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Elastic wave insulation and propagation control based on the programmable curved-beam periodic structure
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作者 Jiajia MAO Hong CHENG Tianxue MA 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI CSCD 2024年第10期1791-1806,共16页
Curved-beams can be used to design modular multistable metamaterials(MMMs)with reprogrammable material properties,i.e.,programmable curved-beam periodic structure(PCBPS),which is promising for controlling the elastic ... Curved-beams can be used to design modular multistable metamaterials(MMMs)with reprogrammable material properties,i.e.,programmable curved-beam periodic structure(PCBPS),which is promising for controlling the elastic wave propagation.The PCBPS is theoretically equivalent to a spring-oscillator system to investigate the mechanism of bandgap,analyze the wave propagation mechanisms,and further form its geometrical and physical criteria for tuning the elastic wave propagation.With the equivalent model,we calculate the analytical solutions of the dispersion relations to demonstrate its adjustability,and investigate the wave propagation characteristics through the PCBPS.To validate the equivalent system,the finite element method(FEM)is employed.It is revealed that the bandgaps of the PCBPS can be turned on-and-off and shifted by varying its physical and geometrical characteristics.The findings are highly promising for advancing the practical application of periodic structures in wave insulation and propagation control. 展开更多
关键词 curved-beam based periodic structure equivalent stiffness spring-oscillator system dispersion relation wave propagation
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Prediction of Superconductivity for Oxides Based on Structural Parameters and Artificial Neural Network Method 被引量:1
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作者 Xueye WANG and Huang SONG (Department of Chemistry, Xiangtan University, Xiangtan 411105, China) Guanzhou QIU and Dianzuo WANG (Department of Mineral Engineering, Central South University of Technology, Changsha 410083, China) 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2000年第4期435-438,共4页
Superconductive properties for oxides were predicted by artificial neural network (ANN) method with structural and chemical parameters as inputs. The predicted properties include superconductivity for oxides, distribu... Superconductive properties for oxides were predicted by artificial neural network (ANN) method with structural and chemical parameters as inputs. The predicted properties include superconductivity for oxides, distributed ranges of the superconductive transition temperature (Tc) for complex oxides, and Tc values for cuprate superconductors. The calculated results indicated that the adjusted ANN can be used to predict superconductive properties for unknown oxides. 展开更多
关键词 Prediction of Superconductivity for Oxides based on structural Parameters and Artificial Neural Network Method
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Synthesis and Crystal Structure of a Zinc(II) Complex Salt with the Schiff Base of Picolinaldehyde N-oxide and Semicarbazone 被引量:5
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作者 YU Qing ZHU Li-Gang BIAN He-Dong DENG Ji-Hua YANG Xiao-E GUO Gui-Quan LIANG Hong 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 北大核心 2005年第11期1271-1275,共5页
The title zinc(Ⅱ) complex salt [Zn(H2O)6](ClO4)2-(PNOS)4, where PNOS is derived from picolinaldehyde N-oxide with semicarbazone, has been prepared and structurally characterized by X-ray single-crystal analys... The title zinc(Ⅱ) complex salt [Zn(H2O)6](ClO4)2-(PNOS)4, where PNOS is derived from picolinaldehyde N-oxide with semicarbazone, has been prepared and structurally characterized by X-ray single-crystal analysis. It crystallizes in triclinic, space group PI with a = 7.529(3), b = 10.206(4), c = 14.678(6)A, a = 86.293(6), β= 87.686(7), γ= 81.382(6)°, C28H44Cl2N16O22Zn, Mr = 1093.06, V = 1112.3(8) ,A^3 Z = 1, Dc = 1.632 g/cm^3, S = 1.089, μ(MoKa) = 0.773 mm^-1, F(000) = 564, the final R = 0.0438 and wR = 0.1076 for 3888 independent reflections with Rint = 0.0224. The crystal structure possesses a [Zn(H2O)6]^2+ cation, two ClO4^- anions and four PNOSs. In the crystal structure, Zn^2+ cation is located at the symcenter and coordinated by six water molecules. In [Zn(H2O)6]^2+, an elongate octahedral complex cation, the average Zn-O bond length is 2.087(2) A. There exist a lot of H bonds in the structure, linking the cation [Zn(H2O)6]^2+, anion ClO4^- and PNOS to form a 3D network. 展开更多
