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In vivo evidence of IGF-I–estrogen crosstalk in mediating the cortical bone response to mechanical strain 被引量:1
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作者 Subburaman Mohan Chetan Girijanand Bhat +1 位作者 Jon E Wergedal Chandrasekhar Kesavan 《Bone Research》 SCIE CAS 2014年第1期55-60,共6页
Although insulin-like growth factor-I (IGF-I) and estrogen signaling pathways have been shown to be involved in mediating the bone anabolic response to mechanical loading, it is not known whether these two signaling... Although insulin-like growth factor-I (IGF-I) and estrogen signaling pathways have been shown to be involved in mediating the bone anabolic response to mechanical loading, it is not known whether these two signaling pathways crosstalk with each other in producing a skeletal response to mechanical loading. To test this, at 5 weeks of age, partial ovariectomy (pOVX) or a sham operation was performed on heterozygous IGF-I conditional knockout (H IGF-I KO) and control mice generated using a Cre-loxP approach. At 10 weeks of age, a 10 N axial load was applied on the right tibia of these mice for a period of 2 weeks and the left tibia was used as an internal non-non-loaded control. At the cortical site, partial estrogen loss reduced total volumetric bone mineral density (BMD) by 5% in control pOVX mice (P=0.05, one-way ANOVA), but not in the H IGF-I KO pOVX mice. At the trabecular site, bone volume/total volume (BV/TV) was reduced by 5%-6% in both control pOVX (P〈0.05) and H IGF-I KO pOVX (P=0.05) mice. Two weeks of mechanical loading caused a 7 %-8% and an 11%-13% (P〈0.05 vs. non-loaded bones) increase in cortical BMD and cortical thickness (Ct.Th), respectively, in the control sham, control pOVX and H IGF-I KO sham groups. By contrast, the magnitude of cortical BMD (4%, P=0.13) and Ct.Th (6%, P〈0.05) responses were reduced by 50% in the H IGF-I KO pOVX mice compared to the other three groups. The interaction between genotype and estrogen deficiency on the mechanical loading-induced cortical bone response was significant (P〈0.05) by two-way ANOVA. Two weeks of axial loading caused similar increases in trabecular BV/TV (13%-17%) and thickness (17%-23%) in all four groups of mice. In conclusion, partial loss of both estrogen and IGF-I significantly reduced cortical but not the trabecular bone response to mechanical loading, providing in vivo evidence of the above crosstalk in mediating the bone response to loading. 展开更多
关键词 BONE IGF estrogen crosstalk in mediating the cortical bone response to mechanical strain
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Effect of Strain Rate on Compression Behavior of Vinyl Ester Resin Casting
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作者 XIONG Tao YANG Bin XIONG Jie XU Xian-jian ZHOU Kai MAO Ming-zhong 《材料工程》 EI CAS CSCD 北大核心 2006年第5期63-67,72,共6页
Quasi-static and high strain rate compressive experiments on vinyl ester casting were carried out by means of MTS (Material Test System) and Hopkinson bar. The behaviors of the compressed unstable and fracture of the ... Quasi-static and high strain rate compressive experiments on vinyl ester casting were carried out by means of MTS (Material Test System) and Hopkinson bar. The behaviors of the compressed unstable and fracture of the resin casting at different strain rates were investigated.The results indicate that the response behavior of the resin casting is controlled by different mechanisms at different strain rate, and some mechanical properties of vinyl ester casting are rate-dependent: the casting are destroyed in toughness model under strain rate 3.3×10 -4~6.6×10 -3/s, while the casting are destroyed in brittleness model under strain rate 950~5800/s. The yield stress, yield strain energy density are all increased with the increasing strain rates at quasi-static as well as at high strain rates. What is interesting is that the yield strain decreased with the strain rates increasing at quasi-static while increased at high strain rates. It is considered that the casting occurred forcing high elastic deformation at high strain rates. The damage of the specimens is mainly controlled by axial stress before unstable deformation, while mainly controlled by shear stress after unstable deformation, and then developed to fracture finally. This progress is rate-dependent: the development of the cracks inside the castings increased with the strain rate increasing. 展开更多
关键词 vinyl ester resin QUASI-STATIC high strain rate strain rate response and crack development
