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Development and formation of wing cuticle based on transcriptomic analysis in Locusta migratoria during metamorphosis
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作者 Jing Zhang Zhaochen Wu +5 位作者 Shuo Li He Huang Suning Liu Weimin Liu Xiaoming Zhao Jianzhen Zhang 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2024年第4期1285-1299,共15页
Wings are an important flight organ of insects.Wing development is a complex process controlled by a series of genes.The flightless wing pad transforms into a mature wing with the function of migratory flight during t... Wings are an important flight organ of insects.Wing development is a complex process controlled by a series of genes.The flightless wing pad transforms into a mature wing with the function of migratory flight during the nymphto-adult metamorphosis.However,the mechanism of wing morphogenesis in locusts is still unclear.This study analyzed the microstructures of the locust wing pads at pre-eclosion and the wings after eclosion and performed the comparative transcriptome analysis.RNA-seq identified 25,334 unigenesand 3,430 differentially expressed genes(DEGs)(1,907 up-regulated and 1,523 down-regulated).The DEGs mainly included cuticle development(LmACPs),chitin metabolism(Lm Idgf4),lipid metabolism-related genes,cell adhesion(Integrin),zinc finger transcription factors(LmSalm,LmZF593 andLmZF521),and others.Functional analysis based on RNA interference and hematoxylin and eosin(H&E)staining showed that the three genes encoded zinc finger transcription factors are essential for forming wing cuticle and maintaining morphology in Locusta migratoria.Finally,the study found that the LmSalm regulates the expression of LmACPs in the wing pads at pre-eclosion,and LmZF593 and LmZF521 regulate the expression of LmIntegrin/LmIdgf4/LmHMT420 in the wings after eclosion.This study revealed that the molecular regulatory axis controls wing morphology in nymphal and adult stages of locusts,offering a theoretical basis for the study of wing development mechanisms in hemimetabolous insects. 展开更多
关键词 Locusta migratoria wing development METAMORPHOSIS RNA-SEQ
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Numerical Investigations on Dynamic Stall Characteristics of a Finite Wing
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作者 JING Simeng CAO Chenkai +2 位作者 GAO Yuan ZHAO Qijun ZHAO Guoqing 《Transactions of Nanjing University of Aeronautics and Astronautics》 EI CSCD 2024年第4期444-457,共14页
The paper examines the dynamic stall characteristics of a finite wing with an aspect ratio of eight in order to explore the 3D effects on flow topology,aerodynamic characteristics,and pitching damping.Firstly,CFD meth... The paper examines the dynamic stall characteristics of a finite wing with an aspect ratio of eight in order to explore the 3D effects on flow topology,aerodynamic characteristics,and pitching damping.Firstly,CFD methods are developed to calculate the aerodynamic characteristics of wings.The URANS equations are solved using a finite volume method,and the two-equation k-ωshear stress transport(SST)turbulence model is employed to account for viscosity effects.Secondly,the CFD methods are used to simulate the aerodynamic characteristics of both a static,rectangular wing and a pitching,tapered wing to verify their effectiveness and accuracy.The numerical results show good agreement with