关键词 zinc(Ⅱ) complex salt picolinaldehyde N-oxide SEMICARBAZONE crystal structure Schiff base
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Optimal design and effectiveness evaluation for inerter-based devices on mitigating seismic responses of base isolated structures 被引量:3
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作者 Li Yafeng Li Shouying Chen Zhengqing 《Earthquake Engineering and Engineering Vibration》 SCIE EI CSCD 2021年第4期1021-1032,共12页
The optimal design and effectiveness of three control systems,tuned viscous mass damper(TVMD),tuned inerter damper(TID)and tuned mass damper(TMD),on mitigating the seismic responses of base isolated structures,were sy... The optimal design and effectiveness of three control systems,tuned viscous mass damper(TVMD),tuned inerter damper(TID)and tuned mass damper(TMD),on mitigating the seismic responses of base isolated structures,were systematically studied.First,the seismic responses of the base isolated structure with each control system under white noise excitation were obtained.Then,the structural parameter optimizations of the TVMD,TID and TMD were conducted by using three different objectives.The results show that the three control systems were all effective in minimizing the root mean square value of seismic responses,including the base shear of the BIS,the absolute acceleration of structural SDOF,and the relative displacement between the base isolation floor and the foundation.Finally,considering the superstructure as a structural MDOF,a series of time history analyses were performed to investigate the effectiveness and activation sensitivity of the three control systems under far field and near fault seismic excitations.The results show that the effectiveness of TID and TMD with optimized parameters on mitigating the seismic responses of base isolated structures increased as the mass ratio increases,and the effectiveness of TID was always better than TMD with the same mass ratio.The TVMD with a lower mass ratio was more efficient in reducing the seismic response than the TID and TMD.Furthermore,the TVMD,when compared with TMD and TID,had better activation sensitivity and a smaller stroke. 展开更多
关键词 base isolated structure inerter optimal design seismic response vibration control
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Structured Illumination Chip Based on Integrated Optics 被引量:1
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作者 刘勇 王辰 +3 位作者 Anastasia Nemkova 胡诗铭 李智勇 俞育德 《Chinese Physics Letters》 SCIE CAS CSCD 2016年第5期46-49,共4页
A compact structured illumination chip based on integrated optics is proposed and fabricated on a silicon-on- insulator platform. Based on the simulation of Caussian beam interference, we adopt a chirped diffraction g... A compact structured illumination chip based on integrated optics is proposed and fabricated on a silicon-on- insulator platform. Based on the simulation of Caussian beam interference, we adopt a chirped diffraction grating to achieve a specific interference pattern. The experimental results match well with the simulations. The portability and flexibility of the structured illumination chip can be increased greatly through horizontal encapsulation. High levels of integration, compared with the conventional structured illumination approach, make this chip very compact, with a footprint of only around 1 mm2. The chip has no optical lenses and can be easily combined with a microfluidic system. These properties would make the chip very suitable for portable 3D scanner and compact super-resolution microscopy applications. 展开更多
关键词 of for Structured Illumination Chip based on Integrated Optics IS on SOI into been
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Polarization-Insensitive Magnetic Quadrupole-Shaped and Electric Quadrupole-Shaped Fano Resonances Based on a Plasmonic Composite Structure 被引量:1
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作者 董晨 李宝 +5 位作者 李韩笑 刘慧 陈孟琪 李冬冬 闫长春 张道华 《Chinese Physics Letters》 SCIE CAS CSCD 2016年第7期68-71,共4页