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Co-seismic changes of well water level and volume strain meter in capital area and its vicinity,due to the Nov.14,2001 Ms8.1 Kunlun Mountain earthquake,China 被引量:3
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作者 Huang Fuqiong Chen Yong +3 位作者 Ji Ping Ren Kexin Gao Fuwang Zhang Lingkong 《Geodesy and Geodynamics》 2015年第6期460-466,共7页
The Kunlunshan Mountain Ms8.1 earthquake, occurred in Nov.14, 2001, is the first event with magnitude more than 8 in the China earthquake monitoring history, specifically at the beginning of digital techniques in prec... The Kunlunshan Mountain Ms8.1 earthquake, occurred in Nov.14, 2001, is the first event with magnitude more than 8 in the China earthquake monitoring history, specifically at the beginning of digital techniques in precursor monitoring networks. Any investigation of recorded data on this earthquake is very important for testing the operation of the digital monitoring networks and understanding the preparation, occurrence, and adjustment of stress/strain of strong continental earthquakes. In this paper we investigated the coseismic response changes of well water level of groundwater and volume strain meter of bore hole in digital earthquake monitoring network of Capital area and its vicinity, due to the Nov.14, 2001 Ms8.1 Kunlun Mountain earthquake. The responding time, shapes or manners, amplitudes, and lasting time of well water level and strain-meters to seismic wave are studied in comparison. Then we discussed the possibility that the response changes of groundwater to strong distant earthquakes can be understood as one kind of observing evidence of stress/strain changes induced by distant earthquake. 展开更多
关键词 Kunlun Mountain earthquake Co-seismic response Groundwater level in wells Volume strain meter in borehole Capital area Digital monitoring network 9th Five-Year Plan Long range correlation
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Elastic strain response in the modified phase-field-crystal model
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作者 周文权 王锦程 +4 位作者 王志军 黄赟浩 郭灿 李俊杰 郭耀麟 《Chinese Physics B》 SCIE EI CAS CSCD 2017年第9期106-113,共8页
To understand and develop new nanostructure materials with specific mechanical properties, a good knowledge of the elastic strain response is mandatory. Here we investigate the linear elasticity response in the modifi... To understand and develop new nanostructure materials with specific mechanical properties, a good knowledge of the elastic strain response is mandatory. Here we investigate the linear elasticity response in the modified phase-field-crystal(MPFC) model. The results show that two different propagation modes control the elastic interaction length and time, which determine whether the density waves can propagate or not. By quantitatively calculating the strain field, we find that the strain distribution is indeed extremely uniform in case of elasticity. Further, we present a detailed theoretical analysis for the orientation dependence and temperature dependence of shear modulus. The simulation results show that the shear modulus reveals strong anisotropy and the one-mode analysis provides a good guideline for determining elastic shear constants until the system temperature falls below a certain value. 展开更多
关键词 elastic response strain distribution shear modulus modified phase-field-crystal model
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Response of rice to inoculation with genetic engineered strains of associative diazotrophs
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作者 SHEN Bingfu,ZHU Hairong,and LI Jie,Shanghai Inst of Plant Physiology,China Acad of Sci,Shanghai 200032,China 《Chinese Rice Research Newsletter》 1996年第3期4-5,共2页
Enhancement of nitrogen fixation in the rhizo-sphere of cereals has attracted a wide interestin biological and agricultural research,insteadof chemicals,for supplying higher plants withcombined nitrogen.Bacteria in as... Enhancement of nitrogen fixation in the rhizo-sphere of cereals has attracted a wide interestin biological and agricultural research,insteadof chemicals,for supplying higher plants withcombined nitrogen.Bacteria in association withrice plant.s were sensitive to the surroundingfactors in the soil,such as NH~+ or O,whichrepressed associative nitrogen fixation between 展开更多
关键词 nifA Response of rice to inoculation with genetic engineered strains of associative diazotrophs NG
