Traditional Chinese Medicine in colorectal cancer treatment:a bibliometrics study and visualization analysis via CiteSpace

Objective:To evaluate the current state of research and areas of interest for traditional Chinese medicine(TCM)in the field of colorectal cancer treatment.Methods:Related papers published between January 1,2012,and November 27,2021,were found using the Web of Science Core Collection Science Citation Index Expanded.Using CiteSpace's network map generation capability,we then determined the top writers,organizations,countries,keywords,co-cited writers,journals,references,and research trends.Results:This investigation yielded a total of 336 relevant papers.China is the most productive country.Shanghai University of Traditional Chinese Medicine is the leading institution.The journal with the most popularity and publishing volume is Evidence-based Complementary and Alternative Medicine.The author with the most citations and centrality is Lin JM.The terms"epithelial-mesenchymal transition,""cell cycle arrest,""apoptosis,"and"autophagy"are highly frequent and have a high betweenness centrality.Conclusion:According to the results,research on natural products,traditional Chinese medicine(TCM)extracts,and the molecular mechanisms of TCM chemical constituents constitutes the primary focus within TCM cancer treatment investigations.In recent years,there has been a surge of interest in exploring the role of gut microbiota in TCM chemical constituents research,particularly in its ability to induce apoptosis and autophagy in tumor cells,thereby suppressing tumor cell proliferation,metastasis,and invasion.However,due to the intricate composition of TCM and existing technical limitations,the underlying principles guiding TCM's efficacy in treating colorectal cancer remain unclear and warrant further investigation.

Comparison Study and Forensic Analysis between Experiment and Coupled Dynamics Simulation for Submerged Floating Tunnel Segment with Free Ends under Wave Excitations

This paper presents dynamic-behavior comparisons and related forensic analyses of a submerged floating tunnel(SFT)between numerical simulation and physical experiment under regular and irregular waves.The experiments are conducted in the 3Dwave tank with 1:33.3 scale,and the corresponding coupled time-domain simulation tool is devised for comparison.The entire SFT systemconsists of a long concrete tunnel and 12 tubular aluminummooring lines.Two numerical simulation models,the Cummins equation with 3D potential theory including second-order wave-body interaction effects and the much simpler Morison-equation-based formula with the lumped-massbased line model,are designed and compared.Forensic analyses for mooring-line adjustments in the simulation are carried out in view of the best representation of the physical system.After that,the measured pre-tension distribution and systemstiffness of twelvemooring lines arewell reproduced in the numericalmodel.Subsequently,the dynamic responses and mooring tensions of the SFT are compared under regular and irregular waves.The measured and simulated results coincide reasonably well for both regular-and irregular-wave conditions.

Associations of Time Spent on Study and Sleep with Anxiety and Depressive Symptoms in Junior High School Students:Report from the Large-Scale Monitoring of Basic Education Data in China

In the context of the COVID-19 pandemic and under the pressure of high competitiveness for higher education in China,junior high school students’mental health is facing greater challenges.Understanding the time allocation of study and sleep is necessary for developing effective prevention and treatment programs.Based on a survey of 31,057 junior high school students in 47 junior high schools in Gansu Province,China's Mainland,the study analyzed the associations of time spent on study and sleep with anxiety and depressive symptoms among junior high school students through chi-square test,ANOVA,logistic regression model and threshold regression model.It was found that 18.4%–21.1%of junior high school students had mild and above anxiety and depressive symptoms.Female junior high school students were more likely to have anxiety and depressive symptoms.In addition,time spent on study was significantly and positively associated with anxiety and depressive symptoms and time spent on sleep was significantly and negatively associated with anxiety and depressive symptoms.Late sleepers were more likely to suffer from anxiety and depressive tendencies.Reducing after-school study time appropriately and getting more sleep are beneficial in reducing anxiety and depression,but it is more important to ensure time of sleep.For the reduction of anxiety and depressive symptoms,the maximum time spent on study after school should not exceed 1.92 h,the minimum time spent on sleep at night should be more than 7 h and a 40-min lunch break should be guaranteed at noon.

Study and Application of Mold Filling Simulation of Shaped Castings

In this paper, an algorithm for simulating fluid flow and heat transfer for mold filling of shaped castings is presented. The main features of the algorithm include: 1) a simple but practical technique based on VOF method to determine free surface, 2) an explicit scheme of enthalpy to solve the energy equation more efficiently, and 3) an effective treatment to modify the flux deviation due to pressure iteration. In order to verify these methods, well controlled experiments have been repeatedly done with both water analog and gray iron pouring experiments to record the flow patterns and temperature variations. The calculated results are in accordance with the experimental ones. For the applications, the simulated initial temperature distribution right after mold filling was used to analyse subsequent solidification and to predict shrinkage defects. Actual castings were poured and tested in a foundry plant. The reuslts show that the defects predication with considering fluid flow effects is more precise than that without considering the effects.

