Calculation of Mass Concrete Temperature and Creep Stress under the Influence of Local Air Heat Transfer

Temperature-induced cracking during the construction of mass concrete is a significant concern.Numerical simulations of concrete temperature have primarily assumed that the concrete is placed in an open environment.The problem of heat transfer between the air and concrete has been simplified to the concrete’s heat dissipation boundary.However,in the case of tubular concrete structures,where air inlet and outlet are relatively limited,the internal air temperature does not dissipate promptly to the external environment as it rises.To accurately simulate the temperature and creep stress in tubular concrete structures with enclosed air spaces during construction,we establish an air–concrete coupled heat transfer model according to the principles of conjugate heat transfer,and the accuracy of the model is verified through experiments.Furthermore,we conduct a case study to analyze the impact of airflow within the ship lock corridor on concrete temperature and creep stress.The results demonstrate that enhancing airflow within the corridor can significantly reduce the maximum concrete temperature.Compared with cases in which airflow within the corridor is neglected,the maximum concrete temperature and maximum tensile stress can be reduced by 12.5℃ and 0.7 MPa,respectively,under a wind speed of 4 m/s.The results of the traditional calculation method are relatively close to those obtained at a wind speed of 1 m/s.However,the temperature reduction process in the traditional method is faster,and the method yields greater tensile stress values for the corridor location.

Characteristics of transfer zones under the influence of preexisting faults and regional stress transformation:Wenchang A subsag,Zhujiang River Mouth Basin,northern South China Sea

A transfer zone in rift basins preserves important information on regional tectonic evolution and plays significant roles in hydrocarbon accumulation.Based on the systematic analysis of 3D seismic data and hydrocarbon accumulation conditions,the geometry,kinematics,and reservoir control of a large synthetic overlapping transfer zone in the south of the Wenchang A subsag in the Zhujiang(Pearl)River Mouth basin were investigated.Results indicate that the development and evolution of the transfer zone was controlled by the interaction between pre-existing faults and regional stress transformation.The intense rifting of the main faults of the transfer zone controlled the development of source rocks and faultcontrolled slope break paleogeomorphology.The strike-slip overprint since the Oligocene is conducive to the formation of a large-scale fault-anticline trap,and the secondary faults in the transfer zone contribute to the hydrocarbon transportation.The conjugate intersection area of the NE-and NW-trending faults offers more opportunity for hydrocarbon migration and accumulation.

Coseismic Coulomb stress changes induced by a 2020-2021 M_(W)>7.0 Alaska earthquake sequence in and around the Shumagin gap and its influence on the Alaska-Aleutian subduction interface

Three M_(W)>7.0 earthquakes in 2020-2021 occurred in the Shumagin seismic gap and its adjacent area of the Alaska-Aleutian subduction zone,including the Mw7.8 Simeonof thrust earthquake on July 22,2020,the M_(W)7.6 Sand Point strike-slip earthquake on October 19,2020,and the M_(W)8.2 Chignik thrust earthquake on July 29,2021.The spatial and temporal proximity of these three earthquakes prompts us to probe stress-triggering effects among them.Here we examine the coseismic Coulomb stress change imparted by the three earthquakes and their influence on the subduction interface.Our results show that:(1)The Simeonof earthquake has strong loading effects on the subsequent Sand Point and Chignik earthquakes,with the Coulomb stress changes of 3.95 bars and 2.89 bars,respectively.The Coulomb stress change caused by the Sand Point earthquake at the hypocenter of the Chignik earthquake is merely around 0.01 bars,suggesting the negligible triggering effect on the latter earthquake;(2)The triggering effects of the Simeonof,Sand Point,and Chignik earthquakes on aftershocks within three months are not well pronounced because of the triggering rates of 38%,14%,and 43%respectively.Other factors may have played an important role in promoting the occurrence of these aftershocks,such as the roughness of the subduction interface,the complicated velocity structure of the lithosphere,and the heterogeneous prestress therein;(3)The three earthquakes caused remarkable coseismic Coulomb stress changes at the subduction interface nearby these mainshocks,with an average Coulomb stress change of 3.2 bars in the shallow region directly inwards the trench.