A combined structure with the unit cell consisting of four sub-units with 90° rotation in turn is designed. Each of sub-units is composed of two gold rods in transverse arrangement and one gold rod in longitudina... A combined structure with the unit cell consisting of four sub-units with 90° rotation in turn is designed. Each of sub-units is composed of two gold rods in transverse arrangement and one gold rod in longitudinal arrangement. Simulating electromagnetic responses of the structure, we verify that the structure exhibits the double Fano resonances, which originate from the coupling between magnetic quadrupoles and electric dipoles and the coupling between electric quadrupoles and electric dipoles. Simulation results also demonstrate that the structure is polarization-insensitive and shows an analogue of electromagnetically induced transparency at the two Fano resonances. Such a plasmonic structure has potential applications in photoelectric elements. 展开更多
关键词 of is it in Polarization-Insensitive Magnetic Quadrupole-Shaped and Electric Quadrupole-Shaped Fano Resonances based on a Plasmonic Composite Structure MODE that on
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PHYLETIC RELATIONSHIP OF PROTEIN STRUCTURES BASED ON SPATIAL PREFERENCE OF RESIDUES
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作者 Chun Xu QU Lu Hun LAI +2 位作者 Xiao Jie XU Xue Mei YUAN You Qi TANG 《Chinese Chemical Letters》 SCIE CAS CSCD 1991年第11期867-870,共4页
A distance measure that infers to indicate the evolutionary relationship of protein structures has been developed based on spatial preference factors of residues. The spatial preference factor is a reflection of the e... A distance measure that infers to indicate the evolutionary relationship of protein structures has been developed based on spatial preference factors of residues. The spatial preference factor is a reflection of the environment of residues in tertiary structure. Compared with the phyletic relationships derived from sequence homologies and three-dimensional structures, we find that the two lines of evolution are similar in general. This approach is applied to a group of glins here. 展开更多
关键词 PHYLETIC RELATIONSHIP OF PROTEIN STRUCTURES baseD ON SPATIAL PREFERENCE OF RESIDUES der
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Syntheses and Crystal Structures of Calix[4]arene Dithiocarbazate Schiff Bases
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作者 SUN Jing LIU Dong-mei WANG Jin-xiang YAN Chao-guo 《Chemical Research in Chinese Universities》 SCIE CAS CSCD 2010年第4期572-577,共6页
The regioselective syntheses of novel p-tert-butylcalix[4]arenes with functional aldehyde and dithiocarbazate Schiff base groups were carried out. p-tert-Butylcalix[4]arene was alkylated with o-, p-(ω-chloroalkoxy)... The regioselective syntheses of novel p-tert-butylcalix[4]arenes with functional aldehyde and dithiocarbazate Schiff base groups were carried out. p-tert-Butylcalix[4]arene was alkylated with o-, p-(ω-chloroalkoxy)- benzaldehydes in the system of K2CO3/KI/CH3CN to give calixarene 1,3-dialdehydes. Then the condensation reactions of active calixarene aldehydes with S-methyl and S-benzyldithiocarbazate, calixarene sulfur-containing Schiff bases were efficiently obtained in satisfied yields. The single crystal analysis of the four representative products shows that calixarene aldehydes and Schiff bases exist in cone conformation and there are interesting intermolecular hydrogen-bands and π...π interaction in the crystals. 展开更多
关键词 CALIXARENE Alkvlation S-Alkvldithiocarbazate Schiff base Crystal structure
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High-Efficiency Green Phosphorescent Organic Light-Emitting Diode Based on Simplified Device Structures
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作者 张宏梅 王丹蓓 +1 位作者 曾文进 闫敏楠 《Chinese Physics Letters》 SCIE CAS CSCD 2015年第9期140-144,共5页
A high-efficiency green phosphorescent organic light emitting diode with a simplified structure is achieved that is free of a hole transport layer. The design of this kind of device structure not only saves the consum... A high-efficiency green phosphorescent organic light emitting diode with a simplified structure is achieved that is free of a hole transport layer. The design of this kind of device structure not only saves the consumption of organic materials but also greatly reduces the structural heterogeneities and effectively facilitates the charge injection into the emissive layer. The resulting green phosphorescent organic light-emitting diodes (PHOLEDs) exhibit higher electroluminescent efficiency. The maximum external quantum efficiency and current efficiency reach 23.7% and 88 cd/A, respectively. Moreover the device demonstrates satisfactory stability, keeping 23.7% and 88cd/A, 22% and 82cd/A, respectively, at a luminance of 100 and 1000cd/m2. The working mechanism for achieving high efficiency based on such a simple device structure is discussed correspondingly. The improved charge carrier injection and transport balance are proved to prominently contribute to achieve the high efficiency and great stability at high luminance in the green PHOLEDs. 展开更多
