Changes in neurotransmitter levels,brain structural characteristics,and their correlation with PANSS scores in patients with firstepisode schizophrenia

BACKGROUND In patients with schizophrenia,the brain structure and neurotransmitter levels change,which may be related to the occurrence and progression of this disease.AIM To explore the relationships between changes in neurotransmitters,brain structural characteristics,and the scores of the Positive and Negative Symptom Scale(PANSS)in patients with first-episode schizophrenia.METHODS The case group comprised 97 patients with schizophrenia,who were evaluated using the Canadian Neurological Scale and confirmed by laboratory tests at Ningbo Mental Hospital from January 2020 to July 2022.The control group comprised 100 healthy participants.For all participants,brain structural characteristics were explored by measuring brain dopamine(DA),glutamic acid(Glu),and gamma-aminobutyric acid(GABA)levels,with magnetic resonance imaging.The case group was divided into negative and positive symptom subgroups using PANSS scores for hierarchical analysis.Linear correlation analysis was used to analyze the correlations between neurotransmitters,brain structural character istics,and PANSS scores.RESULTS Patients in the case group had higher levels of DA and lower levels of Glu and GABA,greater vertical and horizontal distances between the corpus callosum and the inferior part of the fornix and larger ventricle area than patients in the control group(P<0.05).Patients with positive schizophrenia symptoms had significantly higher levels of DA,Glu,and GABA than those with negative symptoms(P<0.05).In patients with positive schizophrenia symptoms,PANSS score was significantly positively correlated with DA,vertical and horizontal distances between the corpus callosum and the infrafornix,and ventricular area,and was significantly negatively correlated with Glu and GABA(P<0.05).In patients with negative schizophrenia symptoms,PANSS score was significantly positively correlated with DA,vertical distance between the corpus callosum and the infrafornix,horizontal distance between the corpus callosum and the infrafornix,and ventricular area,and was significantly negatively correlated with Glu and GABA(P<0.05).CONCLUSION In patients with first-episode schizophrenia,DA levels increased,Glu and GABA levels decreased,the thickness of the corpus callosum increased,and these variables were correlated with PANSS scores.

Diagnostic Study on the Structural Characteristics of a Typical Mei-yu Front System and Its Maintenance Mechanism

In this paper, a typical mei-yu front process with heavy rainfall from June 12 to 15 in 1998 is analyzed. The results show that the mei-yu front is a front system which consists of an iso-theta(e) dense area with strong horizontal gradient, a deep-convective cloud tower band, a passageway transporting warm and moist air flow from the summer monsoon surge in the mid and low levels to the south of the mei-yu front, and a migrating synoptic scale trough to the north of the mei-yu front, which transports cold and dry air southward in the mid and upper levels. The maintenance of the mei-yu front is realized by: (1) is a positive feedback between the moist physical process enhancing frontogenesis and the development of the strong convective system in front of the mei-yu front; (2) the sustaining system to the north of the mei-yu front which is a migrating synoptic scale trough transporting cold and dry air to the mei-yu front and positive vorticity to the mesoscale system in front of the mei-yu front.

Structural Characteristics and their Significance for Hydrocarbon Accumulation in the Northern Slope of the Central Sichuan Paleo-uplift

