The New Holland TT75 tractors currently in service in Chad use a tractor arm with three holes, the middle one of which has recurrent failures due to traction. The purpose of this work is to use a finite element model ...The New Holland TT75 tractors currently in service in Chad use a tractor arm with three holes, the middle one of which has recurrent failures due to traction. The purpose of this work is to use a finite element model to provide an improvement by modifying the geometric parameters to avoid premature failure of the tractor arms of the New Holland TT75. The ultimate force formula of Eurocode 3 was used to determine the maximum pressure to be applied and. A comparative traction study between the current arm and the proposed arm was performed, taking into account the variation in hole size, arm width and applied pressure for the determination of the stress concentration factor Kt. With the determination of Kt and for the arm width (w) less than or equal to 85 mm;the results showed that the proposed arm geometry is better.展开更多
Cemented paste backfill(CPB)is a key technology for green mining in metal mines,in which tailings thickening comprises the primary link of CPB technology.However,difficult flocculation and substandard concentrations o...Cemented paste backfill(CPB)is a key technology for green mining in metal mines,in which tailings thickening comprises the primary link of CPB technology.However,difficult flocculation and substandard concentrations of thickened tailings often occur.The rheological properties and concentration evolution in the thickened tailings remain unclear.Moreover,traditional indoor thickening experiments have yet to quantitatively characterize their rheological properties.An experiment of flocculation condition optimization based on the Box-Behnken design(BBD)was performed in the study,and the two response values were investigated:concentration and the mean weighted chord length(MWCL)of flocs.Thus,optimal flocculation conditions were obtained.In addition,the rheological properties and concentration evolution of different flocculant dosages and ultrafine tailing contents under shear,compression,and compression-shear coupling experimental conditions were tested and compared.The results show that the shear yield stress under compression and compression-shear coupling increases with the growth of compressive yield stress,while the shear yield stress increases slightly under shear.The order of shear yield stress from low to high under different thickening conditions is shear,compression,and compression-shear coupling.Under compression and compression-shear coupling,the concentration first rapidly increases with the growth of compressive yield stress and then slowly increases,while concentration increases slightly under shear.The order of concentration from low to high under different thickening conditions is shear,compression,and compression-shear coupling.Finally,the evolution mechanism of the flocs and drainage channels during the thickening of the thickened tailings under different experimental conditions was revealed.展开更多
Three M_(W)>7.0 earthquakes in 2020-2021 occurred in the Shumagin seismic gap and its adjacent area of the Alaska-Aleutian subduction zone,including the Mw7.8 Simeonof thrust earthquake on July 22,2020,the M_(W)7.6...Three M_(W)>7.0 earthquakes in 2020-2021 occurred in the Shumagin seismic gap and its adjacent area of the Alaska-Aleutian subduction zone,including the Mw7.8 Simeonof thrust earthquake on July 22,2020,the M_(W)7.6 Sand Point strike-slip earthquake on October 19,2020,and the M_(W)8.2 Chignik thrust earthquake on July 29,2021.The spatial and temporal proximity of these three earthquakes prompts us to probe stress-triggering effects among them.Here we examine the coseismic Coulomb stress change imparted by the three earthquakes and their influence on the subduction interface.Our results show that:(1)The Simeonof earthquake has strong loading effects on the subsequent Sand Point and Chignik earthquakes,with the Coulomb stress changes of 3.95 bars and 2.89 bars,respectively.The Coulomb stress change caused by the Sand Point earthquake at the hypocenter of the Chignik earthquake is merely around 0.01 bars,suggesting the negligible triggering effect on the latter earthquake;(2)The triggering effects of the Simeonof,Sand Point,and Chignik earthquakes on aftershocks within three months are not well pronounced because of the triggering rates of 38%,14%,and 43%respectively.Other factors may have played an important role in promoting the occurrence of these aftershocks,such as the roughness of the subduction interface,the complicated velocity structure of the lithosphere,and the heterogeneous prestress therein;(3)The three earthquakes caused remarkable coseismic Coulomb stress changes at the subduction interface nearby these mainshocks,with an average Coulomb stress change of 3.2 bars in the shallow region directly inwards the trench.展开更多
Background:This study explores the relationship between endoplasmic reticulum(ER)stress and diabetes,particularly focusing on the impact of physical exercise on ER stress mechanisms and identifying potential therapeut...Background:This study explores the relationship between endoplasmic reticulum(ER)stress and diabetes,particularly focusing on the impact of physical exercise on ER stress mechanisms and identifying potential therapeutic drugs and targets for diabetes-related sepsis.The research also incorporates traditional physical therapy perspectives,emphasizing the genomic insights gained from exercise therapy in disease management and prevention.Methods:Gene analysis was conducted on the GSE168796 and GSE94717 datasets to identify ER stress-related genes.Gene interactions and immune cell correlations were mapped using GeneCard and STRING databases.A screening of 2,456 compounds from the TCMSP database was performed to identify potential therapeutic agents,with a focus on their docking potential.Techniques such as luciferase reporter gene assay and RNA interference were used to examine the interactions between microRNA-149-5p and MMP9.Results:The study identified 2,006 differentially expressed genes and 616 miRNAs.Key genes like MMP9,TNF-α,and IL1B were linked to an immunosuppressive state.Licorice glycoside E demonstrated high affinity for MMP9,suggesting its potential effectiveness in treating diabetes.The constructed miRNA network highlighted the regulatory roles of MMP9,IL1B,IFNG,and TNF-α.Experimental evidence confirmed the binding of microRNA-149-5p to MMP9,impacting apoptosis in diabetic cells.Conclusion:The findings highlight the regulatory role of microRNA-149-5p in managing MMP9,a crucial gene in diabetes pathophysiology.Licorice glycoside E emerges as a promising treatment option for diabetes,especially targeting MMP9 affected by ER stress.The study also underscores the significance of physical exercise in modulating ER stress pathways in diabetes management,bridging traditional physical therapy and modern scientific understanding.Our study has limitations.It focuses on the microRNA-149-5p-MMP9 network in sepsis,using cell-based methods without animal or clinical trials.Despite strong in vitro findings,in vivo studies are needed to confirm licorice glycoside E’s therapeutic potential and understand the microRNA-149-5p-MMP9 dynamics in real conditions.展开更多
