Data storage solutions are a crucial aspect of any application, significantly impacting data management and system performance. This article explores the rationale behind utilizing both SQL and NoSQL databases, addres...Data storage solutions are a crucial aspect of any application, significantly impacting data management and system performance. This article explores the rationale behind utilizing both SQL and NoSQL databases, addressing key questions about when each type is preferable. The background emphasizes the importance of selecting the appropriate database technology to meet specific application requirements. The purpose of this research is to provide a comprehensive guide for choosing between SQL and NoSQL databases based on various factors, including workload characteristics, scalability needs, and consistency requirements. To achieve this, we examine different strategies for implementing SQL and NoSQL databases in large-scale distributed applications and systems. The research method involves a comparative analysis of the features, advantages, and limitations of both database types. We specifically focus on scenarios involving read-heavy versus write-heavy systems and the trade-offs between availability and consistency. The results of this research indicate that SQL databases, with their relational structure and ACID compliance, are ideal for applications requiring complex queries and data integrity. In contrast, NoSQL databases, offering schema flexibility and horizontal scalability, are better suited for managing extensive datasets and high-velocity data ingestion. In conclusion, the selection of a database depends on the specific needs of the application. SQL databases are preferred for transactional systems with complex relationships, while NoSQL databases excel in scenarios demanding flexibility and scalability. The study provides insights into hybrid approaches, leveraging both database types to optimize system performance.展开更多
We propose a novel high performance carrier stored trench bipolar transistor(CSTBT)with dual shielding structure(DSS-CSTBT).The proposed DSS-CSTBT features a double trench structure with different trench profiles in t...We propose a novel high performance carrier stored trench bipolar transistor(CSTBT)with dual shielding structure(DSS-CSTBT).The proposed DSS-CSTBT features a double trench structure with different trench profiles in the surface,in which a shallow gate trench is shielded by a deep emitter trench and a thick oxide layer under it.Compared with the conventional CSTBT(con-CSTBT),the proposed DSS-CSTBT not only alleviates the negative impact of the shallow gate trench and highly doped CS layer on the breakdown voltage(BV),but also well reduces the gate-collector capacitance CGC,gate charge Q_(G),and turn-off loss E_(OFF)of the device.Furthermore,lower turn-on loss E_(ON)and gate drive loss E_(DR)are also obtained.Simulation results show that with the same CS layer doping concentration N_(CS)=1.5×10^(16)cm^(-3),the BV increases from 1312 V of the con-CSTBT to 1423 V of the proposed DSS-CSTBT with oxide layer thickness under gate(T_(og2))of 1μm.Moreover,compared with the con-CSTBT,the C_(GC)at V_(CE)of 25 V and miller plateau charge(Q_(GC))for the proposed DSS-CSTBT with T_(og2)of 1μm are reduced by 79.4%and 74.3%,respectively.With the VGEincreases from 0 V to 15 V,the total QGfor the proposed DSS-CSTBT with T_(og2)of 1μm is reduced by 49.5%.As a result,at the same on-state voltage drop(V_(CEON))of 1.55 V,the E_(ON)and E_(OFF)are reduced from 20.3 mJ/cm^(2)and 19.3 mJ/cm^(2)for the con-CSTBT to8.2 mJ/cm^(2)and 9.7 mJ/cm^(2)for the proposed DSS-CSTBT with T_(og2)of 1μm,respectively.The proposed DSS-CSTBT not only significantly improves the trade-off relationship between the V_(CEON)and E_(OFF)but also greatly reduces the E_(ON).展开更多
To understand the influence of the initial release conditions on the separation characteristics of the store and improve it under high Mach number(Ma=4)flight conditions,the overset grid method and the Realizable k−ε...To understand the influence of the initial release conditions on the separation characteristics of the store and improve it under high Mach number(Ma=4)flight conditions,the overset grid method and the Realizable k−εturbulence model coupled with an equation with six degrees of freedom are used to simulate the store released from the internal bay.The motion trajectory and the attitude angle of the store separation under the conditions of different centroid,velocity,height and control measures are given by the calculated result.Through analysis,the position of the centroid will affect the separation of the store,which needs to be considered in the design.Increasing the launching height is conducive to the separation of the store.If the store has an initial velocity,it can leave the internal bay more quickly and reduce the probability of collision with the wall.Cylindrical rod and slanted aft wall control measures can improve the attitude of the store and make the store fall more smoothly.展开更多