Based on 2D and 3D seismic data,the latest drilling data and field outcrop data of the northern slope of the Central Sichuan paleo-uplift,the structural analysis method is used to analyze unconformity development characteristics and fault characteristics during the key structural transformation period,discussing the influence of the structural characteristics on the hydrocarbon accumulation of deep carbonate rocks.The results show that:(1)The two key unconformities of the Tongwan and Caledonian periods were primarily developed in deep carbonate rocks.Firstly,Tongwan’s unconformities are characterized by regional disconformities between the second and third members of the Dengying Formation,the top formation of the Sinian and the lower Cambrian,strips of which zigzag through the north and south sides of the study area.Secondly,the Caledonian unconformity is characterized by a regional unconformable contact between the lower Permian and the ower Paleozoic strata.From NE to SW,the age of the strata,which were subject to erosion,changes from new to old,the denudation distribution showing as a nose-shaped structure which inclines towards the ENE.(2)Boundary fault and transtensional strike-slip faults developed in the Sinian to Paleozoic strata.In profile,there are three types of structural styles:steep and erect,flower structures,’Y’and reversed’Y’type faults.In plane view,the Sinian developed extensional boundary faults extending in an almost NS direction,strike-slip faults developing and extending linearly in approximately EW,WNW and NE strikes in the Cambrian,with characteristically more in the south and less in the north.(3)The faults in the northern slope show obvious zonal deformations in transverse view as well as significant stages and stratified activity in a longitudinal direction.Among them,the activity of faults in the Sinian was the strongest,followed by the activity in the Cambrian period,the activity intensity of faults in the Permian period being the weakest.This fault activity can be divided into four periods:Sinian,Cambrian-Permian,the early Indosinian period and the late Indosinian-Himalayan period,the transtensional strikeslip faults being the products of oblique extensions of pre-existing weak zones in the Xingkai and Emei taphrogenesis,with a particular inheritance in the main faults.(4)Combined with hydrocarbon accumulation factors,it is considered that the epigenetic karstification of the Tongwan and Caledonian unconformities in the northern slope controlled the formation and distribution of carbonate karst reservoirs over a large area,also acting as a good pathway for oil and gas migration.The extensional faults developed at the margin of the NS trending rift,controlling the sag-platform sedimentary pattern in the Dengying Formation of the Sinian.Strike-slip faults in NE,WNW and ENE directions may control the microgeomorphological pattern inside the platform and intensify the differential distribution of grain beach facies.The multi-stage hereditary activity of strike-slip faults not only improved the porosity and permeability of the reservoirs,but also acted as the main channel of oil and gas migration,providing favorable conditions for the development of the current multi-layer gasbearing scenario in the northern slope of the Central Sichuan Basin.

COMPARISON OF THE STRUCTURAL CHARACTERISTICS OF DEVELOPED VERSUS UNDEVELOPED MID-LEVEL VORTEXES

Using the NCEP 1°×1°reanalysis data,several obvious differences of the structural characteristics of developed versus undeveloped mid-level vortexes are studied.First,the central vorticity of the developed mid-level vortex increases towards higher levels while the undeveloped one decreases.The low-level convergence structure maintains well in the developed mid-level vortex whereas the undeveloped one does badly.Second,on the one hand,according to the symmetric analysis,the horizontal wind field and wind vertical section of the developed mid-level vortex are well symmetric while those of the undeveloped one are less symmetric.Meanwhile,weak wind vertical shear help the developed mid-level vortex to establish a warm core in upper-and mid-levels of the troposphere.On the other hand,according to the balance analysis,better balance between wind and pressure is shown in the mid-and lower-levels of the troposphere of the developed mid-level vortex than in those of the undeveloped vortex.Third,positive anomaly of potential vorticity is enhanced and developed in the vertical direction of the developed vortex.However,the undeveloped vortex weakens with a weak positive anomaly.

Structural Characteristics of the Suoluogou Gold Deposit in Muli County, West Sichuan Province

The Suoluogou gold deposit in Muli County of Sichuan Province is located in the southern section of the Ganzi- Litang suture zone （Figs. la, b）, which is the largest gold deposit discovered in this suture zone in recent years. At present, the exploration of the Suoluogou gold deposit is still in progress, and the amount of resource is increasing.

Structural Characteristics of Semen coicis Resistant Starch and Its Effect on the Proliferation of Bifidobacterium bifidum

Semen coicis resistant starch is a type of starch which has undergone retrogradation. In this study,the structural characteristics of Semen coicis native starch,high-amylose maize starch,and heat-moisture treated Semen coicis resistant starch were investigated. The field emission scanning electron microscopy results indicated that compared to Semen coicis native starch and high-amylose maize starch,the surface of heat-moisture treated Semen coicis resistant starch was rough and full of irregular layered strips. The Fourier transform infrared spectroscopy measurements indicated the degree of ordered structure values of Semen coicis native starch,high-amylose maize starch,and heat-moisture treated Semen coicis resistant starch are 1.355,1.372,and 1.410,respectively,and the degree of double helix values is 1.931,1.942,and 2.027,respectively,indicating that the degree of ordered structure and double helix structure of heat-moisture treated Semen coicis resistant starch is both higher than those of Semen coicis native starch and high-amylose maize starch. ^（13） C nuclear magnetic resonance spectroscopy showed that Semen coicis native starch and high-amylose maize starch exhibited A-type crystal structures,while heat-moisture treated Semen coicis resistant starch displayed B-type crystal structures. The relative crystallinity of Semen coicis native starch,high-amylose maize starch,and heat-moisture treated Semen coicis resistant starch is 76.41,85.36,and 87.25,respectively,and the percentages of amorphous region are 5.78,4.72,and 4.39,respectively. Additionally,heat-moisture treated Semen coicis resistant starch could increase the proliferation of Bifidobacterium bifidum more than Semen coicis native starch or high-amylose maize starch. Bifidobacterium bifidum displayed a higher tolerance under simulated gastrointestinal tract conditions such as low p H,bile acid,pepsin,and trypsin in heat-moisture treated Semen coicis resistant starch medium than in Semen coicis native starch or high-amylose maize starch media.

