This article studies the fault detection filtering design problem for Roesser type two-dimensional(2-D)nonlinear systems described by uncertain 2-D Takagi-Sugeno(T-S)fuzzy models.Firstly,fuzzy Lyapunov functions are c...This article studies the fault detection filtering design problem for Roesser type two-dimensional(2-D)nonlinear systems described by uncertain 2-D Takagi-Sugeno(T-S)fuzzy models.Firstly,fuzzy Lyapunov functions are constructed and the 2-D Fourier transform is exploited,based on which a finite frequency fault detection filtering design method is proposed such that a residual signal is generated with robustness to external disturbances and sensitivity to faults.It has been shown that the utilization of available frequency spectrum information of faults and disturbances makes the proposed filtering design method more general and less conservative compared with a conventional nonfrequency based filtering design approach.Then,with the proposed evaluation function and its threshold,a novel mixed finite frequency H_(∞)/H_(-)fault detection algorithm is developed,based on which the fault can be immediately detected once the evaluation function exceeds the threshold.Finally,it is verified with simulation studies that the proposed method is effective and less conservative than conventional non-frequency and/or common Lyapunov function based filtering design methods.展开更多
Based on Buckingham's π-Theorem, dimensional analysis has achieved considerable success over the past near-century. Model testing has long been a powerful tool in both scientific studies and engineering applications...Based on Buckingham's π-Theorem, dimensional analysis has achieved considerable success over the past near-century. Model testing has long been a powerful tool in both scientific studies and engineering applications. However, the prototype objects are becoming more and more complicated nowadays, and many of the prototype systems can contain several sub-systems. The conventional theories on model-prototype similarity and dimensional analysis have only limited application since the π-Theorem itself does not distinguish between the original system and subsystems. This is particularly true in the field of structural dynamics, where the structure is often modeled as a multi-degree-of-freedom system. In this paper, we attempt to show that, if a system can be decoupled into several nontrivial subsystems, then, in each subsystem, the number of π-terms will be reduced and therefore simplify the model testing. On the other hand, if a system cannot be decoupled into subsystems, then using model testing with reduced π-term analysis, both experimentally and theoretically, may introduce severe errors.展开更多
This paper investigates the problem of robust finite-time H<sub>∞</sub> filter design for Itô stochastic systems. Based on linear matrix inequalities (LMIS) techniques and stability theory of sto...This paper investigates the problem of robust finite-time H<sub>∞</sub> filter design for Itô stochastic systems. Based on linear matrix inequalities (LMIS) techniques and stability theory of stochastic differential equations, stochastic Lyapunov function method is adopted to design a finite-time H<sub>∞</sub> filter such that, for all admissible uncertainties, the filtering error system is stochastic finite-time stable (SFTS). A sufficient condition for the existence of a finite-time H<sub>∞</sub> filter for the stochastic system under consideration is achieved in terms of LMIS. Moreover, the explicit expression of the desired filter parameters is given. A numerical example is provided to illustrate the effectiveness of the proposed method.展开更多
This paper investigates the finite-time H<sub>∞</sub> control problem of switched nonlinear systems via state-dependent switching and state feedback control. Unlike the existing approach based on time-dep...This paper investigates the finite-time H<sub>∞</sub> control problem of switched nonlinear systems via state-dependent switching and state feedback control. Unlike the existing approach based on time-dependent switching strategy, in which the switching instants must be given in advance, the state-dependent switching strategy is used to design switching signals. Based on multiple Lyapunov-like functions method, several criteria for switched nonlinear systems to be finite-time H<sub>∞</sub> control are derived. Finally, a numerical example with simulation results is provided to show the validity of the conclusions.展开更多
This paper considers the problem of delay-dependent robust optimal H<sub>∞</sub> control for a class of uncertain two-dimensional (2-D) discrete state delay systems described by the general model (GM). Th...This paper considers the problem of delay-dependent robust optimal H<sub>∞</sub> control for a class of uncertain two-dimensional (2-D) discrete state delay systems described by the general model (GM). The parameter uncertainties are assumed to be norm-bounded. A linear matrix inequality (LMI)-based sufficient condition for the existence of delay-dependent g-suboptimal state feedback robust H<sub>∞</sub> controllers which guarantees not only the asymptotic stability of the closed-loop system, but also the H<sub>∞</sub> noise attenuation g over all admissible parameter uncertainties is established. Furthermore, a convex optimization problem is formulated to design a delay-dependent state feedback robust optimal H<sub>∞</sub> controller which minimizes the H<sub>∞</sub> noise attenuation g of the closed-loop system. Finally, an illustrative example is provided to demonstrate the effectiveness of the proposed method.展开更多
