Background:To analyze the distribution of traditional Chinese medicine(TCM)syndromes and the related factors in patients with renal cell carcinoma,and to provide further guidance for the relapse prevention and combina...Background:To analyze the distribution of traditional Chinese medicine(TCM)syndromes and the related factors in patients with renal cell carcinoma,and to provide further guidance for the relapse prevention and combination of traditional Chinese and Western medicine in postoperative renal cancer patients.Methods:A retrospective survey was conducted to establish a postoperative clinical symptom assessment scale for patients with renal cell carcinoma.The distribution of TCM syndromes in 145 patients with renal cell carcinoma was analyzed statistically.Multivariate logistic regression was used to analyze the correlation between different TCM syndromes and risk factors.Results:The postoperative TCM syndromes of patients with cell carcinoma were mainly spleen-kidney deficiency(38.6%),liver-kidney Yin deficiency(15.9%),spleen-kidney Yang deficiency(13.1%),and damp-heat pouring downward(9.7%).The incidence of severe spleen-kidney Qi deficiency syndrome and spleen-kidney Yang deficiency syndrome was statistically different from that of liver-kidney Yin deficiency syndrome(P<0.05).The history of drinking and body mass index≥24 kg/m2 were risk factors for spleen-kidney Qi deficiency syndrome;the history of hypertension was a protective factor for liver-kidney Yin deficiency syndrome after renal cancer surgery;male was a protective factor for patients with renal cancer who had damp-heat pouring downward syndrome;smoking history and drinking history were risk factors for damp-heat pouring downward;age was a protective factor for spleen-kidney Yang deficiency after renal cancer surgery.Conclusion:This study found that spleen-kidney Qi deficiency syndrome,liver-kidney Yin deficiency syndrome,spleen-kidney Yang deficiency syndrome,dampness and heat injection syndrome were the common TCM syndrome types after renal cell carcinoma patients.There was a correlation between the TCM syndromes of renal cell carcinoma and the risk factors such as drinking history,overweight and obesity,smoking history and drinking history.The distribution of TCM syndromes and its correlation with risk factors in renal cell carcinoma patients after surgery can provide ideas for clinical treatment and prognosis.展开更多
Objective:To observe the expression of CTX-I(Ⅰcollagen C-terminal foreign body peptide)and TRACP(tartrate-resistant acid phosphatase)in different syndromes of knee osteoarthritis and their correlation with ADAMTS-4(p...Objective:To observe the expression of CTX-I(Ⅰcollagen C-terminal foreign body peptide)and TRACP(tartrate-resistant acid phosphatase)in different syndromes of knee osteoarthritis and their correlation with ADAMTS-4(polyproteoglycan enzyme-4)and MMPS-3(matrix metalloproteinase-3).Methods:A total of 98 patients diagnosed with knee osteoarthritis were enrolled from the Rehabilitation Pain Department and Rheumatology Department of Wuhan Caidian District People's Hospital.According to their syndrome types,they were divided into 40 cases of Yang deficiency and cold constipation type,28 cases of qi stagnation and blood stasis type,and 30 cases of kidney jing deficiency type.The contents of bone metabolism indexes,ADAMTS-4 and MMPS-3 in different syndromes of the three groups were compared.Correlation of bone metabolism indexes with ADAMTS-4 and MMPS-3.Results:There were statistically significant differences in the contents of CTX-I,TRACP,ADAMTS-4 and MMPS-3 among three groups with different syndromes(P<0.05).There was a positive correlation between CTX-I,TRACP,ADAMTS-4 and MMPS-3(P<0.05).The