Objective:The study aims to review and discuss the outcomes of emergency preparedness training programs among nursing students.Methods:A scoping review was conducted based on the guidelines of Arskey and O’Malley.Dat...Objective:The study aims to review and discuss the outcomes of emergency preparedness training programs among nursing students.Methods:A scoping review was conducted based on the guidelines of Arskey and O’Malley.Databases through PubMed,Science Direct,and Google Scholar were used to obtain the relevant articles within the scoping review.Results:The researchers found 1175 articles.After manual review,28 articles were identified and assessed.The review reported that the emergency preparedness training program significantly affects preparedness,knowledge,performance,self-efficacy,learning motivation,self-confidence,satisfaction,critical decision-making,and problem-solving.Conclusions:Emergency training effectively increases knowledge,skills,confidence,satisfaction,and team performance.展开更多
This study aims to address the problems existing in the ideological and political education of postgraduate students,and combines the implementation of the mentor responsibility system to explore the role orientation,...This study aims to address the problems existing in the ideological and political education of postgraduate students,and combines the implementation of the mentor responsibility system to explore the role orientation,work content,and practical effects of mentors in the ideological and political education of postgraduate students.Through questionnaire surveys,interviews,and other research methods,the current situation of ideological and political education of postgraduate students under the mentor responsibility system is analyzed,and corresponding optimization strategies are proposed.展开更多
The aim of this study was to investigate the adjustment problems of students from the United States enrolled in universities in the East,specifically in Taiwan,their problems related to cultural adaptation,and the pro...The aim of this study was to investigate the adjustment problems of students from the United States enrolled in universities in the East,specifically in Taiwan,their problems related to cultural adaptation,and the process of adjustment to student life in Taiwan.Under investigation were cultural adjustment and coping skills as these students transitioned from West to East.Qualitative data were collected from interviews with participants and faculty members as well as participant observations.Results indicated that U.S.students found their own ways to acclimate to their new academic setting as well as to social relations,cross-cultural issues,and the linguistic environment in Taiwan to achieve effective adaptation.They made changes in themselves to cope with all situations they encountered.This study provides suggestions for international students abroad in Taiwan,for the Taiwan Residents government,and for universities or colleges in terms of what they should offer to current and future international students.展开更多
This article will firstly discuss the context overview of English teaching and learning in China. Under thiscircumstance, a problematic element will be examined of the New Senior English for China Student’s Book 1 an...This article will firstly discuss the context overview of English teaching and learning in China. Under thiscircumstance, a problematic element will be examined of the New Senior English for China Student’s Book 1 and critical appraisal ofhow this element relates to other elements of curriculum development will be analyzed. The recommended changes and demonstrationmechanisms for evaluating the changes are put forward in the last two parts.展开更多
From a combination of Maxwell’s electromagnetism with Planck’s law and the de Broglie hypothesis, we arrive at quantized photonic wave groups whose constant phase velocity is equal to the speed of light c = ω/k and...From a combination of Maxwell’s electromagnetism with Planck’s law and the de Broglie hypothesis, we arrive at quantized photonic wave groups whose constant phase velocity is equal to the speed of light c = ω/k and to their group velocity dω/dk. When we include special relativity expressed in simplest units, we find that, for particulate matter, the square of rest mass , i.e., angular frequency squared minus wave vector squared. This equation separates into a conservative part and a uniform responsive part. A wave function is derived in manifold rank 4, and from it are derived uncertainties and internal motion. The function solves four anomalies in quantum physics: the point particle with prescribed uncertainties;spooky action at a distance;time dependence that is consistent with the uncertainties;and resonant reduction of the wave packet by localization during measurement. A comparison between contradictory mathematical and physical theories leads to similar empirical conclusions because probability amplitudes express hidden variables. The comparison supplies orthodox postulates that are compared to physical principles that formalize the difference. The method is verified by dual harmonics found in quantized quasi-Bloch waves, where the quantum is physical;not axiomatic.展开更多