experimental data.Subsequently,the static and dynamic characteristics of the finite wing are computed and discussed.The results reveal significant 3D flow structures during both static and dynamic stalls,including wing tip vortices,arch vortices,Ω-type vortices,and ring vortices.These phenomena lead to differences in the aerodynamic characteristics of the finite wing compared with a 2D airfoil.Specifically,the finite wing has a smaller lift slope during attached-flow stages,higher stall angles,and more gradual stall behavior.Flow separation initially occurs in the middle spanwise section and gradually spreads to both ends.Regarding aerodynamic damping,the inboard sections mainly generate unstable loading.Furthermore,sections experiencing light stall have a higher tendency to produce negative damping compared with sections experiencing deep dynamic stall. 展开更多
关键词 finite wing dynamic stall aerodynamic damping 3D effects
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An adaptive machine learning-based optimization method in the aerodynamic analysis of a finite wing under various cruise conditions
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作者 Zilan Zhang Yu Ao +1 位作者 Shaofan Li Grace X.Gu 《Theoretical & Applied Mechanics Letters》 CAS CSCD 2024年第1期27-34,共8页
Conventional wing aerodynamic optimization processes can be time-consuming and imprecise due to the complexity of versatile flight missions.Plenty of existing literature has considered two-dimensional infinite airfoil... Conventional wing aerodynamic optimization processes can be time-consuming and imprecise due to the complexity of versatile flight missions.Plenty of existing literature has considered two-dimensional infinite airfoil optimization,while three-dimensional finite wing optimizations are subject to limited study because of high computational costs.Here we create an adaptive optimization methodology built upon digitized wing shape deformation and deep learning algorithms,which enable the rapid formulation of finite wing designs for specific aerodynamic performance demands under different cruise conditions.This methodology unfolds in three stages:radial basis function interpolated wing generation,collection of inputs from computational fluid dynamics simulations,and deep neural network that constructs the surrogate model for the optimal wing configuration.It has been demonstrated that the proposed methodology can significantly reduce the computational cost of numerical simulations.It also has the potential to optimize various aerial vehicles undergoing different mission environments,loading conditions,and safety requirements. 展开更多
关键词 Aerodynamic optimization Computational fluid dynamics Radial basis function Finite wing Deep learning neural network
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南方山地WiNG节点排列高效QC方法
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作者 黄国华 申志恩 +2 位作者 马志虎 尹思奇 张庆元 《物探装备》 2024年第5期322-326,共5页
XCN三维是首个使用WiNG节点的山地物探项目,为了掌握WiNG仪器的Pathfinder、点对点等QC方式在山地使用的性能特点,提高仪器生产效率,首先在工区中选择具有代表性的试验点,使用小排列进行Pathfinder、点对点等QC方式试验,总结出初步的WiN... XCN三维是首个使用WiNG节点的山地物探项目,为了掌握WiNG仪器的Pathfinder、点对点等QC方式在山地使用的性能特点,提高仪器生产效率,首先在工区中选择具有代表性的试验点,使用小排列进行Pathfinder、点对点等QC方式试验,总结出初步的WiNG节点排列山地QC方法。然后在项目大规模WiNG节点排列的QC过程中不断总结纠正,找出山地WiNG节点大排列QC方法的使用特点,从而总结出一套适合南方山地的WiNG节点排列的高效QC方法,达到山地WiNG仪器生产提速、提效、提质的目的。 展开更多
关键词 南方山地 wing PATHFINDER QC
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Thrust Optimization of Flapping Wing via Gradient Descent Technologies