Effect of structural characteristics distribution on strength demand and ductility reduction factor of MDOF systems considering soil-structure interaction

It is known that structural stiffness and strength distributions have an important role in the seismic response of buildings. The effect of using different code-specified lateral load patterns on the seismic performance of fixed-base buildings has been investigated by researchers during the past two decades. However, no investigation has yet been carried out for the case of soil-structure systems. In the present study, through intensive parametric analyses of 21,600 linear and nonlinear MDOF systems and considering five different shear strength and stiffness distribution patterns, including three code-specified patterns as well as uniform and concentric patterns subjected to a group of earthquakes recorded on alluvium and soft soils, the effect of structural characteristics distribution on the strength demand and ductility reduction factor of MDOF fixed-base and soil-structure systems are parametrically investigated. The results of this study show that depending on the level of inelasticity, soil flexibility and number of degrees-of-freedoms (DOFs), structural characteristics distribution can significantly affect the strength demand and ductility reduction factor of MDOF systems. It is also found that at high levels of inelasticity, the ductility reduction factor of low-rise MDOF soil-structure systems could be significantly less than that of fixed-base structures and the reduction is less pronounced as the number of stories increases.

Structural Characteristics of Rapidly Quenched Al-Si Alloys

The structure of rapldly quenched Al-Si alloys (1 and 4 wt-%Si) was systematically studied by optical and transmission electron microscopy (TEM ) as welI as X-ray djffractjon (XRD). ExperimentaIresults show that rapid solidification refines the grain size. extends the solid solubility of Si in Al and Introduces a high density ot defects which exist in the forms of vacancies, dislocations and dislocation loops. etc.. The decomposition process of the alloys was fol lowed by using differential scanning calorimeter (DSC) and the activation energy for precipitation of Si was obtained through Kissinger analysis. The precipitation behaviour of Supersaturated Si in both samples was further examined by TEM. It was found that Si mainly precipitated inside the grains in Al-1 wt-%Si alloy. while in Al-4 wt-%Si alloy. nearly all the Si precipitates distributed along the grain boundaries. This may be due to the structure difference between the alloys in as-quenched state

The Structural Characteristics of Side-Opening Costumes during the Republic Period of China

The structural characteristics of Chinese side-opening costumes during the Republic Period of China were investigated.By measuring and recovering the physical structures of side-opening costume objects from the Folk Costumes Biography Museum of Jiangnan University,three structural characteristics were analyzed.These structural characteristics show that most of the side-opening costumes during the Republic Period of China remain traditional Chinese costume structures.The general structural characteristics of side-opening costumes are concluded and the structural cutting methods can inspire current designs as well as provide useful references for contemporary fashion designers.

Structural characteristics and hydrocarbon accumulation inBashituo area, Tarim Basin

According to well logs, core, seismic and other geological data, the authors studied the tectonic evolution stages, trap formation stages, fault and fracture development in the Bashituo area, and furthermore, analyzed the time of hydrocarbon accumulation, hydrocarbon migration pathways and related controversial issues in the study area. It is believed that the tectonic evolution in the study area can be divided into three stages, namely Late Hercynian, the Early Himalayan and the Late Himalayan. In the Late Hercynian, tectonic movement led to folding and faulting, resulting in the embryonic form of anticlinal traps. In the Early Himalayan, affected by both tectonic movement and transformation, deep faults reactivated and cut through the Lower Tertiary strata. After the Early Himalayan tectonic movement, faulting stopped and no vertical migration pathway was available . Then hydrocarbon migrated laterally along the sand bodies in the Bachu Formation and accumulated in the Carboniferous reservoirs. However, the Carboniferous accumulation was formed late, and the tectonic movement was weak at the Late Himalayan, and faults were underdeveloped, so the reservoirs in the deep Bachu Formation were not disturbed.