We previously reported that miR-124-3p is markedly upregulated in microglia-derived exosomes following repetitive mild traumatic brain injury.However,its impact on neuronal endoplasmic reticulum stress following repet...We previously reported that miR-124-3p is markedly upregulated in microglia-derived exosomes following repetitive mild traumatic brain injury.However,its impact on neuronal endoplasmic reticulum stress following repetitive mild traumatic brain injury remains unclear.In this study,we first used an HT22 scratch injury model to mimic traumatic brain injury,then co-cultured the HT22 cells with BV2 microglia expressing high levels of miR-124-3p.We found that exosomes containing high levels of miR-124-3p attenuated apoptosis and endoplasmic reticulum stress.Furthermore,luciferase reporter assay analysis confirmed that miR-124-3p bound specifically to the endoplasmic reticulum stress-related protein IRE1α,while an IRE1αfunctional salvage experiment confirmed that miR-124-3p targeted IRE1αand reduced its expression,thereby inhibiting endoplasmic reticulum stress in injured neurons.Finally,we delivered microglia-derived exosomes containing miR-124-3p intranasally to a mouse model of repetitive mild traumatic brain injury and found that endoplasmic reticulum stress and apoptosis levels in hippocampal neurons were significantly reduced.These findings suggest that,after repetitive mild traumatic brain injury,miR-124-3 can be transferred from microglia-derived exosomes to injured neurons,where it exerts a neuroprotective effect by inhibiting endoplasmic reticulum stress.Therefore,microglia-derived exosomes containing miR-124-3p may represent a novel therapeutic strategy for repetitive mild traumatic brain injury.展开更多
In order to ensure safe mining and reduce surface damage in shallow multi-seam mining,the failure characteristics of interburden strata with different coal pillars offset distances between pillars in the upper and low...In order to ensure safe mining and reduce surface damage in shallow multi-seam mining,the failure characteristics of interburden strata with different coal pillars offset distances between pillars in the upper and lower seams,the distribution characteristics of stress concentration in coal pillars,and the development characteristics of stratum cracks and subsidence were investigated by physical and UDEC2D simulation.Meanwhile,the effect of different coal pillar offset distances on stress concentration of coal pillar and development of stratum cracks were studied.Based on those results,a formula for safe mining and reducing surface damage was established,which provided a theoretical basis for safe and environmentally friendly mining in shallow multi-seam.According to the results,the optimal coal pillar offset distance(the side to side horizontal distance of the upper and lower coal pillars)between the upper and lower coal seams was developed to reduce the stress concentration of coal pillars and surface damage.The results of this study have been applied in Ningtiaota coal mine and have achieved good results in safe and environmentally friendly mining.展开更多
In this paper,the dynamic stress concentration and scattering of SH-waves by bi-material structures that possess an interface elliptic cavity are investigated.First,by using the complex function method,the Green's...In this paper,the dynamic stress concentration and scattering of SH-waves by bi-material structures that possess an interface elliptic cavity are investigated.First,by using the complex function method,the Green's function is constructed.This yields the solution of the displacement field for an elastic half space with a semi-elliptic canyon impacted by an anti-plane harmonic line source loading on the horizontal surface.Then,the problem is divided into an upper and lower half space along the horizontal interface,regarded as a harmony model.In order to satisfy the integral continuity condition, the unknown anti-plane forces are applied to the interface.The integral equations with unknown forces can be established through the continuity condition,and after transformation,the algebraic equations are solved numerically.Finally,the distribution of the dynamic stress concentration factor(DSCF)around the elliptic cavity is given and the effect of different parameters on DSCF is discussed.展开更多
In order to avoid stress concentration, the shape boundary must be properly designed via shape optimiza- tion. Traditional shape optimization approach eliminates the stress concentration effect by using free-form curv...In order to avoid stress concentration, the shape boundary must be properly designed via shape optimiza- tion. Traditional shape optimization approach eliminates the stress concentration effect by using free-form curve to present the design boundaries without taking the machin- ability into consideration. In most numerical control (NC) machines, linear as well as circular interpolations are used to generate the tool path. Non-circular curves, such as non- uniform rotational B-spline (NURBS), need other more ad- vanced interpolation functions to formulate the tool path. Forming the circular tool path by approximating the opti- mal free curve boundary with arcs or biarcs is another op- tion. However, these two approaches are both at a cost of sharp expansion of program code and long machining time consequently. Motivated by the success of recent researches on biarcs, a reliable shape optimization approach is pro- posed in this work to directly optimize the shape boundaries with biarcs while the efficiency and precision of traditional method are preserved. Finally, the approach is validated by several illustrative examples.展开更多
In engineering practice, tubular X-joints have been widely used in offshore structures. The fatigue failure of tubular X-joints in offshore engineering is mainly caused by axial tensile stress. In this study, the stre...In engineering practice, tubular X-joints have been widely used in offshore structures. The fatigue failure of tubular X-joints in offshore engineering is mainly caused by axial tensile stress. In this study, the stress concentration factor distribution along the weld toe in the hot spot stress region for tubular X-joints subject to axial loads have been analyzed by use of finite element method. Through numerical analysis, it has been found that the peak stress concentration factor is located at the saddle position. Thereafter, 80 models have been analyzed, and the effect of the geometric parameters of a tubular X-joint on the stress concentration factor has been investigated. Based on the experimental values of the numerical stress concentration factor, a parametric equation to calculate the stress concentration factor of tubular X-joints has been proposed. The accuracy of this equation has been verified against the requirement of the Fatigue Guidance Review Panel, and the proposed equation is found capable of producing reasonably accurate stress concentration factor values for tubular X-joints subject to axial loads.展开更多