Disasters resulting in mass casualty incidents can rapidly overwhelm the Emergency Department(ED).To address critical manpower needs in the ED’s disaster response,medical student involvement has been advocated.Duke-N...Disasters resulting in mass casualty incidents can rapidly overwhelm the Emergency Department(ED).To address critical manpower needs in the ED’s disaster response,medical student involvement has been advocated.Duke-National University of Singapore Medical School is in proximity to Singapore General Hospital and represents an untapped manpower resource.With appropriate training and integration into ED disaster workflows,medical students can be leveraged upon as qualified manpower.This review provides a snapshot of the conceptualization and setting up of the Disaster Volunteer Corps-a programme where medical students were recruited to receive regular training and assessment from emergency physicians on disaster response principles to fulfil specific roles during a crisis,while working as part of a team under supervision.We discuss overall strategy and benefits to stakeholders,emphasizing the close symbiotic relationship between academia and healthcare services.展开更多
Objective:To explore the correlations between five-pattern personality scores and autonomic nervous response indicators in Chinese female college students,to provide a foundation for further exploration of the modern ...Objective:To explore the correlations between five-pattern personality scores and autonomic nervous response indicators in Chinese female college students,to provide a foundation for further exploration of the modern physiological basis of these personality types.Methods:Subjects were asked to fill in 'The Five-Pattern Personality Inventory' (revised edition 2008).Taiyang,Shaoyang,yin-yang balance,Taiyin,and Shaoyin personalities were scored.The galvanic skin response and heart rate,and the low frequency (LF),high frequency (HF),and LF/HF ratio of heart rate variability were collected using a 16-channel physiological recorder (BIOPAC MP150).Relationship between the five-pattern personality scores and autonomic nervous response indicators was analyzed using bivariate correlation.Results:The five-pattern personality scores of the subjects were compared with national averages.The Taiyang and Shaoyang personality scores of the subjects were significantly lower than the overall national average,the national female average,and the national female average in the 18-29-year-old age group (all P <.05).The Taiyang personality score was negatively correlated with both the LF and the HF (P =.009 and P =.001,respectively),and the yin-yang balance personality score was significantly negatively correlated with the galvanic skin response (P =.026).Conclusion:There is a relationship between five-pattern personality scores and autonomic nervous response indicators in Chinese female college students.The higher the Taiyang personality score,the lower the sympathetic and vagus nerve excitability;the higher the yinyang balance personality score,the lower the sympathetic nerve excitability.展开更多
The general problem of this research was how students respond to hate speech.The purpose of the study was to obtain an overview of(1)perceptions;(2)attitudes;and(3)student actions/participation towards hate speech.The...The general problem of this research was how students respond to hate speech.The purpose of the study was to obtain an overview of(1)perceptions;(2)attitudes;and(3)student actions/participation towards hate speech.The research approach used was quantitative and descriptive with survey method.The population of this study was all the administrators of the student executive board in UNTAN,IAIN,and IKIP PGRI Pontianak totaling 162 students.The number of research samples was 115 students determined by Slovin formula.The respondents were choosen randomly.Data collection used a questionnaire.Data analysis used percentage quantitative descriptive analysis techniques.The general conclusion of the study shows that student responses to hate speech are good.Specific conclusions of the study are:(1)student perceptions(knowledge)of hate speech are on average 78.26%know and 21.74%do not know about the utterances of hatred;(2)student attitudes towards hate speech are on average 78.14%students do not agree with hate speech and 21.86%agree;and(3)student actions or participation in hate speech are on average 78.51%students never take acts in hate speech and 21.49%ever.展开更多
A numerical method is designed to examine the response properties of real sea areas to open ocean forcing. The application of this method to modeling the China's adjacent seas shows that the Bohai Sea has a highest p...A numerical method is designed to examine the response properties of real sea areas to open ocean forcing. The application of this method to modeling the China's adjacent seas shows that the Bohai Sea has a highest peak response frequency (PRF) of 1.52 d^-1; the northern Yellow Sea has a PRF of 1.69 d^-1; the Gyeonggi Bay has a high amplitude gain plateau in the frequency band roughly from 1.7 to 2.7 d^-1; the Yellow Sea (includ- ing the Gyeonggi Bay), the East China Sea shelf and the Taiwan Strait have a common high amplitude gain band with frequencies around 1.76 to 1.78 d^-1 and are shown to be a system that responds to the open ocean forcing in favor of amplifying the waves with frequencies in this band; the Beibu Gulf, the Gulf of Thailand and the South China Sea deep basin have PRFs of 0.91, 1.01 and 0.98 d^-1 respectively. In addition, the East China Sea has a Poincare mode PRF of 3.91 d^-1. The PRFs of the Bohal Sea, the northern Yellow Sea, the Bei- bu Gulf and the South China Sea can be explained by a classical quarter (half for the Bohai Sea) wavelength resonance theory. The results show that further investigations are needed for the response dynamics of the Yellow Sea-East China Sea-Taiwan Strait system, the East China Sea Poincare mode, the Talwan Strait, and the Gulf of Thailand.展开更多