Exercise-induced modulation of miR-149-5p and MMP9 in LPS-triggered diabetic myoblast ER stress: licorice glycoside E as a potential therapeutic target

Background:This study explores the relationship between endoplasmic reticulum(ER)stress and diabetes,particularly focusing on the impact of physical exercise on ER stress mechanisms and identifying potential therapeutic drugs and targets for diabetes-related sepsis.The research also incorporates traditional physical therapy perspectives,emphasizing the genomic insights gained from exercise therapy in disease management and prevention.Methods:Gene analysis was conducted on the GSE168796 and GSE94717 datasets to identify ER stress-related genes.Gene interactions and immune cell correlations were mapped using GeneCard and STRING databases.A screening of 2,456 compounds from the TCMSP database was performed to identify potential therapeutic agents,with a focus on their docking potential.Techniques such as luciferase reporter gene assay and RNA interference were used to examine the interactions between microRNA-149-5p and MMP9.Results:The study identified 2,006 differentially expressed genes and 616 miRNAs.Key genes like MMP9,TNF-α,and IL1B were linked to an immunosuppressive state.Licorice glycoside E demonstrated high affinity for MMP9,suggesting its potential effectiveness in treating diabetes.The constructed miRNA network highlighted the regulatory roles of MMP9,IL1B,IFNG,and TNF-α.Experimental evidence confirmed the binding of microRNA-149-5p to MMP9,impacting apoptosis in diabetic cells.Conclusion:The findings highlight the regulatory role of microRNA-149-5p in managing MMP9,a crucial gene in diabetes pathophysiology.Licorice glycoside E emerges as a promising treatment option for diabetes,especially targeting MMP9 affected by ER stress.The study also underscores the significance of physical exercise in modulating ER stress pathways in diabetes management,bridging traditional physical therapy and modern scientific understanding.Our study has limitations.It focuses on the microRNA-149-5p-MMP9 network in sepsis,using cell-based methods without animal or clinical trials.Despite strong in vitro findings,in vivo studies are needed to confirm licorice glycoside E’s therapeutic potential and understand the microRNA-149-5p-MMP9 dynamics in real conditions.

Exosomes derived from microglia overexpressing miR-124-3p alleviate neuronal endoplasmic reticulum stress damage after repetitive mild traumatic brain injury

We previously reported that miR-124-3p is markedly upregulated in microglia-derived exosomes following repetitive mild traumatic brain injury.However,its impact on neuronal endoplasmic reticulum stress following repetitive mild traumatic brain injury remains unclear.In this study,we first used an HT22 scratch injury model to mimic traumatic brain injury,then co-cultured the HT22 cells with BV2 microglia expressing high levels of miR-124-3p.We found that exosomes containing high levels of miR-124-3p attenuated apoptosis and endoplasmic reticulum stress.Furthermore,luciferase reporter assay analysis confirmed that miR-124-3p bound specifically to the endoplasmic reticulum stress-related protein IRE1α,while an IRE1αfunctional salvage experiment confirmed that miR-124-3p targeted IRE1αand reduced its expression,thereby inhibiting endoplasmic reticulum stress in injured neurons.Finally,we delivered microglia-derived exosomes containing miR-124-3p intranasally to a mouse model of repetitive mild traumatic brain injury and found that endoplasmic reticulum stress and apoptosis levels in hippocampal neurons were significantly reduced.These findings suggest that,after repetitive mild traumatic brain injury,miR-124-3 can be transferred from microglia-derived exosomes to injured neurons,where it exerts a neuroprotective effect by inhibiting endoplasmic reticulum stress.Therefore,microglia-derived exosomes containing miR-124-3p may represent a novel therapeutic strategy for repetitive mild traumatic brain injury.