In order to improve the bending load-carrying capacity (BLCC) of undermatched butt joint under three-point bending load, the influence of joint geometric parameters on stress concentration factors (SCF) at the wel...In order to improve the bending load-carrying capacity (BLCC) of undermatched butt joint under three-point bending load, the influence of joint geometric parameters on stress concentration factors (SCF) at the weld bottom center and the weld toe of uudermatched butt joint with single V-groove are studied respectively based on the finite element method in this paper. Results show that the reinforcement height and the cover pass width play decisive role in the BLCC for undermatched butt joint. BLCC of undermatched butt joint can be improved by choosing the appropriate joint geometric parameters.展开更多
In this paper,the influence of geometric parameters on the stress concentration factors due to three different types of axial loading on 81 TY tubular structures is studied.Our results reveal that,geometric parameters...In this paper,the influence of geometric parameters on the stress concentration factors due to three different types of axial loading on 81 TY tubular structures is studied.Our results reveal that,geometric parameters have a considerable impact on the variation of stress concentration factors on tubular TY-joints under axial loads.Thus,the highest stress concentration factor values are observed on the vertical brace than on the inclined one.The finite element results of the tubular structures were verified by parametric equations and experimental data.A parametric study was carried out by analyses using the nonlinear regression method to obtain parametric equations.These equations are used to calculate stress concentration factors and to analyse the fatigue resistance of TY-joints due to axial loads.展开更多
The aim of this work is to study the stress distributions and the location of hot spots stress in the vicinity of the intersection lines of the tubular elements of the tubular TY-joints.Using the finite element models...The aim of this work is to study the stress distributions and the location of hot spots stress in the vicinity of the intersection lines of the tubular elements of the tubular TY-joints.Using the finite element models,we analyze the effects of geometrical parameters on the stress concentration factor in the case of in-plane bending and out-of-plane bending loads,around the weld toe of the tubular joints.Our results reveal the location of the maximum stress concentration factor at the heel or toe in the case of in-plane bending loads and at the saddle point in the case of out-of-plane bending loads.Six parametric equations are established and used to calculate the stress concentration factor at critical locations using the non-linear regression method.The results obtained from the finite element analysis are close to the results of the parametric equations and the experimental data from the previous work.展开更多
The photo-elastic method has been employed to determine stress concentration factor (SCF) for square plates containing holes and inclined slots when the plate edges are subjected to in-plane tension combined with comp...The photo-elastic method has been employed to determine stress concentration factor (SCF) for square plates containing holes and inclined slots when the plate edges are subjected to in-plane tension combined with compression. Analyses given of the isochromatic fringe pattern surrounding the hole provides the SCF conveniently. The model material is calibrated from the known solution to the stress raiser arising from a small circular hole in a plate placed under biaxial tension-compression. These results also compare well with a plane stress FE analysis. Consequently, photo-elasticity has enabled SCF’s to be determined experimentally for a biaxial stress ratio, nominally equal to –4, in plates containing a long, thin slot arranged to be in alignment with each stress axis. The two, principal stresses lying along axes of symmetry in the region surrounding the notch are separated within each isochromatic fringe by the Kuske method [1]. FE provides a comparable full-field view in which contours of maximum shear stress may be identified with the isochromatic fringe pattern directly. The principal stress distributions referred to the plate axes show their maximum concentrations at the notch boundary. Here up to a fourfold magnification occurs in the greater of the two nominal stresses under loads applied to the plate edges. Thus, it is of importance to establish the manner in which the tangential stress is distributed around the slot boundary. Conveniently, it is shown how this distribution is also revealed from an isochro-matic fringe pattern, within which lie the points of maximum tension and maximum compression.展开更多
The complex function method was used in the solution of micropolar elasticity theory around cavity in an infinite elasticity plane. In complex plane, the general solution of two dimension micropolar elasticity theory ...The complex function method was used in the solution of micropolar elasticity theory around cavity in an infinite elasticity plane. In complex plane, the general solution of two dimension micropolar elasticity theory is given. The solution comes from analytic function and 'Zonal Function'. The boundary conditions of non-circular cavity are satisfied by using the conformal mapping method. Based on the method, a general approach solving the stress concentration in micropolar elasticity theory is established. Finally, the numerical calculation is carried out to the stress concentration coefficient of circular cavity.展开更多
A notch sensitivity factor was derived in order to evaluate the stress concentration sensitivity of Al Li based alloys. The factor values for the Al Li alloy sheets containing various contents of impurities and ceri...A notch sensitivity factor was derived in order to evaluate the stress concentration sensitivity of Al Li based alloys. The factor values for the Al Li alloy sheets containing various contents of impurities and cerium addition were evaluated by determining the mechanical properties. It is found that the impurities Fe, Si, Na and K significantly enhance the stress concentration sensitivity of the alloys 2090 and 8090, whereas cerium addition reduces the stress concentration sensitivity to a certain degree for the high strength alloys. However, an excess amount of cerium addition in the high ductility alloy 1420 can significantly increase the stress concentration sensitivity. As compared with conventional aluminum alloys, the Al Li based alloys generally show high stress concentration sensitivity. Therefore, a special attention must be paid to this problem in the practical application of Al Li based alloys.展开更多