STUDY AND APPLICATION OF THE AERIAL PASSIVE MICROWAVE REMOTE SENSING

Ⅰ. Introduction Over the past two decades, microwave remote sensing has evolved into a focal point in the remote sensing area. This is due to the fact that in microwave band, we can acquire physical parameters about ocean, terrain and atmosphere on all weather condition. Research and application work about the aerial passive micro wave remote sensors has been done at Changchun Institute of Geography since 1973, under the unitary planning of Academia Sinica. Microwave radiometers of six freqency bands have been developed. Numerous remote sensing experiments were carried out, and large amount of scientific data were accumulated. Recently, theoretical models have

Chemical Indicator of Spinel During Partial Melting and Subsolidus Equilibration of Mantle Peridotite:Experimental Study and Application to Natural Rocks

Systematic experimental studies on partial melting and subsolidus equilibration of three reconstituted spinel-peridotites have been carried out at temperatures ranging from 1000 to 1380℃ and pressures of 1.0 and 1.5 GPa. The results shows (1) during partial melting, Mg# [=Mg/(Mg+Fe)]and Cr# [=Cr/(Cr-Al)]of spinel increase with an increase in degrees of melting) (2) during subsolidus equilibration, with increasing temperatures, Mg# of spinel increases but Cr# of spinel remains almost unchanged in dunite and increases slightly in Iherzolite and harzburgite. The negative and quasi-linear Mg# -Cr# correlation of spinel represents an isotherm of total non-equilibrium. The same results have been obtained by means of mathematical modelling. It is also proved by Mg# -Cr# correlation of spinel in natural peridotites. As a result of the spinel subsolidus equilibration, only variation of Cr# of spinel is limited, and then Cr# of spinel can be used to estimate the relative degree of melting undergone by host rocks. The bigger Cr# of spinel is, the higher the degree of melting will be. By contrast, during crystallization magma, Mg# and Cr# of spinel decrease with decreasing temperatures. Likewise, Cr# of spinel in basalts may be used to indicate the feature of Cr2O3/Al2O3 of magma, and the compositional zoning of spinel may be used to study the evolution of magma (cooling rate and contamination).

Comparative Study and Spatial-Temporal Distribution of Regolith and Rock Geochemical Data from Xingmeng-North China

1 Introduction Geochemical mapping at national and continental scales continues to present challenges worldwide due to variations in geologic and geotectonic units.Use of the proper sampling media can provide rich information on

STUDY AND APPLICATION OF SPECTROPHOTOMETRIC DETERMINATION OF MICRO AMOUNTS OF BISMUTH WITH MESO—TETRAKIS—(4—N—TRIMETHYL AMMONIUMPHENYL)PORPHINE

A new highly sensitive spectrophotometric method has been developed for the determination of micro amounts of bismuth (Ⅲ), based on the formation of Bi (Ⅲ)—meso—tetrakis—(4—N—trimethylammonium phenyl) porphine [T (4TMAP) P] complex. In the presence of Cd (Ⅱ), Bi(Ⅲ) reacts almost instantaneously with T (4TMAP)P in a 0. 6 mol/l NaAc—HAC buffer (PH5.8) at room temperature. The composition of the complex is T(4TMAP)P: Bi=1:1. The absorbance complex obeys Beer's law over the Bi(Ⅲ) concentration range 0.1—1.4 μg/ml. The linear relative coefficient γ is 0.9998. The apparent molar absorptivity was 1.75×10~5 1. mol^(-1). cm^(-1) at 463nm. The relative standard deviation of the method is 1.50％ for Bi(Ⅲ) 7ug/10ml (10 determinations). The interference of foreign ions has been examined. This simple and rapid method can be applied to the assay of Bi(Ⅲ) in some tablets directly.

THE BRIEF INTRODUCTION OF CHANGCHUN JINGYUETAN OPEN REMOTE SENSING STUDY AND TEST SITE OF THE CHINESE ACADEMY OF SCIENCES

In 1979, the Changchun Jingyuetan Remote Sensing Study and Test Site (RSSTS)began its work, and it was formally established in 1985. The RSSTS is subordinated the Changchun Branch of Chinese Academy of Sciences and is supported by the Changchun Institute of Geography and Changchun Institute of Optics and Fine Machnics, Chinese Academy of Sciences. It is under the management of the Resource & Environment Bureau of Chinese Academy of Sciences and it is the study base of remote sensing basis and application tests in China. The RSSTS is situated in the Jingyuetan scenic spot of the suburbs of Changchun City, Jilin Province. It is located at 43°40′—43°50′N and 125°18′-125°18′E.

Magnetic nanotechnology to study and promote axon growth

After injury of the central and peripheral nervous systems,functional recovery is impaired by axon regeneration failure.Various approaches for promoting axon growth have been attempted but their low efficacy has prevented them from being clinically applicable.