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Measured load spectra of the bearing in high-speed train gearbox under different gear meshing conditions 被引量:2
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作者 Yu Hou Xi Wang +7 位作者 Shouguang Sun Hongbo Que Rubing Guo Xinhai Lin Siqin Jin Chengpan Wu Yue Zhou Xiaolong Liu 《Railway Engineering Science》 2023年第1期37-51,共15页
The load spectrum is a crucial factor for assess-ing the fatigue reliability of in-service rolling element bear-ings in transmission systems.For a bearing in a high-speed train gearbox,a measurement technique based on... The load spectrum is a crucial factor for assess-ing the fatigue reliability of in-service rolling element bear-ings in transmission systems.For a bearing in a high-speed train gearbox,a measurement technique based on strain detection of bearing outer ring was used to instrument the bearing and determine the time histories of the distributed load in the bearing under different gear meshing conditions.Accordingly,the load spectrum of the total radial load car-ried by the bearing was compiled.The mean value and class interval of the obtained load spectrum were found to vary non-monotonously with the speed and torque of gear mesh-ing,which was considered to be caused by the vibration of the shaft and the bearing cage.As the realistic service load input of bearing life assessment,the measured load spectrum under different gear meshing conditions can be used to pre-dict gearbox bearing life realistically based on the damage-equivalent principle and actual operating conditions. 展开更多
关键词 Gearbox bearing High-speed train strain response Load spectra Gear meshing conditions
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Study on dynamic response of high speed train window glass under tunnel aerodynamic effects
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作者 Xiaogen Liu Shuang Qi +1 位作者 Detian Wan Dezhi Zheng 《Railway Sciences》 2023年第2期211-224,共14页
Purpose-This paper aims to analyze the bearing characteristics of the high speed train window glass under aerodynamic load effects.Design/methodology/approach-In order to obtain the dynamic strain response of passenge... Purpose-This paper aims to analyze the bearing characteristics of the high speed train window glass under aerodynamic load effects.Design/methodology/approach-In order to obtain the dynamic strain response of passenger compartment window glass during high-speed train crossing the tunnel,taking the passenger compartment window glass of the CRH3 high speed train onWuhan-Guangzhou High Speed Railway as the research object,this study tests the strain dynamic response and maximum principal stress of the high speed train passing through the tunnel entrance and exit,the tunnel and tunnel groups as well as trains meeting in the tunnel at an average speed of 300 km$h-1.Findings-The results show that while crossing the tunnel,the passenger compartment window glass of high speed train is subjected to the alternating action of positive and negative air pressures,which shows the typical mechanic characteristics of the alternating fatigue stress of positive-negative transient strain.The maximum principal stress of passenger compartment window glass for high speed train caused by tunnel aerodynamic effects does not exceed 5 MPa,and the maximum value occurs at the corresponding time of crossing the tunnel groups.The high speed train window glass bears medium and low strain rates under the action of tunnel aerodynamic effects,while the maximum strain rate occurs at the meeting moment when the window glass meets the train head approaching from the opposite side in the tunnel.The shear modulus of laminated glass PVB film that makes up high speed train window glass is sensitive to the temperature and action time.The dynamically equivalent thickness and stiffness of the laminated glass and the dynamic bearing capacity of the window glass decrease with the increase of the action time under tunnel aerodynamic pressure.Thus,the influence of the loading action time and fatigue under tunnel aerodynamic effects on the glass strength should be considered in the design for the bearing performance of high speed train window glass.Originality/value-The research results provide data support for the analysis of mechanical characteristics,damage mechanism,strength design and structural optimization of high speed train glass. 展开更多
关键词 High speed train window glass Tunnel aerodynamic effect strain dynamic response Maximum principal stress strain rate Bearing characteristics
