Background Several studies have reported an association of hyperglycemia with increased mortality and complications in hospital patients with acute coronary syndrome （ACS）. However, the influence of stress hyperglyc...Background Several studies have reported an association of hyperglycemia with increased mortality and complications in hospital patients with acute coronary syndrome （ACS）. However, the influence of stress hyperglycemia （SH） on the medium- and long-term prognoses in ACS patients has not yet been determined. Methods Random venous blood glucose levels were determined in 433 ACS patients and the patients were divided into two groups based on blood glucose results and disease histories. The 171 patients included in the experimental group had no history of diabetes, had no diabetes and/or glucose metabolism disorders during hospitalization and follow-up and had fasting blood glucose levels of I〉 7.0 mmol/L and random blood glucose levels 1〉 11.1 mmol/L. The 262 patients included in the control group had no history of diabetes, had no diabetes and/or glucose metabolism disorders during hospitalization and follow-up, and had fasting blood glucose levels 〈 6.1 mmoL/L and random blood glucose levels 〈 7.8 mmol/L. Basic clinical information, coronary angiographic lesion characteristics, PCI success rate, complication rate, incidence and morbidity rate of cardiovascular events during the hospitalization period and 6 years of follow-up were compared between the two groups. Results There was no significant difference in age, gender or disease history between the two groups. The triglyceride levels and the left ventricular ejection fractions were significantly higher （P = 0.00） and significantly lower （P = 0.03） in the experimental group than in the control group, respectively. Both groups were subjected to coronary angiography and PCI. The PCI success rates of the two groups did not differ significantly （P = 0.63）. The experimental group had more type B2 lesions, but fewer type A lesions compared with the control group. The experimental group had significantly more stents implanted compared with the control group （P 〈 0.05）. The cardiovascular events were significantly increased （P = 0.01） in the experimental group compared with the control group 1 year after discharge. The incidence of cardiovascular events did not differ significantly between the two groups 1-2 years after discharge. The event incidences were significantly higher （P -- 0.05） in the experimental group than in the control group at the end of follow-up. The experimental group was more prone to myocardial infarction and ischemic target vessel revascularization than the control group, but the control group was more prone to unstable stenocardia and heart failure than the experimental group. The psychogenic mortality of the two groups were similar. The interval and the overall mortality rates （P = 0.054） of the two groups were also similar. Conclusions Patients with ACS complicated by SH were more likely to have cardiovascular events 1 year after PCI, whereas SH did not affect the mid- or long-term prognoses of these patients. SH is an independent risk factor for cardiovascular events.展开更多
Post-acute ischemic stroke hyperglycemia increases the risk of hemorrhagic transformation,which is associated with blood-brain barrier disruption.Brain microvascular endothelial cells are a major component of the bloo...Post-acute ischemic stroke hyperglycemia increases the risk of hemorrhagic transformation,which is associated with blood-brain barrier disruption.Brain microvascular endothelial cells are a major component of the blood-brain barrier.Intercellular mitochondrial transfer has emerged as a novel paradigm for repairing cells with mitochondrial dysfunction.In this study,we first investigated whether mitochondrial transfer exists between brain microvascular endothelial cells,and then investigated the effects of post-acute ischemic stroke hyperglycemia on mitochondrial transfer between brain microvascular endothelial cells.We found that healthy brain microvascular endothelial cells can transfer intact mitochondria to oxygen glucose deprivation-injured brain microvascular endothelial cells.However,post-oxygen glucose deprivation hyperglycemia hindered mitochondrial transfer and exacerbated mitochondrial dysfunction.We established an in vitro brain microvascular endothelial cell model of the blood-brain barrier.We found that post-acute ischemic stroke hyperglycemia reduced the overall energy metabolism levels of brain microvascular endothelial cells and increased permeability of the blood-brain barrier.In a clinical study,we retrospectively analyzed the relationship between post-acute ischemic stroke hyperglycemia and the severity of hemorrhagic transformation.We found that post-acute ischemic stroke hyperglycemia serves as an independent predictor of severe hemorrhagic transformation.These findings suggest that post-acute ischemic stroke hyperglycemia can aggravate disruption of the blood-brain barrier by inhibiting mitochondrial transfer.展开更多
