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How to exert the student-center approach in middle school English teaching
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作者 ZHOU Gui-shuang(Nanning Sanmei Middle School,Guangxi Nanning 530021) 《广西大学学报(哲学社会科学版)》 2007年第S2期164-166,共3页
In order to train a student to be a person with ability,who can self-study,use knowledge flexibly and bring firth new ideas constantly,the constant development of society demands a full exertion of student-center appr... In order to train a student to be a person with ability,who can self-study,use knowledge flexibly and bring firth new ideas constantly,the constant development of society demands a full exertion of student-center approach in the process of education.Therefore,how to exert the student-center approach is a question that every teacher is facing.I think that we can exert the student-center approach from the following aspects.One,a teacher must change his teaching conception.He should know that it's the students who are the main body of teaching and the teacher can act as a guider.The other,by all means,we ought to make the students know the purpose of their study and the function of themselves in learning.We also ought to culture their interest in learning,inspire and strengthen their main body consciousness.the teacher should,on the basis of full understanding his students and textbook,exert the leading function of himself.In the course of teaching,the teacher can exert the advantage of advanced teaching method,such as situational language teaching,and advanced teaching instrument,such as multimedia,which will inspire the students' interest and conscious activities.We can train the students' imagining ability through encouragement 、guiding and extracurricular activities.We can improve the students' ability of self-study.Thus,the students' main body function will reach a better exertion and the effect of teaching will be improved.This will train the students to suit the need of society. 展开更多
关键词 student-center approach MAIN BODY function English TEACHING exert
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Application of Student-centered Learning Approach to English Listening and Speaking Class in Vocational Schools
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作者 江韵 《疯狂英语(教师版)》 2012年第3期84-87,共4页
Student-centered learning approach is focused on the students' demands and interests.Applying student-centered approach puts forward higher requirement to English teachers.This article first analyzes the theory of... Student-centered learning approach is focused on the students' demands and interests.Applying student-centered approach puts forward higher requirement to English teachers.This article first analyzes the theory of student-centered learning approach and compares teacher-centered approach with it.Based on the research information and teaching experience,the author summarizes four strategies about how to apply student-centered learning approach to English listening and speaking class in vocational schools. 展开更多
关键词 student-centered Learning approach English listening and speaking class STRATEGIES
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Complication rates after direct anterior vs posterior approach for hip hemiarthroplasty in elderly individuals with femoral neck fractures 被引量:2
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作者 Tatiana Charles Nicolas Bloemers +1 位作者 Bilal Kapanci Marc Jayankura 《World Journal of Orthopedics》 2024年第1期22-29,共8页
BACKGROUND Dislocation rates after hemiarthroplasty reportedly vary from 1%to 17%.This serious complication is associated with increased morbidity and mortality rates.Approaches to this surgery are still debated,with ... BACKGROUND Dislocation rates after hemiarthroplasty reportedly vary from 1%to 17%.This serious complication is associated with increased morbidity and mortality rates.Approaches to this surgery are still debated,with no consensus regarding the superiority of any single approach.AIM To compare early postoperative complications after implementing the direct anterior and posterior approaches(PL)for hip hemiarthroplasty after femoral neck fractures.METHODS This is a comparative,retrospective,single-center cohort study conducted at a university hospital.Between March 2008 and December 2018,273 patients(a total of 280 hips)underwent bipolar hemiarthroplasties(n=280)for displaced femoral neck fractures using either the PL(n=171)or the minimally invasive direct anterior approach(DAA)(n=109).The choice of approach was related to the surgeons’practices;the implant types were similar and unrelated to the approach.Dislocation rates and other complications were reviewed after a minimum followup of 6 mo.RESULTS Both treatment groups had similarly aged patients(mean age:82 years),sex ratios,patient body mass indexes,and