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Modulation of phase boundary and domain structures to engineer strain properties in BNT-based ferroelectrics
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作者 Yule Yang Zhiyong Liu +7 位作者 Pengrong Ren Yuqing Mao Haijun Sun Bingliang Liang Pu Mao Kun Guo Bing Xie Longlong Shu 《Journal of Advanced Ceramics》 SCIE EI CAS CSCD 2024年第7期967-975,共9页
Bismuth sodium titanate(BNT)ceramics exhibit outstanding strain responses but are unfavorable for application in high-sensitivity displacement actuators due to the large negative strain resulting from irreversible cha... Bismuth sodium titanate(BNT)ceramics exhibit outstanding strain responses but are unfavorable for application in high-sensitivity displacement actuators due to the large negative strain resulting from irreversible changes in their phase transition and domain structure.Here,(1−x)Bi_(0.50)Na_(0.41)K_(0.09)TiO_(3)-xNaNbO_(3)(BNKT−xNN)solid solutions were prepared to improve the strain properties through the strategy of modulating the phase boundary and domain structures.The introduction of sodium niobate could effectively regulate the relative content of the tetragonal(P4bm)and rhombohedral(R3c)phases in the phase boundary region.The ferroelectric-to-relaxor phase transition(T_(F−R))was reduced,and the ergodic relaxor(ER)state was nurtured at room temperature.Excellent zero-negative strain properties of S=0.41%and d_(33)^(*)=742 pm/V were achieved from the reversible transition between the ER and ferroelectric states under an applied electric field(x=0.04).Additionally,understanding the domain states via piezoelectric force microscopy(PFM)and firstorder reversal curve(FORC)revealed that the superior strain responses originated from the reversible inter-transformation of substable macrodomains and polar nanoregions(PNRs)in the phase boundary.This study provides new insight into the interplay between the evolution of phase boundaries and domain structures and the strain properties of BNT-based ceramics. 展开更多
关键词 bismuth sodium titanate(BNT) domain structure phase boundary strain response relaxor state
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Optimizing strain response in lead-free(Bi_(0.5)Na_(0.5))TiO_(3)-BaTiO_(3)-NaNbO_(3)solid solutions via ferroelectric/(non-)ergodic relaxor phase boundary engineering 被引量:2
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作者 Zhe Wang Jinyan Zhao +12 位作者 Nan Zhang Wei Ren Kun Zheng Yi Quan Jian Zhuang Yijun Zhang Luyue Jiang Lingyan Wang Gang Niu Ming Liu Zhuangde Jiang Yulong Zhao Zuo-Guang Ye 《Journal of Materiomics》 SCIE CSCD 2023年第2期244-255,共12页
Lead-free bismuth sodium titanate(Bi_(0.5)Na_(0.5))TiO_(3)(BNT)and related solid solutions are potential piezoelectric materials for such applications as actuators and transducers if their excellent strain responses a... Lead-free bismuth sodium titanate(Bi_(0.5)Na_(0.5))TiO_(3)(BNT)and related solid solutions are potential piezoelectric materials for such applications as actuators and transducers if their excellent strain responses and piezoelectric properties can be optimized.In this work,a large strain response of 0.61%is achieved in lead-free(0.94-x%)(Bi_(0.5)Na_(0.5))TiO_(3)-0.06BaTiO_(3)-x%NaNbO_(3)(x=0 e6,BNT-6BT-xNN)ceramics with the composition of x=3.5 in a pseudo-cubic structure.Coexistence of ferroelectric(FE)and relaxor(RE)domain structures is observed in all the unpoled ceramics and the enhanced strain response is believed to be related to the evolution of the ergodic relaxor(ER)and non-ergodic(NR)states thanks to the substitution of antiferroelectric NN.BNT-6BT-3.5NN is a critical composition near the FE/NR/ER phase boundary close to room temperature(RT)and its high strain response arises from a synergistic combination of a reversible electric-field-induced phase transition and an active domain switching in the mixed NR/ER state.This work provides new insights into the dynamic interplay between mesoscopic domains and macroscopic electrical properties in the BNT-based piezoceramics. 展开更多
关键词 Lead-free piezoceramics strain responses Relaxor behavior Domain state Reversible phase transition Phase boundary engineering
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DAMAGE DETECTION STRATEGY FOR RETICULATED STRUCTURES BASED ON INCOMPLETE STRAIN MODE 被引量:1
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作者 Zhao-Dong Xu Ke-Yi Wu 《Acta Mechanica Solida Sinica》 SCIE EI 2011年第4期308-317,共10页