syndrome of qi stagnation and blood stasis was positively correlated with TRACP and ADAMTS-4,and negatively correlated with MMPS-3(P<0.05).The renal essence deficiency syndrome was positively correlated with CTX-I,ADAMTS-4 and MMPS-3(P<0.05).Bone metabolic indexes(CTX-I,TRACP)were positively correlated with ADAMTS-4 and MMPS-3(P<0.05).Conclusion:Different syndromes of knee osteoarthritis are correlated with bone metabolism indexes,ADAMTS-4 and MMPS-3,which can provide a certain objective basis for clinical TCM syndrome differentiation and classification。展开更多
目的:研究结肠息肉的中医证型分布,同时探讨其中医证型与病理类型及发病因素的相关性,旨在为结肠息肉临床辨证和中医防治提供依据。方法:通过回顾性研究的方法获取并整理结肠息肉患者的基本信息、中医证型、病理分型、血脂程度及结肠镜...目的:研究结肠息肉的中医证型分布,同时探讨其中医证型与病理类型及发病因素的相关性,旨在为结肠息肉临床辨证和中医防治提供依据。方法:通过回顾性研究的方法获取并整理结肠息肉患者的基本信息、中医证型、病理分型、血脂程度及结肠镜结果等信息,包括性别、年龄、饮食习惯、吸烟饮酒量、三酰甘油(Triglycerides,TG)、总胆固醇(Total Cholesterol,TC)、高密度脂蛋白(High-density Lipoprotein,HDL)、低密度脂蛋白(Low Density Lipoprotein,LDL)、息肉病理类型。统计分析结肠息肉中医证型与病理类型及发病因素之间的相关性。结果:①中医证型分布规律:大肠湿热证199例(39.5%)>肝郁气滞证127例(25.2%)>脾胃虚弱证101例(20.0%)>瘀血内停证46例(9.1%)>寒湿内阻证30例(5.9%)。②结肠息肉患者年龄大多≥45岁,447例,占88.86%;饮食习惯以肥甘厚味为主,有208例,占41.35%;吸烟者232例,占46.13%;饮酒者136例,占27.04%。③结肠息肉患者中腺瘤性息肉患者295例,占58.65%,非腺瘤性息肉患者208例,占41.35%。④非高总胆固醇血症124例,占24.65%,高总胆固醇血症379例,占75.35%;非高甘油三酯血症136例,占27.03%,高甘油三酯血症367例,占72.97%;非高脂血症139例,占27.63%,高脂血症364例,占72.37%;非低高密度脂蛋白血症222例,占44.13%,低高密度脂蛋白血症281例,占55.87%。结论:结肠息肉中医证型以大肠湿热证多见。腺瘤性息肉中医证型以大肠湿热证为主,非腺瘤性息肉中炎性息肉以大肠湿热证为主,增生性息肉以肝郁气滞证多见,差异具有统计学意义(P<0.05)。不同证型高总胆固醇血症分布具有差异(P<0.05),以大肠湿热证多见;不同证型高总胆固醇血症、高脂血症、低高密度脂蛋白血症分布无差异(P>0.05)。展开更多
文摘Background:To analyze the distribution of traditional Chinese medicine(TCM)syndromes and the related factors in patients with renal cell carcinoma,and to provide further guidance for the relapse prevention and combination of traditional Chinese and Western medicine in postoperative renal cancer patients.Methods:A retrospective survey was conducted to establish a postoperative clinical symptom assessment scale for patients with renal cell carcinoma.The distribution of TCM syndromes in 145 patients with renal cell carcinoma was analyzed statistically.Multivariate logistic regression was used to analyze the correlation between different TCM syndromes and risk factors.Results:The postoperative TCM syndromes of patients with cell carcinoma were mainly spleen-kidney deficiency(38.6%),liver-kidney Yin deficiency(15.9%),spleen-kidney Yang deficiency(13.1%),and damp-heat pouring downward(9.7%).The incidence of severe spleen-kidney Qi deficiency syndrome and spleen-kidney Yang deficiency syndrome was statistically different from that of liver-kidney Yin deficiency syndrome(P<0.05).The history of drinking and body mass index≥24 kg/m2 were risk factors for spleen-kidney Qi deficiency syndrome;the history of hypertension was a protective factor for liver-kidney Yin deficiency syndrome after renal cancer surgery;male was a protective factor for patients with renal cancer who had damp-heat pouring downward syndrome;smoking history and drinking history were risk factors for damp-heat pouring downward;age was a protective factor for spleen-kidney Yang deficiency after renal cancer surgery.Conclusion:This study found that spleen-kidney Qi deficiency syndrome,liver-kidney Yin deficiency syndrome,spleen-kidney Yang deficiency syndrome,dampness and heat injection syndrome were the common TCM syndrome types after renal cell carcinoma patients.There was a correlation between the TCM syndromes of renal cell carcinoma and the risk factors such as drinking history,overweight and obesity,smoking history and drinking history.The distribution of TCM syndromes and its correlation with risk factors in renal cell carcinoma patients after surgery can provide ideas for clinical treatment and prognosis.