patient comorbidities.Surgical data(surgery delay time,operative time,and blood loss volume)did not differ significantly between the groups.The 30 d mortality rate was higher in the PL group(9.9%)than in the DAA group(3.7%),but the difference was not statistically significant(P=0.052).Among the one-month survivors,a significantly higher rate of dislocation was observed in the PL group(14/154;9.1%)than in the DAA group(0/105;0%)(P=0.002).Of the 14 patients with dislocation,8 underwent revision surgery for recurrent instability(posterior group),and one of them had 2 additional procedures due to a deep infection.The rate of other complications(e.g.,perioperative and early postoperative periprosthetic fractures and infection-related complications)did not differ significantly between the groups.CONCLUSION These findings suggest that the DAA to bipolar hemiarthroplasty for patients with femoral neck fractures is associated with a lower dislocation rate(<1%)than the PL. 展开更多
关键词 HEMIARTHROPLASTY Femoral neck fracture Direct anterior approach Posterior approach DISLOCATION MORTALITY
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Which approach of total hip arthroplasty is the best efficacy and least complication? 被引量:1
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作者 Lertkong Nitiwarangkul Natthapong Hongku +3 位作者 Oraluck Pattanaprateep Sasivimol Rattanasiri Patarawan Woratanarat Ammarin Thakkinstian 《World Journal of Orthopedics》 2024年第1期73-93,共21页
BACKGROUND Total hip arthroplasty is as an effective intervention to relieve pain and improve hip function.Approaches of the hip have been exhaustively explored about pros and cons.The efficacy and the complications o... BACKGROUND Total hip arthroplasty is as an effective intervention to relieve pain and improve hip function.Approaches of the hip have been exhaustively explored about pros and cons.The efficacy and the complications of hip approaches remains inconclusive.This study conducted an umbrella review to systematically appraise previous meta-analysis(MAs)including conventional posterior approach(PA),and minimally invasive surgeries as the lateral approach(LA),direct anterior approach(DAA),2-incisions method,mini-lateral approach and the newest technique direct superior approach(DSA)or supercapsular percutaneouslyassisted total hip(SuperPath).AIM To compare the efficacy and complications of hip approaches that have been published in all MAs and randomized controlled trials(RCTs).METHODS MAs were identified from MEDLINE and Scopus from inception until 2023.RCTs were then updated from the latest MA to September 2023.This study included studies which compared hip approaches and reported at least one outcome such as Harris Hip Score(HHS),dislocation,intra-operative fracture,wound compliData were independently selected,extracted and assessed by two reviewers.Network MA and cluster rank and surface under the cumulative ranking curve(SUCRA)were estimated for treatment efficacy and safety.RESULTS Finally,twenty-eight MAs(40 RCTs),and 13 RCTs were retrieved.In total 47 RCTs were included for reanalysis.The results of corrected covered area showed high degree(13.80%).Among 47 RCTs,most of the studies were low risk of bias in part of random process and outcome reporting,while other domains were medium to high risk of bias.DAA significantly provided higher HHS at three months than PA[pooled unstandardized mean difference(USMD):3.49,95%confidence interval(CI):0.98,6.00 with SUCRA:85.9],followed by DSA/SuperPath(USMD:1.57,95%CI:-1.55,4.69 with SUCRA:57.6).All approaches had indifferent dislocation and intraoperative fracture rates.SUCRA comparing early functional outcome and composite complications(dislocation,intra-operative fracture,wound complication,and nerve injury)found DAA was the best approach followed by DSA/SuperPath.CONCLUSION DSA/SuperPath had better earlier functional outcome than PA,but still could not overcome the result of DAA.This technique might be the other preferred option with acceptable complications. 展开更多
关键词 Total hip arthroplasty Total hip replacement approach Supercapsular percutaneously-assisted total hip Harris Hip Score Intra-operative fracture
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Minimalistic approach to left atrial appendage occlusion guided by cardiac computed tomography angiography
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作者 Xian-Sai MENG Qing-Song WANG +7 位作者 Xin-Yan WANG Xu LU Yang MU Jing WANG Ting-Ting SONG Yun-Dai CHEN Tao CHEN Jun GUO 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2024年第4期431-442,共12页