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作者 Jeshwanth Kundem 《Open Journal of Fluid Dynamics》 2024年第2期83-99,共17页
The current work aims at employing a gradient descent algorithm for optimizing the thrust of a flapping wing. An in-house solver has been employed, along with mesh movement methodologies to capture the dynamics of flo... The current work aims at employing a gradient descent algorithm for optimizing the thrust of a flapping wing. An in-house solver has been employed, along with mesh movement methodologies to capture the dynamics of flow around the airfoil. An efficient framework for implementing the coupled solver and optimization in a multicore environment has been implemented for the generation of optimized solutionsmaximizing thrust performance & computational speed. 展开更多
关键词 Steepest Descent CFD Flapping wing Airfoil Thrust Performance
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Wingsuit Flying
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作者 颜丹(译) 《中学生英语》 2024年第22期21-21,共1页
Wingsuit Flying,alsocalled wingsuiting,is a variation of skydiving.In this sport,a person will fly in the air using a special jumpsuit called a wingsuit.This wingsuit comprises of two arm wings and a single leg wing w... Wingsuit Flying,alsocalled wingsuiting,is a variation of skydiving.In this sport,a person will fly in the air using a special jumpsuit called a wingsuit.This wingsuit comprises of two arm wings and a single leg wing which has inflatable nylon cells.The modern wingsuits were developed in the 1990's.They are sometimes referred to as birdman suits or flying squirrel suits. 展开更多
关键词 wingS NYLON wing
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Wings-FDY一步法生产ITY的工艺研究
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作者 周龙 余锡攀 +2 位作者 李振宇 孙建杰 杜杨洋 《聚酯工业》 CAS 2024年第3期26-28,共3页
通过设备改造及工艺优化,成功实现了ITY在Wings-FDY设备上一步法生产。研究结果表明:风压设定为30 Pa,调整纺丝/卷绕上油比例为6:4,预热辊温度51℃,定型辊温度124℃,拉伸倍数3.2,卷绕速度3550 m/min时,ITY 148dtex/108f纺况稳定,物理指... 通过设备改造及工艺优化,成功实现了ITY在Wings-FDY设备上一步法生产。研究结果表明:风压设定为30 Pa,调整纺丝/卷绕上油比例为6:4,预热辊温度51℃,定型辊温度124℃,拉伸倍数3.2,卷绕速度3550 m/min时,ITY 148dtex/108f纺况稳定,物理指标均匀,满足客户定制化的产品需求。 展开更多
关键词 ITY wings-FDY 设备改造
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WingsFDY设备生产22dtex/24f细旦涤纶的工艺探讨
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作者 翟佳羽 袁礼栋 +2 位作者 李婧楠 苏宏新 赵毛毛 《合成纤维》 CAS 2024年第8期18-22,共5页
对22dtex/24f细旦涤纶全拉伸丝(FDY)生产中的熔体输送工艺、纺丝工艺、冷却工艺和牵伸定形等工艺进行了详细的分析与探讨。生产实践表明,该产品生产中采用的巴马格8辊WingsFDY设备具有高效节能、流程短的优势,能够有效降低FDY的生产成本... 对22dtex/24f细旦涤纶全拉伸丝(FDY)生产中的熔体输送工艺、纺丝工艺、冷却工艺和牵伸定形等工艺进行了详细的分析与探讨。生产实践表明,该产品生产中采用的巴马格8辊WingsFDY设备具有高效节能、流程短的优势,能够有效降低FDY的生产成本,对设备应用及新品种的开发具有一定的实践指导意义。 展开更多
关键词 细旦涤纶DTY 巴马格wingsFDY设备 工艺
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Structural design and modal behaviors analysis of a new swept baffled inflatable wing 被引量:1
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作者 Nuo Ma Li Liu +1 位作者 Fanmin Meng Junhui Meng 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2023年第6期382-398,共17页