This paper investigates the problem of robust optimal H<sub>∞</sub> control for uncertain two-dimensional (2-D) discrete state-delayed systems described by the general model (GM) with norm-bounded uncerta...This paper investigates the problem of robust optimal H<sub>∞</sub> control for uncertain two-dimensional (2-D) discrete state-delayed systems described by the general model (GM) with norm-bounded uncertainties. A sufficient condition for the existence of g-suboptimal robust H<sub><sub></sub></sub><sub>∞</sub> state feedback controllers is established, based on linear matrix inequality (LMI) approach. Moreover, a convex optimization problem is developed to design a robust optimal state feedback controller which minimizes the H<sub><sub><sub></sub></sub></sub><sub>∞</sub> noise attenuation level of the resulting closed-loop system. Finally, two illustrative examples are given to demonstrate the effectiveness of the proposed method.展开更多
Objective: This study was to investigate the role of hsa-miR-155-3p and hsa-miR-155-5p as biomarkers and regulators of biological behavior in Systemic Sclerosis. Methods: A total of 10 SSc patients and 10 healthy cont...Objective: This study was to investigate the role of hsa-miR-155-3p and hsa-miR-155-5p as biomarkers and regulators of biological behavior in Systemic Sclerosis. Methods: A total of 10 SSc patients and 10 healthy controls were selected for the study. The expression levels of hsa-miR-155-3p and hsa-miR-155-5p in peripheral blood mononuclear cells of SSc patients and healthy controls were measured using RT-qPCR. The diagnostic value of these miRNAs was explored using Receiver Operating Characteristic curve analysis. Pearson or Spearman correlation analysis was performed to assess the correlation between miRNAs and clinical indicators in SSc patients. Potential target genes of hsa-miR-155-3p and hsa-miR-155-5p were predicted using miRDB, Targetscan, and miRDIP databases. GO functional annotation, KEGG pathway enrichment analysis, protein-protein interaction network construction, and selection of central genes were conducted. Results: The expression levels of hsa-miR-155-3p and hsa- miR-155-5p were significantly higher in PBMCs of SSc patients compared to healthy controls (P<0.001). The ROC curve analysis showed that hsa-miR-155-3p and hsa-miR-155-5p had a high diagnostic value for SSc (AUC=1, P<0.001). Correlation analysis revealed that hsa- miR-155-3p, hsa-miR-155-5p, and clinical indicators such as high-resolution CT, neutrophil percentage, lymphocyte percentage, and albumin to globulin ratio were correlated (P<0.05). The signaling pathways enriched with target genes of hsa-miR-155-3p and hsa-miR-155- 5p were closely associated with the occurrence and development of SSc fibrosis, immunity, and inflammation. Conclusions: hsa-miR-155-3p and hsa-miR-155-5p may be involved in regulating the occurrence and development of SSc fibrosis, immunity, and inflammation. They have the potential to serve as biomarkers for clinical diagnosis and treatment of SSc.展开更多
Based on energy dissipation and structural control principle, a new structural configuration, called the megasub controlled structure (MSCS) with friction damped braces (FDBs), is first presented. Meanwhile, to ca...Based on energy dissipation and structural control principle, a new structural configuration, called the megasub controlled structure (MSCS) with friction damped braces (FDBs), is first presented. Meanwhile, to calculate the damping coefficient in the slipping state a new analytical method is proposed. The damping characteristics of one-storey friction damped braced frame (FDBF) are investigated, and the influence of the structural parameters on the energy dissipation and the practical engineering design are discussed. The nonlinear dynamic equations and the analytical model of the MSCS with FDBs are established. Three building structures with different structural configurations, which were designed with reference to the conventional mega-sub structures such as used in Tokyo City Hall, are comparatively investigated. The results illustrate that the structure presented in the paper has excellent dynamic properties and satisfactory control effectiveness.展开更多
