The epidermis, and in particular its outermost layer, the stratum corneum, contributes much of the barrier function of the skin and is a readily visible representation of skin health. Maintaining the health of the ski...The epidermis, and in particular its outermost layer, the stratum corneum, contributes much of the barrier function of the skin and is a readily visible representation of skin health. Maintaining the health of the skin barrier has arguably become more important than ever in the modern world, in which a large majority of people are exposed to environmental insults. These external factors can damage the integrity of the skin barrier and prematurely age the skin. Therefore, it has become increasingly important to maintain and protect the stratum corneum. Here, we briefly review the complex, multilayered structure of the skin and relate it to clinically translatable function, with an emphasis on the stratum corneum. In the context of epidermal structure and function, the formulation and clinical data for Phelityl® Reviving Cream will be reviewed. Phelityl Reviving Cream was shown to be associated with improvements in both immediate- and long-term parameters, including a significant positive effect on the skin barrier and immediate and long-lasting hydration.展开更多
Human skin is the largest organ and also the main barrier that prevents foreign substances from entering the body.The surface properties of the skin are relevant for transdermal drug delivery and cosmetics.Yucatan mic...Human skin is the largest organ and also the main barrier that prevents foreign substances from entering the body.The surface properties of the skin are relevant for transdermal drug delivery and cosmetics.Yucatan micropig skin is used as a substitute for human skin.A microplasma electrode is used for surface modification of the skin epidermal layer of the Yucatan micropig.Microplasma dielectric barrier discharge has a thin dielectric as a barrier (~50 μm) and a frequency of 25 kHz.The surface properties of the epidermal layer were characterized by the measurement of the contact angle of the water droplet.The effects of different gases such as air,nitrogen,oxygen,helium or argon were compared.The change of the contact angle is temporal and it is returned to its initial state after several hours.Among the gases used for plasma ignition,oxygen and argon were the most effective for skin treatment.The distance of the skin from the electrode and the treatment time played a crucial roles in the increasing water contact angle.Changes of surface atomic concentration were determined by x-ray photoelectron spectroscopy.After microplasma treatment,the oxygen and nitrogen concentration increased at the skin surface.展开更多
The structure of the stratum corneum contributes to the barrier function of the epidermis. Skin barrier recovery is of utmost importance after epidermal tissue damage. The aim of this study was to describe, at the cel...The structure of the stratum corneum contributes to the barrier function of the epidermis. Skin barrier recovery is of utmost importance after epidermal tissue damage. The aim of this study was to describe, at the cellular level, the structural effects resulting from topical application of a hand-cream onto normal skin and to investigate the potential repair mechanisms induced by the emollient on altered tissue. Transmission electron microscopy (TEM) was used to compare the architectures of the horny layers from: 1) ex-vivo cultured human skin;2) skin treated by topical application of a hand-cream emulsion;3) explants exposed to sodium lauryl sulfate (SLS);4) SLS-treated explants that underwent subsequent topical application of the emollient emulsion. These TEM assessments allowed identifying the structural changes occurring in the stratum corneum of skin explants exposed to SLS and/or treated with an emollient. Results strongly suggest that both, SLS-induced damage and emollient-driven repair process take place in the stratum corneum, at the cellular level. One can envisage that the observed restructuring effects after topical application of the skin-care product are likely to ameliorate or restore the barrier function of the stratum corneum. In this, the properties of the emollient go beyond the cosmetic feel.展开更多
文摘The epidermis, and in particular its outermost layer, the stratum corneum, contributes much of the barrier function of the skin and is a readily visible representation of skin health. Maintaining the health of the skin barrier has arguably become more important than ever in the modern world, in which a large majority of people are exposed to environmental insults. These external factors can damage the integrity of the skin barrier and prematurely age the skin. Therefore, it has become increasingly important to maintain and protect the stratum corneum. Here, we briefly review the complex, multilayered structure of the skin and relate it to clinically translatable function, with an emphasis on the stratum corneum. In the context of epidermal structure and function, the formulation and clinical data for Phelityl® Reviving Cream will be reviewed. Phelityl Reviving Cream was shown to be associated with improvements in both immediate- and long-term parameters, including a significant positive effect on the skin barrier and immediate and long-lasting hydration.
文摘Human skin is the largest organ and also the main barrier that prevents foreign substances from entering the body.The surface properties of the skin are relevant for transdermal drug delivery and cosmetics.Yucatan micropig skin is used as a substitute for human skin.A microplasma electrode is used for surface modification of the skin epidermal layer of the Yucatan micropig.Microplasma dielectric barrier discharge has a thin dielectric as a barrier (~50 μm) and a frequency of 25 kHz.The surface properties of the epidermal layer were characterized by the measurement of the contact angle of the water droplet.The effects of different gases such as air,nitrogen,oxygen,helium or argon were compared.The change of the contact angle is temporal and it is returned to its initial state after several hours.Among the gases used for plasma ignition,oxygen and argon were the most effective for skin treatment.The distance of the skin from the electrode and the treatment time played a crucial roles in the increasing water contact angle.Changes of surface atomic concentration were determined by x-ray photoelectron spectroscopy.After microplasma treatment,the oxygen and nitrogen concentration increased at the skin surface.
文摘The structure of the stratum corneum contributes to the barrier function of the epidermis. Skin barrier recovery is of utmost importance after epidermal tissue damage. The aim of this study was to describe, at the cellular level, the structural effects resulting from topical application of a hand-cream onto normal skin and to investigate the potential repair mechanisms induced by the emollient on altered tissue. Transmission electron microscopy (TEM) was used to compare the architectures of the horny layers from: 1) ex-vivo cultured human skin;2) skin treated by topical application of a hand-cream emulsion;3) explants exposed to sodium lauryl sulfate (SLS);4) SLS-treated explants that underwent subsequent topical application of the emollient emulsion. These TEM assessments allowed identifying the structural changes occurring in the stratum corneum of skin explants exposed to SLS and/or treated with an emollient. Results strongly suggest that both, SLS-induced damage and emollient-driven repair process take place in the stratum corneum, at the cellular level. One can envisage that the observed restructuring effects after topical application of the skin-care product are likely to ameliorate or restore the barrier function of the stratum corneum. In this, the properties of the emollient go beyond the cosmetic feel.
文摘目的探讨果酸换肤术联合强脉冲光在中度寻常性痤疮(acne vulgaris,AC)患者中的疗效。方法方便选取2020年3月—2022年6月阳光融和医院收治的96例中度AC患者,按随机数表法分为对照组(n=48)采用果酸换肤术治疗,观察组(n=48)在对照组基础上加用强脉冲光治疗。两组患者均于治疗后持续随访12周。对比两组患者皮肤屏障功能、经表皮失水率(trans epidermal water loss,TEWL)水平、临床疗效及并发症。结果观察组治疗后角质层含水量高于对照组,皮脂水平低于对照组,差异有统计学意义(P<0.05);观察组治疗后TEWL水平低于对照组,差异有统计学意义(P<0.05);观察组临床总有效率(95.83%)高于对照组(83.33%),差异有统计学意义(χ^(2)=4.019,P<0.05);观察组并发症发生率(4.17%)低于对照组(16.67%),差异有统计学意义(P<0.05)。结论果酸换肤术联合强脉冲光能够改善中度AC患者皮肤屏障功能,降低TEWL水平,疗效显著,还可减少并发症的发生。