Due to the recently increased requirements of e-learning systems,multiple educational institutes such as kindergarten have transformed their learning towards virtual education.Automated student health exercise is a di...Due to the recently increased requirements of e-learning systems,multiple educational institutes such as kindergarten have transformed their learning towards virtual education.Automated student health exercise is a difficult task but an important one due to the physical education needs especially in young learners.The proposed system focuses on the necessary implementation of student health exercise recognition(SHER)using a modified Quaternion-basedfilter for inertial data refining and data fusion as the pre-processing steps.Further,cleansed data has been segmented using an overlapping windowing approach followed by patterns identification in the form of static and kinematic signal patterns.Furthermore,these patterns have been utilized to extract cues for both patterned signals,which are further optimized using Fisher’s linear discriminant analysis(FLDA)technique.Finally,the physical exercise activities have been categorized using extended Kalmanfilter(EKF)-based neural networks.This system can be implemented in multiple educational establishments including intelligent training systems,virtual mentors,smart simulations,and interactive learning management methods.展开更多
At 8 weeks after intragastric administration of icariin to senescence-accelerated mice (P8 strain), Morris water maze results showed that escape latency was shortened, and the number of platform crossings was increa...At 8 weeks after intragastric administration of icariin to senescence-accelerated mice (P8 strain), Morris water maze results showed that escape latency was shortened, and the number of platform crossings was increased. Immunohistochemical staining and western blot assay detected significantly increased levels of cyclic adenosine monophosphate response element binding protein These results suggest that icariin upregulates phosphorylated cyclic adenosine monophosphate response element binding protein levels and improves learning and memory functions in hippocampus of the senescence-accelerated mouse.展开更多
A study on dynamic response of transversely isotropic saturated poroelastic media under a circular non-axisymmetrical harmonic source has been presented by Huang Yi et al. using the technique of Fourier expansion and ...A study on dynamic response of transversely isotropic saturated poroelastic media under a circular non-axisymmetrical harmonic source has been presented by Huang Yi et al. using the technique of Fourier expansion and Hankel transform. However, the method may not always be valid. The work is extended to the general case being in the rectangular coordinate. The purpose is to study the 3-d dynamic response of transversely isotropic saturated soils under a general source distributing in arbitrary rectangular zoon on the medium surface. Based on Biot's theory for fluid- saturated porous media, the 3-d wave motion equations in rectangular coordinate for transversely isotropic saturated poroelastic media were transformed into the two uncoupling governing differential equations of 6-order and 2-order respectively by means of the displacement functions. Then, using the technique of double Fourier transform, the governing differential equations were easily solved. Integral solutions of soil skeleton displacements and pore pressure as well as the total stresses for poroelastic media were obtained. Furthermore, a systematic study on half-space problem in saturated soils was performed. Integral solutions for surface displacements under the general harmonic source distributing on arbitrary surface zone, considering both case of drained surface and undrained surface, were presented.展开更多
Immunotherapy for Alzheimer's disease (AD) is effective in improving cognitive function in transgenic mouse models of AD. Because the AN1792 [beta-amyloid (Aβ) 1-42] vaccine was halted because of T cell mediated...Immunotherapy for Alzheimer's disease (AD) is effective in improving cognitive function in transgenic mouse models of AD. Because the AN1792 [beta-amyloid (Aβ) 1-42] vaccine was halted because of T cell mediated meningoencephalitis, many scientists are searching for a nove) vaccine to avoid the T cell mediated immune response caused by the Aβ1-42. Importantly, the time when the immunization is begun can influence the immune effect. In this study, an adenovirus vaccine was constructed containing 10 x Aβ3-10 repeats and gene adjuvant CpG DNA. Transgenic AD mice were immunized intranasally for 3 months. After 10 × Aβ3-10 vaccine immunization, high titers of anti-Aβ42 IgG1 predominant antibodies were induced. In spatial learning ability and probe tests, the 10 × Aβ3-10 immunized mice showed significantly improved memories compared to control mice. The 10 × Aβ3-10 vaccine resulted in a robust Th2 dominant humoral immune response and reduced learning deficits in AD mice. In addition, the 10 × Aβ3-10 vaccine might be more efficient if administered before Aβ aggregation at an early stage in the AD mouse brain. Thus, the adenovirus vector encoding 10 × Aβ-10 is a promising vaccine for AD.展开更多