Since 2006, the superconducting toroidal field(TF) coils of the Experimental Advanced Superconducting Tokomak(EAST) have been successfully cooled by supercritical helium at a temperature of 4.5 K and a pressure of...Since 2006, the superconducting toroidal field(TF) coils of the Experimental Advanced Superconducting Tokomak(EAST) have been successfully cooled by supercritical helium at a temperature of 4.5 K and a pressure of 4 bara in eleven experiments. To obtain higher operating currents and magnetic fields it is necessary to lower the operating temperature of the TF coils.The EAST sub-cooling helium cryogenic system, with a warm oil ring pump(ORP), was tested twice in cool-down experiments, which made the TF coils operate at 3.8 K. However, the long term operational stability of the sub-cooling system cannot be guaranteed because of the ORP's poor mechanical and control performance. In this paper, the present status of the EAST subcooling helium cryogenic system is described, and then several cooling methods below 4.2 K and their merits are presented and analyzed. Finally, an upgrading method with a cold compressor for an EAST sub-cooling helium cryogenic system is proposed. The new process flow and thermodynamic calculation of the sub-cooling helium system, and the main parameters of the cold compressor, are also presented in detail. This work will provide a reference for the future upgrading of the sub-cooling helium system for higher operation parameters of the EAST device.展开更多
Background: The morbidity and mortality of systemic lupus erythematosus are largely due to accelerated atherosclerosis. This is partly related to the high prevalence of traditional cardiovascular risk factors. The aim...Background: The morbidity and mortality of systemic lupus erythematosus are largely due to accelerated atherosclerosis. This is partly related to the high prevalence of traditional cardiovascular risk factors. The aim of our study was to determine the frequency of these factors in lupus patients compared to a control population in a department of internal medicine. Methods: We realized a case-control study in patients with systemic lupus erythematosus according to ACR criteria in 1997. Patients were matched by age and gender with controls subjects without autoimmune disease. We studied the frequency of traditional cardiovascular risk factors in both populations. The study was done in the department of internal medicine of Aristide Le Dantec teaching Hospital, in Senegal, during the period from August 2017 to December 2018. The statistical analysis was performed with SPSS 23.0 software and the level of significance was retained for a p-value Results: We recruited 100 subjects including 50 patients and 50 controls. The mean age was 33.5 ± 11.3 years in cases and 33.3 ± 11.3 years in controls. Dyslipidemia was significantly associated with systemic lupus erythematosus (p = 0.009). Levels of triglycerides (p Conclusion: Traditional cardiovascular risk factors including dyslipidemia and hyperuricemia were more common in patients. Similarly, renal failure was associated with lupus.展开更多
The concept of the liquid Li17Pb83 and Helium gas dual-cooled Fuel Breeding Blanket (FBB) for the Fusion-Driven sub-critical System (FDS) is presented and analyzed. Taking self-sustaining tritium (TBR >1.05) and an...The concept of the liquid Li17Pb83 and Helium gas dual-cooled Fuel Breeding Blanket (FBB) for the Fusion-Driven sub-critical System (FDS) is presented and analyzed. Taking self-sustaining tritium (TBR >1.05) and annual output of 100 kg or more fissile 239Pu (FBR > 0.238) as objective parameters, and based on the three-dimensional Monte Carlo neutron-photon transport code MCNP/4A, a neutronics-optimizated calculation of different cases was carried out and the concept is proved feasible. In addition, the total breeding ratio ( BR = TBR + FBR ) is listed corresponding to different cases.展开更多
This paper deals with the problem of decentralized robustcontrol for a class of interconnected uncertain systemswith state delays.The parameter uncertainties are un-known but norm-bounded.A new sufficient condition is...This paper deals with the problem of decentralized robustcontrol for a class of interconnected uncertain systemswith state delays.The parameter uncertainties are un-known but norm-bounded.A new sufficient condition isobtained for each subsystem and overall system to be sta-bilizable via linear memoryless state feedback robust de-centralized controllers.The results depend on the size of the delays and are given in terms of linear matrix ine-qualities,so they are less conservative than those of delay-independent.Moreover,matching condition is not a necessary condition.Finally,an example is presented to illustrative the effectiveness of the proposed method.展开更多
This paper presents the design of a robust fixed-order H<sub>∞</sub> controller to damp out the inter-area oscillations and to enhance the stability of the power system. The proposed H<sub>...This paper presents the design of a robust fixed-order H<sub>∞</sub> controller to damp out the inter-area oscillations and to enhance the stability of the power system. The proposed H<sub>∞</sub> approach is based on shaping the open-loop transfer function in the Nyquist diagram through minimizing the quadratic error between the actual and the desired open loop transfer functions in the frequency domain under linear constraints that guarantee robustness and stability. The proposed approach is robust with respect to multi-model uncertainty closed-loop sensitivity functions in the Nyquist diagram through the constraints on their infinity norm. The H<sub>∞</sub> constraints are linearized with the help of a desired open-loop transfer function. The controller is designed using the convex optimization techniques in which the difference between the open-loop transfer function and the desired one is minimized. The two-area four-machine test system is selected to evaluate the performance of the designed controller under different load conditions as well as different levels of wind penetrations.展开更多
