An important problem facing stress-strain response modeling of concrete is the complexity of the compressive strength grades. 21 groups of speeimens with different cubic compressive strength （56.3- 164.9 MPa ） hate ...An important problem facing stress-strain response modeling of concrete is the complexity of the compressive strength grades. 21 groups of speeimens with different cubic compressive strength （56.3- 164.9 MPa ） hate beets numerically analyzed. Using only the compressive strength, a stress-strain response model of different concrete grade was established. The numerical simulation model not only qualitatively reproduces the relationship of uniaxial compressive strength, peak value stress and cubic compressive strength, but realizes the consistence of the ascending branch of stress-strain cunts with different strength grades by introducing the correction coefficient k. The results indicate k increases gradually from 0 to approximate 1 with the increase of the compressive strength, corresponding to the transition from the paracurve to straight line branch in stress-strain curves. When k is 0, the madel is identical to the Hognestad equation. A good agreement with the experiment data was obtained.展开更多
How the wave propagation analysis plays a key role in the studies of dynamic response of materials at high strain rates is analyzed. For the wave propagation technique, the followings are important: the loading and un...How the wave propagation analysis plays a key role in the studies of dynamic response of materials at high strain rates is analyzed. For the wave propagation technique, the followings are important: the loading and unloading constitutive relation presumed, the positions of the sensors embedded, the interactions between loading waves and unloading waves. For the split Hopkinson pressure bar (SHPB) technique, the assumption of one-dimensional stress wave propagation and the assumption of stress uniformity along the specimen should be satisfied. When the larger diameter bars are employed, the wave dispersion effects should be considered, including the high frequency oscillations, non-uniform stress distribution across the bar section, increase of rise time, and amplitude attenuation. The stress uniformity along the specimen is influenced by the reflection times in specimen, the wave impedance ratio of the specimen and the bar, and the waveform.展开更多
This paper analyzed the characteristics of welding solidification crack of stainless steels,and clearly re- vealed the the of the deformation in the molten - the pool and the solidification shrinkage on the stress -...This paper analyzed the characteristics of welding solidification crack of stainless steels,and clearly re- vealed the the of the deformation in the molten - the pool and the solidification shrinkage on the stress - strain fields in the trail of molten - weld pool.Moreover, rheologic properties of the alloys in solid - liquid zone were also obtained by measuring the hading and unloading deform curves of the steels.As a result, a numerical model for simulation of stress - strain distributions of welding solidifi- cation crack was developed. On the basis of the model,the thesis simulated the driving force of solidifi- cation crack of stainless steels, that is, stress - strain fields in the trail of molten-weld pool with fi- nite element method.展开更多
An analytical model for dynamic recrystallization (DRX) is studied based on the relative grain size model proposed by Sakai and Jonas, and the characteristic flow behaviors under DRX are analyzed and simulated. Int...An analytical model for dynamic recrystallization (DRX) is studied based on the relative grain size model proposed by Sakai and Jonas, and the characteristic flow behaviors under DRX are analyzed and simulated. Introducing the variation of dynamic grain size and the heterogeneous distribution of disolo- cation densities densities under DRX,a simple method for modeling and simulating DRX processes is developed by using Laplace transformation theory. The results derived from the present model agree well with the experimental results in literatures. This simulation can reproduce a number of features in DRX flow behaviors, for example,single and multiple peak flow behaviors followed by a steady state flow, the transition between them, and so on.展开更多
The serine proteinase inhibitor α-1 antitrypsin(AAT) is produced principally by the liver at the rate of 2 g/d.It is secreted into the circulation and provides an antiprotease protective screen throughout the body bu...The serine proteinase inhibitor α-1 antitrypsin(AAT) is produced principally by the liver at the rate of 2 g/d.It is secreted into the circulation and provides an antiprotease protective screen throughout the body but most importantly in the lung,where it can neutralise the activity of the serine protease neutrophil elastase.Mutations leading to def iciency in AAT are associated with liver and lung disease.The most notable is the Z AAT mutation,which encodes a misfolded variant of the AAT protein in which the glutamic acid at position 342 is replaced by a lysine.More than 95% of all individuals with AAT def iciency carry at least one Z allele.ZAAT protein is not secreted effectively and accumulates intracellularly in the endoplasmic reticulum(ER) of hepatocytes and other AAT-producing cells.This results in a loss of function associated with decreased circulating and intrapulmonary levels of AAT.However,the misfolded protein acquires a toxic gain of function that impacts on the ER.A major function of the ER is to ensure correct protein folding.ZAAT interferes with this function and promotes ER stress responses and inflammation.Here the signalling pathways activated during ER stress in response to accumulation of ZAAT are described and therapeutic strategies that can potentially relieve ER stress are discussed.展开更多