BACKGROUND Stress hyperglycemia(SH)is a common phenomenon that is present in about 50%of patients with acute ischemic stroke(AIS).It is thought to be a main risk factor for poor functional outcome among patients with ...BACKGROUND Stress hyperglycemia(SH)is a common phenomenon that is present in about 50%of patients with acute ischemic stroke(AIS).It is thought to be a main risk factor for poor functional outcome among patients with AIS undergoing intravenous thrombolysis(IVT).AIM To investigate the predictive value of glycemic indicators for early neurological outcomes(ENOs)in patients with AIS treated with IVT.METHODS We retrospectively reviewed a prospectively collected database of patients with AIS who underwent IVT at the Department of Neurology,Second Affiliated Hospital of Xuzhou Medical University,between January 2017 and June 2022.ENO included early neurological improvement(ENI)and early neurological deterioration(END),defined as a decrease or increase in the National Institutes of Health Stroke Scale(NIHSS)score between baseline and 24 hours after IVT.We analyzed the associations between glycemic indicators[including admission hyperglycemia(AH),fasting blood glucose(FBG),and SH ratio(SHR)]and ENO in all patients and in subgroups stratified by diabetes mellitus(DM).RESULTS A total of 819 patients with AIS treated with IVT were included.Among these,AH was observed in 329 patients(40.2%).Compared with patients without AH,those with AH were more likely to have a higher prevalence of DM(P<0.001)and hypertension(P=0.031)and presented with higher admission NIHSS scores(P<0.001).During the first 24 hours after IVT,END occurred in 208 patients(25.4%)and ENI occurred in 156 patients(19.0%).Multivariate mixed logistic regression analyses indicated that END was independently associated with AH[odds ratio(OR):1.744,95%confidence interval(CI):1.236-2.463;P=0.002].Subjects were classified into four groups representing quartiles.Compared with Q1,patients in the higher quartiles of SHR(Q2:OR:2.306,95%CI:1.342-3.960;P=0.002)(Q3:OR:2.284,95%CI:1.346-3.876;P=0.002)(Q4:OR:3.486,95%CI:2.088-5.820;P=0.001)and FBG(Q3:OR:1.746,95%CI:1.045-2.917;P=0.033)(Q4:OR:2.436,95%CI:1.476-4.022;P=0.001)had a significantly higher risk of END in the overall population.However,none of the glycemic indicators were found to be associated with ENI in patients with or without DM.CONCLUSION Our study demonstrated that glycemic indicators in patients with stroke treated with IVT were associated with the presence of END rather than ENI during the first 24 hours after admission.展开更多
The aim of this study was to identify the correlation between stress, lifestyle, and hyperglycemia among middle-aged Japanese male workers. We also analyzed the obese (OB) and non-obese (non- OB) groups pertaining to ...The aim of this study was to identify the correlation between stress, lifestyle, and hyperglycemia among middle-aged Japanese male workers. We also analyzed the obese (OB) and non-obese (non- OB) groups pertaining to the risk of hyperglycemia. A total of 353 male employees aged between 50 and 59 years taking health checkup sat a company in Japan were examined. The data were collected using validated scales of occupational stress and medical examination. Of the 353 employees, 335 (effective response rate 95%) were analyzed. “Support from colleagues” and “reward from work” reported by the OB group were lower than the non-OB group. The items “eating until satiety” and “having greasy meal often” were significantly more common in the OB group than in the non-OB group. There was a significant correlation between less sleep time and hyperglycemia in the OB group than in the non-OB group. The non-OB group reported more overtime hours than the OB group. Hyperglycemia in the non-OB group was positively correlated with long working hours, “workload,” and “mental workload.” The results indicated that the OB group would benefit from lifestyle interventions, for example, improvement in sleep time and eating habits may prevent hyperglycemia and eventually in obesity. Furthermore, it was suggested that stress in response to “workload” and “mental workload” owing to long working hours leads to hyperglycemia in the non-OB group. Therefore, the improvement of the workplace environment, reducing the number of hours at work, and stress management are required to prevent hyperglycemia in the non-OB group.展开更多
目的:探讨应激性高血糖比率(stress hyperglycemia ratio,SHR)与重症慢性阻塞性肺病(COPD)患者30天死亡率的相关性。方法:本研究基于重症监护医疗信息市场IV(Medical Information Mart for Intensive Care-Ⅳ,MIMIC-IV)数据库,纳入诊断...目的:探讨应激性高血糖比率(stress hyperglycemia ratio,SHR)与重症慢性阻塞性肺病(COPD)患者30天死亡率的相关性。方法:本研究基于重症监护医疗信息市场IV(Medical Information Mart for Intensive Care-Ⅳ,MIMIC-IV)数据库,纳入诊断为COPD的患者。主要结局事件为30天死亡率。根据SHR的四分位数将患者分组,采用生存分析与Cox回归分析评估SHR与30天死亡率的关联,并通过限制性立方样条分析确定其非线性关系。结果:SHR最高四分位组的30天死亡率显著高于其他组。经混杂因素校正后,与最低四分位组相比,最高四分位组的死亡风险显著增加。限制性立方样条图分析表明,SHR与30天死亡率之间存在“J”型非线性关系。结论:SHR升高与重症COPD患者30天死亡率的增加独立相关,SHR与重症COPD患者30天死亡率呈“J”型非线性关系。展开更多
基金supported by Medical Scientific Research Foundation of Guangdong Province,China(No.B2013401)