Damage detection based on strain responses of vibration is highly attractive for monitoring long-span reticulated structures.However,there are a lot of structure members in reticulated structures and it is impossible ... Damage detection based on strain responses of vibration is highly attractive for monitoring long-span reticulated structures.However,there are a lot of structure members in reticulated structures and it is impossible to install strain sensors in each member.Therefore,how to locate and quantify damages with the incomplete mode shapes obtained from few strain sensors is a challenge topic.A new strategy,named incomplete strain mode damage detection(ISMDD) strategy,is proposed in this paper.In the strategy,the distribution of the strain sensors in the reticulated structures can be optimized through sensitive analysis on strain mode perturbation matrix,which can be obtained by perturbation theory.Mode assurance criterion(MAC) value is applied in damage location,and the members with relative large MAC values are defined as damage members.In addition,damage index obtained by solving the perturbation equation is used for damage quantification.Numerical analysis on a long-span reticulated structure,including damage location and quantification for single-and multi-member damages,detection for different damage quantity,the effect analysis of sensor quantity,are performed to verify the effectiveness of the proposed ISMDD strategy.It can be shown from the analysis that the ISMDD strategy is effective in damage location and quantification for both single-and multi-member damages.And the quantity of strain sensors has effect on damage location,but has no obvious influence on damage quantification.Additionally,the anti-noise pollution ability analysis of the ISMDD strategy is carried out,which shows that the ISMDD strategy has excellent anti-noise pollution ability for both single-and multi-damaged members. 展开更多
关键词 damage detection reticulated structure strain responses optimal sensor placement
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Highly integrated smart mountaineering clothing with dual-mode synergistic heating and sensitive sensing for personal thermal management and human health monitoring
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作者 Yifan Cui Guolin Zheng +4 位作者 Zhe Jiang Man Zhou Yuanyuan Yu Ping Wang Qiang Wang 《Journal of Materials Science & Technology》 SCIE EI CAS 2024年第15期12-21,共10页
The development of multifunctional textiles is an effective strategy to improve the quality of human life.Normal single-mode heaters and strain sensors have been developed,but their low integration leads to multiple d... The development of multifunctional textiles is an effective strategy to improve the quality of human life.Normal single-mode heaters and strain sensors have been developed,but their low integration leads to multiple devices being installed on the garment,which greatly increases the weight of the garment and thus reduces its wearability.Here,bio-enzymatic polymerization and a simple shaking deposition method were used to prepare poly(3,4-ethylenedioxythiophene)(PEDOT)and copper(Ⅱ)sulfide(CuS)onto the surface of the elastic nylon fabrics,which endowed the fabrics with excellent dual-mode heating properties and sensitive sensing properties,and used to develop highly integrated multifunctional and smart mountaineering clothing.In electro-driven heating mode,low-voltage(6 V)and high-voltage(12 V)heating can be used for joint heat therapy and active rapid deicing,respectively.In photo-driven heating mode,low intensity(0.3 sun)and high intensity(1.5 sun)heating can be used for joint heat therapy and rapid antibacterial,respectively.In addition,the fabric has the ability of dual-mode synergistic heating,and the surface temperature of the fabric can exhibit an ultra-high temperature of 137.9℃ under the external stimulation of 0.3 sun and 12 V.The fabric will greatly enhance the deicing and antibacterial efficiencies under the synergistic effect.This work provides a facile strategy for the fabrication of flexible and highly integrated multifunctional electronic devices,and therefore has great potential for the design and development of all-in-one multifunctional electronic devices such as personal thermal management,soft robotics,and human-computer interaction. 展开更多
关键词 Synergistic heating Negative response strain In situ enzymatic polymerization Rapid photothermal antibacterial On-demand hyperthermia
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