To explore the impact of lateral stress concentration in interlayer rock stratum on the exploitation of protected coal seam, a field experiment was carried out in a multi-seam mining structure. Lateral stress redistri...To explore the impact of lateral stress concentration in interlayer rock stratum on the exploitation of protected coal seam, a field experiment was carried out in a multi-seam mining structure. Lateral stress redistribution and interlayer rock failure behavior were surveyed. Then an assistant numerical investigation was implemented to evolve the effect of liberated seam mining and its influence on stress reconstruction in surrounding rock mass. The cause of lateral stress concentration and its impact were discussed finally. Key findings turn out that a certain lateral stress increases in interlayer rock stratum and concentrates on its lower region. Lateral stress concentration and interlayer rock failure are interactional. The former is an inducing factor of the latter;the latter promotes the increase of concentration degree. Extent of lateral stress concentration increases to the maximum as seam distance is about 50 m. But the efficacy of liberated seam mining decreases as the seam spacing gets larger. Protected seam mining is then classified based upon the impact of lateral stress concentration, which helps to prevent the rock burst hazard and then to achieve a reliable mining in deep mines.展开更多
The fatigue performance of optimized welded detail has been investigated by fatigue experiments of three welded specimens under different loadings.In addition,local finite element models of this welded detail were est...The fatigue performance of optimized welded detail has been investigated by fatigue experiments of three welded specimens under different loadings.In addition,local finite element models of this welded detail were established using finite element software ANSYS.The influences of different factors such as plate thickness,plate gap and initial geometric imperfections on the stress concentration coefficient(SCC) were discussed.The experimental results indicate that the fatigue life of three specimens for this welded detail is 736,000,1,044,200 and 1,920,300 times,respectively.The web thickness,the filler plate thickness and the initial geometric imperfection have relatively less effect on the SCCs of this welded detail.However,cope-hole radius is influential on the SCCs of the web and the weld.The SCC of weld is significantly affected by the weld size and plate gap,but the SCCs of other parts of the welded detail are hardly affected by the plate gap.展开更多
A numerical evaluation of stress concentrations of corroded plate surfaces of small-scale corroded steel specimens is compared with the experimentally estimated ones.Eleven specimens were cut from a steel box girder,w...A numerical evaluation of stress concentrations of corroded plate surfaces of small-scale corroded steel specimens is compared with the experimentally estimated ones.Eleven specimens were cut from a steel box girder,which was initially corroded in real seawater conditions.The surface of all corroded specimens was analysed applying photogrammetry techniques,and a statistical description of an idealised corroded surface of each specimen was established.Fatigue lives of specimens are determined from the fatigue tests.Based on experimentally obtained fatigue lives,the stress concentration factors are calculated concerning the ideally smooth specimens.The correlation between the statistical parameters of the corroded specimen surfaces and the estimated stress concentration factors is analysed.Idealised corroded surfaces,converted in graphical format,are then used for the finite element modelling in ABAQUS software,and stress concentration factors are estimated from the finite element results.A convergence study is performed to determine the appropriate finite element mesh density.Comparison between experimentally obtained and numerically estimated stress concentration factors is performed as well as correlation analysis between actual and finite element predicted crack locations.展开更多
The method of wave-function expansion in elliptical coordinates,elliptical cosine half-range expansion and Mathieu function were applied to obtain an exact analytical solution of the dynamic stress concentration facto...The method of wave-function expansion in elliptical coordinates,elliptical cosine half-range expansion and Mathieu function were applied to obtain an exact analytical solution of the dynamic stress concentration factor(DSCF)around an elliptical cavity in a shallow,semi-elliptical hill.An infinite system of simultaneous linear equations for solving this problem was established by substituting the wave expression obtained by the Mathieu function including the standing wave expression of elliptical lining given herein into the boundary condition obtained by the region-matching method.The finite equations system with unknown coefficients obtained by truncation were solved numerically,and the results in the case of an ellipse degenerating into a circle were compared with previous results to verify the accuracy of the method.The effects of different aspect ratios,incident wave angles and aperture ratios on the dynamic stress concentration around the elliptical cavity were described.Some numerical results,when the elliptical hill was changed into a circular one,were analyzed and compared in detail.In engineering,this model can be regarded as a semi-cylindrical hill with an elliptical cylindrical unlined tunnel under the action of SH waves,and the results are significant in aseismic design.展开更多
This paper uses the TSA (therrnoelastic stress analysis) technique to determine the stress concentration factor (Kt) of a U-notch in an aluminum plate, and then compares the results with those obtained from a FEA ...This paper uses the TSA (therrnoelastic stress analysis) technique to determine the stress concentration factor (Kt) of a U-notch in an aluminum plate, and then compares the results with those obtained from a FEA (finite elements analysis) of the same specimen. In order to do so, it devises a calculation procedure to extrapolate the thermoelastic data near the tip of the notch and then applies the resulting algorithm to seven distinct experiments that had different loading frequencies, mean loads and load ranges. The overall positive results suggest that the technique may be suitable for Kt measurements in real-world structures. A discussion about the calibration factor of the thermoelastic data is included by confronting the calibration results using independent tensile uniaxial tests and using the U-notch TSA and FEA paired specimen data.展开更多
文摘The New Holland TT75 tractors currently in service in Chad use a tractor arm with three holes, the middle one of which has recurrent failures due to traction. The purpose of this work is to use a finite element model to provide an improvement by modifying the geometric parameters to avoid premature failure of the tractor arms of the New Holland TT75. The ultimate force formula of Eurocode 3 was used to determine the maximum pressure to be applied and. A comparative traction study between the current arm and the proposed arm was performed, taking into account the variation in hole size, arm width and applied pressure for the determination of the stress concentration factor Kt. With the determination of Kt and for the arm width (w) less than or equal to 85 mm;the results showed that the proposed arm geometry is better.