Structural Characteristics and Risks of China's Economic Transformation and Paths to Efficiency Improvement

Based on the expanded growth accounting framework,this paper discussed the structural characteristics of China's economic transformation and its related issues and came up with the following conclusions:(1) China's economic growth has six structural characteristics-- demographic transition,industrial productivity redistribution,income distribution adjustments,increasing urbanization,decreasing capital efficiency and little room for total factor productivity improvement.These factors together may cause a slowdown in economic growth.(2) The risk of economic slowdown in China's economic transformation may be due to the readjustment of income distribution,excessive ineffective investment,increasing economic leverage ratio and fast growing service sector of industrial structure.(3) In response to the potential risks of China's economic slowdown,improving capital efficiency should be the focus of our policy.To establish an inefficient-enterpriseclearing mechanism as well as deepening the reform of corresponding system is the only way to a steady economic growth in the future.

Simulation of Structural Characteristics and Depth Filtration Elements in Interconnected Nanofibrous Membrane Based on Adaptive Image Analysis

Due to their unique structural features, electrospun membranes have gained considerable attention for use in applications where quality of depth filtration is a dominant performance factor. To elucidate the depth filtration phenomena it is important to quantify the intrinsic structural properties independent from the dynamics of transport media. Several methods have been proposed for structural characterization of such membranes. However, these methods do not meet the requirement for the quantification of intrinsic structural properties in depth filtration. This may be due to the complex influence of transport media dynamics and structural elements in the depth filtration process. In addition, the different morphological architectures of electrospun membranes present obstacles to precise quantification. This paper seeks to quantify the structural characteristics of electrospun membranes by introducing a robust image analysis technique and exploiting it to evaluate the permeation-filtration mechanism. To this end, a nanostructured fibrous network was simulated as an ideal membrane using adaptive local criteria in the image analysis. The reliability of the proposed approach was validated with measurements and comparison of structural characteristics in different morphological conditions. The results were found to be well compatible with empirical observations of perfect membrane structures. This approach, based on optimization of electrospinning parameters, may pave the way for producing optimal membrane structures for boosting the performance of electrospun membranes in end-use applications.

Study of Structural Characteristics of Cellulose Esters with Different Degrees of Substitution

In this article,structural characteristics of amorphous mono-,di-,and tri-substituted esters of cellulose have been studied.These esters were synthesized under homogenous conditions using anhydrides of various aliphatic acids.The specific gravity of the highly substituted samples was measured by a pycnometric method in the aqueous medium.To calculate the molar,Van der Waals,and free volumes,as well as the packing coefficient of amorphous esters the method of additive contributions of partial volumes of atoms and atom groups in the volumes of polymers was used.Based on the molar volume,also specific gravity of cellulose esters was calculated.The coincidence of calculated and experimental characteristics was shown.In addition,the relationship between glass transition temperature and free volume was found for the esters.The theoretical equations were derived,which provide predicting the structural characteristics of cellulose esters with different degrees of substitution.

Characteristics of geological structures in Shiling and Zhuanshanhu areas of Yehe Uplift,NE China

The basin marginal fault system is the key to understand the formation and evolution of Songliao Basin.In order to investigate the influence of marginal fault system on the structural evolution of Songliao Basin,a comprehensive study was conducted on Shiling Town and Zhuanshanhu area of Yehe Town in Siping City of Jilin Province,where is the southeastern margin of the Songliao Basin and there are a series of well-exposed fault,fold and intrusive bodies belonging to the main marginal fault system of the Songliao Basin known as the Jiamusi-Yitong(Jia-Yi)fault zone.Through profile measurement and field investigation,samples with various lithologies and distinctive features were collected.Detailed field and laboratory works include component and microstructure analysis of these samples,rock-rock contact analysis,main strike measurement and statistics analysis.These data reveal the structural characteristics of the fold,fault and intrusive bodies in the study area.The research results show that the folds are distributed in the Mesozoic strata near the main fault of the eastern branch of the Jia-Yi fault zone,and the folded strata involve the Cretaceous Denglouku and Quantou formations.In addition,the section is dominated by high-angle strikeslip thrust faults.Light-colored veins and dark-colored veins are extensively distributed in the exposed granites.Statistical analysis of joint and fault attitudes in the study area reveals a right-lateral strike-sliping along the main fault.The large-scale right-lateral strike-slip and thrust fault system in Shiling Town occurred in right-lateral transpressive stage in Late Cretaceous.Based on the results above,tectonic evolution sequence in Shiling section of the Jia-Yi fault zone during the Mesozoic can be divided into five stages:Middle Jurassic left-lateral ductile strike-slip stage,Late Jurassic compression stage,Early Cretaceous tension stage,Early Cretaceous extension stage and Late Cretaceous right-lateral transpressive stage.These may have important constraint on understanding the Mesozoic evolution of the Songliao Basin.