Inflatable wing has significant application value in the design of loitering munitions because of its advantages such as lightweight and foldability.However,due to the flexible characteristics,aeroelastic behaviors of... Inflatable wing has significant application value in the design of loitering munitions because of its advantages such as lightweight and foldability.However,due to the flexible characteristics,aeroelastic behaviors of inflatable wings such as flutter are nonnegligible in flight.By designing a certain angle between the inflatable beam and the wing span,the structural dynamic and even the aeroelastic performance of the inflatable wing can be effectively improved.Based on the analysis of the mechanical and geometric characteristics of the inflatable structure,a new inflatable wing with sweep arranged inflatable beams is proposed,and the main design variables and methods are analyzed.For purpose of investigating the aeroelastic performance of the swept baffled inflatable wing,the modal behaviors by considering the wet mode are studied.In consideration of the deficiencies of the traditional wet modal analysis method,by introducing the influence on the additional stiffness of flow field,an added massstiffness method is proposed in this paper,and the advantages are verified by ground vibration experiments.On this basis,the effects of baffles sweep angle,pressure,and boundary conditions on the modal parameters and aeroelastic performance of inflatable wing are analyzed.The results show that the aeroelastic performance of the inflatable wing can be designed by changing the baffles sweep angle,which is enlightened for the aeroelastic tailoring design on inflatable wings. 展开更多
关键词 Inflatable wing Structural design Wet mode Flutter analysis
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WiNG节点仪器应用简介 被引量:1
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作者 吴青松 佴小君 +1 位作者 刘都让 付淼星 《物探装备》 2023年第5期299-302,306,共5页
WiNG节点仪器是Sercel公司的第三代节点仪器产品,具有轻便、续航时间长、无线实时质控、数据下载与充电一体化、数据管理软件操作简单、桩号自动拟合、RFID标签等特点;其无线质控有近距离的点对点直连,用于获取详细的节点运行状态数据... WiNG节点仪器是Sercel公司的第三代节点仪器产品,具有轻便、续航时间长、无线实时质控、数据下载与充电一体化、数据管理软件操作简单、桩号自动拟合、RFID标签等特点;其无线质控有近距离的点对点直连,用于获取详细的节点运行状态数据、运行测试、查看噪音等,和通过接力回传实现远距离节点站状态结果信息获取。2022年底国内首次引进该节点仪器系统并在中石化山东某三维地震勘探工区实施了大规模应用,取得了良好的应用效果。本文结合实际应用介绍了WiNG节点仪器的功能特点。 展开更多
关键词 地震勘探 节点仪器 wing 远程无线实时质控
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Quantitative analysis of the morphing wing mechanism of raptors:Morphing kinematics of Falco peregrinus wing
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作者 唐迪 车婧琦 +4 位作者 金伟杰 崔亚辉 范忠勇 杨茵 刘大伟 《Chinese Physics B》 SCIE EI CAS CSCD 2023年第4期68-77,共10页
Raptors are getting more attention from researchers because of their excellent flight abilities.And the excellent wing morphing ability is critical for raptors to achieve high maneuvering flight,which can be a good bi... Raptors are getting more attention from researchers because of their excellent flight abilities.And the excellent wing morphing ability is critical for raptors to achieve high maneuvering flight,which can be a good bionic inspiration for unmanned aerial vehicles(UAV)design.However,morphing wing motions of Falco peregrinus with multi postures cannot be consulted since such a motion database was nonexistent.This study aimed to provide data reference for future research in wing morphing kinetics.We used the computed tomography(CT)approach to obtain nine critical postures of the Falco peregrinus wing skeleton,followed with motion analysis of each joint and bone.Based on the obtained motion database,a six-bar kinematic model was proposed to regenerate wing motions with a high fidelity. 展开更多
关键词 RAPTOR wing morphing skeletal mechanism CT scans six-bar model
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Wings-plus设备生产全消光FDY工艺探讨 被引量:1