基金financially supported by the National Natural Science Foundation of China(Nos.52130404 and 52304121)the Fundamental Research Funds for the Central Universities(No.FRF-TP-22-112A1)+4 种基金the Guangdong Basic and Applied Basic Research Foundation(No.2021A 1515110161)the ANID(Chile)through Fondecyt project 1210610the Centro de Modelamiento Matemático(BASAL funds for Centers of Excellence FB210005)the CRHIAM project ANID/FONDAP/15130015 and ANID/FONDAP/1523A0001the Anillo project ANID/ACT210030。
文摘Cemented paste backfill(CPB)is a key technology for green mining in metal mines,in which tailings thickening comprises the primary link of CPB technology.However,difficult flocculation and substandard concentrations of thickened tailings often occur.The rheological properties and concentration evolution in the thickened tailings remain unclear.Moreover,traditional indoor thickening experiments have yet to quantitatively characterize their rheological properties.An experiment of flocculation condition optimization based on the Box-Behnken design(BBD)was performed in the study,and the two response values were investigated:concentration and the mean weighted chord length(MWCL)of flocs.Thus,optimal flocculation conditions were obtained.In addition,the rheological properties and concentration evolution of different flocculant dosages and ultrafine tailing contents under shear,compression,and compression-shear coupling experimental conditions were tested and compared.The results show that the shear yield stress under compression and compression-shear coupling increases with the growth of compressive yield stress,while the shear yield stress increases slightly under shear.The order of shear yield stress from low to high under different thickening conditions is shear,compression,and compression-shear coupling.Under compression and compression-shear coupling,the concentration first rapidly increases with the growth of compressive yield stress and then slowly increases,while concentration increases slightly under shear.The order of concentration from low to high under different thickening conditions is shear,compression,and compression-shear coupling.Finally,the evolution mechanism of the flocs and drainage channels during the thickening of the thickened tailings under different experimental conditions was revealed.
基金supported by grants from the National Natural Science Foundation of China(Grant No.sU2139205,41774011,41874011)the National Key Research and Development Program of China(Grant No.2018YFC1503605)。
文摘Three M_(W)>7.0 earthquakes in 2020-2021 occurred in the Shumagin seismic gap and its adjacent area of the Alaska-Aleutian subduction zone,including the Mw7.8 Simeonof thrust earthquake on July 22,2020,the M_(W)7.6 Sand Point strike-slip earthquake on October 19,2020,and the M_(W)8.2 Chignik thrust earthquake on July 29,2021.The spatial and temporal proximity of these three earthquakes prompts us to probe stress-triggering effects among them.Here we examine the coseismic Coulomb stress change imparted by the three earthquakes and their influence on the subduction interface.Our results show that:(1)The Simeonof earthquake has strong loading effects on the subsequent Sand Point and Chignik earthquakes,with the Coulomb stress changes of 3.95 bars and 2.89 bars,respectively.The Coulomb stress change caused by the Sand Point earthquake at the hypocenter of the Chignik earthquake is merely around 0.01 bars,suggesting the negligible triggering effect on the latter earthquake;(2)The triggering effects of the Simeonof,Sand Point,and Chignik earthquakes on aftershocks within three months are not well pronounced because of the triggering rates of 38%,14%,and 43%respectively.Other factors may have played an important role in promoting the occurrence of these aftershocks,such as the roughness of the subduction interface,the complicated velocity structure of the lithosphere,and the heterogeneous prestress therein;(3)The three earthquakes caused remarkable coseismic Coulomb stress changes at the subduction interface nearby these mainshocks,with an average Coulomb stress change of 3.2 bars in the shallow region directly inwards the trench.