Structural characteristics and implication on tectonic evolution of the Daerbute strike-slip fault in West Junggar area, NW China

The Daerbute fault zone, located in the northwestern margin of the Junggar basin, in the Central Asian Orogenic Belt, is a regional strike-slip fault with a length of 400 km. The NE-SW trending Daerbute fault zone presents a distinct linear trend in plain view, cutting through both the Zair Mountain and the Hala＇alate Mountain. Because of the intense contraction and shearing, the rocks within the fault zone experienced high degree of cataclasis, schistosity, and mylonization, resulting in rocks that are easily eroded to form a valley with a width of 300- 500 m and a depth of 50-100 m after weathering and erosion. The well-exposed outcrops along the Daerbute fault zone present sub-horizontal striations and sub-vertical fault steps, indicating sub-horizontal shearing along the observed fault planes. Flower structures and horizontal drag folds are also observed in both the well-exposed outcrops and high-resolution satellite images. The distribution of accommodating strike-slip splay faults, e.g., the 973-pluton fault and the Great Jurassic Trough fault, are in accordance with the Riedel model of simple shear. The seismic and time-frequency electromagnetic （TFEM） sections also demonstrate the typical strike-slip characteristics of the Daerbute fault zone. Based on detailed field observations of well-exposed outcrops and seismic sections, the Daerbute fault can be subdivided into two segments： the western segment presents multiple fault cores and damage zones, whereas the eastern segment only presents a single fault core, in which the rocks experienced a higher degree of rock cataclasis, schistosity, and mylonization. In the central overlapping portion between the two segments, the sediments within the fault zone are primarily reddish sandstones, conglomerates, and some mudstones, of which the palynological tests suggest middle Permian as the timing of deposition. The deformation timing of the Daerbute fault was estimated by integrating the depocenters＇ basinward migration and initiation of the splay faults （e.g., the Great Jurassic Trough fault and the 973-pluton fault）. These results indicate that there were probably two periods of faulting deformation for the Daerbute fault. By integrating our study with previous studies, we speculate that the Daerbute fault experienced a two-phase strike-slip faulting deformation, commencing with the initial dextral strike-slip faulting in mid-late Permian, and then being inversed to sinistral strike-slip faulting since the Triassic. The results of this study can provide useful insights for the regional tectonics and local hydrocarbon exploration.

Effects of extrusion and enzymatic debranching on the structural characteristics and digestibility of corn and potato starches

Amylose content has a profound impact on the contents of slowly digestible starch and resistant starch.Enzymatic debranching is a safe method to increase the amylose content,however,the lower substrate concentration and high viscosity of fully gelatinized starch limit the efficiency and yield of this method.This paper aims to explore the effects of extrusion and enzymatic debranching on increasing the amylose content thereby increasing slowly digestible starch and resistant starch contents.Different starch concentrations (10%,15%,and 20%) of extruded corn starch (ECS) and extruded potato starch (EPS) were used to debranch.Both debranched ECS and debranched EPS showed high amylose content of approximately 90%,indicating that all samples with different starch concentrations achieved high-efficiency enzymatic debranching.The high-performance liquid chromatograph results indicated that the samples were mainly short amylose.The samples exhibit a typical B-type crystalline structure and the relative crystallinity of them exceeds 37%.The short amylose exhibited rapid rearrangement ability,with the gelatinization temperature range of rescanning determined as 80–125℃,this will facilitate the formation of slowly digestible starch and resistant starch.The slowly digestible starch and resistant starch contents of the samples (debranched ECS and debranched EPS) were between 23% and 30% and between 31% and 37%,respectively.These results indicate that the extrusion and enzymatic debranching of a high substrate concentration can efficiently increase the amylose content,thereby significantly reducing the digestibility of starch,and has broad prospects of the actual production of slowly digestible starch and resistant starch.