STUDY AND APPLICATION OF A NOVEL CHEMILUMINESCENCE REACTION

The present paper reports a novel chemiluminescence,i.e,isopropyl alcohol-C10^--H_2O_2 system.The chemiluminescence intensity is proportional to the concentration of C10^- within certain range.Based on this fact,a new chemiluminescence method for the determination of micro amount of C10^- has been developed.The detection limit is 2.6 x 10^(-8)g/ml C10^- and the dynamic linear range is 2.6 x 10^(-8)g/ml to 2.3 x 10^(-5)g/ml C10^-.The method has good selectivlty and reproducibility.

Gene Study and Application in China

1.China’s Human Genome DevelopmentThe international programe--sequencingof human genome, honored as the "MoonLanding Program" started in 1990, havingmany scientists from the United States,Japan, Germany, France and

Registers Study and Poetic Language

Poetic language is distinguished from other roles of language by its creativity in linguistic uses,among which register deviation and register mixing are the most conspicuous.A register study of poetic works is therefore beneficial to our understanding of the works in case.The present thesis adopts a Hallidayian Functional approach to analyze two short poems,illustrating this feature of poetic language and demonstrating a register study in a poetic context.

First standard released to regulate the study and use of stem cells

China’s first general standard for stem cells officially released on November 22,2017 is expected to lay a foundation for regulating the application of stem cells technology.Stem cells are a group of self-renewal cells that can differentiate into specialized cells.They are now used for the treatment of many diseases.Despite a series of documents for regulating basic research and achievement transformation of stem cells,the clinical application and industrialization still face great challenges due to

Clinical imaging study and meta-analysis of ossification of the ligamentum flavum

Objective To study the clinical epidemiology of ossification of ligamentum flavum(OLF)and evaluate its characteristics of prevalence, morphology, and distribution in a common population.Some factors associated with its occurrence were analyzed

Speech at the Symposium on Study and Implementation of the Spirit of the 19^(th) CPC National Congress at the China Society for Human Rights Studies

Following the successful conclusion of the 19thCommunist Party of China National Congress,there has been a nationwide upsurge in the study and implementation of the spirit of the Congress.It was therefore both necessary and timely for the China Society for Human Rights Studies to organize a symposium on the study and implementation of the spirit of the Congress.I’d like to express my understanding of the study and implementation of the spirit of the 19th CPC National Congress from three aspects:

China Society for Human Rights Studies Organizes Forum to Study and Implement Guidelines of 3rd Plenum of 18th CPC Central Committee

The China Society for Human Rights Studies （CSHRS） organized on Nov. 28 a forum to study and implement the guidelines of the third plenary session of the 18th Central Committee of the Communist Party of China （CPC）. Executive members of CSHRS and other CSHRS members in Beijing discussed improvement of judicial protection for human rights and legal construction in China. CSHRS President Luo Haocai, who was vice chairman of the 10th National Committee of the Chinese People＇s Political Consultative Conference, delivered a speech at the forum.

Clinical study and differential diagnosis of intracranial hemangiopericytomas

Objective Intracranial hemangiopericytomas (HPCs) were rare neoplasms with relatively high rates of recurrence and extracranial metastasis.The differential diagnoses from angiomatous meningiomas and solitary fibrous tumors(SFTs) are very important. This study aimes to reveal differences in the specific immunohistochemical features of HPCs,angiomatous meningiomas and SFTs by newly

Genome-wide association study and genomic prediction of Fusarium ear rot resistance in tropical maize germplasm

Fusarium ear rot(FER)is a destructive maize fungal disease worldwide.In this study,three tropical maize populations consisting of 874 inbred lines were used to perform genomewide association study(GWAS)and genomic prediction(GP)analyses of FER resistance.Broad phenotypic variation and high heritability for FER were observed,although it was highly influenced by large genotype-by-environment interactions.In the 874 inbred lines,GWAS with general linear model(GLM)identified 3034 single-nucleotide polymorphisms(SNPs)significantly associated with FER resistance at the P-value threshold of 1×10^(-5),the average phenotypic variation explained(PVE)by these associations was 3%with a range from 2.33%to 6.92%,and 49 of these associations had PVE values greater than 5%.The GWAS analysis with mixed linear model(MLM)identified 19 significantly associated SNPs at the P-value threshold of 1×10^(-4),the average PVE of these associations was 1.60%with a range from 1.39%to 2.04%.Within each of the three populations,the number of significantly associated SNPs identified by GLM and MLM ranged from 25 to 41,and from 5 to 22,respectively.Overlapping SNP associations across populations were rare.A few stable genomic regions conferring FER resistance were identified,which located in bins 3.04/05,7.02/04,9.00/01,9.04,9.06/07,and 10.03/04.The genomic regions in bins 9.00/01 and 9.04 are new.GP produced moderate accuracies with genome-wide markers,and relatively high accuracies with SNP associations detected from GWAS.Moderate prediction accuracies were observed when the training and validation sets were closely related.These results implied that FER resistance in maize is controlled by minor QTL with small effects,and highly influenced by the genetic background of the populations studied.Genomic selection(GS)by incorporating SNP associations detected from GWAS is a promising tool for improving FER resistance in maize.