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作者 冯斌 朱昌波 +3 位作者 褚冬生 郑伟 唐晓凯 崔利 《聚酯工业》 CAS 2023年第4期45-47,共3页
在大容量聚酯熔体直纺生产线上进行设备技术改造,在熔体输送管道上通过在线添加注射设备将全消光母粒注射进入熔体,并在动态混合器中混合均匀,得到全消光聚酯熔体,采用巴马格的Wings-plus FDY生产设备的一步拉伸工艺生产全消光FDY纤维... 在大容量聚酯熔体直纺生产线上进行设备技术改造,在熔体输送管道上通过在线添加注射设备将全消光母粒注射进入熔体,并在动态混合器中混合均匀,得到全消光聚酯熔体,采用巴马格的Wings-plus FDY生产设备的一步拉伸工艺生产全消光FDY纤维。该方法成本投入小,得到的全消光纤维物理指标可以满足中高端客户需求。 展开更多
关键词 全消光FDY wings-plus设备 生产技术改造
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Damage assessment of aircraft wing subjected to blast wave with finite element method and artificial neural network tool
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作者 Meng-tao Zhang Yang Pei +1 位作者 Xin Yao Yu-xue Ge 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2023年第7期203-219,共17页
Damage assessment of the wing under blast wave is essential to the vulnerability reduction design of aircraft. This paper introduces a critical relative distance prediction method of aircraft wing damage based on the ... Damage assessment of the wing under blast wave is essential to the vulnerability reduction design of aircraft. This paper introduces a critical relative distance prediction method of aircraft wing damage based on the back-propagation artificial neural network(BP-ANN), which is trained by finite element simulation results. Moreover, the finite element method(FEM) for wing blast damage simulation has been validated by ground explosion tests and further used for damage mode determination and damage characteristics analysis. The analysis results indicate that the wing is more likely to be damaged when the root is struck from vertical directions than others for a small charge. With the increase of TNT equivalent charge, the main damage mode of the wing gradually changes from the local skin tearing to overall structural deformation and the overpressure threshold of wing damage decreases rapidly. Compared to the FEM-based damage assessment, the BP-ANN-based method can predict the wing damage under a random blast wave with an average relative error of 4.78%. The proposed method and conclusions can be used as a reference for damage assessment under blast wave and low-vulnerability design of aircraft structures. 展开更多
关键词 VULNERABILITY wing structural damage Blast wave Battle damage assessment Back-propagation artificial neural network
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In-flight deformation measurement for high-aspect-ratio wing based on 3D speckle correlation
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作者 张兴国 HU Binghua +3 位作者 WANG Yuanliang YAN Hui MA Xiaodong GE Quanbo 《High Technology Letters》 EI CAS 2023年第3期257-268,共12页
In order to get an effective solution of the in-flight wing deformation measurement for high-wing aircrafts with high-aspect-ratio,a method based on three-dimensional(3D)speckle correlation technique is proposed.First... In order to get an effective solution of the in-flight wing deformation measurement for high-wing aircrafts with high-aspect-ratio,a method based on three-dimensional(3D)speckle correlation technique is proposed.Firstly,an in-flight wing deformation measurement system with two sets of conjugate cameras is designed based on structural characteristics and test requirements of high-wing aircrafts with large-aspect-ratio.Secondly,the in-flight wing deformation measurement method based on 3D speckle correlation technique is introduced including three aspects:measuring system