From May, 2000 to June, 2001, 27 patients with Parkinson disease (PD), including 10 cases of rigidity, 13 cases of tremor, 4 cases of rigidity and tremor, were treated by microelectrode guided technique. Among them, ...From May, 2000 to June, 2001, 27 patients with Parkinson disease (PD), including 10 cases of rigidity, 13 cases of tremor, 4 cases of rigidity and tremor, were treated by microelectrode guided technique. Among them, phlebotomy was carried out in 17 cases and thalamotomy in 10 cases. All the targets of lesion were anatomically located by using MR and neurophysiological signals on microelectrode. Our results showed that the efficiency of microelectrode guided technique for treatment of PD was 98 %. The postoperative unified parkinson disease rating scale were 12.3±9.1 and 13.2±8.9 respectively, which significantly improved as compared with those before operation. It was concluded that by recognizing special electrical signals in neurons microelectrode guided neuropsychological techniques can locate target at cellular level, which overcomes the individual difference in anatomy and function, and allow more accuracy, safety and efficiency of operation. This is especially true of PD patients who fail to respond to medical treatment.展开更多
The application ofstereotactic technique is rapidly growing. For instance, deep brain stimulation （DBS）, an important neurostimulation technique in the treatment of Parkinson＇s disease, dystonia, essential tremor, ...The application ofstereotactic technique is rapidly growing. For instance, deep brain stimulation （DBS）, an important neurostimulation technique in the treatment of Parkinson＇s disease, dystonia, essential tremor, and other diseases, uses the stereotactic method to implant electrodes.展开更多
文摘From May, 2000 to June, 2001, 27 patients with Parkinson disease (PD), including 10 cases of rigidity, 13 cases of tremor, 4 cases of rigidity and tremor, were treated by microelectrode guided technique. Among them, phlebotomy was carried out in 17 cases and thalamotomy in 10 cases. All the targets of lesion were anatomically located by using MR and neurophysiological signals on microelectrode. Our results showed that the efficiency of microelectrode guided technique for treatment of PD was 98 %. The postoperative unified parkinson disease rating scale were 12.3±9.1 and 13.2±8.9 respectively, which significantly improved as compared with those before operation. It was concluded that by recognizing special electrical signals in neurons microelectrode guided neuropsychological techniques can locate target at cellular level, which overcomes the individual difference in anatomy and function, and allow more accuracy, safety and efficiency of operation. This is especially true of PD patients who fail to respond to medical treatment.
基金This study was supported by grants from National Natural Science Foundation of China，Administration of Hospitals Clinical Medicine Development of Special Funding，Scientific Research Common Program of Beijing Municipal Commission of Education
文摘The application ofstereotactic technique is rapidly growing. For instance, deep brain stimulation （DBS）, an important neurostimulation technique in the treatment of Parkinson＇s disease, dystonia, essential tremor, and other diseases, uses the stereotactic method to implant electrodes.