OBJECTIVE To assess the feasibility and safety of the minimalistic approach to left atrial appendage occlusion(LAAO) guided by cardiac computed tomography angiography(CCTA).METHODS Ninety consecutive patients who unde... OBJECTIVE To assess the feasibility and safety of the minimalistic approach to left atrial appendage occlusion(LAAO) guided by cardiac computed tomography angiography(CCTA).METHODS Ninety consecutive patients who underwent LAAO, with or without CCTA-guided, were matched(1:2). Each step of the LAAO procedure in the computed tomography(CT) guidance group(CT group) was directed by preprocedural CT planning. In the control group, LAAO was performed using the standard method. All patients were followed up for 12 months, and device surveillance was conducted using CCTA.RESULTS A total of 90 patients were included in the analysis, with 30 patients in the CT group and 60 matched patients in the control group. All patients were successfully implanted with Watchman devices. The mean ages for the CT group and the control group were 70.0 ± 9.4 years and 68.4 ± 11.9 years(P = 0.52), respectively. The procedure duration(45.6 ± 10.7 min vs. 58.8 ± 13.0 min,P < 0.001) and hospital stay(7.5 ± 2.4 day vs. 9.6 ± 2.8 day, P = 0.001) in the CT group was significantly shorter compared to the control group. However, the total radiation dose was higher in the CT group compared to the control group(904.9 ± 348.0 m Gy vs.711.9 ± 211.2 m Gy, P = 0.002). There were no significant differences in periprocedural pericardial effusion(3.3% vs. 6.3%, P = 0.8) between the two groups. The rate of postprocedural adverse events(13.3% vs. 18.3%, P = 0.55) were comparable between both groups at 12 months follow-up.CONCLUSIONS CCTA is capable of detailed LAAO procedure planning. Minimalistic LAAO with preprocedural CCTA planning was feasible and safe, with shortened procedure time and acceptable increased radiation and contras consumption. For patients with contraindications to general anesthesia and/or transesophageal echocardiography, this promising method may be an alternative to conventional LAAO. 展开更多
关键词 ANESTHESIA matched approach
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Virtual source approach for maximizing resolution in high-penetration gamma-ray imaging
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作者 Yuchi Wu Shaoyi Wang +14 位作者 Bin Zhu Yonghong Yan Minghai Yu Gang Li Xiaohui Zhang Yue Yang Fang Tan Feng Lu Bi Bi Xiaoqin Mao Zhonghai Wang Zongqing Zhao Jingqin Su Weimin Zhou Yuqiu Gu 《Matter and Radiation at Extremes》 SCIE EI CSCD 2024年第3期19-30,共12页
High-energy gamma-ray radiography has exceptional penetration ability and has become an indispensable nondestructive testing(NDT)tool in various fields.For high-energy photons,point projection radiography is almost th... High-energy gamma-ray radiography has exceptional penetration ability and has become an indispensable nondestructive testing(NDT)tool in various fields.For high-energy photons,point projection radiography is almost the only feasible imaging method,and its spatial resolution is primarily constrained by the size of the gamma-ray source.In conventional industrial applications,gamma-ray sources are commonly based on electron beams driven by accelerators,utilizing the process of bremsstrahlung radiation.The size of the gamma-ray source is dependent on the dimensional characteristics of the electron beam.Extensive research has been conducted on various advanced accelerator technologies that have the potential to greatly improve spatial resolution in NDT.In our investigation of laser-driven gamma-ray sources,a spatial resolution of about 90μm is achieved when the areal density of the penetrated object is 120 g/cm^(2).A virtual source approach is proposed to optimize the size of the gamma-ray source used for imaging,with the aim of maximizing spatial resolution.In this virtual source approach,the gamma ray can be considered as being emitted from a virtual source within the convertor,where the equivalent gamma-ray source size in imaging is much smaller than the actual emission area.On the basis of Monte Carlo simulations,we derive a set of evaluation formulas for virtual source scale and gamma-ray emission angle.Under optimal conditions,the virtual source size can be as small as 15μm,which can significantly improve the spatial resolution of high-penetration imaging to less than 50μm. 展开更多
关键词 RESOLUTION approach utilizing
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On Application of the Student-centered Approach in English Classroom Teaching of Chinese Vocational Colleges
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作者 荣宁宁 《海外英语》 2011年第6X期158-160,共3页