公铁合建钢混板-桁斜拉桥悬挑式钢锚箱受力特性及结构优化

为研究大跨度公铁合建钢混板-桁斜拉桥主梁悬挑式索梁钢锚箱结构的受力特性及结构优化,以主跨808 m的洪奇沥特大桥钢锚箱为背景,采用仿真分析方法,研究钢锚箱3个设计方案主要板件应力、焊缝应力以及推荐方案锚箱节点的传力特性和锚箱参数对钢锚箱受力的影响。结果表明:锚箱尺寸较大、顶底板加肋方案的主要板件应力最大为300 MPa,小于其他2种方案,且6条焊缝的最大应力和应力不均匀系数较优,因此确定该方案为最终设计方案;索力首先由锚垫板直接向钢锚箱顶、底板和内外腹板较为均匀传递,最终边弦杆底板、内腹板和外腹板分别承担了22.2%,46.4%和31.4%的索力;节点处副桁斜杆、近桥塔侧和远桥塔侧边弦杆、混凝土桥面、节点横梁分别传递约66.71%,9.72%,9.32%,9.68%和4.56%的斜拉索竖向分力;板件应力随顶底板厚度增加而减小,顶底板深入边弦杆长度增加可以降低底板-内腹板焊缝峰值应力,顶底板间距减小可降低内外腹板和顶底板与锚垫板接触区域应力;顶底板厚44 mm、锚箱顶底板深入边弦杆长度1800 mm、顶底板间距660 mm时较为合理。

二元应对在行体外受精-胚胎移植不孕症女性患者配偶知觉压力与负性情绪之间的中介效应

目的探讨二元应对在行体外受精-胚胎移植不孕症女性患者配偶知觉压力与负性情绪之间的中介效应。方法选取接受体外受精-胚胎移植的208名不孕症女性患者的配偶作为研究对象,采用知觉压力量表(PSS)、二元应对量表(DCI)及医院焦虑抑郁量表(HADS)对其进行调查。分析3个量表总得分的相关性。使用SPSS软件PROCESS宏程序中的Model 4进行中介效应分析,采用Bootstrap法检验中介效应。结果208名不孕症女性患者配偶的PSS、DCI和HADS总得分别为(14.26±4.89)分、(123.95±16.34)分和(11.43±5.01)分,其中焦虑、抑郁发生率分别为36.06%(75/208)、24.52%(51/208)。相关性分析结果显示,不孕症女性患者配偶的PSS总得分与HADS总得分呈正相关、与DCI总得分呈负相关,DCI总得分与HADS总得分呈负相关(P<0.05)。中介效应分析及检验结果提示,二元应对在知觉压力与负性情绪之间具有部分中介效应,中介效应值为0.058(0.013,0.112),占总效应的9.7%。结论不孕症女性患者配偶的知觉压力呈中等水平,知觉压力可以直接正向作用于负性情绪,也可以通过二元应对间接影响负性情绪。因此,医护人员可提高不孕症女性患者配偶的二元应对能力,以降低其负性情绪的发生。

On stress-forecasting strategy of earthquakes from stress buildup,stress shadow and stress transfer(SSS) based on numerical approach

Global Positioning System （GPS） and Interferometric Synthetic Aperture Radar （InSAR）, used for monitoring crust deformation, are found to be very promising in earthquake prediction subject to stress-forecasting. However, it is recognized that unless we can give reasonable explanations of these curious precursory phenomena that continue to be serendipitously observed from time to time, such high technology of GPS or InSAR is difficult to be efficiently used. Therefore, a proper model revealing the relation between earthquake evolution and stress variation, such as the phenomena of stress buildup, stress shadow and stress transfer （SSS）, is crucial to the GPS or InSAR based earthquake prediction. Here we address this question through a numerical approach of earthquake development using an intuitive physical model with a map-like configuration of discontinuous fault system. The simulation provides a physical basis for the principle of stress-forecasting of earthquakes based on SSS and for the application of GPS or InSAR in earthquake prediction. The observed SSS associated phenomena with images of stress distribution during the failure process can be continuously simulated. It is shown that the SSS are better indicators of earthquake precursors than that of seismic foreshocks, suggesting a predictability of earthquakes based on stress-forecasting strategy.