and wing datum calibration,speckle image matching and 3D reconstruction,and wing deformation analysis.Fi-nally,ground simulation test of dynamic deformation measurement of a scaled model wing and flight test of dynamic deformation measurement of a large transport wing are carried out.The test results show that the measuring accuracy of single point coordinate in ground simulation test is better than 0.1 mm/m,in the airborne vibration environment,the static single-point positioning accuracy is bet-ter than 5 mm,and the in-flight wing deformation measurement data is well received by the flight test engineers.This method can satisfy the requirements of stability,reliability,high precision,non-con-tact and full-field measurement for dynamic deformation measurement of aircraft wing with high-as-pect-ratio. 展开更多
关键词 HIGH-ASPECT-RATIO three-dimensional(3D)speckle wing datum
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Decomposition of Mathematical Programming Models for Aircraft Wing Design Facilitating the Use of Dynamic Programming Approach
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作者 Prashant K. Tarun Herbert W. Corley 《American Journal of Operations Research》 2023年第5期111-131,共21页
Aircraft designers strive to achieve optimal weight-reliability tradeoffs while designing an aircraft. Since aircraft wing skins account for more than fifty percent of their structural weight, aircraft wings must be d... Aircraft designers strive to achieve optimal weight-reliability tradeoffs while designing an aircraft. Since aircraft wing skins account for more than fifty percent of their structural weight, aircraft wings must be designed with utmost care and attention in terms of material types and thickness configurations. In particular, the selection of thickness at each location of the aircraft wing skin is the most consequential task for aircraft designers. To accomplish this, we present discrete mathematical programming models to obtain optimal thicknesses either to minimize weight or to maximize reliability. We present theoretical results for the decomposition of these discrete mathematical programming models to reduce computer memory requirements and facilitate the use of dynamic programming for design purposes. In particular, a decomposed version of the weight minimization problem is solved for an aircraft wing with thirty locations (or panels) and fourteen thickness choices for each location to yield an optimal minimum weight design. 展开更多
关键词 Aircraft wing Design Maximum Reliability Design Minimum Weight Design Dynamic Programming OPTIMIZATION DECOMPOSITION
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飞翼布局飞行器研究现状分析 被引量:1
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作者 陈清阳 辛宏博 +3 位作者 王鹏 朱炳杰 王玉杰 鲁亚飞 《国防科技大学学报》 EI CAS CSCD 北大核心 2024年第3期39-58,共20页
对飞翼布局飞行器的发展脉络进行了梳理,涵盖了从其早期的进化史到现阶段的研究进展,并对未来的发展方向进行了思考和展望。同时,论述了飞翼布局飞行器的几个主要控制难点,具体包括:宽速域非线性状态下的姿态控制问题、多效应耦合下的... 对飞翼布局飞行器的发展脉络进行了梳理,涵盖了从其早期的进化史到现阶段的研究进展,并对未来的发展方向进行了思考和展望。同时,论述了飞翼布局飞行器的几个主要控制难点,具体包括:宽速域非线性状态下的姿态控制问题、多效应耦合下的高精度自主起降控制问题、气动模型近似及强扰动状态下的鲁棒控制难题,以及因多舵面冗余而引起的控制分配问题。此外,还深入讨论了当前重点研究的飞翼布局飞行器的流动控制问题,并对接下来主动流动控制技术的研究动向进行了阐述。 展开更多
关键词 飞翼布局飞行器 控制系统 主动流动控制
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集体记忆与历史重述——左翼作家的“左翼文学”回忆 被引量:1
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作者 李跃力 《广州大学学报(社会科学版)》 CAS CSSCI 2024年第1期129-139,共11页