关键词 HTL NPB High-Efficiency Green Phosphorescent Organic Light-Emitting Diode based on Simplified Device Structures OLEDS PEDOT
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Syntheses, Crystal Structures and Antibacterial Activities of Cobalt(Ⅱ) and Manganese(Ⅱ) Complexes with Schiff Base Ligand Derived from Tryptamine
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作者 刘超 牛俊峰 +2 位作者 李阳 徐基贵 刘新华 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 2016年第7期1002-1010,共9页
Two new mononuclear complexes, namely [Co(L)2](1) and [Mn(L)2](2)(HL = N-(3-methylsalicylidene)tryptamine), have been synthesized by the reactions of the ligand with cobalt acetate or manganese acetate in ... Two new mononuclear complexes, namely [Co(L)2](1) and [Mn(L)2](2)(HL = N-(3-methylsalicylidene)tryptamine), have been synthesized by the reactions of the ligand with cobalt acetate or manganese acetate in anhydrous ethanol. The crystal structures of the complexes were characterized by IR spectrum, elemental analysis, PXRD and single-crystal X-ray diffraction analysis. Complex 1 crystallizes in monoclinic, space group C2/c, with a = 23.146(2), b = 9.4864(10), c = 13.9261(15)A, β = 102.898(2)°, V = 2980.6(5) ?3, Z = 4, Dc = 1.367 g/cm3, F(000) = 1284 and μ = 0.616 mm^-1. Complex 2 crystallizes in monoclinic, space group P21/n, with a = 14.807(11), b = 13.118(10), c = 16.663(13) A, β = 111.237(14)°, V = 3017(4) A^3, Z = 4, Dc = 1.342 g/cm^3, F(000) = 1276 and μ = 0.477 mm-1. The units of complex 1 are linked by intermolecular N–H…π hydrogen bonds into infinite 1D chains, which are further extended into a 3D supramolecular structure by a series of π···π stacking interactions. The units of complex 2 are linked by intermolecular N–H…π hydrogen bonds and C–H…π hydrogen bonds into an infinite 3D supramolecular structure. Meanwhile, the antibacterial activities of the ligand and its complexes have been tested against four kinds of bacteria. The results show that the three compounds all have excellent antibacterial activities and that 1 and 2 possess stronger inhibiting effects against the bacteria than the Schiff base. 展开更多
关键词 antibacterial activity crystal structure Schiff base Co(Ⅱ) complex Mn(Ⅱ)
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Memory Behaviors Based on ITO/Graphene Oxide/Al Structure
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作者 仪明东 郭佳林 +4 位作者 胡波 夏先海 范曲立 解令海 黄维 《Chinese Physics Letters》 SCIE CAS CSCD 2015年第7期138-141,共4页
We investigate the memory properties of the ITO/graphene oxide/Al diodes. It is found that the devices show different memory behaviors with the diverse geometry and thickness of Al. When the thickness of the Al electr... We investigate the memory properties of the ITO/graphene oxide/Al diodes. It is found that the devices show different memory behaviors with the diverse geometry and thickness of Al. When the thickness of the Al electrode is relatively thick, the device of the cross-point Al electrode shows a three-level memory effect, and the counterpart device of the cross-bar Al electrode exhibits a volatile static random access memory effect. When the thickness of the AI electrode is thinner, the above devices demonstrate a flash memory effect. The different memory behaviors of ITO/GO/AI diodes are ascribed to the mode and degree of reduction and oxidation of GO. 展开更多
关键词 GO Memory Behaviors based on ITO/Graphene Oxide/Al Structure ITO AL
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Study on the Interior Market Network Structure and Its Efficiency in a Knowledge Based Company
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作者 Zuanhuang Lin Yuqi Han Liping Lin 《Chinese Business Review》 2005年第7期49-53,62,共6页