文摘Background:This study explores the relationship between endoplasmic reticulum(ER)stress and diabetes,particularly focusing on the impact of physical exercise on ER stress mechanisms and identifying potential therapeutic drugs and targets for diabetes-related sepsis.The research also incorporates traditional physical therapy perspectives,emphasizing the genomic insights gained from exercise therapy in disease management and prevention.Methods:Gene analysis was conducted on the GSE168796 and GSE94717 datasets to identify ER stress-related genes.Gene interactions and immune cell correlations were mapped using GeneCard and STRING databases.A screening of 2,456 compounds from the TCMSP database was performed to identify potential therapeutic agents,with a focus on their docking potential.Techniques such as luciferase reporter gene assay and RNA interference were used to examine the interactions between microRNA-149-5p and MMP9.Results:The study identified 2,006 differentially expressed genes and 616 miRNAs.Key genes like MMP9,TNF-α,and IL1B were linked to an immunosuppressive state.Licorice glycoside E demonstrated high affinity for MMP9,suggesting its potential effectiveness in treating diabetes.The constructed miRNA network highlighted the regulatory roles of MMP9,IL1B,IFNG,and TNF-α.Experimental evidence confirmed the binding of microRNA-149-5p to MMP9,impacting apoptosis in diabetic cells.Conclusion:The findings highlight the regulatory role of microRNA-149-5p in managing MMP9,a crucial gene in diabetes pathophysiology.Licorice glycoside E emerges as a promising treatment option for diabetes,especially targeting MMP9 affected by ER stress.The study also underscores the significance of physical exercise in modulating ER stress pathways in diabetes management,bridging traditional physical therapy and modern scientific understanding.Our study has limitations.It focuses on the microRNA-149-5p-MMP9 network in sepsis,using cell-based methods without animal or clinical trials.Despite strong in vitro findings,in vivo studies are needed to confirm licorice glycoside E’s therapeutic potential and understand the microRNA-149-5p-MMP9 dynamics in real conditions.
基金supported by the Haihe Laboratory of Cell Ecosystem Innovation Fund,No.22HHXBSS00047(to PL)the National Natural Science Foundation of China,Nos.82072166(to PL),82071394(to XG)+4 种基金Science and Technology Planning Project of Tianjin,No.20YFZCSY00030(to PL)Science and Technology Project of Tianjin Municipal Health Commission,No.TJWJ2021QN005(to XG)Tianjin Key Medical Discipline(Specialty)Construction Project,No.TJYXZDXK-006ATianjin Municipal Education Commission Scientific Research Program Project,No.2020KJ164(to JZ)China Postdoctoral Science Foundation,No.2022M712392(to ZY).
文摘We previously reported that miR-124-3p is markedly upregulated in microglia-derived exosomes following repetitive mild traumatic brain injury.However,its impact on neuronal endoplasmic reticulum stress following repetitive mild traumatic brain injury remains unclear.In this study,we first used an HT22 scratch injury model to mimic traumatic brain injury,then co-cultured the HT22 cells with BV2 microglia expressing high levels of miR-124-3p.We found that exosomes containing high levels of miR-124-3p attenuated apoptosis and endoplasmic reticulum stress.Furthermore,luciferase reporter assay analysis confirmed that miR-124-3p bound specifically to the endoplasmic reticulum stress-related protein IRE1α,while an IRE1αfunctional salvage experiment confirmed that miR-124-3p targeted IRE1αand reduced its expression,thereby inhibiting endoplasmic reticulum stress in injured neurons.Finally,we delivered microglia-derived exosomes containing miR-124-3p intranasally to a mouse model of repetitive mild traumatic brain injury and found that endoplasmic reticulum stress and apoptosis levels in hippocampal neurons were significantly reduced.These findings suggest that,after repetitive mild traumatic brain injury,miR-124-3 can be transferred from microglia-derived exosomes to injured neurons,where it exerts a neuroprotective effect by inhibiting endoplasmic reticulum stress.Therefore,microglia-derived exosomes containing miR-124-3p may represent a novel therapeutic strategy for repetitive mild traumatic brain injury.
基金The article was funded by the National Natural Science Foundation of China(Nos.51674190 and 52074211)the Natural Science Basic Research Program of Shaanxi(Nos.2019JQ-798 and 2019JLP-08).The authors also thank the reviewers for their patient work.
文摘In order to ensure safe mining and reduce surface damage in shallow multi-seam mining,the failure characteristics of interburden strata with different coal pillars offset distances between pillars in the upper and lower seams,the distribution characteristics of stress concentration in coal pillars,and the development characteristics of stratum cracks and subsidence were investigated by physical and UDEC2D simulation.Meanwhile,the effect of different coal pillar offset distances on stress concentration of coal pillar and development of stratum cracks were studied.Based on those results,a formula for safe mining and reducing surface damage was established,which provided a theoretical basis for safe and environmentally friendly mining in shallow multi-seam.According to the results,the optimal coal pillar offset distance(the side to side horizontal distance of the upper and lower coal pillars)between the upper and lower coal seams was developed to reduce the stress concentration of coal pillars and surface damage.The results of this study have been applied in Ningtiaota coal mine and have achieved good results in safe and environmentally friendly mining.
文摘In this paper,the dynamic stress concentration and scattering of SH-waves by bi-material structures that possess an interface elliptic cavity are investigated.First,by using the complex function method,the Green's function is constructed.This yields the solution of the displacement field for an elastic half space with a semi-elliptic canyon impacted by an anti-plane harmonic line source loading on the horizontal surface.Then,the problem is divided into an upper and lower half space along the horizontal interface,regarded as a harmony model.In order to satisfy the integral continuity condition, the unknown anti-plane forces are applied to the interface.The integral equations with unknown forces can be established through the continuity condition,and after transformation,the algebraic equations are solved numerically.Finally,the distribution of the dynamic stress concentration factor(DSCF)around the elliptic cavity is given and the effect of different parameters on DSCF is discussed.