The hydroelastic responses of a submerged horizontal solid/porous plate attached at the front of a very large rectangular floating structure(VLFS)under wave action has been investigated in the context of linear water ...The hydroelastic responses of a submerged horizontal solid/porous plate attached at the front of a very large rectangular floating structure(VLFS)under wave action has been investigated in the context of linear water wave theory.Darcy’s law is adopted to represent energy dissipation in pores.It is assumed that the porous plates are made of material with very fine pores so that the normal velocity across the perforated porous is linearly associated with the pressure drop.In the analytic method,the eigenfunction expansion-matching method(EEMM)for multiple domains is applied to solve the hydrodynamic problem and the elastic equation of motion is solved by the modal expansion method.The performance of the proposed submerged horizontal solid/porous plate can be significantly enhanced by selecting optimal design parameters,such as plate length,horizontal position,submerged depth and porosity.It is concluded that good damping effect can be achieved through installation of solid and porous plate.Porous plate has better damping effect at low frequencies,while solid plate has better damping effect at high frequencies.The optimal ratio of plate length to water depth is 0.25-0.375,and the optimal ratio of submerged depth to water depth is 0.09-0.181.展开更多
To investigate genetic factors that might help define which Crohn’s disease (CD) patients are likely to benefit from anti-tumor necrosis factor (TNF) therapy. METHODSThis was a prospective cohort study. Patients were...To investigate genetic factors that might help define which Crohn’s disease (CD) patients are likely to benefit from anti-tumor necrosis factor (TNF) therapy. METHODSThis was a prospective cohort study. Patients were recruited from a university digestive disease practice database. We included CD patients who received anti-TNF therapy, had available medical records (with information on treatment duration and efficacy) and who consented to participation. Patients with allergic reactions were excluded. Patients were grouped as ever-responders or non-responders. Genomic DNA was extracted from peripheral blood, and 7 single nucleotide polymorphisms (SNPs) were assessed. The main outcome measure (following exposure to the drug) was response to therapy. The patient genotypes were assessed as the predictors of outcome. Possible confounders and effect modifiers included age, gender, race, and socioeconomic status disease, as well as disease characteristics (such as Montreal criteria). RESULTS121 patients were included. Twenty-one were non-responders, and 100 were ever-responders. Fas ligand SNP (rs763110) genotype frequencies, TNF gene -308 SNP (rs1800629) genotype frequencies, and their combination, were significantly different between groups on multivariable analysis controlling for Montreal disease behavior and perianal disease. The odds of a patient with a Fas ligand CC genotype being a non-responder were four-fold higher as compared to a TC or TT genotype (P = 0.009, OR = 4.30, 95%CI: 1.45-12.80). The presence of the A (minor) TNF gene -308 allele correlated with three-fold higher odds of being a non-responder (P = 0.049, OR = 2.88, 95%CI: 1.01-8.22). Patients with the combination of the Fas ligand CC genotype and the TNF -308 A allele had nearly five-fold higher odds of being a non-responder (P = 0.015, OR = 4.76, 95%CI: 1.35-16.77). No difference was seen for the remaining SNPs. CONCLUSIONThe Fas-ligand SNP and TNF gene -308 SNP are associated with anti-TNF treatment response in CD and may help select patients likely to benefit from therapy.展开更多
The driving necessities of cost reduction and the need to develop fields at ever increasing water depths have led to the use of floating structures. Among these structures are the Floating Production Storage and Offlo...The driving necessities of cost reduction and the need to develop fields at ever increasing water depths have led to the use of floating structures. Among these structures are the Floating Production Storage and Offloading (FPSO) units whose motion analysis is considered in this paper. In actual environmental condition, it is required to accurately determine or predict large amplitude motion of the FPSO before any offshore operation. This paper seeks to present a detailed method of computing the Response Amplitude Operator(s) (RAOs) for the six (6) degrees of freedom using ANSYS AQWA. The results indicate for Heave motion a tendency for the heave peak value to move slightly higher dimensionless encounter-frequency as the wave moves from Head sea to Beam sea direction. A MATLAB source code was developed to validate the result for heave motion at head sea. Although a small difference in predicted heave motion occurred, it is pertinent to note that the comparisons between results generated in the MATLAB program and ANSYS AQWA demonstrate generally good agreement, and the roll response of the FPSO is noted to be critical.展开更多