Interfacial stress transfer behavior in a specially-shaped fiber/matrix pullout test

Specially designed fibers are widely used in engineering practice because the specially-designed shape can help to improve the bonding strength of the fiber and the interface. Studied in this paper is the interfacial shear stress transfer behavior on both sides of the specially designed fiber when it is being pulled out; in which automatic analysis of three-dimensional photoelasticity is employed and the finite element method is adopted. The results show that the stress transfer occurs mainly in the region near the fiber＇s embedded end where the stress reaches its critical point, leading to debonding of the interface. Before debonding, as the pullout loading increases, the peak value of shear stress transfers along the fiber from the embedded end to the interior of the matrix, and then stops at the hooked part of the fiber because of its impediment. When the interface begins to debond as the load increases, the shear stress can be transferred to the hooked part.

体外受精-胚胎移植患者生育压力评估工具的研究进展

本文对体外受精-胚胎移植患者生育压力的普适性、特异性评估工具的主要内容、特征及应用现状进行综述,提出未来研究者应进一步进行相关量表的开发和汉化工作,有效识别和管理体外受精-胚胎移植患者的生育压力。

Stagnation-point flow of couple stress fluid with melting heat transfer

Melting heat transfer in the boundary layer flow of a couple stress fluid over a stretching surface is investigated. The developed differential equations are solved for homotopic solutions. It is observed that the velocity and the boundary layer thickness are decreasing functions of the couple stress fluid parameter. However, the temperature and surface heat transfer increase when the values of the couple stress fluid parameter increase. The velocity and temperature fields increase with an increase in the melting process of the stretching sheet.

褪黑素对卵巢及体外受精-胚胎移植影响的研究进展

褪黑素是一种主要由松果体合成释放的胺类激素,在人类生殖过程中起重要作用。褪黑素可对抗卵巢氧化应激,保护卵母细胞免受自由基损伤,延缓卵巢衰老,有利于卵巢生育力保存。此外,褪黑素可改善多囊卵巢综合征的相关症状。在辅助生殖技术体内、体外培养中给予褪黑素,可提高卵母细胞和胚胎的数量与质量、受精率和活产率,改善辅助生殖技术的结局。本文主要阐述褪黑素对卵巢的保护作用及体外受精-胚胎移植影响的研究进展。

Post-acute ischemic stroke hyperglycemia aggravates destruction of the blood-brain barrier

Post-acute ischemic stroke hyperglycemia increases the risk of hemorrhagic transformation,which is associated with blood-brain barrier disruption.Brain microvascular endothelial cells are a major component of the blood-brain barrier.Intercellular mitochondrial transfer has emerged as a novel paradigm for repairing cells with mitochondrial dysfunction.In this study,we first investigated whether mitochondrial transfer exists between brain microvascular endothelial cells,and then investigated the effects of post-acute ischemic stroke hyperglycemia on mitochondrial transfer between brain microvascular endothelial cells.We found that healthy brain microvascular endothelial cells can transfer intact mitochondria to oxygen glucose deprivation-injured brain microvascular endothelial cells.However,post-oxygen glucose deprivation hyperglycemia hindered mitochondrial transfer and exacerbated mitochondrial dysfunction.We established an in vitro brain microvascular endothelial cell model of the blood-brain barrier.We found that post-acute ischemic stroke hyperglycemia reduced the overall energy metabolism levels of brain microvascular endothelial cells and increased permeability of the blood-brain barrier.In a clinical study,we retrospectively analyzed the relationship between post-acute ischemic stroke hyperglycemia and the severity of hemorrhagic transformation.We found that post-acute ischemic stroke hyperglycemia serves as an independent predictor of severe hemorrhagic transformation.These findings suggest that post-acute ischemic stroke hyperglycemia can aggravate disruption of the blood-brain barrier by inhibiting mitochondrial transfer.