基金supported by the National Natural Science Foundation of China(90916027,11002113,51275424,and 11172236)973 Program(2011CB610304)+1 种基金the 111 Project(B07050)the NPU Foundation for Fundamental Research(JC20120229)
文摘In order to avoid stress concentration, the shape boundary must be properly designed via shape optimiza- tion. Traditional shape optimization approach eliminates the stress concentration effect by using free-form curve to present the design boundaries without taking the machin- ability into consideration. In most numerical control (NC) machines, linear as well as circular interpolations are used to generate the tool path. Non-circular curves, such as non- uniform rotational B-spline (NURBS), need other more ad- vanced interpolation functions to formulate the tool path. Forming the circular tool path by approximating the opti- mal free curve boundary with arcs or biarcs is another op- tion. However, these two approaches are both at a cost of sharp expansion of program code and long machining time consequently. Motivated by the success of recent researches on biarcs, a reliable shape optimization approach is pro- posed in this work to directly optimize the shape boundaries with biarcs while the efficiency and precision of traditional method are preserved. Finally, the approach is validated by several illustrative examples.
基金The research work was financially supported by the National Natural Scientice Foundation of China(Grant No.10142001)by the Shandong Provincial Natural Scientice Foundation(Grant No.Y2006F46)
文摘In engineering practice, tubular X-joints have been widely used in offshore structures. The fatigue failure of tubular X-joints in offshore engineering is mainly caused by axial tensile stress. In this study, the stress concentration factor distribution along the weld toe in the hot spot stress region for tubular X-joints subject to axial loads have been analyzed by use of finite element method. Through numerical analysis, it has been found that the peak stress concentration factor is located at the saddle position. Thereafter, 80 models have been analyzed, and the effect of the geometric parameters of a tubular X-joint on the stress concentration factor has been investigated. Based on the experimental values of the numerical stress concentration factor, a parametric equation to calculate the stress concentration factor of tubular X-joints has been proposed. The accuracy of this equation has been verified against the requirement of the Fatigue Guidance Review Panel, and the proposed equation is found capable of producing reasonably accurate stress concentration factor values for tubular X-joints subject to axial loads.
基金The authors are grateful to be financially supported by Projects of Natural Science Foundation of Heilongjiang Province (No. E201458) , State Key Lab of Advanced Welding and Joining, Har- bin Institute of Technology (AWJ-M13-14) and Hei longjiang Prov- ince Department of Education (12541679).
文摘In order to improve the bending load-carrying capacity (BLCC) of undermatched butt joint under three-point bending load, the influence of joint geometric parameters on stress concentration factors (SCF) at the weld bottom center and the weld toe of uudermatched butt joint with single V-groove are studied respectively based on the finite element method in this paper. Results show that the reinforcement height and the cover pass width play decisive role in the BLCC for undermatched butt joint. BLCC of undermatched butt joint can be improved by choosing the appropriate joint geometric parameters.
文摘In this paper,the influence of geometric parameters on the stress concentration factors due to three different types of axial loading on 81 TY tubular structures is studied.Our results reveal that,geometric parameters have a considerable impact on the variation of stress concentration factors on tubular TY-joints under axial loads.Thus,the highest stress concentration factor values are observed on the vertical brace than on the inclined one.The finite element results of the tubular structures were verified by parametric equations and experimental data.A parametric study was carried out by analyses using the nonlinear regression method to obtain parametric equations.These equations are used to calculate stress concentration factors and to analyse the fatigue resistance of TY-joints due to axial loads.
文摘The aim of this work is to study the stress distributions and the location of hot spots stress in the vicinity of the intersection lines of the tubular elements of the tubular TY-joints.Using the finite element models,we analyze the effects of geometrical parameters on the stress concentration factor in the case of in-plane bending and out-of-plane bending loads,around the weld toe of the tubular joints.Our results reveal the location of the maximum stress concentration factor at the heel or toe in the case of in-plane bending loads and at the saddle point in the case of out-of-plane bending loads.Six parametric equations are established and used to calculate the stress concentration factor at critical locations using the non-linear regression method.The results obtained from the finite element analysis are close to the results of the parametric equations and the experimental data from the previous work.
文摘The photo-elastic method has been employed to determine stress concentration factor (SCF) for square plates containing holes and inclined slots when the plate edges are subjected to in-plane tension combined with compression. Analyses given of the isochromatic fringe pattern surrounding the hole provides the SCF conveniently. The model material is calibrated from the known solution to the stress raiser arising from a small circular hole in a plate placed under biaxial tension-compression. These results also compare well with a plane stress FE analysis. Consequently, photo-elasticity has enabled SCF’s to be determined experimentally for a biaxial stress ratio, nominally equal to –4, in plates containing a long, thin slot arranged to be in alignment with each stress axis. The two, principal stresses lying along axes of symmetry in the region surrounding the notch are separated within each isochromatic fringe by the Kuske method [1]. FE provides a comparable full-field view in which contours of maximum shear stress may be identified with the isochromatic fringe pattern directly. The principal stress distributions referred to the plate axes show their maximum concentrations at the notch boundary. Here up to a fourfold magnification occurs in the greater of the two nominal stresses under loads applied to the plate edges. Thus, it is of importance to establish the manner in which the tangential stress is distributed around the slot boundary. Conveniently, it is shown how this distribution is also revealed from an isochro-matic fringe pattern, within which lie the points of maximum tension and maximum compression.
文摘The complex function method was used in the solution of micropolar elasticity theory around cavity in an infinite elasticity plane. In complex plane, the general solution of two dimension micropolar elasticity theory is given. The solution comes from analytic function and 'Zonal Function'. The boundary conditions of non-circular cavity are satisfied by using the conformal mapping method. Based on the method, a general approach solving the stress concentration in micropolar elasticity theory is established. Finally, the numerical calculation is carried out to the stress concentration coefficient of circular cavity.