Vibration mode of the constrained damping cantilever is built up according to the mode superposition of the elastic cantilever beam. The control equation of the constrained damping cantilever beam is then derived usin...Vibration mode of the constrained damping cantilever is built up according to the mode superposition of the elastic cantilever beam. The control equation of the constrained damping cantilever beam is then derived using Lagrange's equation. Dynamic response of the constrained damping cantilever beam is obtained according to the principle of virtual work, when the concentrated force is suddenly unloaded. Frequencies and transient response of a series of constrained damping cantilever beams are calculated and tested. Influence of parameters of the damping layer on the response time is analyzed. Analyitcal and experimental approaches are used for verification. The results show that the method is reliable.展开更多
文摘Objective:The study aims to review and discuss the outcomes of emergency preparedness training programs among nursing students.Methods:A scoping review was conducted based on the guidelines of Arskey and O’Malley.Databases through PubMed,Science Direct,and Google Scholar were used to obtain the relevant articles within the scoping review.Results:The researchers found 1175 articles.After manual review,28 articles were identified and assessed.The review reported that the emergency preparedness training program significantly affects preparedness,knowledge,performance,self-efficacy,learning motivation,self-confidence,satisfaction,critical decision-making,and problem-solving.Conclusions:Emergency training effectively increases knowledge,skills,confidence,satisfaction,and team performance.
基金Chang’an University Graduate Student Ideological and Political Education Innovation Demonstration Pro-ject(No.300103740013)Education Science Research Project of China Association of Transportation Education(No.JT2022YB222)+1 种基金Research Project on Education and Teaching Reform at Chang’an Dublin International College of Transpor-tation at Chang’an University(No.CDIC-JG-200301)Construction Project for Continuous Improvement of National First-Class Courses on Interchangeability and Measurement Technology(No.300103230119)。
文摘This study aims to address the problems existing in the ideological and political education of postgraduate students,and combines the implementation of the mentor responsibility system to explore the role orientation,work content,and practical effects of mentors in the ideological and political education of postgraduate students.Through questionnaire surveys,interviews,and other research methods,the current situation of ideological and political education of postgraduate students under the mentor responsibility system is analyzed,and corresponding optimization strategies are proposed.
文摘The aim of this study was to investigate the adjustment problems of students from the United States enrolled in universities in the East,specifically in Taiwan,their problems related to cultural adaptation,and the process of adjustment to student life in Taiwan.Under investigation were cultural adjustment and coping skills as these students transitioned from West to East.Qualitative data were collected from interviews with participants and faculty members as well as participant observations.Results indicated that U.S.students found their own ways to acclimate to their new academic setting as well as to social relations,cross-cultural issues,and the linguistic environment in Taiwan to achieve effective adaptation.They made changes in themselves to cope with all situations they encountered.This study provides suggestions for international students abroad in Taiwan,for the Taiwan Residents government,and for universities or colleges in terms of what they should offer to current and future international students.
文摘This article will firstly discuss the context overview of English teaching and learning in China. Under thiscircumstance, a problematic element will be examined of the New Senior English for China Student’s Book 1 and critical appraisal ofhow this element relates to other elements of curriculum development will be analyzed. The recommended changes and demonstrationmechanisms for evaluating the changes are put forward in the last two parts.
文摘From a combination of Maxwell’s electromagnetism with Planck’s law and the de Broglie hypothesis, we arrive at quantized photonic wave groups whose constant phase velocity is equal to the speed of light c = ω/k and to their group velocity dω/dk. When we include special relativity expressed in simplest units, we find that, for particulate matter, the square of rest mass , i.e., angular frequency squared minus wave vector squared. This equation separates into a conservative part and a uniform responsive part. A wave function is derived in manifold rank 4, and from it are derived uncertainties and internal motion. The function solves four anomalies in quantum physics: the point particle with prescribed uncertainties;spooky action at a distance;time dependence that is consistent with the uncertainties;and resonant reduction of the wave packet by localization during measurement. A comparison between contradictory mathematical and physical theories leads to similar empirical conclusions because probability amplitudes express hidden variables. The comparison supplies orthodox postulates that are compared to physical principles that formalize the difference. The method is verified by dual harmonics found in quantized quasi-Bloch waves, where the quantum is physical;not axiomatic.