This paper is concerned with the problems of robust admissibility and static output feedback( SOF)stabilization for a class of discrete-time switched singular systems with norm-bounded parametric uncertainties.The obj...This paper is concerned with the problems of robust admissibility and static output feedback( SOF)stabilization for a class of discrete-time switched singular systems with norm-bounded parametric uncertainties.The objective is to design a suitable robust SOF controller guaranteeing the regularity,causality and asymptotic stability of the resulting closed-loop system under arbitrary switching laws. Based on the basic matrix inequality sufficient condition for checking the admissibility of switched singular systems,together with some matrix inequality convexifying techniques,the SOF controller synthesis is developed for the underlying systems. It is shown that the controller gains can be obtained by solving a set of strict linear matrix inequalities( LMIs). A simulation example is given to show the effectiveness of the proposed method.展开更多
This article reviews the current works on ultra-compact double-degenerate binaries in the presence of magnetic interaction, in particular, unipolar induction. The orbital dynamics and evolution of compact white-dwarf ...This article reviews the current works on ultra-compact double-degenerate binaries in the presence of magnetic interaction, in particular, unipolar induction. The orbital dynamics and evolution of compact white-dwarf pairs are discussed in detail. Models and predictions of electron cyclotron masers from unipolar-inductor compact binaries and unipolar-inductor white-dwarf planetary systems are presented. Einstein-Laub effects in compact binaries are briefly discussed.展开更多
This paper deals with a multidimensional examination of the infrastructural, technical/technological, operational, economic, social, and environmental performances of high-speed rail (HSR) systems, including their o...This paper deals with a multidimensional examination of the infrastructural, technical/technological, operational, economic, social, and environmental performances of high-speed rail (HSR) systems, including their overview, analysis of some real-life cases, and limited (analytical) modeling. The infrastructural performances reflect design and geometrical characteristics of the HSR lines and stations. The technical/technological performances relate to the characteristics of rolling stock, i.e., high-speed trains, and supportive facilities and equipment, i.e., the power supply, signaling, and traffic control and management system(s). The operational performances include the capacity and productivity of HSR lines and rolling stock, and quality of services. The economic per- formances refer to the HSR systems' costs, revenues, and their relationship. The social performances relate to the impacts of HSR systems on the society such as congestion, noise, and safety, and their externalities, and the effects in terms of contribution to the local and global/country social- economic development. Finally, the environmental performances of the HSR systems reflect their energy consumption and related emissions of green house gases, land use, and corresponding externalities.展开更多
Scale-up synthesis of sub-micron ZSM-5 molecular sieve in a quasi-solid system was investigated. Compared with traditional hydrothermal synthesis, the synthesis in a quasi-solid system has the advantages of high yield...Scale-up synthesis of sub-micron ZSM-5 molecular sieve in a quasi-solid system was investigated. Compared with traditional hydrothermal synthesis, the synthesis in a quasi-solid system has the advantages of high yield, short crystallization time, low energy consumption as well as low emissions. However, the high solid content in the quasi-solid system can cause the mass and heat transfer problems and make scalable production difficult. In order to solve the problem, we have developed a method for the optimization of the mass and heat transfer. By this method one can vary the flow field in the reactor by changing the stirrer speed. Scale-up synthesis of the sub-micron ZSM-5 molecular sieve in a quasi-solid system was carried out in a 5 L reactor with double propeller-type agitators. The process was investigated with product characterization using X-ray diffraction (XRD) and scanning electron microscopy (SEM) and the flow field information was collected using laser Doppler velocimetry (LDV). The results showed that the flow field patterns can be tuned by using different stirrer speeds, the morphology and size of assynthesized of ZSM-5 can be effectively controlled.展开更多