Simulation on flow, heat transfer and stress characteristics of large-diameter thick-walled gas cylinders in quenching process under different water spray volumes

Cooling strength is one of the important factors affecting microstructure and properties of gas cylinders during quenching process,and reasonable water spray volume can effectively improve the quality of gas cylinders and reduce production costs.To find the optimal water spray parameters,a fluid-solid coupling model with three-phase flow was established in consideration of water-vapor conversion.The inner and outer walls of gas cylinder with the dimensions of d914 mm×38 mm×12000 mm were quenched using multi-nozzle water spray system.The internal pressure,average heat transfer coefficient(have)and stress of the gas cylinder under different water spray volumes during quenching process were studied.Finally,the mathematical model was experimentally verified.The results show that both the internal pressure and have increase along with the increase of spray volume.The internal pressure increases slowly first and then rapidly,but have increases rapidly first and then slowly.To satisfy hardenability of gas cylinders,the minimum spray volume should not be less than 40 m^3/(h·m).The results of stress indicate that water spray quenching will not cause deformation of bottle body in the range of water volume from 40 to 290 m^3/(h·m).

森田疗法护理干预在初次体外受精-胚胎移植患者中的应用效果

目的 探讨森田疗法护理干预对初次体外受精-胚胎移植(IVF-ET)患者应激感受、就医体验的影响,以期为临床完善护理措施提供可参考依据。方法 选择河南省人民医院经五路院区2020年3月至2023年3月接收的94例初次IVF-ET患者作为研究对象,依据随机数字表法分成森田组与常规组,每组47例。常规组接受常规护理干预,森田组在常规组基础上加用森田疗法护理干预,持续干预3个月,统计两组就医体验以及干预前、干预3个月应激感受[应激感受量表(PSS)]、心理状态[抑郁自评量表(SDS)、焦虑自评量表(SAS)]以及自我效应感[自我效能感量表(GSES)]。结果 干预3个月森田组PSS分值、SDS分值、SAS分值少于常规组,GSES分值高于常规组(P<0.05);森田组流程效率分值、诊疗行为分值、信息化就医体验分值、人文关怀分值以及医患关系分值高于常规组(P<0.05)。结论 森田疗法护理干预应用于初次IVF-ET患者,可有效改善负性心理,减轻应激感受,提升自我效能感,并优化就医体验。

The soybean GmPUB21-interacting protein GmDi19-5 responds to drought and salinity stresses via an ABA-dependent pathway

Drought-induced protein 19(Di19) is a Cys2/His2 zinc-finger protein that functions in plant growth and development and in tolerance to abiotic stresses.Gm PUB21,an E3 ubiquitin ligase,negatively regulates drought and salinity response in soybean.We identified potential interaction target proteins of Gm PUB21by yeast two-hybrid c DNA library screening,Gm Di19-5 as a candidate.Bimolecular fluorescence complementation and glutathionine-S-transferase pull-down assays confirmed the interaction between Gm Di19-5 and Gm PUB21.Gm Di19-5 was induced by Na Cl,drought,and abscisic acid(ABA) treatments.Gm Di19-5 was expressed in the cytoplasm and nucleus.Gm Di19-5 overexpression conferred hypersensitivity to drought and high salinity,whereas Gm Di19-5 silencing increased drought and salinity tolerance.Transcripts of ABA-and stress response-associated genes including Gm RAB18 and Gm DREB2A were downregulated in Gm Di19-5-overexpressing plants under drought and salinity stresses.ABA decreased the protein level of Gm Di19-5 in vivo,whereas Gm PUB21 increased the decrease of Gm Di19-5 after exogenous ABA application.The accumulation of Gm PUB21 was also inhibited by Gm Di19-5.We conclude that Gm PUB21 and Gm Di19-5 collaborate to regulate drought and salinity tolerance via an ABA-dependent pathway.