Nowadays, people have been more critical about the traditional ways of teaching and advocate the student-centered teaching approach. This paper focuses on the student- centered approach in English classroom teaching i... Nowadays, people have been more critical about the traditional ways of teaching and advocate the student-centered teaching approach. This paper focuses on the student- centered approach in English classroom teaching in vocational colleges. It points out that the students' English levels, the current mainstream of teaching in English class as well as the teaching materials in Chinese vocational college are all important factors that influence the outcome of the student-centered teaching approach. Meanwhile, the paper proves that college students can gain more in the student-centered English class. In the end, some suggestions are provided. 展开更多
关键词 student-centerED VOCATIONAL COLLEGES CLASSROOM TEACHING
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Debate on direct-anterior vs posterior approach for hip hemiarthroplasty:The authors’insights
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作者 Deepak Kumar Tarkik Thami Manjunath Nishani 《World Journal of Orthopedics》 2024年第5期486-488,共3页
We read and discussed the study entitled“Complication rates after direct anterior vs posterior approach for Hip Hemiarthroplasty in elderly individuals with femoral neck fractures”with great interest.The authors hav... We read and discussed the study entitled“Complication rates after direct anterior vs posterior approach for Hip Hemiarthroplasty in elderly individuals with femoral neck fractures”with great interest.The authors have done justice to the topic of comparison of anterior and posterior surgical approaches for bipolar hemiarthroplasty which has been an everlasting debate in the existing literature.However,there are certain aspects of this study that need clarification from the authors. 展开更多
关键词 COMMENTARY Direct anterior approach Posterior approach Hip hemiarthroplasty
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A Case Study on the Student-centered Approach to English Teaching for Students of Polytechnics
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作者 刘维娜 《海外英语》 2017年第21期224-225,共2页
Insights obtained from this study may be useful in improving college English teaching in the aim of better preparing teachers to assume teaching responsibilities.This study may also contribute to an understanding of h... Insights obtained from this study may be useful in improving college English teaching in the aim of better preparing teachers to assume teaching responsibilities.This study may also contribute to an understanding of how administrators can improve training programs to better meet the needs,experiences,and beliefs of college students.The information may be useful in improving programs designed to facilitate the development of college teachers' beliefs about teaching and teaching skills and specifically those target the development of inquiry teaching. 展开更多
关键词 student-centerED English Teaching Inquiry-teaching
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Direct anterior compared to posterior approach for hip hemiarthroplasty following femoral neck fractures
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作者 Kevin A Wu Alexandra N Krez Albert T Anastasio 《World Journal of Orthopedics》 2024年第6期605-607,共3页
The differences in complication rates between the direct anterior and posterior approaches for hemiarthroplasty in elderly patients with femoral neck fractures are not yet fully understood.Dislocation,a severe complic... The differences in complication rates between the direct anterior and posterior approaches for hemiarthroplasty in elderly patients with femoral neck fractures are not yet fully understood.Dislocation,a severe complication associated with increased mortality and often requiring additional surgery,may occur less frequently with the direct anterior approach compared to the posterior approach.Careful consideration of patient demographics is essential when planning the surgical approach.Future research in this area should focus on robust randomized controlled trials involving elderly patients recovering from femoral neck fractures. 展开更多
关键词 Direct anterior approach Posterior approach HEMIARTHROPLASTY Femoral neck fractures ARTHROPLASTY DISLOCATION Surgical technique
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A FLEXIBLE OBJECTIVE-CONSTRAINT APPROACH AND A NEW ALGORITHM FOR CONSTRUCTING THE PARETO FRONT OF MULTIOBJECTIVE OPTIMIZATION PROBLEMS
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作者 N.HOSEINPOOR M.GHAZNAVI 《Acta Mathematica Scientia》 SCIE CSCD 2024年第2期702-720,共19页
In this article, a novel scalarization technique, called the improved objective-constraint approach, is introduced to find efficient solutions of a given multiobjective programming problem. The presented scalarized pr... In this article, a novel scalarization technique, called the improved objective-constraint approach, is introduced to find efficient solutions of a given multiobjective programming problem. The presented scalarized problem extends the objective-constraint problem. It is demonstrated that how adding variables to the scalarized problem, can lead to find conditions for (weakly, properly) Pareto optimal solutions. Applying the obtained necessary and sufficient conditions, two algorithms for generating the Pareto front approximation of bi-objective and three-objective programming problems are designed. These algorithms are easy to implement and can achieve an even approximation of (weakly, properly) Pareto optimal solutions. These algorithms can be generalized for optimization problems with more than three criterion functions, too. The effectiveness and capability of the algorithms are demonstrated in test problems. 展开更多