文摘Background Several studies have reported an association of hyperglycemia with increased mortality and complications in hospital patients with acute coronary syndrome （ACS）. However, the influence of stress hyperglycemia （SH） on the medium- and long-term prognoses in ACS patients has not yet been determined. Methods Random venous blood glucose levels were determined in 433 ACS patients and the patients were divided into two groups based on blood glucose results and disease histories. The 171 patients included in the experimental group had no history of diabetes, had no diabetes and/or glucose metabolism disorders during hospitalization and follow-up and had fasting blood glucose levels of I〉 7.0 mmol/L and random blood glucose levels 1〉 11.1 mmol/L. The 262 patients included in the control group had no history of diabetes, had no diabetes and/or glucose metabolism disorders during hospitalization and follow-up, and had fasting blood glucose levels 〈 6.1 mmoL/L and random blood glucose levels 〈 7.8 mmol/L. Basic clinical information, coronary angiographic lesion characteristics, PCI success rate, complication rate, incidence and morbidity rate of cardiovascular events during the hospitalization period and 6 years of follow-up were compared between the two groups. Results There was no significant difference in age, gender or disease history between the two groups. The triglyceride levels and the left ventricular ejection fractions were significantly higher （P = 0.00） and significantly lower （P = 0.03） in the experimental group than in the control group, respectively. Both groups were subjected to coronary angiography and PCI. The PCI success rates of the two groups did not differ significantly （P = 0.63）. The experimental group had more type B2 lesions, but fewer type A lesions compared with the control group. The experimental group had significantly more stents implanted compared with the control group （P 〈 0.05）. The cardiovascular events were significantly increased （P = 0.01） in the experimental group compared with the control group 1 year after discharge. The incidence of cardiovascular events did not differ significantly between the two groups 1-2 years after discharge. The event incidences were significantly higher （P -- 0.05） in the experimental group than in the control group at the end of follow-up. The experimental group was more prone to myocardial infarction and ischemic target vessel revascularization than the control group, but the control group was more prone to unstable stenocardia and heart failure than the experimental group. The psychogenic mortality of the two groups were similar. The interval and the overall mortality rates （P = 0.054） of the two groups were also similar. Conclusions Patients with ACS complicated by SH were more likely to have cardiovascular events 1 year after PCI, whereas SH did not affect the mid- or long-term prognoses of these patients. SH is an independent risk factor for cardiovascular events.
基金supported by the Ningbo Public Welfare Science and Technology Program,No.2022S023(to JY)Ningbo Natural Science Foundation,No.2022J211(to JS)+2 种基金Ningbo Medical and Health Brand Discipline,No.PPXK2018-04(to XG)Ningbo Top Medical and Health Research Program,No.2022020304(to XG)Key Laboratory of Precision Medicine for Atherosclerotic Diseases of Zhejiang Province,No.2022E10026(to YH)。
文摘Post-acute ischemic stroke hyperglycemia increases the risk of hemorrhagic transformation,which is associated with blood-brain barrier disruption.Brain microvascular endothelial cells are a major component of the blood-brain barrier.Intercellular mitochondrial transfer has emerged as a novel paradigm for repairing cells with mitochondrial dysfunction.In this study,we first investigated whether mitochondrial transfer exists between brain microvascular endothelial cells,and then investigated the effects of post-acute ischemic stroke hyperglycemia on mitochondrial transfer between brain microvascular endothelial cells.We found that healthy brain microvascular endothelial cells can transfer intact mitochondria to oxygen glucose deprivation-injured brain microvascular endothelial cells.However,post-oxygen glucose deprivation hyperglycemia hindered mitochondrial transfer and exacerbated mitochondrial dysfunction.We established an in vitro brain microvascular endothelial cell model of the blood-brain barrier.We found that post-acute ischemic stroke hyperglycemia reduced the overall energy metabolism levels of brain microvascular endothelial cells and increased permeability of the blood-brain barrier.In a clinical study,we retrospectively analyzed the relationship between post-acute ischemic stroke hyperglycemia and the severity of hemorrhagic transformation.We found that post-acute ischemic stroke hyperglycemia serves as an independent predictor of severe hemorrhagic transformation.These findings suggest that post-acute ischemic stroke hyperglycemia can aggravate disruption of the blood-brain barrier by inhibiting mitochondrial transfer.
基金Supported by the Foundation of Jiangsu Provincial Commission of Health and Family Planning,No.QNRC2016353the Commission of Health and Family Planning Xuzhou,No.KC22206.