Three-dimensional finite element analysis of process-induced residual stress in resin transfer molding process

A three-dimensional finite element analysis of process-induced residual stress in resin transfer molding (RTM) process is presented. The finite element method (FEM) was employed to solve the coupled equations involved in the transient heat transfer and the cure kinetics of the resin, and the distributions of internal temperature and cure degree of the composite at any instant time were obtained. The self-consistent field micro-mechanics model was used to predict the cure-dependent mechanical properties of the composites. Thermal expansion and cure shrinkage were included in the analysis. The thermo-elastic mechanical governing equations were solved using the incremental stress-strain relationship based FEM and the residual stress development was predicted. The present results were validated by the comparisons with the pertinent literature. The numerical example of a half cylinder was presented. The results show that it is necessary to carry out the three-dimensional analysis due to the complex distributions of temperatures, cure degrees and process-induced stress for thick parts, which can be predicted at any point within composite structures in the present analysis.

Stress Transfer and the Impact of the India-Eurasia Collision and the Western Pacific Subduction on the Geodynamics of the Asian Continent

The interaction between the India-Eurasia collision and the Western Pacific subduction and their contribution to recent geodynamics of the Asian continent are discussed. We perform a comparative analysis of the data available from world literature and new data on the slow strain and earthquake migration from the India-Eurasia collision and the Western Pacific subduction zones. Based on the concepts of wave dynamics of the deformation processes, a localization scheme is constructed illustrating the migration of slow strain fronts in central and eastern Asia, and the wave geodynamic impact of collision and subduction on the Asian continent is shown.

光伏板传热-应力模型多场耦合特性研究

针对光伏板的设计和拆解问题,采用多组温度传感器和热红外成像仪测量光伏板表面温度分布,并以光伏板表面温度分布实测数据为参考,使用热-流-力耦合模型进行了多场耦合模拟。结果表明,光照量较小时测点之间温差较小,光伏板表面测点温度、测点之间温差随着光照增加逐渐增加,测点温度、测点之间温差在13:00左右时达到最大值,其后逐渐减小;光伏板表面局部受遮挡导致光照量较小、温度较低,致使光伏板表面存在较大的温度差,温差最大值接近30℃;环境温度是影响光伏板使用的重要因素,外界环境温度与光伏板表面温度呈正相关,并且盖板与背板的温差会随着外界温度的增加而逐渐加大,此时光伏板形变量也变大;涡旋改变了通道内流体的运动方向,造成流体换热不均匀,温度波动引起了应力波动,使光伏板周围形成受力不均现象。

基于实桥测试的大跨径混合梁钢梁-混凝土梁结合段传力机理

为研究大跨径混合梁钢梁-混凝土梁结合段的传力性能和纵桥向应力传递路径,以韩庄运河特大桥为工程背景,通过实桥测试与数值模拟相结合的方式,分析主梁钢梁-混凝土梁结合段应力分布与传递规律。对钢板和混凝土进行应变监测,获取其应力分布与传递规律;采用软件ABAQUS建立钢梁-混凝土梁结合段精细化有限元计算模型,对比分析实桥数据与计算模型分析结果。结果表明:在钢梁-混凝土梁结合段应力从承压板传递到混凝土梁的过程中,随距承压板距离的增大,应力逐渐减小,混凝土梁段应力最小;承压板的最大应力出现在预应力锚固处,越接近承压板中心和承压板边缘,应力越小;承压板顶部整体应力在吊装阶段较大,底部应力在张拉阶段较大,现场采集数据与有限元模型应力传递规律一致。