文摘A notch sensitivity factor was derived in order to evaluate the stress concentration sensitivity of Al Li based alloys. The factor values for the Al Li alloy sheets containing various contents of impurities and cerium addition were evaluated by determining the mechanical properties. It is found that the impurities Fe, Si, Na and K significantly enhance the stress concentration sensitivity of the alloys 2090 and 8090, whereas cerium addition reduces the stress concentration sensitivity to a certain degree for the high strength alloys. However, an excess amount of cerium addition in the high ductility alloy 1420 can significantly increase the stress concentration sensitivity. As compared with conventional aluminum alloys, the Al Li based alloys generally show high stress concentration sensitivity. Therefore, a special attention must be paid to this problem in the practical application of Al Li based alloys.
文摘To explore the impact of lateral stress concentration in interlayer rock stratum on the exploitation of protected coal seam, a field experiment was carried out in a multi-seam mining structure. Lateral stress redistribution and interlayer rock failure behavior were surveyed. Then an assistant numerical investigation was implemented to evolve the effect of liberated seam mining and its influence on stress reconstruction in surrounding rock mass. The cause of lateral stress concentration and its impact were discussed finally. Key findings turn out that a certain lateral stress increases in interlayer rock stratum and concentrates on its lower region. Lateral stress concentration and interlayer rock failure are interactional. The former is an inducing factor of the latter;the latter promotes the increase of concentration degree. Extent of lateral stress concentration increases to the maximum as seam distance is about 50 m. But the efficacy of liberated seam mining decreases as the seam spacing gets larger. Protected seam mining is then classified based upon the impact of lateral stress concentration, which helps to prevent the rock burst hazard and then to achieve a reliable mining in deep mines.
基金supported by the National Natural Science Foundation of China(51308467 and 51378431)China railway corporation research and development of science and technology key project(2013G001-A-2)
文摘The fatigue performance of optimized welded detail has been investigated by fatigue experiments of three welded specimens under different loadings.In addition,local finite element models of this welded detail were established using finite element software ANSYS.The influences of different factors such as plate thickness,plate gap and initial geometric imperfections on the stress concentration coefficient(SCC) were discussed.The experimental results indicate that the fatigue life of three specimens for this welded detail is 736,000,1,044,200 and 1,920,300 times,respectively.The web thickness,the filler plate thickness and the initial geometric imperfection have relatively less effect on the SCCs of this welded detail.However,cope-hole radius is influential on the SCCs of the web and the weld.The SCC of weld is significantly affected by the weld size and plate gap,but the SCCs of other parts of the welded detail are hardly affected by the plate gap.
基金The work is supported by the Croatian Science Foundation within the projects IP-2013-11-8658 and lP-2019-04-2085This work is also performed within the scope of the Strategic Research Plan of the Centre for Marine Technology and Ocean Engineering(CENTEC)which is financed by the Portuguese Foundation for Science and Technology(Fundação para a Ciência e Tecnologia-FCT)under contract UIDB/UIDP/00134/2020.
文摘A numerical evaluation of stress concentrations of corroded plate surfaces of small-scale corroded steel specimens is compared with the experimentally estimated ones.Eleven specimens were cut from a steel box girder,which was initially corroded in real seawater conditions.The surface of all corroded specimens was analysed applying photogrammetry techniques,and a statistical description of an idealised corroded surface of each specimen was established.Fatigue lives of specimens are determined from the fatigue tests.Based on experimentally obtained fatigue lives,the stress concentration factors are calculated concerning the ideally smooth specimens.The correlation between the statistical parameters of the corroded specimen surfaces and the estimated stress concentration factors is analysed.Idealised corroded surfaces,converted in graphical format,are then used for the finite element modelling in ABAQUS software,and stress concentration factors are estimated from the finite element results.A convergence study is performed to determine the appropriate finite element mesh density.Comparison between experimentally obtained and numerically estimated stress concentration factors is performed as well as correlation analysis between actual and finite element predicted crack locations.
基金Fundamental Research Funds for Central Universities under Grant No.3072019CF0205。
文摘The method of wave-function expansion in elliptical coordinates,elliptical cosine half-range expansion and Mathieu function were applied to obtain an exact analytical solution of the dynamic stress concentration factor(DSCF)around an elliptical cavity in a shallow,semi-elliptical hill.An infinite system of simultaneous linear equations for solving this problem was established by substituting the wave expression obtained by the Mathieu function including the standing wave expression of elliptical lining given herein into the boundary condition obtained by the region-matching method.The finite equations system with unknown coefficients obtained by truncation were solved numerically,and the results in the case of an ellipse degenerating into a circle were compared with previous results to verify the accuracy of the method.The effects of different aspect ratios,incident wave angles and aperture ratios on the dynamic stress concentration around the elliptical cavity were described.Some numerical results,when the elliptical hill was changed into a circular one,were analyzed and compared in detail.In engineering,this model can be regarded as a semi-cylindrical hill with an elliptical cylindrical unlined tunnel under the action of SH waves,and the results are significant in aseismic design.
文摘This paper uses the TSA (therrnoelastic stress analysis) technique to determine the stress concentration factor (Kt) of a U-notch in an aluminum plate, and then compares the results with those obtained from a FEA (finite elements analysis) of the same specimen. In order to do so, it devises a calculation procedure to extrapolate the thermoelastic data near the tip of the notch and then applies the resulting algorithm to seven distinct experiments that had different loading frequencies, mean loads and load ranges. The overall positive results suggest that the technique may be suitable for Kt measurements in real-world structures. A discussion about the calibration factor of the thermoelastic data is included by confronting the calibration results using independent tensile uniaxial tests and using the U-notch TSA and FEA paired specimen data.