文摘BACKGROUND Stress hyperglycemia(SH)is a common phenomenon that is present in about 50%of patients with acute ischemic stroke(AIS).It is thought to be a main risk factor for poor functional outcome among patients with AIS undergoing intravenous thrombolysis(IVT).AIM To investigate the predictive value of glycemic indicators for early neurological outcomes(ENOs)in patients with AIS treated with IVT.METHODS We retrospectively reviewed a prospectively collected database of patients with AIS who underwent IVT at the Department of Neurology,Second Affiliated Hospital of Xuzhou Medical University,between January 2017 and June 2022.ENO included early neurological improvement(ENI)and early neurological deterioration(END),defined as a decrease or increase in the National Institutes of Health Stroke Scale(NIHSS)score between baseline and 24 hours after IVT.We analyzed the associations between glycemic indicators[including admission hyperglycemia(AH),fasting blood glucose(FBG),and SH ratio(SHR)]and ENO in all patients and in subgroups stratified by diabetes mellitus(DM).RESULTS A total of 819 patients with AIS treated with IVT were included.Among these,AH was observed in 329 patients(40.2%).Compared with patients without AH,those with AH were more likely to have a higher prevalence of DM(P<0.001)and hypertension(P=0.031)and presented with higher admission NIHSS scores(P<0.001).During the first 24 hours after IVT,END occurred in 208 patients(25.4%)and ENI occurred in 156 patients(19.0%).Multivariate mixed logistic regression analyses indicated that END was independently associated with AH[odds ratio(OR):1.744,95%confidence interval(CI):1.236-2.463;P=0.002].Subjects were classified into four groups representing quartiles.Compared with Q1,patients in the higher quartiles of SHR(Q2:OR:2.306,95%CI:1.342-3.960;P=0.002)(Q3:OR:2.284,95%CI:1.346-3.876;P=0.002)(Q4:OR:3.486,95%CI:2.088-5.820;P=0.001)and FBG(Q3:OR:1.746,95%CI:1.045-2.917;P=0.033)(Q4:OR:2.436,95%CI:1.476-4.022;P=0.001)had a significantly higher risk of END in the overall population.However,none of the glycemic indicators were found to be associated with ENI in patients with or without DM.CONCLUSION Our study demonstrated that glycemic indicators in patients with stroke treated with IVT were associated with the presence of END rather than ENI during the first 24 hours after admission.
文摘The aim of this study was to identify the correlation between stress, lifestyle, and hyperglycemia among middle-aged Japanese male workers. We also analyzed the obese (OB) and non-obese (non- OB) groups pertaining to the risk of hyperglycemia. A total of 353 male employees aged between 50 and 59 years taking health checkup sat a company in Japan were examined. The data were collected using validated scales of occupational stress and medical examination. Of the 353 employees, 335 (effective response rate 95%) were analyzed. “Support from colleagues” and “reward from work” reported by the OB group were lower than the non-OB group. The items “eating until satiety” and “having greasy meal often” were significantly more common in the OB group than in the non-OB group. There was a significant correlation between less sleep time and hyperglycemia in the OB group than in the non-OB group. The non-OB group reported more overtime hours than the OB group. Hyperglycemia in the non-OB group was positively correlated with long working hours, “workload,” and “mental workload.” The results indicated that the OB group would benefit from lifestyle interventions, for example, improvement in sleep time and eating habits may prevent hyperglycemia and eventually in obesity. Furthermore, it was suggested that stress in response to “workload” and “mental workload” owing to long working hours leads to hyperglycemia in the non-OB group. Therefore, the improvement of the workplace environment, reducing the number of hours at work, and stress management are required to prevent hyperglycemia in the non-OB group.
文摘目的:探讨应激性高血糖比率(stress hyperglycemia ratio,SHR)与重症慢性阻塞性肺病(COPD)患者30天死亡率的相关性。方法:本研究基于重症监护医疗信息市场IV(Medical Information Mart for Intensive Care-Ⅳ,MIMIC-IV)数据库,纳入诊断为COPD的患者。主要结局事件为30天死亡率。根据SHR的四分位数将患者分组,采用生存分析与Cox回归分析评估SHR与30天死亡率的关联,并通过限制性立方样条分析确定其非线性关系。结果:SHR最高四分位组的30天死亡率显著高于其他组。经混杂因素校正后,与最低四分位组相比,最高四分位组的死亡风险显著增加。限制性立方样条图分析表明,SHR与30天死亡率之间存在“J”型非线性关系。结论:SHR升高与重症COPD患者30天死亡率的增加独立相关,SHR与重症COPD患者30天死亡率呈“J”型非线性关系。