关键词 multiobjective optimization Pareto front SCALARIZATION objective-constraint approach proper efficient solution
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A Deep Learning Based Broadcast Approach for Image Semantic Communication over Fading Channels
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作者 Ma Kangning Shi Yuxuan +1 位作者 Shao Shuo Tao Meixia 《China Communications》 SCIE CSCD 2024年第7期78-94,共17页
We consider an image semantic communication system in a time-varying fading Gaussian MIMO channel,with a finite number of channel states.A deep learning-aided broadcast approach scheme is proposed to benefit the adapt... We consider an image semantic communication system in a time-varying fading Gaussian MIMO channel,with a finite number of channel states.A deep learning-aided broadcast approach scheme is proposed to benefit the adaptive semantic transmission in terms of different channel states.We combine the classic broadcast approach with the image transformer to implement this adaptive joint source and channel coding(JSCC)scheme.Specifically,we utilize the neural network(NN)to jointly optimize the hierarchical image compression and superposition code mapping within this scheme.The learned transformers and codebooks allow recovering of the image with an adaptive quality and low error rate at the receiver side,in each channel state.The simulation results exhibit our proposed scheme can dynamically adapt the coding to the current channel state and outperform some existing intelligent schemes with the fixed coding block. 展开更多
关键词 broadcast approach deep learning fading channels semantic communication
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Lychrel Numbers in Base 10: A Probabilistic Approach
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作者 Rostand S. Kuitché 《Advances in Pure Mathematics》 2024年第8期667-694,共28页
For decades, Lychrel numbers have been studied on many bases. Their existence has been proven in base 2, 11 or 17. This paper presents a probabilistic proof of the existence of Lychrel number in base 10 and provides s... For decades, Lychrel numbers have been studied on many bases. Their existence has been proven in base 2, 11 or 17. This paper presents a probabilistic proof of the existence of Lychrel number in base 10 and provides some properties which enable a mathematical extraction of new Lychrel numbers from existing ones. This probabilistic approach has the advantage of being extendable to other bases. The results show that palindromes can also be Lychrel numbers. 展开更多
关键词 Probabilistic approach PALINDROMES Lychrel Numbers Iteration Function DIGITS
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Probabilistic Analysis of Slope Using Finite Element Approach and Limit Equilibrium Approach around Amalpata Landslide of West Central, Nepal
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作者 Mahendra Acharya Khomendra Bhandari +2 位作者 Sandesh Dhakal Aasish Giri Prabin Kafle 《International Journal of Geosciences》 CAS 2024年第5期416-432,共17页
The stability study of the ongoing and recurring Amalpata landslide in Baglung in Nepal’s Gandaki Province is presented in this research. The impacted slope is around 200 meters high, with two terraces that have diff... The stability study of the ongoing and recurring Amalpata landslide in Baglung in Nepal’s Gandaki Province is presented in this research. The impacted slope is around 200 meters high, with two terraces that have different slope inclinations. The lower bench, located above the basement, consistently fails and sets others up for failure. The fluctuating water level of the slope, which travels down the slope masses, exacerbates the slide problem. The majority of these rocks are Amalpata landslide area experiences several structural disruptions. The area’s stability must be evaluated in order to prevent and control more harm from occurring to the nearby agricultural land and people living along the slope. The slopes’ failures increase the damages of house existing in nearby area and the erosion of the slope. Two modeling techniques the finite element approach and the limit equilibrium method were used to simulate the slope. The findings show that, in every case, the terrace above the basement is where the majority of the stress is concentrated, with a safety factor of near unity. Using probabilistic slope stability analysis, the failure probability was predicted to be between 98.90% and 100%. 展开更多