Purpose-This paper aims to analyze the bearing characteristics of the high speed train window glass under aerodynamic load effects.Design/methodology/approach-In order to obtain the dynamic strain response of passenge...Purpose-This paper aims to analyze the bearing characteristics of the high speed train window glass under aerodynamic load effects.Design/methodology/approach-In order to obtain the dynamic strain response of passenger compartment window glass during high-speed train crossing the tunnel,taking the passenger compartment window glass of the CRH3 high speed train onWuhan-Guangzhou High Speed Railway as the research object,this study tests the strain dynamic response and maximum principal stress of the high speed train passing through the tunnel entrance and exit,the tunnel and tunnel groups as well as trains meeting in the tunnel at an average speed of 300 km$h-1.Findings-The results show that while crossing the tunnel,the passenger compartment window glass of high speed train is subjected to the alternating action of positive and negative air pressures,which shows the typical mechanic characteristics of the alternating fatigue stress of positive-negative transient strain.The maximum principal stress of passenger compartment window glass for high speed train caused by tunnel aerodynamic effects does not exceed 5 MPa,and the maximum value occurs at the corresponding time of crossing the tunnel groups.The high speed train window glass bears medium and low strain rates under the action of tunnel aerodynamic effects,while the maximum strain rate occurs at the meeting moment when the window glass meets the train head approaching from the opposite side in the tunnel.The shear modulus of laminated glass PVB film that makes up high speed train window glass is sensitive to the temperature and action time.The dynamically equivalent thickness and stiffness of the laminated glass and the dynamic bearing capacity of the window glass decrease with the increase of the action time under tunnel aerodynamic pressure.Thus,the influence of the loading action time and fatigue under tunnel aerodynamic effects on the glass strength should be considered in the design for the bearing performance of high speed train window glass.Originality/value-The research results provide data support for the analysis of mechanical characteristics,damage mechanism,strength design and structural optimization of high speed train glass.展开更多
通过垃圾土的三轴固结排水剪切试验结果,研究了垃圾土的抗剪强度机理,纤维材料在压缩剪切过程中产生的拉力是垃圾土抗剪强度得以提高的关键所在。基于试验结果,提出以垃圾土应力-应变关系曲线的硬化点作为破坏标准来计算垃圾土的强度参...通过垃圾土的三轴固结排水剪切试验结果,研究了垃圾土的抗剪强度机理,纤维材料在压缩剪切过程中产生的拉力是垃圾土抗剪强度得以提高的关键所在。基于试验结果,提出以垃圾土应力-应变关系曲线的硬化点作为破坏标准来计算垃圾土的强度参数,这样可确保垃圾土强度参数的唯一性,又可避免因选定的应变水平较小而低估垃圾土的强度,得到本文垃圾土的黏聚力为71.3 k Pa,内摩擦角为35.9°。最后,提出了新的描述垃圾土应力-应变关系的非线性模型,该模型能够反映小应变和大应变情况下的非线性,克服了已有线性和非线性模型的缺陷,能够很好地吻合试验数据。展开更多
基金Funded by the National Natural Science Foundation of China(No.59338120) and Doctoral Foundation of Ministry of Education ofChina(No.1999062002)
文摘An important problem facing stress-strain response modeling of concrete is the complexity of the compressive strength grades. 21 groups of speeimens with different cubic compressive strength （56.3- 164.9 MPa ） hate beets numerically analyzed. Using only the compressive strength, a stress-strain response model of different concrete grade was established. The numerical simulation model not only qualitatively reproduces the relationship of uniaxial compressive strength, peak value stress and cubic compressive strength, but realizes the consistence of the ascending branch of stress-strain cunts with different strength grades by introducing the correction coefficient k. The results indicate k increases gradually from 0 to approximate 1 with the increase of the compressive strength, corresponding to the transition from the paracurve to straight line branch in stress-strain curves. When k is 0, the madel is identical to the Hognestad equation. A good agreement with the experiment data was obtained.
文摘How the wave propagation analysis plays a key role in the studies of dynamic response of materials at high strain rates is analyzed. For the wave propagation technique, the followings are important: the loading and unloading constitutive relation presumed, the positions of the sensors embedded, the interactions between loading waves and unloading waves. For the split Hopkinson pressure bar (SHPB) technique, the assumption of one-dimensional stress wave propagation and the assumption of stress uniformity along the specimen should be satisfied. When the larger diameter bars are employed, the wave dispersion effects should be considered, including the high frequency oscillations, non-uniform stress distribution across the bar section, increase of rise time, and amplitude attenuation. The stress uniformity along the specimen is influenced by the reflection times in specimen, the wave impedance ratio of the specimen and the bar, and the waveform.
文摘This paper analyzed the characteristics of welding solidification crack of stainless steels,and clearly re- vealed the the of the deformation in the molten - the pool and the solidification shrinkage on the stress - strain fields in the trail of molten - weld pool.Moreover, rheologic properties of the alloys in solid - liquid zone were also obtained by measuring the hading and unloading deform curves of the steels.As a result, a numerical model for simulation of stress - strain distributions of welding solidifi- cation crack was developed. On the basis of the model,the thesis simulated the driving force of solidifi- cation crack of stainless steels, that is, stress - strain fields in the trail of molten-weld pool with fi- nite element method.