文摘Disasters resulting in mass casualty incidents can rapidly overwhelm the Emergency Department(ED).To address critical manpower needs in the ED’s disaster response,medical student involvement has been advocated.Duke-National University of Singapore Medical School is in proximity to Singapore General Hospital and represents an untapped manpower resource.With appropriate training and integration into ED disaster workflows,medical students can be leveraged upon as qualified manpower.This review provides a snapshot of the conceptualization and setting up of the Disaster Volunteer Corps-a programme where medical students were recruited to receive regular training and assessment from emergency physicians on disaster response principles to fulfil specific roles during a crisis,while working as part of a team under supervision.We discuss overall strategy and benefits to stakeholders,emphasizing the close symbiotic relationship between academia and healthcare services.
基金This study was supported by the National Natural Science Foundation of China(81473598).
文摘Objective:To explore the correlations between five-pattern personality scores and autonomic nervous response indicators in Chinese female college students,to provide a foundation for further exploration of the modern physiological basis of these personality types.Methods:Subjects were asked to fill in 'The Five-Pattern Personality Inventory' (revised edition 2008).Taiyang,Shaoyang,yin-yang balance,Taiyin,and Shaoyin personalities were scored.The galvanic skin response and heart rate,and the low frequency (LF),high frequency (HF),and LF/HF ratio of heart rate variability were collected using a 16-channel physiological recorder (BIOPAC MP150).Relationship between the five-pattern personality scores and autonomic nervous response indicators was analyzed using bivariate correlation.Results:The five-pattern personality scores of the subjects were compared with national averages.The Taiyang and Shaoyang personality scores of the subjects were significantly lower than the overall national average,the national female average,and the national female average in the 18-29-year-old age group (all P <.05).The Taiyang personality score was negatively correlated with both the LF and the HF (P =.009 and P =.001,respectively),and the yin-yang balance personality score was significantly negatively correlated with the galvanic skin response (P =.026).Conclusion:There is a relationship between five-pattern personality scores and autonomic nervous response indicators in Chinese female college students.The higher the Taiyang personality score,the lower the sympathetic and vagus nerve excitability;the higher the yinyang balance personality score,the lower the sympathetic nerve excitability.
文摘The general problem of this research was how students respond to hate speech.The purpose of the study was to obtain an overview of(1)perceptions;(2)attitudes;and(3)student actions/participation towards hate speech.The research approach used was quantitative and descriptive with survey method.The population of this study was all the administrators of the student executive board in UNTAN,IAIN,and IKIP PGRI Pontianak totaling 162 students.The number of research samples was 115 students determined by Slovin formula.The respondents were choosen randomly.Data collection used a questionnaire.Data analysis used percentage quantitative descriptive analysis techniques.The general conclusion of the study shows that student responses to hate speech are good.Specific conclusions of the study are:(1)student perceptions(knowledge)of hate speech are on average 78.26%know and 21.74%do not know about the utterances of hatred;(2)student attitudes towards hate speech are on average 78.14%students do not agree with hate speech and 21.86%agree;and(3)student actions or participation in hate speech are on average 78.51%students never take acts in hate speech and 21.49%ever.
基金The National Natural Science Foundation of China under contract Nos 40676009 and 40606006the Basic Research Project of Qingdao Science and Technology Program of China under contract No.11-1-4-98-jch
文摘A numerical method is designed to examine the response properties of real sea areas to open ocean forcing. The application of this method to modeling the China's adjacent seas shows that the Bohai Sea has a highest peak response frequency (PRF) of 1.52 d^-1; the northern Yellow Sea has a PRF of 1.69 d^-1; the Gyeonggi Bay has a high amplitude gain plateau in the frequency band roughly from 1.7 to 2.7 d^-1; the Yellow Sea (includ- ing the Gyeonggi Bay), the East China Sea shelf and the Taiwan Strait have a common high amplitude gain band with frequencies around 1.76 to 1.78 d^-1 and are shown to be a system that responds to the open ocean forcing in favor of amplifying the waves with frequencies in this band; the Beibu Gulf, the Gulf of Thailand and the South China Sea deep basin have PRFs of 0.91, 1.01 and 0.98 d^-1 respectively. In addition, the East China Sea has a Poincare mode PRF of 3.91 d^-1. The PRFs of the Bohal Sea, the northern Yellow Sea, the Bei- bu Gulf and the South China Sea can be explained by a classical quarter (half for the Bohai Sea) wavelength resonance theory. The results show that further investigations are needed for the response dynamics of the Yellow Sea-East China Sea-Taiwan Strait system, the East China Sea Poincare mode, the Talwan Strait, and the Gulf of Thailand.