关键词 Finite Element approach Limit Equilibrium Method SLOPE Factor of Safety
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“Instruction-Category” Approach of Test Suite Construction for Oven Embedded System
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作者 Mengqing Tanli Jiyi Xiao Ying Zhang 《Journal of Software Engineering and Applications》 2024年第9期713-730,共18页
Being different from testing for popular GUI software, the “instruction-category” approach is proposed for testing embedded system. This approach is constructed by three steps including refining items, drawing instr... Being different from testing for popular GUI software, the “instruction-category” approach is proposed for testing embedded system. This approach is constructed by three steps including refining items, drawing instruction-brief and instruction-category, and constructing test suite. Consequently, this approach is adopted to test oven embedded system, and detail process is deeply discussed. As a result, the factual result indicates that the “instruction-category” approach can be effectively applied in embedded system testing as a black-box method for conformity testing. 展开更多
关键词 “Instruction-Category” approach Test Suite Construction Embedded System
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Watson-Jones Anatomical Approach for Open Reduction and Internal Fixation of Proximal Femoral Fractures without Image Intensifier in a Low-Resource Setting
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作者 Loïc Fonkoue Gaspary Fodjeu +6 位作者 Kennedy Olivier Muluem Olivier Ngongang Theophile Nana Marie Ange Ngo Yamben DésiréAkaba Urich Tambekou Daniel Eone Handy 《Open Journal of Orthopedics》 2024年第4期173-186,共14页
Introduction: Standard procedures for surgical fixation of proximal femoral fractures (PFF) require an image intensifier which in developing countries remains a luxury. We hypothesized that, with a well-codified techn... Introduction: Standard procedures for surgical fixation of proximal femoral fractures (PFF) require an image intensifier which in developing countries remains a luxury. We hypothesized that, with a well-codified technique, the Watson Jones approach (WJA) without image intensifier nor traction table, can allow open reduction and internal fixation (ORIF) of PFF using Dynamic hip screw (DHS), with satisfactory outcome. Patients and methods: Forty one consecutive patients (mean age 59.5 ± 21.6 years, 61% males) who were followed in a Teaching Hospital for PFF treated by ORIF using the WJA and DHS from January 2016 to December 2020 were reassessed. The outcome measures were the quality of the reduction, the positioning of the implants, the tip-apex distance (TAD), the rate and delay of consolidation, the functional results using Postel Merle d’Aubigné (PMA) score, the rate of surgical site infection (SSI) and the overall mortality. Logistic regression was used to determine factors associated with mechanical failure. Results: The mean follow-up period was 33.8 ± 15.0 months. Fracture reduction was good in 31 (75.6%) cases and acceptable in 8(19.5%) cases. Implant position was fair to good in 37 (90.2%) patients. The mean TAD was 26.1 ± 3.9 mm. Three patients developed SSI. Consolidation was achieved in 38 (92.6%) patients. The functional results were good to excellent in 80.5% of patients. The overall mortality rate was 7.3%. There were an association between mechanical failure and osteoporosis (p = 0.04), fracture reduction (p = 0.003), and TAD (p = 0.025). In multivariate logistic regression, no independent factors were predictive of mechanical failure. Conclusion: This study shows that ORIF using DHS for PFF via the Watson-Jones approach without an image intensifier can give satisfactory anatomical and functional outcomes in low-resource settings. It provides and validates a reliable and reproducible technique that deserves to be diffused to surgeons in austere areas over the world. 展开更多
关键词 Proximal Femoral Fracture Watson-Jones approach Dynamic Hip Screw Low Resource Setting
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Gastrointestinal tuberculosis:Diagnostic approaches for this uncommon pathology
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作者 Lottie Brown Michael Colwill Andrew Poullis 《World Journal of Clinical Cases》 SCIE 2024年第23期5283-5287,共5页