左翼作家对“左翼文学”的回忆蔚为大观,构成现代中国不容忽略而又意味深远的文化景观。其重构历史的强烈意图,与当下政治生态、社会现实之间的深层互动,使其足以作为实践中国现代文学研究“记忆的转向”的典型样本。左翼作家通过个人... 左翼作家对“左翼文学”的回忆蔚为大观,构成现代中国不容忽略而又意味深远的文化景观。其重构历史的强烈意图,与当下政治生态、社会现实之间的深层互动,使其足以作为实践中国现代文学研究“记忆的转向”的典型样本。左翼作家通过个人史、“左联”史和左翼文学史的叙述,完成形象重塑、身份认同、重构历史、接续传统等多种意图,充分体现话语生产与意识形态之间的紧密关系。“左翼文学”回忆对社会框架十分依赖,呈现出明显的“集体记忆”特征,打上了社会主导思想和主流意识形态的深深印记,但“个体记忆”又常常逸出“社会框架”,对集体记忆构成冲击与反抗,使得左翼作家的回忆呈现出微妙的张力。然而无论如何,左翼作家的“左翼文学”回忆都在很大程度上重构了中国现代文学史,深度影响了我们对左翼文学的认知。 展开更多
关键词 左翼文学 左翼作家 集体记忆 历史重述
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Structural Design and Analysis of Small Flapping Wing Aircraft Based on the Crank Slider Mechanism
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作者 Minghui Ma Fengli Liu Yongping Hao 《Journal of Electronic Research and Application》 2023年第1期25-31,共7页
In this project,the miniaturization of the aircraft was realized under the premise of strong maneuverability,high concealability,and driving a certain load,and the flight mode and structural characteristics of birds w... In this project,the miniaturization of the aircraft was realized under the premise of strong maneuverability,high concealability,and driving a certain load,and the flight mode and structural characteristics of birds were imitated.A small bionic flapping wing aircraft was built.The flapping of the wing was realized by the crank slider mechanism,and the sizes of each part were calculated according to the bionics formula.The wingspan was 360.37 mm,the body width was 22 mm,the body length was 300 mm,the wing area was 0.05 m^(2),the flapping amplitude was 71°.ADAMS software was used to simulate the dynamics of the designed aircraft,and the variation of flapping amplitude and angular velocity during the movement of the aircraft was obtained,which verified the feasibility of the mechanism.The prototype aircraft was made for flight test,and the designed bionic flapping wing aircraft achieved the expected effect.It provides a theoretical basis and data support for the design and manufacture of small flapping wing aircraft. 展开更多
关键词 Flapping wing aircraft Structural design Dynamic simulation
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创新教育背景下工业设计专业“一体两翼四驱动”教学模式研究 被引量:2
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作者 张义峰 张颖 +2 位作者 丁成富 曲庆峰 秦海彬 《农机使用与维修》 2024年第2期131-134,共4页
近年来,国家倡导素质教育,提倡在高等院校加大实践能力和创新能力的培养,各高校不断进行教学模式改革和创新,取得了一定成效,但仍没能摆脱传统观念和教学模式的束缚。为适应行业发展趋势和需求,坚持以人为本的教育理念,紧跟时代步伐,引... 近年来,国家倡导素质教育,提倡在高等院校加大实践能力和创新能力的培养,各高校不断进行教学模式改革和创新,取得了一定成效,但仍没能摆脱传统观念和教学模式的束缚。为适应行业发展趋势和需求,坚持以人为本的教育理念,紧跟时代步伐,引入“一体两翼四驱动”教学模式,开展“一体两翼四驱动”协同育人改革实践,以培养高素质创新复合型人才为主要目的,增强学生实践能力和创新能力,从根本上提升人才培养质量,以满足高速发展的社会需求,为高校人才培养模式变革提供参考依据。 展开更多
关键词 创新教育 “一体两翼四驱动” 协同育人 培养模式
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基于网络药理学探索鬼箭羽治疗糖尿病的机制 被引量:1
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作者 汪洋 叶河杨 申小年 《中国中医药现代远程教育》 2024年第4期87-91,共5页
目的 通过网络药理学预测鬼箭羽治疗糖尿病的作用机制。方法 鬼箭羽药物成分靶点来自中药系统药理学数据库及分析平台(TCMSP)。用基因数据库查询相应基因,利用Cytoscape软件构建网络图。采用基因本体论(GO)功能富集分析和京都基因与基... 目的 通过网络药理学预测鬼箭羽治疗糖尿病的作用机制。方法 鬼箭羽药物成分靶点来自中药系统药理学数据库及分析平台(TCMSP)。用基因数据库查询相应基因,利用Cytoscape软件构建网络图。采用基因本体论(GO)功能富集分析和京都基因与基因组百科全书(KEGG)通路富集分析,预测鬼箭羽治疗糖尿病的作用机制及潜在靶点。结果 “药物-化合物-靶点-疾病”网络图包含了21种活性成分和154个交叉靶点,主要靶点包括视网膜母细胞瘤基因1(RB1)、细胞周期蛋白D1(CCND1)、丝氨酸/苏氨酸激酶(AKT1)和丝裂原活化蛋白激酶(MAPK)。通过GO功能富集分析,共获得了20个项目(P<0.05)。KEGG通路富集分析筛选了13条信号通路(P<0.05),其中的脂质和动脉粥样硬化、流体剪切应力与动脉粥样硬化、高级糖基化终末产物-受体(AGE-RAGE)信号通路,对糖尿病有作用。结论 鬼箭羽的活性成分可通过作用于RB1、CCND1、AKT1、MAPK1、MAPK3等多个靶点来调节胰岛素的分泌,从而对糖尿病发挥治疗作用。 展开更多
关键词 鬼箭羽 糖尿病 网络药理学
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