Besides pumped hydropower, Compressed Air Energy Storage (CAES) is the other solution for large energy storage capacity. It can balance fluctuations in supply and demand of electricity. CAES is essential part of smart...Besides pumped hydropower, Compressed Air Energy Storage (CAES) is the other solution for large energy storage capacity. It can balance fluctuations in supply and demand of electricity. CAES is essential part of smart power grids. Linked with the flow structure and dynamic characteristic of electricity generation subsystem and its components, a simulation model is proposed. Thermo-dynamical performance on off-design conditions have been analyzed with constant air mass flux and constant gas combustion temperature. Some simulation diagrams of curve are plotted too. The contrast of varied operation mode thermal performance is made between CAES power plant and simple gas turbine power plant.展开更多
In this article, the peak to average power ratio (PAPR) performance of 8 quadrature amplitude modulation-orthogonal frequency division multiplexing (8QAM-OFDM) optical signals has been researched in broadband optical ...In this article, the peak to average power ratio (PAPR) performance of 8 quadrature amplitude modulation-orthogonal frequency division multiplexing (8QAM-OFDM) optical signals has been researched in broadband optical access system. The complementary cumulative distribution functions (CCDFs) are analyzed of two different 8QAM-OFDMsignals with 16, 32, 64, 128, 256, 512 sub- carriers by simulation. The simulation results show that, with the increase of the number of subcarrier, the PAPR value becomes higher. When the numbers of subcarrier are16 and 512, the PAPR of 8QAM-OFDM optical signals are smaller than 5.2 dB and 5.3 dB respectively. Hence, the number of sub-carriers should be chosen according to practical application.展开更多
Based on the statistical data, we analyzed and evaluated the degree of coupling and coordination of the eco-economic system in Yanchi County for the period spanning from 1983 to 2014. The eco-economic system can be di...Based on the statistical data, we analyzed and evaluated the degree of coupling and coordination of the eco-economic system in Yanchi County for the period spanning from 1983 to 2014. The eco-economic system can be divided into socioeconomic and ecological sub-systems and their relationship can reveal the interaction state between the two sub-systems and help the local government to establish a coordinated development mode. An index system was constructed to assess the development of the two sub-systems before the evaluation of the degree of coupling and coordination. The principal component regression analysis was adopted to quantitatively assess the influences of natural, economic and social factors on the degree of coupling and coordination of the eco-economic system. Results showed that, from 1983 to 2014, the development trends of both sub-systems were increasing with the ecological sub-system having more fluctuations. The degree of coupling and coordination of the eco-economic system in the study area increased gradually from 1983 to 2014, but experienced five different development stages from the verge of disorder to favorable coordination. The development of the local social and economic conditions was the most important factor influencing the degree of coupling and coordination. The second most important factor was the financial support from the local government. In addition, the environment protection policies also played undeniable roles. Due to the diversity of the influence factors, the government should take comprehensive measures to promote the sustainable development of the eco-economic system.展开更多
基金supported in part by the National Natural Science Foundation of China(62373152,62333005,U21B6001,62073143,62273121)in part by the Natural Science Funds for Excellent Young Scholars of Hebei Province in 2022(F2022202014)+1 种基金in part by Science and Technology Research Project of Colleges and Universities in Hebei Province(BJ2020017)in part by the China Postdoctoral Science Foundation(2022M711639,2023T160320).
文摘This article studies the fault detection filtering design problem for Roesser type two-dimensional(2-D)nonlinear systems described by uncertain 2-D Takagi-Sugeno(T-S)fuzzy models.Firstly,fuzzy Lyapunov functions are constructed and the 2-D Fourier transform is exploited,based on which a finite frequency fault detection filtering design method is proposed such that a residual signal is generated with robustness to external disturbances and sensitivity to faults.It has been shown that the utilization of available frequency spectrum information of faults and disturbances makes the proposed filtering design method more general and less conservative compared with a conventional nonfrequency based filtering design approach.Then,with the proposed evaluation function and its threshold,a novel mixed finite frequency H_(∞)/H_(-)fault detection algorithm is developed,based on which the fault can be immediately detected once the evaluation function exceeds the threshold.Finally,it is verified with simulation studies that the proposed method is effective and less conservative than conventional non-frequency and/or common Lyapunov function based filtering design methods.