The urban grass-roots library is an important part of the public cultural service system,and also a place to carry out national reading and lifelong learning,which is of great significance to the construction of a lea...The urban grass-roots library is an important part of the public cultural service system,and also a place to carry out national reading and lifelong learning,which is of great significance to the construction of a learning society.In this paper,the development and evolution of urban grassroots libraries in China are reviewed,and the current situation and usage issues of grassroots libraries in Beijing are analyzed.Moreover,the development strategy of idea stores in London,UK is studied,and characteristics are summarized,and possible references are sought.In the new era,urban grassroots libraries should integrate into communities with multiple functions and play a more sufficient role in public education,learning and training,and other aspects.展开更多
Recent studies in secretory pathway calcium ATPases （SPCA） revealed novel functions of SPCA2 in interacting with store-operated Ca2＋ channel Oral I and inducing Ca2＋ influx at the cell surface. Importantly, SPCA2-...Recent studies in secretory pathway calcium ATPases （SPCA） revealed novel functions of SPCA2 in interacting with store-operated Ca2＋ channel Oral I and inducing Ca2＋ influx at the cell surface. Importantly, SPCA2-mediated Ca2＋ signaling is uncoupled from its conventional role of Ca2＋-ATPase and independent of store-operated Ca2＋ signaling pathway. SPCA2-induced store-independent Ca2＋ entry （SICE） plays essential roles in many important physiological processes, while unbalanced SICE leads to enhanced cell proliferation and tumorigenesis. Finally, we have summarized the clinical implication of SICE in oral cancer prognosis and treatment. Inhibition of SICE may be a new target for the development of cancer therapeutics.展开更多
Insects are major pests of stored grains. In sub Sahara Africa, stored grain insect pests are mainly Coleoptera or Lepidoptera. In the Logone Valley, area covering the Far North Region of Cameroon and South-West of Ch...Insects are major pests of stored grains. In sub Sahara Africa, stored grain insect pests are mainly Coleoptera or Lepidoptera. In the Logone Valley, area covering the Far North Region of Cameroon and South-West of Chad, to our knowledge, the diversity of insect pests noxious to stored products is not established. These beetles and weevils （Insecta：Coleoptera） during their development depreciate food in storage, were able to destroy a whole stock in a very short period of time if no protection of stored food is made. To achieve the diversity of insect pests, inspections of granaries were done in 209 villages of Logone Valley where insect pests were collected and identified. Secondly, the stored grains were sampled in peasant＇s granaries of Logone Valley and reared in incubators in the Unit of Entomological Research of the University of Ngaound6r6. After their emergence, insects were removed, collected and identified. Their noxious efficiency on stored grains is done by the calculation of the density of each insect pests per gram of grains. This study indicates that 12 species of harmful insects attack cereals and leguminous grains in the Logone Valley during storage. The Bruchids were the main insect pests of legumes. Callosobruchus maculatus was the main pest of legume and attacking mainly cowpeas （34.92 bruchids/g of seed） and peanuts （20.75 bruchids/g of seed）. Seven harmful species destroy the cereals. Sitophilus zeamais is the main pest of maize （15.86 weevils/g of maize） and S. oryzae, for sorghum （36.59 weevils/g of maize）. Tribolium castaneum were the main secondary pest. T. castaneum infests both cereals and leguminous. This work summarizes the importance and the diversification of stored grain pests in Logone Valley. Knowing the pest diversity is an important step in the strategy to develop a friendly and ecological control method of these harmful insects.展开更多
The effects of hepatic ischemia/reperfusion (I/R) injuries on hepatocellular viability and store-operated calcium current (Isoc) in isolated rat hepatocytes and the effects of 2-APB on store-operated calcium current (...The effects of hepatic ischemia/reperfusion (I/R) injuries on hepatocellular viability and store-operated calcium current (Isoc) in isolated rat hepatocytes and the effects of 2-APB on store-operated calcium current (Isoc) in isolated rat hepatocytes after hepatic ischemia/reperfusion injuries were studied. Hepatic ischemia and reperfusion injury model was established and whole cell patch-clamp techniques were used to investigate the effects of 2-APB on Isoc. The results showed that ischemia/reperfusion injuries could significantly reduce hepatocellular viability and further increase Isoc in hepatocytes and 2-APB (20, 40, 60, 80, 100 μmol/L) produced a concentration-dependent decrease of Isoc with IC 50 value of 64.63±10.56 μmol/L (n=8). It was concluded that ischemia/reperfusion injuries could reduce hepatocellular viability, probably through increased Isoc in hepatocytes and 2-APB had a protective effect on ischemia/reperfusion-induced liver injury, probably though inhibiting Isoc.展开更多