A knowledge based company is the microcosmic foundation of the knowledge economy, the design of its organization structure should amplify the company competence to be agile to the knowledge elements. This paper expoun... A knowledge based company is the microcosmic foundation of the knowledge economy, the design of its organization structure should amplify the company competence to be agile to the knowledge elements. This paper expounds an interior market network structure which is fit for the company intellectual capital operation, and analyses this organization pattern about the reasons of existence, the effectiveness of growing up in scale, the economies of knowledge distribution and the efficiency of operation, and it will provide some beneficial theoretical guidance about how can a company improve its competition competence in the knowledge environment through organization innovation. 展开更多
关键词 knowledge based company interior market network structure efficiency intellectual capital operation
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Syntheses and Crystal Structures of Hg(Ⅱ)and Ag(Ⅰ)Complexes Containing 2-Acetylpyridine-paminobenzoylhydrazone Ligand 被引量:2
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作者 黄超 陈冬梅 朱必学 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 2017年第3期471-477,共7页
The two complexes [HgI_2L](DMF)(1) and [AgL_2](ClO_4)(CH_3CN)(2) were synthesized from the reaction of Schiff base ligand(2-acetylpyridine-p-aminobenzoylhydrazone)(L) with HgI_2 or AgClO_4 respectively. ... The two complexes [HgI_2L](DMF)(1) and [AgL_2](ClO_4)(CH_3CN)(2) were synthesized from the reaction of Schiff base ligand(2-acetylpyridine-p-aminobenzoylhydrazone)(L) with HgI_2 or AgClO_4 respectively. The compounds are characterized by ^1H NMR,FTIR and elemental analysis. The structures of the ligand and two complexes are measured via single-crystal X-ray diffraction. In these two complexes,the structures are both distorted triangular bipyramids with five-coordinated centers. 展开更多
关键词 Schiff base acylhydrazone complex crystal structure
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Crystal Structure of a Hexanuclear Silver(Ⅰ) Compound [Ag_6L^66]·4DMF and Luminescence Discussion of a Series of Silver(Ⅰ) Clusters 被引量:1
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作者 孙巧珍 刘恢 柴立元 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 2013年第5期667-672,共6页
A new silver(Ⅰ) compound 6 ([Ag6L66]·4DMF) containing thiosemicarbazone with the group of 2-chloro-1-benzene was synthesized and structurally characterized by single-crystal X-ray diffraction, elemental anal... A new silver(Ⅰ) compound 6 ([Ag6L66]·4DMF) containing thiosemicarbazone with the group of 2-chloro-1-benzene was synthesized and structurally characterized by single-crystal X-ray diffraction, elemental analysis and fluorescence spectrum. The title compound 6 crystallizes in monoclinic, space group C2/c with a = 26.9236(18), b = 15.2553(8), c = 24.6237(13) , β = 103.0680(10)°, V = 9851.7(10)3, C58H66Ag6Cl6N20O3S6, Mr = 2143.59, Dc = 1.445 g/cm3, μ(MoKα) = 1.503 mm-1, F(000) = 4232, Z = 4, the final R = 0.0565 and wR = 0.1654 for 5831 observed reflections (Ⅰ 〉 2σ(Ⅰ)). Similar to the structure of the compounds we have reported, compound 6 also exhibits a hexanuclear silver(Ⅰ) cluster. In the cluster, the S atom of ligand L6 (L6 = 2-chloro-1-benzaldehyde thiosemicarbazone) served as a triply bridged chelator to connect the six silver atoms into a Ag6L66 cluster. The luminescence property of compound 6 was investigated at room temperature and compared with other similar compounds in order to find the factors influencing their luminescent property. 展开更多
关键词 hexanuclear sliver(Ⅰ) cluster thiosemicarbazone Schiff base crystal structure LUMINESCENCE
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Structural-acoustic topology optimization analysis based on evolutionary structural optimization approach 被引量:1
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作者 CHEN Luyun WANG Deyu (State Key Laboratory of Ocean Eng.,Shanghai Jiao Tong University Shanghai 200030) 《Chinese Journal of Acoustics》 2009年第4期332-342,共11页
The continuum structural-acoustic topology optimization with external loading is investigated herein. Finite element method (FEM) is used to obtain the structural frequency response and boundary element method (BEM... The continuum structural-acoustic topology optimization with external loading is investigated herein. Finite element method (FEM) is used to obtain the structural frequency response and boundary element method (BEM) is adopted to perform exterior acoustic radiation analysis. The evolutionary structural optimization (ESO) is served as an optimization method in structural-acoustic radiation topology analysis. The acoustic radiation optimization of a plate under harmonic excitation is given for example. The numerical results show that using ESO solution to analyze structural-acoustic topology optimization is feasible and effective. 展开更多