基金supported by a Grant(2021R1F1A1063634)of the Basic Science Research Program through the National Research Foundation(NRF)funded by the Ministry of Education,Republic of Korea.
文摘Due to the recently increased requirements of e-learning systems,multiple educational institutes such as kindergarten have transformed their learning towards virtual education.Automated student health exercise is a difficult task but an important one due to the physical education needs especially in young learners.The proposed system focuses on the necessary implementation of student health exercise recognition(SHER)using a modified Quaternion-basedfilter for inertial data refining and data fusion as the pre-processing steps.Further,cleansed data has been segmented using an overlapping windowing approach followed by patterns identification in the form of static and kinematic signal patterns.Furthermore,these patterns have been utilized to extract cues for both patterned signals,which are further optimized using Fisher’s linear discriminant analysis(FLDA)technique.Finally,the physical exercise activities have been categorized using extended Kalmanfilter(EKF)-based neural networks.This system can be implemented in multiple educational establishments including intelligent training systems,virtual mentors,smart simulations,and interactive learning management methods.
文摘At 8 weeks after intragastric administration of icariin to senescence-accelerated mice (P8 strain), Morris water maze results showed that escape latency was shortened, and the number of platform crossings was increased. Immunohistochemical staining and western blot assay detected significantly increased levels of cyclic adenosine monophosphate response element binding protein These results suggest that icariin upregulates phosphorylated cyclic adenosine monophosphate response element binding protein levels and improves learning and memory functions in hippocampus of the senescence-accelerated mouse.
文摘A study on dynamic response of transversely isotropic saturated poroelastic media under a circular non-axisymmetrical harmonic source has been presented by Huang Yi et al. using the technique of Fourier expansion and Hankel transform. However, the method may not always be valid. The work is extended to the general case being in the rectangular coordinate. The purpose is to study the 3-d dynamic response of transversely isotropic saturated soils under a general source distributing in arbitrary rectangular zoon on the medium surface. Based on Biot's theory for fluid- saturated porous media, the 3-d wave motion equations in rectangular coordinate for transversely isotropic saturated poroelastic media were transformed into the two uncoupling governing differential equations of 6-order and 2-order respectively by means of the displacement functions. Then, using the technique of double Fourier transform, the governing differential equations were easily solved. Integral solutions of soil skeleton displacements and pore pressure as well as the total stresses for poroelastic media were obtained. Furthermore, a systematic study on half-space problem in saturated soils was performed. Integral solutions for surface displacements under the general harmonic source distributing on arbitrary surface zone, considering both case of drained surface and undrained surface, were presented.
基金the National Natural Science Foundation of China, No. 30471927
文摘Immunotherapy for Alzheimer's disease (AD) is effective in improving cognitive function in transgenic mouse models of AD. Because the AN1792 [beta-amyloid (Aβ) 1-42] vaccine was halted because of T cell mediated meningoencephalitis, many scientists are searching for a nove) vaccine to avoid the T cell mediated immune response caused by the Aβ1-42. Importantly, the time when the immunization is begun can influence the immune effect. In this study, an adenovirus vaccine was constructed containing 10 x Aβ3-10 repeats and gene adjuvant CpG DNA. Transgenic AD mice were immunized intranasally for 3 months. After 10 × Aβ3-10 vaccine immunization, high titers of anti-Aβ42 IgG1 predominant antibodies were induced. In spatial learning ability and probe tests, the 10 × Aβ3-10 immunized mice showed significantly improved memories compared to control mice. The 10 × Aβ3-10 vaccine resulted in a robust Th2 dominant humoral immune response and reduced learning deficits in AD mice. In addition, the 10 × Aβ3-10 vaccine might be more efficient if administered before Aβ aggregation at an early stage in the AD mouse brain. Thus, the adenovirus vector encoding 10 × Aβ-10 is a promising vaccine for AD.