文摘Data storage solutions are a crucial aspect of any application, significantly impacting data management and system performance. This article explores the rationale behind utilizing both SQL and NoSQL databases, addressing key questions about when each type is preferable. The background emphasizes the importance of selecting the appropriate database technology to meet specific application requirements. The purpose of this research is to provide a comprehensive guide for choosing between SQL and NoSQL databases based on various factors, including workload characteristics, scalability needs, and consistency requirements. To achieve this, we examine different strategies for implementing SQL and NoSQL databases in large-scale distributed applications and systems. The research method involves a comparative analysis of the features, advantages, and limitations of both database types. We specifically focus on scenarios involving read-heavy versus write-heavy systems and the trade-offs between availability and consistency. The results of this research indicate that SQL databases, with their relational structure and ACID compliance, are ideal for applications requiring complex queries and data integrity. In contrast, NoSQL databases, offering schema flexibility and horizontal scalability, are better suited for managing extensive datasets and high-velocity data ingestion. In conclusion, the selection of a database depends on the specific needs of the application. SQL databases are preferred for transactional systems with complex relationships, while NoSQL databases excel in scenarios demanding flexibility and scalability. The study provides insights into hybrid approaches, leveraging both database types to optimize system performance.
基金the National Key Research and Development Program of China(Grant No.2018YFB1201802)the Key Realm R&D Program of Guangdong Province,China(Grant No.2018B010142001)the Guangdong Basic and Applied Basic Research Foundation,China(Grant No.2020A1515010128).
文摘We propose a novel high performance carrier stored trench bipolar transistor(CSTBT)with dual shielding structure(DSS-CSTBT).The proposed DSS-CSTBT features a double trench structure with different trench profiles in the surface,in which a shallow gate trench is shielded by a deep emitter trench and a thick oxide layer under it.Compared with the conventional CSTBT(con-CSTBT),the proposed DSS-CSTBT not only alleviates the negative impact of the shallow gate trench and highly doped CS layer on the breakdown voltage(BV),but also well reduces the gate-collector capacitance CGC,gate charge Q_(G),and turn-off loss E_(OFF)of the device.Furthermore,lower turn-on loss E_(ON)and gate drive loss E_(DR)are also obtained.Simulation results show that with the same CS layer doping concentration N_(CS)=1.5×10^(16)cm^(-3),the BV increases from 1312 V of the con-CSTBT to 1423 V of the proposed DSS-CSTBT with oxide layer thickness under gate(T_(og2))of 1μm.Moreover,compared with the con-CSTBT,the C_(GC)at V_(CE)of 25 V and miller plateau charge(Q_(GC))for the proposed DSS-CSTBT with T_(og2)of 1μm are reduced by 79.4%and 74.3%,respectively.With the VGEincreases from 0 V to 15 V,the total QGfor the proposed DSS-CSTBT with T_(og2)of 1μm is reduced by 49.5%.As a result,at the same on-state voltage drop(V_(CEON))of 1.55 V,the E_(ON)and E_(OFF)are reduced from 20.3 mJ/cm^(2)and 19.3 mJ/cm^(2)for the con-CSTBT to8.2 mJ/cm^(2)and 9.7 mJ/cm^(2)for the proposed DSS-CSTBT with T_(og2)of 1μm,respectively.The proposed DSS-CSTBT not only significantly improves the trade-off relationship between the V_(CEON)and E_(OFF)but also greatly reduces the E_(ON).
文摘To understand the influence of the initial release conditions on the separation characteristics of the store and improve it under high Mach number(Ma=4)flight conditions,the overset grid method and the Realizable k−εturbulence model coupled with an equation with six degrees of freedom are used to simulate the store released from the internal bay.The motion trajectory and the attitude angle of the store separation under the conditions of different centroid,velocity,height and control measures are given by the calculated result.Through analysis,the position of the centroid will affect the separation of the store,which needs to be considered in the design.Increasing the launching height is conducive to the separation of the store.If the store has an initial velocity,it can leave the internal bay more quickly and reduce the probability of collision with the wall.Cylindrical rod and slanted aft wall control measures can improve the attitude of the store and make the store fall more smoothly.
基金the National Natural Science Foundation of China(51708001).