A case report entitled“Primary gastroduodenal tuberculosis presenting as gastric outlet obstruction”recently published in the World Journal of Clinical Cases presented a rare cause of gastric outlet obstruction and ... A case report entitled“Primary gastroduodenal tuberculosis presenting as gastric outlet obstruction”recently published in the World Journal of Clinical Cases presented a rare cause of gastric outlet obstruction and highlighted the atypical manner in which gastrointestinal tuberculosis(TB)can present.The literature with regards to this rare pathology is limited to case reports and case series with the largest being published using data from between 2003 and 2013.However,since then the diagnostic tools available have significantly changed with more modern and increasingly accurate tests now available.This editorial reviews the current state of the art with regards to diagnosis in gastrointestinal TB. 展开更多
关键词 Gastrointestinal tuberculosis Diagnostic approach MICROBIOLOGY SEROLOGY Molecular diagnosis Infectious disease
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Carbamazepine in osteoarthritis treatment:A novel approach targeting Nav1.7 channels
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作者 Rayyan Vaid Afra Sohail Nabiha Amir 《World Journal of Orthopedics》 2024年第6期602-604,共3页
Osteoarthritis(OA)presents a growing health concern,with substantial societal and healthcare burdens.Current management focuses on symptom relief,lacking disease-modifying options.Emerging research suggests the sodium... Osteoarthritis(OA)presents a growing health concern,with substantial societal and healthcare burdens.Current management focuses on symptom relief,lacking disease-modifying options.Emerging research suggests the sodium channel Nav1.7 as a pivotal target in OA treatment.Preclinical studies demonstrate carbamazepine's efficacy in Nav1.7 blockade,offering significant joint protection in animal models.However,human trials are needed to validate these findings.Carbamazepine's repurposing holds promise for OA management,potentially revolutionizing treatment paradigms.Further research is essential to bridge the gap between preclinical evidence and clinical application,offering hope for improved OA management and enhanced patient quality of life. 展开更多
关键词 OSTEOARTHRITIS Joint illness Treatment approaches Pain management Healthcare expenses
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Relaxed Stability Criteria for Time-Delay Systems:A Novel Quadratic Function Convex Approximation Approach
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作者 Shenquan Wang Wenchengyu Ji +2 位作者 Yulian Jiang Yanzheng Zhu Jian Sun 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2024年第4期996-1006,共11页
This paper develops a quadratic function convex approximation approach to deal with the negative definite problem of the quadratic function induced by stability analysis of linear systems with time-varying delays.By i... This paper develops a quadratic function convex approximation approach to deal with the negative definite problem of the quadratic function induced by stability analysis of linear systems with time-varying delays.By introducing two adjustable parameters and two free variables,a novel convex function greater than or equal to the quadratic function is constructed,regardless of the sign of the coefficient in the quadratic term.The developed lemma can also be degenerated into the existing quadratic function negative-determination(QFND)lemma and relaxed QFND lemma respectively,by setting two adjustable parameters and two free variables as some particular values.Moreover,for a linear system with time-varying delays,a relaxed stability criterion is established via our developed lemma,together with the quivalent reciprocal combination technique and the Bessel-Legendre inequality.As a result,the conservatism can be reduced via the proposed approach in the context of constructing Lyapunov-Krasovskii functionals for the stability analysis of linear time-varying delay systems.Finally,the superiority of our results is illustrated through three numerical examples. 展开更多
关键词 Equivalent reciprocal combination technique quadratic function convex approximation approach STABILITY timevarying delay
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The Student-Centered and Topic-Based Approach in College English Teaching
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作者 郭婧 《海外英语》 2010年第12X期23-24,共2页
The Natural Approach has got through the debates and is proved to be helpful in foreign language teaching.Based on this,the student-centered & topic-based approach is proved to be an appropriate way in college Eng... The Natural Approach has got through the debates and is proved to be helpful in foreign language teaching.Based on this,the student-centered & topic-based approach is proved to be an appropriate way in college English teaching.This paper is devoted to justifying the effectiveness of this approach in the college English classroom,and providing an organization of a typical college English class. 展开更多
关键词 student-centerED & topic-based approach natural approach COLLEGE English teaching
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