文摘Based on Buckingham's π-Theorem, dimensional analysis has achieved considerable success over the past near-century. Model testing has long been a powerful tool in both scientific studies and engineering applications. However, the prototype objects are becoming more and more complicated nowadays, and many of the prototype systems can contain several sub-systems. The conventional theories on model-prototype similarity and dimensional analysis have only limited application since the π-Theorem itself does not distinguish between the original system and subsystems. This is particularly true in the field of structural dynamics, where the structure is often modeled as a multi-degree-of-freedom system. In this paper, we attempt to show that, if a system can be decoupled into several nontrivial subsystems, then, in each subsystem, the number of π-terms will be reduced and therefore simplify the model testing. On the other hand, if a system cannot be decoupled into subsystems, then using model testing with reduced π-term analysis, both experimentally and theoretically, may introduce severe errors.
文摘This paper investigates the problem of robust finite-time H<sub>∞</sub> filter design for Itô stochastic systems. Based on linear matrix inequalities (LMIS) techniques and stability theory of stochastic differential equations, stochastic Lyapunov function method is adopted to design a finite-time H<sub>∞</sub> filter such that, for all admissible uncertainties, the filtering error system is stochastic finite-time stable (SFTS). A sufficient condition for the existence of a finite-time H<sub>∞</sub> filter for the stochastic system under consideration is achieved in terms of LMIS. Moreover, the explicit expression of the desired filter parameters is given. A numerical example is provided to illustrate the effectiveness of the proposed method.
文摘This paper investigates the finite-time H<sub>∞</sub> control problem of switched nonlinear systems via state-dependent switching and state feedback control. Unlike the existing approach based on time-dependent switching strategy, in which the switching instants must be given in advance, the state-dependent switching strategy is used to design switching signals. Based on multiple Lyapunov-like functions method, several criteria for switched nonlinear systems to be finite-time H<sub>∞</sub> control are derived. Finally, a numerical example with simulation results is provided to show the validity of the conclusions.
文摘This paper considers the problem of delay-dependent robust optimal H<sub>∞</sub> control for a class of uncertain two-dimensional (2-D) discrete state delay systems described by the general model (GM). The parameter uncertainties are assumed to be norm-bounded. A linear matrix inequality (LMI)-based sufficient condition for the existence of delay-dependent g-suboptimal state feedback robust H<sub>∞</sub> controllers which guarantees not only the asymptotic stability of the closed-loop system, but also the H<sub>∞</sub> noise attenuation g over all admissible parameter uncertainties is established. Furthermore, a convex optimization problem is formulated to design a delay-dependent state feedback robust optimal H<sub>∞</sub> controller which minimizes the H<sub>∞</sub> noise attenuation g of the closed-loop system. Finally, an illustrative example is provided to demonstrate the effectiveness of the proposed method.
文摘This paper investigates the problem of robust optimal H<sub>∞</sub> control for uncertain two-dimensional (2-D) discrete state-delayed systems described by the general model (GM) with norm-bounded uncertainties. A sufficient condition for the existence of g-suboptimal robust H<sub><sub></sub></sub><sub>∞</sub> state feedback controllers is established, based on linear matrix inequality (LMI) approach. Moreover, a convex optimization problem is developed to design a robust optimal state feedback controller which minimizes the H<sub><sub><sub></sub></sub></sub><sub>∞</sub> noise attenuation level of the resulting closed-loop system. Finally, two illustrative examples are given to demonstrate the effectiveness of the proposed method.