关键词 ESO structural-acoustic topology optimization analysis based on evolutionary structural optimization approach
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Synthesis and Crystal Structure of a Novel Bis(chlorido)-bridged One-dimensional Chain-like Copper(Ⅱ) Polymer 被引量:1
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作者 张雷 赵斌 +2 位作者 田来进 侯克宁 李言信 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 2016年第4期633-639,共7页
A copper(Ⅱ) complex [LCu2Cl4]n was synthesized by a new bis-Schiff base ligand containing quinoline unit, 1,4-bis[2-(4-fluorophenyl)iminomethyl-8-quinolinoxy]butane(L). X-ray crystal structure shows that it is ... A copper(Ⅱ) complex [LCu2Cl4]n was synthesized by a new bis-Schiff base ligand containing quinoline unit, 1,4-bis[2-(4-fluorophenyl)iminomethyl-8-quinolinoxy]butane(L). X-ray crystal structure shows that it is a binuclear complex, and the crystal belongs to the triclinic system, space group P1, with a = 9.387(2), b = 9.968(2), c = 10.291(2) ?, α = 87.532(3), β = 63.762(2), γ = 86.628(3)o, V = 862.1(3) ?^3, Z = 1, Dc = 1.640 Mg/m^3, F(000) = 428, R = 0.0416 and wR = 0.1141. Each Cu(Ⅱ) metal ion coordinates with a quinoline N atom, an imine N atom, an ether oxygen atom and three chlorides, forming a distorted six-coordinated octahedronal structure. Each copper(Ⅱ) complexation unit links with one of the adjacent ligand copper complexation units through the chlorido bridging groups, thus generating an infinite one-dimensional chain structure. Such 1D chains further construct a 2D network structure by π-π stacking interactions. 展开更多
关键词 Schiff base copper complex polymer crystal structure quinoline derivatives
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Synthesis, Structure and Comparison of Luminescent Property between Two Hexanuclear Silver(Ⅰ) Thiosemicarbazone Clusters
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作者 孙巧珍 廖松义 +3 位作者 柴立元 徐效文 姚俊俊 方琼佳丽 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 2012年第9期1229-1234,共6页
A new silver(Ⅰ) compound 4 containing thiosemicarbazone with group 2-quinoline was synthesized and structurally characterized by single-crystal X-ray diffraction, elemental analysis and fluorescence spectrum. Compo... A new silver(Ⅰ) compound 4 containing thiosemicarbazone with group 2-quinoline was synthesized and structurally characterized by single-crystal X-ray diffraction, elemental analysis and fluorescence spectrum. Compound 4 crystallizes in triclinic, space group P1 with a = 12.2710(9), b = 16.9281(13), c = 17.2984(13), α = 112.8500(10), β = 103.4890(10), γ = 102.6860(10)°, V = 3020.9(4) 3, C80H94Ag6N28O6S6, Mr = 2383.41, Dc = 1.310 g/cm3, μ(MoKα) = 1.108 mm-1, F(000) = 1196, Z = 1, the final R = 0.0567 and wR = 0.1368 for 5112 observed reflections (I 〉 2σ(I)). Similar to the structure of compound 2 we have reported, compound 4 also exhibits a hexanuclear silver(Ⅰ) cluster. In the cluster, the S atom of ligand L4 (L4 = 2-quinolinecarboxaldehyde thiosemicarbazone) serves as a triply bridged chelator to connect the six silver atoms into a Ag6L46 cluster. The luminescence property of 4 is investigated at room temperature and compared with that of 2. 展开更多
关键词 hexanuclear siver(1) cluster thiosemicarbazone Schiff base crystal structure LUMINESCENCE
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Synthesis and Crystal Structure of 5-Nitro-4-salicylidene-amino-3-methyl-1,2,4-triazol-5-thione
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作者 WENLi-rong LIMing +3 位作者 WANGShu-wen ZHANGShu-sheng LIXue-mei OUYANGPing-kai 《Chemical Research in Chinese Universities》 SCIE CAS CSCD 2004年第6期722-724,共3页
The crystal structure of 5-nitro-4-salicylideneamino-3-methyl-1,2,4-triazole-5-thione ([C 10 H 9N 5O 3S]·HCON(CH 3) 2, M r=352.38)(CCDC No. 216094) was determined by the single crystal X-ray diffraction... The crystal structure of 5-nitro-4-salicylideneamino-3-methyl-1,2,4-triazole-5-thione ([C 10 H 9N 5O 3S]·HCON(CH 3) 2, M r=352.38)(CCDC No. 216094) was determined by the single crystal X-ray diffraction method. The crystal belongs to a triclinic system, the space group is P1 with unit cell constants a= 0.6113(2) nm, b=1.0836(4) nm, c=1.3132(5) nm, α=74.523(7)°, β=117.68(3)°, γ= 79.769(7)°, V=0.8245(5) nm 3, Z=2, D c=1.419 g/cm 3, μ=0.228 mm -1 , F(000)=368, R and wR are 0.0579 and 0.1040, respectively, beasd on 3348 unique reflections of which 1925 reflections were observed[I>2σ(I)]. The results indicate that the title compound can be assigned to the thione tautomeric form rather than the thiol tautomeric form. It contains a five membered triazole ring and a phenyl ring with a dihedral angle of 4.35°. The intermolecular hydrogen bond N3_H3…S1, O1_H1…O4 can be observed. 展开更多