基金Research Project Funding of Health and Family Planning Commission of Wuhan(No.WZ20Q12)Key Program of the National Natural Science Fund of China(No.81590955)。
文摘Objective:To observe the expression of CTX-I(Ⅰcollagen C-terminal foreign body peptide)and TRACP(tartrate-resistant acid phosphatase)in different syndromes of knee osteoarthritis and their correlation with ADAMTS-4(polyproteoglycan enzyme-4)and MMPS-3(matrix metalloproteinase-3).Methods:A total of 98 patients diagnosed with knee osteoarthritis were enrolled from the Rehabilitation Pain Department and Rheumatology Department of Wuhan Caidian District People's Hospital.According to their syndrome types,they were divided into 40 cases of Yang deficiency and cold constipation type,28 cases of qi stagnation and blood stasis type,and 30 cases of kidney jing deficiency type.The contents of bone metabolism indexes,ADAMTS-4 and MMPS-3 in different syndromes of the three groups were compared.Correlation of bone metabolism indexes with ADAMTS-4 and MMPS-3.Results:There were statistically significant differences in the contents of CTX-I,TRACP,ADAMTS-4 and MMPS-3 among three groups with different syndromes(P<0.05).There was a positive correlation between CTX-I,TRACP,ADAMTS-4 and MMPS-3(P<0.05).The syndrome of qi stagnation and blood stasis was positively correlated with TRACP and ADAMTS-4,and negatively correlated with MMPS-3(P<0.05).The renal essence deficiency syndrome was positively correlated with CTX-I,ADAMTS-4 and MMPS-3(P<0.05).Bone metabolic indexes(CTX-I,TRACP)were positively correlated with ADAMTS-4 and MMPS-3(P<0.05).Conclusion:Different syndromes of knee osteoarthritis are correlated with bone metabolism indexes,ADAMTS-4 and MMPS-3,which can provide a certain objective basis for clinical TCM syndrome differentiation and classification。
文摘目的:研究结肠息肉的中医证型分布,同时探讨其中医证型与病理类型及发病因素的相关性,旨在为结肠息肉临床辨证和中医防治提供依据。方法:通过回顾性研究的方法获取并整理结肠息肉患者的基本信息、中医证型、病理分型、血脂程度及结肠镜结果等信息,包括性别、年龄、饮食习惯、吸烟饮酒量、三酰甘油(Triglycerides,TG)、总胆固醇(Total Cholesterol,TC)、高密度脂蛋白(High-density Lipoprotein,HDL)、低密度脂蛋白(Low Density Lipoprotein,LDL)、息肉病理类型。统计分析结肠息肉中医证型与病理类型及发病因素之间的相关性。结果:①中医证型分布规律:大肠湿热证199例(39.5%)>肝郁气滞证127例(25.2%)>脾胃虚弱证101例(20.0%)>瘀血内停证46例(9.1%)>寒湿内阻证30例(5.9%)。②结肠息肉患者年龄大多≥45岁,447例,占88.86%;饮食习惯以肥甘厚味为主,有208例,占41.35%;吸烟者232例,占46.13%;饮酒者136例,占27.04%。③结肠息肉患者中腺瘤性息肉患者295例,占58.65%,非腺瘤性息肉患者208例,占41.35%。④非高总胆固醇血症124例,占24.65%,高总胆固醇血症379例,占75.35%;非高甘油三酯血症136例,占27.03%,高甘油三酯血症367例,占72.97%;非高脂血症139例,占27.63%,高脂血症364例,占72.37%;非低高密度脂蛋白血症222例,占44.13%,低高密度脂蛋白血症281例,占55.87%。结论:结肠息肉中医证型以大肠湿热证多见。腺瘤性息肉中医证型以大肠湿热证为主,非腺瘤性息肉中炎性息肉以大肠湿热证为主,增生性息肉以肝郁气滞证多见,差异具有统计学意义(P<0.05)。不同证型高总胆固醇血症分布具有差异(P<0.05),以大肠湿热证多见;不同证型高总胆固醇血症、高脂血症、低高密度脂蛋白血症分布无差异(P>0.05)。
文摘目的探讨新型冠状病毒感染(corona virus disease 2019,COVID-19)恢复期合并高血压病患者的中医证候特征及分子通路机制。方法按照临床流行病学方法收集武汉11家医院的1314例COVID-19患者的临床资料,建立“新型冠状病毒感染病例登记系统”(http://covid-19.keyanyun.com),选取120例COVID-19恢复期合并高血压病患者的临床资料作为研究对象并进行长期随访,收集其出院后的中医四诊资料,通过真实世界研究(realworld study,RWS)方法进行双向队列研究,采用频数统计、因子分析、聚类分析等统计学方法,统计其主要症状、病位、病性及中医证型分布。结合前方得出的各证型中医证候特征,以“症状”为切入点,利用生物信息学方法,获得本研究疾病靶点及各证型中医证候表型靶点,进行京都基因与基因组百科全书(Kyoto encyclopedia of genes and genomes,KEGG)通路富集分析。结果中医症状以喘促气短、乏力、胸闷、健忘、失眠、咽干口渴、自汗、咳嗽、咳痰、神疲、痰白、口苦为主,舌象以苔白、舌胖大、苔黄为主,脉象以脉细、脉沉多见。因子分析共提取8个公因子,病位证素主要为肺、脾、肝、肾、心,病性证素主要是气虚、阴虚、湿、热。聚类分析表明中医证型以肺脾气虚证、气阴两虚证、肝火犯肺证、肺肾气虚证为主。4个证型的目标靶点数目分别为202、201、155、212,KEGG通路富集结果表明对应通路大致相似,但各证型的信号通路侧重点不同。除肺肾气虚证外,其余3个证型都对Toll样受体信号通路、IL-17信号通路、TNF信号通路等具有较强干预作用。结论COVID-19恢复期合并高血压病的中医证候分散性良好,中医证型以肺脾气虚证、气阴两虚证、肝火犯肺证、肺肾气虚证为主,病机表现为邪气未尽、正气未复,信号通路主要与病毒感染、免疫炎症相关,可为临床辨证用药提供中医学及分子生物学借鉴。
