BIM-based construction technologies for precast foamed lightweight concrete wallboards

To promote the visualisation and informatisation of the construction process of precast foamed lightweight concrete wallboards(PFLCWs),from the analysis of the construction requirements of PFLCWs,three key construction technologies based on building information modelling(BIM),namely,parameterised modelling for the PFLCW layout design,drawing generation to draw the PFLCW layout and quantity statistics for extracting PFLCW quantities,are proposed.Then,a reinforced concrete(RC)frame infilled with PFLCW is considered the test model to verify the feasibility of the aforementioned technologies.The results show that PFLCW layout design can be accomplished rapidly and visually using parameterised modelling technology.The PFLCW layout diagram can be generated directly using drawing generation technology.The proposed quantity statistics technology enables the automatic export of PFLCW bills of quantities.The built parameterised model helps construction workers rapidly and intuitively understand the specific layout details of PFLCWs.Moreover,the generated layout drawing and the bills of quantities based on the parameterised model can guide the production and on-site installation of PFLCWs.The research conclusions can serve as a practical guide and technical support for PFLCW engineering applications.

Detection of the Urinary Biomarkers PYD, CTX-Ⅱ, and DPD in Patients with Kashin-Beck Disease in the Qinghai Province of China

Kashin-Beck disease（KBD） is an endemic degenerative osteoarthropathy of uncertain etiology. The aim of our study was to identify changes in C-telopeptide of type Ⅱ collagen（CTX-Ⅱ）, pyridinoline（PYD）, and deoxypyridinoline（DPD） among KBD patients. 54 KBD patients and 78 healthy controls were included this study. Urinary samples were collected and measured by ELISA. The median quantities of PYD, CTX-Ⅱ, and DPD of KBD patients were 1107.73 ng/μmol.cre, 695.11 ng/μmol.cre, and 1342.34 pml/μmol.cre, while the median quantities of healthy controls were 805.59 ng/μmol.cre, 546.47 ng/μmol.cre, and 718.15 pml/μmol.cre, respectively. The differences between KBD patients and healthy controls were statistically significant（Z = 4.405, 3.653, and 3.724; P 〈 0.001）. The higher levels of PYD, CTX-Ⅱ, and DPD detected in KBD patients indicate that they could be used as biomarkers of KBD.

Quantitative analysis of gene expression systems

Gene expression is a complex biochemical process, involving many specific processes such as transcription, translation, switching between promoter states, and regulation. All these biochemical processes inevitably lead to fluctuations in mRNA and protein abundances. This noise has been identified as an important factor underlying the observed phenotypic variability of genetically identical cells in homogeneous environments. Quantifying the contributions of different sources of noise using stochastic models of gene expression is an important step towards understanding fundamental cellular processes and cell-to-cell variability in expression levels. In this paper, we review progresses in quantitative study of simple gene expression systems, including some results that we have not published. We analytically show how specific processes associated with gene expression affect expression levels. In particular, we derive the analytical decomposition of expression noise, which is important for understanding the roles of the factorial noise in controlling phenotypic variability. We also introduce a new index （called attribute factor） to quantify expression noise, which has more advantages than the commonly-used noise indices such as noise intensity and Fano factor.