文摘An analytical model for dynamic recrystallization (DRX) is studied based on the relative grain size model proposed by Sakai and Jonas, and the characteristic flow behaviors under DRX are analyzed and simulated. Introducing the variation of dynamic grain size and the heterogeneous distribution of disolo- cation densities densities under DRX,a simple method for modeling and simulating DRX processes is developed by using Laplace transformation theory. The results derived from the present model agree well with the experimental results in literatures. This simulation can reproduce a number of features in DRX flow behaviors, for example,single and multiple peak flow behaviors followed by a steady state flow, the transition between them, and so on.
基金Supported by The U.S. Alpha One Foundation,the Health Research Board of Ireland,the Medical Research Charities Group,the Programmes for Research in Third Level Institutes administered by the Higher Education Authority and the Children’s Medical and Research Centre,Crumlin Hospital
文摘The serine proteinase inhibitor α-1 antitrypsin(AAT) is produced principally by the liver at the rate of 2 g/d.It is secreted into the circulation and provides an antiprotease protective screen throughout the body but most importantly in the lung,where it can neutralise the activity of the serine protease neutrophil elastase.Mutations leading to def iciency in AAT are associated with liver and lung disease.The most notable is the Z AAT mutation,which encodes a misfolded variant of the AAT protein in which the glutamic acid at position 342 is replaced by a lysine.More than 95% of all individuals with AAT def iciency carry at least one Z allele.ZAAT protein is not secreted effectively and accumulates intracellularly in the endoplasmic reticulum(ER) of hepatocytes and other AAT-producing cells.This results in a loss of function associated with decreased circulating and intrapulmonary levels of AAT.However,the misfolded protein acquires a toxic gain of function that impacts on the ER.A major function of the ER is to ensure correct protein folding.ZAAT interferes with this function and promotes ER stress responses and inflammation.Here the signalling pathways activated during ER stress in response to accumulation of ZAAT are described and therapeutic strategies that can potentially relieve ER stress are discussed.
基金supported by the National Natural Science Foundation of China (Grant Nos.52072356 and 52032011)the 2019 Zaozhuang High-level Talents Project (Grant No.ZZYF-01).
文摘Purpose-This paper aims to analyze the bearing characteristics of the high speed train window glass under aerodynamic load effects.Design/methodology/approach-In order to obtain the dynamic strain response of passenger compartment window glass during high-speed train crossing the tunnel,taking the passenger compartment window glass of the CRH3 high speed train onWuhan-Guangzhou High Speed Railway as the research object,this study tests the strain dynamic response and maximum principal stress of the high speed train passing through the tunnel entrance and exit,the tunnel and tunnel groups as well as trains meeting in the tunnel at an average speed of 300 km$h-1.Findings-The results show that while crossing the tunnel,the passenger compartment window glass of high speed train is subjected to the alternating action of positive and negative air pressures,which shows the typical mechanic characteristics of the alternating fatigue stress of positive-negative transient strain.The maximum principal stress of passenger compartment window glass for high speed train caused by tunnel aerodynamic effects does not exceed 5 MPa,and the maximum value occurs at the corresponding time of crossing the tunnel groups.The high speed train window glass bears medium and low strain rates under the action of tunnel aerodynamic effects,while the maximum strain rate occurs at the meeting moment when the window glass meets the train head approaching from the opposite side in the tunnel.The shear modulus of laminated glass PVB film that makes up high speed train window glass is sensitive to the temperature and action time.The dynamically equivalent thickness and stiffness of the laminated glass and the dynamic bearing capacity of the window glass decrease with the increase of the action time under tunnel aerodynamic pressure.Thus,the influence of the loading action time and fatigue under tunnel aerodynamic effects on the glass strength should be considered in the design for the bearing performance of high speed train window glass.Originality/value-The research results provide data support for the analysis of mechanical characteristics,damage mechanism,strength design and structural optimization of high speed train glass.
文摘通过垃圾土的三轴固结排水剪切试验结果,研究了垃圾土的抗剪强度机理,纤维材料在压缩剪切过程中产生的拉力是垃圾土抗剪强度得以提高的关键所在。基于试验结果,提出以垃圾土应力-应变关系曲线的硬化点作为破坏标准来计算垃圾土的强度参数,这样可确保垃圾土强度参数的唯一性,又可避免因选定的应变水平较小而低估垃圾土的强度,得到本文垃圾土的黏聚力为71.3 k Pa,内摩擦角为35.9°。最后,提出了新的描述垃圾土应力-应变关系的非线性模型,该模型能够反映小应变和大应变情况下的非线性,克服了已有线性和非线性模型的缺陷,能够很好地吻合试验数据。