基金financially supported by the National Key R&D Program of China(Grant No.2019YFC1407700)the National Natural Science Foundation of China(Grant No.51779038)。
文摘The hydroelastic responses of a submerged horizontal solid/porous plate attached at the front of a very large rectangular floating structure(VLFS)under wave action has been investigated in the context of linear water wave theory.Darcy’s law is adopted to represent energy dissipation in pores.It is assumed that the porous plates are made of material with very fine pores so that the normal velocity across the perforated porous is linearly associated with the pressure drop.In the analytic method,the eigenfunction expansion-matching method(EEMM)for multiple domains is applied to solve the hydrodynamic problem and the elastic equation of motion is solved by the modal expansion method.The performance of the proposed submerged horizontal solid/porous plate can be significantly enhanced by selecting optimal design parameters,such as plate length,horizontal position,submerged depth and porosity.It is concluded that good damping effect can be achieved through installation of solid and porous plate.Porous plate has better damping effect at low frequencies,while solid plate has better damping effect at high frequencies.The optimal ratio of plate length to water depth is 0.25-0.375,and the optimal ratio of submerged depth to water depth is 0.09-0.181.
文摘To investigate genetic factors that might help define which Crohn’s disease (CD) patients are likely to benefit from anti-tumor necrosis factor (TNF) therapy. METHODSThis was a prospective cohort study. Patients were recruited from a university digestive disease practice database. We included CD patients who received anti-TNF therapy, had available medical records (with information on treatment duration and efficacy) and who consented to participation. Patients with allergic reactions were excluded. Patients were grouped as ever-responders or non-responders. Genomic DNA was extracted from peripheral blood, and 7 single nucleotide polymorphisms (SNPs) were assessed. The main outcome measure (following exposure to the drug) was response to therapy. The patient genotypes were assessed as the predictors of outcome. Possible confounders and effect modifiers included age, gender, race, and socioeconomic status disease, as well as disease characteristics (such as Montreal criteria). RESULTS121 patients were included. Twenty-one were non-responders, and 100 were ever-responders. Fas ligand SNP (rs763110) genotype frequencies, TNF gene -308 SNP (rs1800629) genotype frequencies, and their combination, were significantly different between groups on multivariable analysis controlling for Montreal disease behavior and perianal disease. The odds of a patient with a Fas ligand CC genotype being a non-responder were four-fold higher as compared to a TC or TT genotype (P = 0.009, OR = 4.30, 95%CI: 1.45-12.80). The presence of the A (minor) TNF gene -308 allele correlated with three-fold higher odds of being a non-responder (P = 0.049, OR = 2.88, 95%CI: 1.01-8.22). Patients with the combination of the Fas ligand CC genotype and the TNF -308 A allele had nearly five-fold higher odds of being a non-responder (P = 0.015, OR = 4.76, 95%CI: 1.35-16.77). No difference was seen for the remaining SNPs. CONCLUSIONThe Fas-ligand SNP and TNF gene -308 SNP are associated with anti-TNF treatment response in CD and may help select patients likely to benefit from therapy.
文摘The driving necessities of cost reduction and the need to develop fields at ever increasing water depths have led to the use of floating structures. Among these structures are the Floating Production Storage and Offloading (FPSO) units whose motion analysis is considered in this paper. In actual environmental condition, it is required to accurately determine or predict large amplitude motion of the FPSO before any offshore operation. This paper seeks to present a detailed method of computing the Response Amplitude Operator(s) (RAOs) for the six (6) degrees of freedom using ANSYS AQWA. The results indicate for Heave motion a tendency for the heave peak value to move slightly higher dimensionless encounter-frequency as the wave moves from Head sea to Beam sea direction. A MATLAB source code was developed to validate the result for heave motion at head sea. Although a small difference in predicted heave motion occurred, it is pertinent to note that the comparisons between results generated in the MATLAB program and ANSYS AQWA demonstrate generally good agreement, and the roll response of the FPSO is noted to be critical.
基金Project supported by the National Natural Science Foundation of China (No. 10572150)the Natural Science Foundation of Naval University of Engineering (No. HGDQNJJ008)
文摘Vibration mode of the constrained damping cantilever is built up according to the mode superposition of the elastic cantilever beam. The control equation of the constrained damping cantilever beam is then derived using Lagrange's equation. Dynamic response of the constrained damping cantilever beam is obtained according to the principle of virtual work, when the concentrated force is suddenly unloaded. Frequencies and transient response of a series of constrained damping cantilever beams are calculated and tested. Influence of parameters of the damping layer on the response time is analyzed. Analyitcal and experimental approaches are used for verification. The results show that the method is reliable.