文摘The urban grass-roots library is an important part of the public cultural service system,and also a place to carry out national reading and lifelong learning,which is of great significance to the construction of a learning society.In this paper,the development and evolution of urban grassroots libraries in China are reviewed,and the current situation and usage issues of grassroots libraries in Beijing are analyzed.Moreover,the development strategy of idea stores in London,UK is studied,and characteristics are summarized,and possible references are sought.In the new era,urban grassroots libraries should integrate into communities with multiple functions and play a more sufficient role in public education,learning and training,and other aspects.
基金supported by grant GM62142 from the National Institution of Health to Rajini RaoAmerican Heart Association Pre-doctoral Fellowship 0815058E to Ming-Ye Fengsupported by Open Fund of State Key Laboratory of Oral Diseases, Sichuan University
文摘Recent studies in secretory pathway calcium ATPases （SPCA） revealed novel functions of SPCA2 in interacting with store-operated Ca2＋ channel Oral I and inducing Ca2＋ influx at the cell surface. Importantly, SPCA2-mediated Ca2＋ signaling is uncoupled from its conventional role of Ca2＋-ATPase and independent of store-operated Ca2＋ signaling pathway. SPCA2-induced store-independent Ca2＋ entry （SICE） plays essential roles in many important physiological processes, while unbalanced SICE leads to enhanced cell proliferation and tumorigenesis. Finally, we have summarized the clinical implication of SICE in oral cancer prognosis and treatment. Inhibition of SICE may be a new target for the development of cancer therapeutics.
文摘Insects are major pests of stored grains. In sub Sahara Africa, stored grain insect pests are mainly Coleoptera or Lepidoptera. In the Logone Valley, area covering the Far North Region of Cameroon and South-West of Chad, to our knowledge, the diversity of insect pests noxious to stored products is not established. These beetles and weevils （Insecta：Coleoptera） during their development depreciate food in storage, were able to destroy a whole stock in a very short period of time if no protection of stored food is made. To achieve the diversity of insect pests, inspections of granaries were done in 209 villages of Logone Valley where insect pests were collected and identified. Secondly, the stored grains were sampled in peasant＇s granaries of Logone Valley and reared in incubators in the Unit of Entomological Research of the University of Ngaound6r6. After their emergence, insects were removed, collected and identified. Their noxious efficiency on stored grains is done by the calculation of the density of each insect pests per gram of grains. This study indicates that 12 species of harmful insects attack cereals and leguminous grains in the Logone Valley during storage. The Bruchids were the main insect pests of legumes. Callosobruchus maculatus was the main pest of legume and attacking mainly cowpeas （34.92 bruchids/g of seed） and peanuts （20.75 bruchids/g of seed）. Seven harmful species destroy the cereals. Sitophilus zeamais is the main pest of maize （15.86 weevils/g of maize） and S. oryzae, for sorghum （36.59 weevils/g of maize）. Tribolium castaneum were the main secondary pest. T. castaneum infests both cereals and leguminous. This work summarizes the importance and the diversification of stored grain pests in Logone Valley. Knowing the pest diversity is an important step in the strategy to develop a friendly and ecological control method of these harmful insects.
基金This project was supported by the National Natural Sci ence Foundation of China (No. 30270532), the Trans Cen tury Excellent Talent Development Plan Fund of Ministry ofEducation of China (Official Letter No. 2002 48) and Shu guang Program Project of Shanghai Educational Committee(No. 02SG20).
文摘The effects of hepatic ischemia/reperfusion (I/R) injuries on hepatocellular viability and store-operated calcium current (Isoc) in isolated rat hepatocytes and the effects of 2-APB on store-operated calcium current (Isoc) in isolated rat hepatocytes after hepatic ischemia/reperfusion injuries were studied. Hepatic ischemia and reperfusion injury model was established and whole cell patch-clamp techniques were used to investigate the effects of 2-APB on Isoc. The results showed that ischemia/reperfusion injuries could significantly reduce hepatocellular viability and further increase Isoc in hepatocytes and 2-APB (20, 40, 60, 80, 100 μmol/L) produced a concentration-dependent decrease of Isoc with IC 50 value of 64.63±10.56 μmol/L (n=8). It was concluded that ischemia/reperfusion injuries could reduce hepatocellular viability, probably through increased Isoc in hepatocytes and 2-APB had a protective effect on ischemia/reperfusion-induced liver injury, probably though inhibiting Isoc.