关键词 1 2 4-Triazole-5-thione Schiff base Crystal structure Synthesis
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Identification of Novel CDK9 Inhibitors with Better Inhibitory Activity and Higher Selectivity for Cancer Treatment by an Effective Two-Stage Virtual Screening Strategy
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作者 Szu-Hung Chen Yu-Ru Wang +2 位作者 Yih Ho Shu-Juan Lin Hsuan-Liang Liu 《Journal of Biomedical Science and Engineering》 2021年第12期371-390,共20页
The aberrant overexpression of cyclin-dependent kinase 9 (CDK9) in cancer cells results in the loss of proliferative control, making it an attractive therapeutic target for various cancers. However, the highly structu... The aberrant overexpression of cyclin-dependent kinase 9 (CDK9) in cancer cells results in the loss of proliferative control, making it an attractive therapeutic target for various cancers. However, the highly structural similarity between CDK9 and CDK2 makes the development of novel selective CDK9 inhibitors a challenging task and thus limits their clinical applications. Here, an effective two-stage virtual screening strategy was developed to identify novel CDK9 inhibitors with better inhibitory activity and higher selectivity. The first screening stage aims to select potential compounds with better inhibitory activity than Roniciclib, one of the most effective CDK9 inhibitors, through reliable structure-based pharmacophoric virtual screening and accurate molecular docking analyses. The second stage employs a very detailed visual inspection process, in which several structural criteria describing the major difference between the binding pockets of CDK9 and CDK2 are taken into consideration, to identify compounds with higher selectivity than CAN508, one of the CDK9 inhibitors with distinguished selectivity. Finally, three compounds (NCI207113 from NCI database and TCM0004 and TCM3282 from TCM database) with better inhibitory activity and higher selectivity were successfully identified as novel CDK9 inhibitors. These three compounds also display excellent binding stabilities, great pharmacokinetic properties and low toxicity in MD simulations and ADMET predictions. Besides, the results of binding free energy calculations suggest that enhancing van der Waals interaction and nonpolar solvation energy and/or reducing polar solvation energy can significantly improve the binding affinity of these CDK9 inhibitors. Their clinical potentials to serve as anticancer drug candidates can be further evaluated through a series of <em>in vitro/in vivo</em> bioassays in the future. To the best of our knowledge, this is the first attempt to identify novel CDK9 inhibitors with both better inhibitory activity and higher selectivity through an effective two-stage virtual screening strategy. 展开更多
关键词 Cyclin-Dependent Kinase 9 (CDK9) Structure based Pharmacophore Modeling Virtual Screening
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Synthesis,Crystal Structure and Biological Activity of(E)-3-Chloro-2-(2-(2-methylbenzylidene)-hydrazinyl)pyridine
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作者 孙国香 石延霞 +5 位作者 翟志文 杨明艳 翁建全 谭成侠 刘幸海 李宝聚 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 2016年第4期640-644,共5页
The novel Schiff base(E)-3-chloro-2-(2-(2-methylbenzylidene)hydrazinyl)pyridine was synthesized and characterized by ^1H NMR, MS, elemental analysis and X-ray diffraction. The compound crystallizes in monoclinic... The novel Schiff base(E)-3-chloro-2-(2-(2-methylbenzylidene)hydrazinyl)pyridine was synthesized and characterized by ^1H NMR, MS, elemental analysis and X-ray diffraction. The compound crystallizes in monoclinic space group Pbca with a = 14.6638(3), b = 7.7522(2), c = 20.3850(4) A, V = 2317.30(9) A^3, Z = 8, R = 0.063 and w R = 0.1922. The title compound exhibits good antifungal activity against Stemphylium lycopersici(Enjoji) Yamamoto and Fusarium oxysporum sp. cucumebrium. 展开更多
关键词 Schiff base synthesis crystal structure antifungal activity
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