A Preliminary Outline of the Statistical Inference Process in Genetic Association Studies

The genome-wide association study (GWAS) is a powerful experimental design that is applied to detect disease susceptible genetic variants. The main goal of these studies is to provide a better understanding of the biology of disease, which further facilitates prevention or better treatment. A statistical inferential process is finally carried out in this study, where an association is usually observed between the single-nucleotide polymorphism (SNPs) and the traits in a case-control setting. To detect the disease responsible loci correctly, the investigation of the statistical association should be carefully conducted along with the other necessary steps. This research provides an introductory guideline for conducting such statistical association tests for these studies using SNP genotype data.

Information geometry in optimization,machine learning and statistical inference

The present article gives an introduction to information geometry and surveys its applications in the area of machine learning,optimization and statistical inference.Information geometry is explained intuitively by using divergence functions introduced in a manifold of probability distributions and other general manifolds.They give a Riemannian structure together with a pair of dual flatness criteria.Many manifolds are dually flat.When a manifold is dually flat,a generalized Pythagorean theorem and related projection theorem are introduced.They provide useful means for various approximation and optimization problems.We apply them to alternative minimization problems,Ying-Yang machines and belief propagation algorithm in machine learning.

Inference and optimal design on step-stress partially accelerated life test for hybrid system with masked data

Under Type-Ⅱ progressively hybrid censoring, this paper discusses statistical inference and optimal design on stepstress partially accelerated life test for hybrid system in presence of masked data. It is assumed that the lifetime of the component in hybrid systems follows independent and identical modified Weibull distributions. The maximum likelihood estimations(MLEs)of the unknown parameters, acceleration factor and reliability indexes are derived by using the Newton-Raphson algorithm. The asymptotic variance-covariance matrix and the approximate confidence intervals are obtained based on normal approximation to the asymptotic distribution of MLEs of model parameters. Moreover,two bootstrap confidence intervals are constructed by using the parametric bootstrap method. The optimal time of changing stress levels is determined under D-optimality and A-optimality criteria.Finally, the Monte Carlo simulation study is carried out to illustrate the proposed procedures.

Exact Distribution of Difference of Two Sample Proportions and Its Inferences

Comparing two population proportions using confidence interval could be misleading in many cases, such as the sample size being small and the test being based on normal approximation. In this case, the only one option that we have is to collect a large sample. Unfortunately, the large sample might not be possible. One example is a person suffering from a rare disease. The main purpose of this journal is to derive a closed formula for the exact distribution of the difference between two independent sample proportions, and use it to perform related inferences such as a confidence interval, regardless of the sample sizes and compare with the existing Wald, Agresti-Caffo and Score. In this journal, we have derived a closed formula for the exact distribution of the difference between two independent sample proportions. This distribution doesn’t need any requirements, and can be used to perform inferences such as: a hypothesis test for two population proportions, regardless of the nature of the distribution and the sample sizes. We claim that exact distribution has the least confidence width among Wald, Agresti-Caffo and Score, so it is suitable for inferences of the difference between the population proportion regardless of sample size.

Distributed Estimator of Market Beta under Extreme Conditions

Market beta is a measure of the volatility or systematic risk of a security or portfolio compared to the market as a whole. This paper considers the distributed estimation of market beta in the case of massive data, and obtains the consistency and asymptotic normality of the estimator. Further, simulations show the finite sample properties of this estimator.

Effect of observation time on source identification of diffusion in complex networks

This paper examines the effect of the observation time on source identification of a discrete-time susceptible-infectedrecovered diffusion process in a network with snapshot of partial nodes.We formulate the source identification problem as a maximum likelihood(ML)estimator and develop a statistical inference method based on Monte Carlo simulation(MCS)to estimate the source location and the initial time of diffusion.Experimental results in synthetic networks and real-world networks demonstrate evident impact of the observation time as well as the fraction of the observers on the concerned problem.

On Probabilistic Distribution of Fatigue Strength

In this paper, a probabilistic distribution of fatigue strength as a function of fatigue life is discussed. The transformation method between fatigue life and fatigue strength developed in the past by other methods did not deal with the fact that the scatter factor of fatigue life increases at a low stress level. A modified model of fatigue strength distribution based on the fatigue scatter investigation is presented in this paper. The results of the statistical inferences from a large sample fatigue test indicate that the proposed model can be accepted at a 10% level of significance.

Distribution of the Maximum and Minimum of a Random Number of Bounded Random Variables

We study a new family of random variables that each arise as the distribution of the maximum or minimum of a random number N of i.i.d. random variables X1, X2,…, XN, each distributed as a variable X with support on [0, 1]. The general scheme is first outlined, and several special cases are studied in detail. Wherever appropriate, we find estimates of the parameter θ in the one-parameter family in question.

Autoregressive moving average model for matrix time series

In the paper,the autoregressive moving average model for matrix time series(MARMA)is inves-tigated.The properties of the MARMA model are investigated by using the conditional least square estimation,the conditional maximum likelihood estimation,the projection theorem in Hilbert space and the decomposition technique of time series,which include necessary and suf-ficient conditions for stationarity and invertibility,model parameter estimation,model testing and model forecasting.

Estimating the basic reproduction number for single-strain dengue fever epidemics

Background:Dengue,an infectious tropical disease,has recently emerged as one of the most important mosquito-borne viral diseases in the world.We perform a retrospective analysis of the 2011 dengue fever epidemic in Pakistan in order to assess the transmissibility of the disease.We obtain estimates of the basic reproduction number R0 from epidemic data using different methodologies applied to different epidemic models in order to evaluate the robustness of our estimate.Results:We first estimate model parameters by fitting a deterministic ODE vector-host model for the transmission dynamics of single-strain dengue to the epidemic data,using both a basic ordinary least squares(OLS)as well as a generalized least squares(GLS)scheme.Moreover,we perform the same analysis for a direct-transmission ODE model,thereby allowing us to compare our results across different models.In addition,we formulate a direct-transmission stochastic model for the transmission dynamics of dengue and obtain parameter estimates for the stochastic model using Markov chain Monte Carlo(MCMC)methods.In each of the cases we have considered,the estimate for the basic reproduction number R0 is initially greater than unity leading to an epidemic outbreak.However,control measures implemented several weeks after the initial outbreak successfully reduce R0 to less than unity,thus resulting in disease elimination.Furthermore,it is observed that there is strong agreement in our estimates for the pre-control value of R0,both across different methodologies as well across different models.However,there are also significant differences between our estimates for the post-control value of the basic reproduction number across the two different models.Conclusion:In conclusion,we have obtained robust estimates for the value of the basic reproduction number R0 associated with the 2011 dengue fever epidemic before the implementation of public health control measures.Furthermore,we have shown that there is close agreement between our estimates for the post-control value of R0 across the different methodologies.Nevertheless,there are also significant differences between the estimates for the post-control value of R0 across the two different models.