Effect of size polydispersity on the structural and vibrational characteristics of two-dimensional granular assemblies

Two-dimensional disordered granular assemblies composed of 2048 polydispersed frictionless disks are simulated using the discrete element method. The height of the first peak of the pair correlation function, gl, the local and global bond orientational parameters ψ6^1 and ψ6^g, and the fluctuations of these parameters decrease with increasing polydispersity s, implying the transition from a polycrystalline state to an amorphous state in the system. As s increases, the peak position of the boson peak aJBp shifts towards a lower frequency and the intensity of the boson peak D（ωBP）/ωBp increases, indicating that the position and the strength of the boson peak are controlled by the polydispersity of the system. Moreover, the inverse of the boson peak intensity ωBP/D（ωBP）, the shear modulus G, and the basin curvature SIS all have a similar dependence on s, implying that the s dependence of the vibrational density of states at low frequencies likely originates from the s dependence of the basin curvature.

Load Distribution Assessment of Reinforced Concrete Buildings During Construction with Structural Characteristic Parameter Approach

High-rise reinforced concrete buildings are in great demand in developing countries with rapid urbanization. Construction engineers are facing more and more safety control challenges. One major issue is the understanding of the load distributions, especially the maximum slab load, of structures under construction, which is time dependent. Previous methods were mainly targeted to specific examples, providing specific solutions without addressing the fundamental issues of finding general solutions for load distributions in reinforced concrete buildings with different geometrical and material characteristics during construction. The concept of a structural characteristic parameter is used here to parametedze the main geometrical and material characteristics of concrete structures for generalized assessments of load distributions during construction. The maximum slab load for 20 different construction shoring/reshoring schemes is presented. The results indicate that the traditional simplified method may underestimate or overestimate the maximum slab load, depending mainly on the shoring/reshoring schemes. The structural characteristic parameter approach was specifically developed to assist construction engineers to estimate load distributions to assure safe construction procedures.

A deep insight into the structural characteristics of Yilan oil shale kerogen through selective oxidation

The structural characteristics of oil shale are important to its application.In this work,a deep insight into the structural characteristics of Yilan oil shale kerogen(YLK)was studied using alkali-oxygen oxidation at different times and ruthenium ion catalyzed oxidation(RICO).The results indicate that YLK is gradually converted to humic acids(HAs),water-soluble acids(WSAs),carboxylic acids(CAs),CO_(2)and H_(2)O.^(13)C NMR analyses of YLK,residues and HAs indicate that C-O bonds,especially C_(ar)-O bonds of YLK,are easily cleaved.The condensed aromatic rings and long alkyl chains are difficult to be oxidized during the oxidation process.With increasing oxidation time,the molar fraction of aromatic bridgehead carbon(Xb)of YLK and the residues increases from 0.174 to 0.201,and that of HAs increases from 0.225 to 0.267.The result indicates that the aromatic structures of YLK are composed of 1-ring aromatic clusters(26.5%),2-ring aromatic clusters(67.1%)and 3 or more-ring aromatic clusters(6.4%).Also,the average methylene chain(Cn)of YLK and the residues increases from 2.0 to 5.1,and that of HAs increases from 1.3 to 2.7,indicating that the alkyl chain length is not average but has a distribution.2.5%methylene carbons exist as long n-alkyl chains in the alkyl side chains groups(SCGs)on the aromatic rings in YLK.The carbon number of SCGs ranges from 5 to 22,and C_(15)and C_(17)are predominant.3.8%methylene carbons exist as alkyl bridges linkages(BLs)connecting aromatic rings in YLK.The carbon number of BLs connecting aromatic rings ranges from 6 to 19,and C_(8)is predominant.Because of the existence of above long n-alkyl chains,93.7%methylene carbons in YLK exist as alkyl chains with an average length of 1.84.

Exploring the Multi-Layer Structural Properties of the Bus-Subway Transportation Network of Shanghai

Buses and subways are essential to urban public transportation systems and an important engine for activating high-quality urban development. Traditional multi-modal transportation networks focus on the structural feature mining of single-layer networks or each layer, ignoring the structural association of multi-layer networks. In this paper, we examined the multi-layer structural property of the bus-subway network of Shanghai at both global and nodal scales. A dual-layer model of the city’s bus and subway system was built. Single-layer complex network indicators were also extended. The paper also explored the spatial coupling properties of the city’s bus and subway system and identified its primary traffic nodes. It was found that 1) the dual-layer network increased the network’s connectivity to a certain extent and broke through the spatial limitation in terms of physical structure, making the connection between any two locations more direct. 2) The dual-layer network changed the topological characteristics of the transit network, increasing the centrality value and bit order in degree centrality, betweenness centrality, and closeness centrality to different degrees, and making each centrality tend to converge to the city center in spatial distribution. Enhancing the management of critical network nodes would help the integrated public transportation system operate more effectively and provide higher-quality services.