The method of numerical simulation was applied to investigate gas preheating and start-up process in a drained aluminum reduction cell. The transient temperature and velocity fields of a 156 kA drained aluminum reduct...The method of numerical simulation was applied to investigate gas preheating and start-up process in a drained aluminum reduction cell. The transient temperature and velocity fields of a 156 kA drained aluminum reduction cell were numerically calculated. The results show that the method of gas preheating and bake-out can basically meet the technical requirements of the start-up process for the drained cell. If the same distributing scheme of gas nozzle as that in the general cells is used, there are problems of great temperature gradients and low temperature zone at the top of cathode near the side of nozzles. In order to promote the effect of gas preheating and baking the drained cell, the jetting angle of end nozzle is adjusted and the temperature distribution in the drained cell is obviously improved. By means of simulating the temperature field in the case that jetting angle varies from 0? to 30?, it is concluded that better temperature distribution can be obtained if the jetting angle of end nozzle is approximately 15?.展开更多
Multiple sclerosis(MS) is a chronic inflammatory condition of the central nervous system determined by a presumed autoimmune process mainly directed against myelin components but also involving axons and neurons. Acut...Multiple sclerosis(MS) is a chronic inflammatory condition of the central nervous system determined by a presumed autoimmune process mainly directed against myelin components but also involving axons and neurons. Acute demyelination shows as clinical relapses that may fully or partially resolve, while chronic demyelination and neuroaxonal injury lead to persistent and irreversible neurological symptoms, often progressing over time. Currently approved disease-modifying therapies are immunomodulatory or immunosuppressive drugs that significantly although variably reduce the frequency of attacks of the relapsing forms of the disease. However, they have limited efficacy in preventing the transition to the progressive phase of MS and are of no benefit after it has started. It is therefore likely that the potential advantage of a given treatment is condensed in a relatively limited window of opportunity for each patient, depending on individual characteristics and disease stage, most frequently but not necessarily in the early phase of the disease. In addition, a sizable proportion of patients with MS may have a very mild clinical course not requiring a disease-modifying therapy. Finally, individual response to existing therapies for MS varies significantly across subjects and the risk of serious adverse events remains an issue, particularly for the newest agents. The present review is aimed at critically describing current treatment strategies for MS with a particular focus on the decision of starting, switching and stopping commercially available immunomodulatory and immunosuppressive therapies.展开更多
基金Project(G1999064903) supported by the National Basic Research Program of China
文摘The method of numerical simulation was applied to investigate gas preheating and start-up process in a drained aluminum reduction cell. The transient temperature and velocity fields of a 156 kA drained aluminum reduction cell were numerically calculated. The results show that the method of gas preheating and bake-out can basically meet the technical requirements of the start-up process for the drained cell. If the same distributing scheme of gas nozzle as that in the general cells is used, there are problems of great temperature gradients and low temperature zone at the top of cathode near the side of nozzles. In order to promote the effect of gas preheating and baking the drained cell, the jetting angle of end nozzle is adjusted and the temperature distribution in the drained cell is obviously improved. By means of simulating the temperature field in the case that jetting angle varies from 0? to 30?, it is concluded that better temperature distribution can be obtained if the jetting angle of end nozzle is approximately 15?.
文摘Multiple sclerosis(MS) is a chronic inflammatory condition of the central nervous system determined by a presumed autoimmune process mainly directed against myelin components but also involving axons and neurons. Acute demyelination shows as clinical relapses that may fully or partially resolve, while chronic demyelination and neuroaxonal injury lead to persistent and irreversible neurological symptoms, often progressing over time. Currently approved disease-modifying therapies are immunomodulatory or immunosuppressive drugs that significantly although variably reduce the frequency of attacks of the relapsing forms of the disease. However, they have limited efficacy in preventing the transition to the progressive phase of MS and are of no benefit after it has started. It is therefore likely that the potential advantage of a given treatment is condensed in a relatively limited window of opportunity for each patient, depending on individual characteristics and disease stage, most frequently but not necessarily in the early phase of the disease. In addition, a sizable proportion of patients with MS may have a very mild clinical course not requiring a disease-modifying therapy. Finally, individual response to existing therapies for MS varies significantly across subjects and the risk of serious adverse events remains an issue, particularly for the newest agents. The present review is aimed at critically describing current treatment strategies for MS with a particular focus on the decision of starting, switching and stopping commercially available immunomodulatory and immunosuppressive therapies.
