during directional solidification under magnetic field.

Behavior of molten steel flow in continuous casting mold with different static magnetic field configurations

A three-dimensional mathematical model was established to investigate the behavior of molten steel flow and steel/slag interface with different processes and electromagnetic parameters under two different static magnetic field configurations [ruler-type electromagnetic brake （EMBr ruler） and vertical electromagnetic brake （V-EMBr）] in a continuous casting mold. The results showed that the brake effect of EMBr ruler is significantly influenced by its configuration parameters, the distance between the pole and bottom of the submerged entry nozzle （SEN）, and the port angle of the SEN outlet; therefore, it is not helpful to depress the diffusion of jet flow along the thickness direction of mold. For a constant SEN depth and port angle, there is a reasonable pole position （P = 0 mm） where the pole simultaneously covers three key zones, i.e., the jet flow impact zone and the upward and downward backflow zones. For V-EMBr, the magnetic field can simultaneously cover the three key zones and depress the diffusion of jet flow along the casting and thickness directions of the mold. Both the meniscus height and the impact intensity of the jet flow can be obviously depressed by V-EMBr even if the SEN depth and port angle have changed in the continuous casting process.

Numerical Analysis of Fluctuation Behavior of Steel/Slag Interface in Continuous Casting Mold with Static Magnetic Field

Utilizing ANSYS CFX commercial software and volume fraction of fluid （VOF） model, fluctuation behav- ior of steel/slag interface was numerically simulated in continuous casting mold with static magnetic field, and the influence of metal jet characteristics on the behavior of steel/slag interface was investigated. The results indicated that the behavior of steel/slag interface is similar at different process parameters, which is closely related to the characteristic of the flow field. The steel/slag interface has an obvious trough characteristic, which can be divided in- to three zones： frontal valley zone, back valley zone and horizontal zone~ as the magnetic flux density increases, the fluctuation of liquid level increases firstly and then decreases, and a reasonable magnetic flux density can make steel/ slag interface obtain a relatively flat interface, which can prevent slag from being entrapped into liquid steel. For a thin slab continuous casting process, when the casting speed is 4 m/min, a reasonable magnetic flux density is about 0.5 T, and the interfacial fluctuation is weaker. No matter the position of magnetic field is horizontal or vertical, for different operating parameters, there is a corresponding reasonable magnetic field position where the steel/slag inter- face fluctuation can be properly controlled and slag entrapment can be prevented.

Grain Refinement During Directionally Solidifying GCr18Mo Steel at Low Pulling Speeds Under an Axial Static Magnetic Field

The present work investigates how axial static magnetic field affects the solidification structure and the solute distribution in directionally solidified GCr18Mo steel. Experimental results show that grain refinement and the colunmar to equiaxed transition is enhanced with the increases in the magnetic field intensity （B） and temperature gradient （G） and the decrease in the growth speed. This phenomenon is simultaneously accompanied by more uniformly distributed alloying elements. The corresponding numerical simulations verify a thermoelectric （TE） magnetic convection pattern in the mushy zone due to the interaction between the magnetic field and TE current. The TE magnetic convection in the liquid should be responsible for the motion of dendrite fragments. The TE magnetic force acting on the dendrite is one of the driving forces trigging fragmentation.

Tailoring Microstructure and Microsegregation in a Directionally Solidified Ni-Based SX Superalloy by a Weak Transverse Static Magnetic Field

A weak transverse static magnetic field(WTSMF,0–0.5 T)is applied to the directional solidification process of a DD3 Ni-based SX superalloy,aiming to tailor the microstructure and microsegregation of alloys.The mechanisms of microstructural refinement and microsegregation distribution caused by a WTSMF during directional solidification are discussed.It is shown that the primary dendrite arm spacing is rapidly reduced from 181 to 143μm,and the average size ofγ′phase is significantly refined from 0.85 to 0.25μm as the magnetic field increases from 0 to 0.5 T.At the same time,the volumefractions ofγ/γ′eutectic and the segregation coefficient are also gradually decreased.The 3D numerical simulations of the multiscale convection in liquid phase show that the modifications of the microstructure and microsegregation in DD3 are mainly attributed to the enhanced liquid flow caused by thermoelectric magnetic convection(TEMC)at dendrite/sample scale under the WTSMF.The maximum of the TEMC increases with increasing the magnetic field intensity.This work paves a simple way to optimize the microstructure and microsegregation in directionally solidified Ni-based SX superalloys without changing the processing parameters and composition.

Static magnetic field analysis of hollow-cup motor model and bow-shaped permanent magnet design

The hollow-cup Permanent Magnet(PM) motors have the characteristics of low power consumption, and are widely used in the aerospace field. At present, the tile-shaped PMs used by hollow-cup PM motors have poor sinusoidal characteristics of the air gap magnetic flux density waveform, which will cause torque ripple. The existing method for improving the air gap magnetic flux density waveform is not very effective when applied to hollow cup, a special motor with no stator core and large air gap. A bow-shaped PMs structure is designed for the hollow-cup motor in this paper. First, the equivalent surface current method is used to calculate the analytical formula of the static magnetic field of the model. Then, the Finite Element(FE) method is used to calculate the static air gap flux density waveform of conventional tile-shaped PMs and bow-shaped PMs with different bow heights, and the corresponding harmonics and sine distortion are obtained by Fourier decomposition. The simulation results show that the bow-shaped PMs can effectively improve the sinusoidal characteristics of the static air gap flux density waveform. And the suitable bow height is determined. Finally, a prototype is made based on the suitable bow height for experiments, and compared with the analytical result and the FE result, and the accuracy and effectiveness of the bow-shaped PMs with the suitable bow height are verified.

Preparing High Silicon Steel by Sintering Fe-6.5%Si Powder Compacts in Static Magnetic Field

In this research,sintering Fe-6.5wt%Si Compact specimen in static magnetic field is proposed for preparing high silicon steel.It is found that the densifications of the compacts are affected remarkably by superimposing magnetic field.The density of the compacts can be increased when the MFD is higher than 0.2 T.The highest relative density of the samples is 97.2%.The magnetic property of silicon steel could be improved when superimpose static magnetic field in sintering process,the permeability of the compact are two times of that without magnetic field,and the magnetic property parallel to the direction of the magnetic field was evidently higher than that in perpendicular direction.

Effect of axial static magnetic field on cleanliness and microstructure in magnetically controlled electroslag remelted bearing steel

The effect of the axial static magnetic field(ASMF)on cleanliness and microstructure in magnetically controlled electroslag remelted GCr15 bearing steel ingots was investigated experimentally.The results show that a magnetically controlled spin-vibration induced by the interaction of the ASMFs and the remelting current exists at the consumable electrode tip,resulting in thinner liquid melt film and smaller droplets.With the increase in magnetic flux density,the optimization effect of ASMFs on electroslag remelting process increases and reaches the peak with a 40 mT ASMF,then decreases.The cleanliness of the ingots was improved,and the count of inclusions larger than 5μm was reduced.The microstructure of the ingots processed with a 40 mT ASMF was significantly refined.The depth of the metallic molten pool was reduced from 45.2 to 17.5 mm with the application of 40 mT ASMF.The tensile strength,impact toughness,and Rockwell hardness of the ingots obtained under the 40 mT ASMF were significantly improved.The mechanisms of the spin-vibration occurring at the electrode tip end were interpreted in detail to elucidate the effect of ASMFs.