基金National Natural Science Foundation of China(No.8186029481860295)Natural Science Foundation of Inner Mongolia Autonomous Region(No.2019MS080552021MS08045)Science and Technology Plan Project of Inner Mongolia Autonomous Region(No.2018020892019GG052)。
文摘Objective: This study was to investigate the role of hsa-miR-155-3p and hsa-miR-155-5p as biomarkers and regulators of biological behavior in Systemic Sclerosis. Methods: A total of 10 SSc patients and 10 healthy controls were selected for the study. The expression levels of hsa-miR-155-3p and hsa-miR-155-5p in peripheral blood mononuclear cells of SSc patients and healthy controls were measured using RT-qPCR. The diagnostic value of these miRNAs was explored using Receiver Operating Characteristic curve analysis. Pearson or Spearman correlation analysis was performed to assess the correlation between miRNAs and clinical indicators in SSc patients. Potential target genes of hsa-miR-155-3p and hsa-miR-155-5p were predicted using miRDB, Targetscan, and miRDIP databases. GO functional annotation, KEGG pathway enrichment analysis, protein-protein interaction network construction, and selection of central genes were conducted. Results: The expression levels of hsa-miR-155-3p and hsa- miR-155-5p were significantly higher in PBMCs of SSc patients compared to healthy controls (P<0.001). The ROC curve analysis showed that hsa-miR-155-3p and hsa-miR-155-5p had a high diagnostic value for SSc (AUC=1, P<0.001). Correlation analysis revealed that hsa- miR-155-3p, hsa-miR-155-5p, and clinical indicators such as high-resolution CT, neutrophil percentage, lymphocyte percentage, and albumin to globulin ratio were correlated (P<0.05). The signaling pathways enriched with target genes of hsa-miR-155-3p and hsa-miR-155- 5p were closely associated with the occurrence and development of SSc fibrosis, immunity, and inflammation. Conclusions: hsa-miR-155-3p and hsa-miR-155-5p may be involved in regulating the occurrence and development of SSc fibrosis, immunity, and inflammation. They have the potential to serve as biomarkers for clinical diagnosis and treatment of SSc.
基金Science and Technology Fund of NWPU Under Grant No. M450211 Seed Fund of NWPU Under Grant No. Z200729
文摘Based on energy dissipation and structural control principle, a new structural configuration, called the megasub controlled structure (MSCS) with friction damped braces (FDBs), is first presented. Meanwhile, to calculate the damping coefficient in the slipping state a new analytical method is proposed. The damping characteristics of one-storey friction damped braced frame (FDBF) are investigated, and the influence of the structural parameters on the energy dissipation and the practical engineering design are discussed. The nonlinear dynamic equations and the analytical model of the MSCS with FDBs are established. Three building structures with different structural configurations, which were designed with reference to the conventional mega-sub structures such as used in Tokyo City Hall, are comparatively investigated. The results illustrate that the structure presented in the paper has excellent dynamic properties and satisfactory control effectiveness.
基金supported by National Natural Science Foundation of China(No.11505237)
文摘Since 2006, the superconducting toroidal field(TF) coils of the Experimental Advanced Superconducting Tokomak(EAST) have been successfully cooled by supercritical helium at a temperature of 4.5 K and a pressure of 4 bara in eleven experiments. To obtain higher operating currents and magnetic fields it is necessary to lower the operating temperature of the TF coils.The EAST sub-cooling helium cryogenic system, with a warm oil ring pump(ORP), was tested twice in cool-down experiments, which made the TF coils operate at 3.8 K. However, the long term operational stability of the sub-cooling system cannot be guaranteed because of the ORP's poor mechanical and control performance. In this paper, the present status of the EAST subcooling helium cryogenic system is described, and then several cooling methods below 4.2 K and their merits are presented and analyzed. Finally, an upgrading method with a cold compressor for an EAST sub-cooling helium cryogenic system is proposed. The new process flow and thermodynamic calculation of the sub-cooling helium system, and the main parameters of the cold compressor, are also presented in detail. This work will provide a reference for the future upgrading of the sub-cooling helium system for higher operation parameters of the EAST device.
文摘Background: The morbidity and mortality of systemic lupus erythematosus are largely due to accelerated atherosclerosis. This is partly related to the high prevalence of traditional cardiovascular risk factors. The aim of our study was to determine the frequency of these factors in lupus patients compared to a control population in a department of internal medicine. Methods: We realized a case-control study in patients with systemic lupus erythematosus according to ACR criteria in 1997. Patients were matched by age and gender with controls subjects without autoimmune disease. We studied the frequency of traditional cardiovascular risk factors in both populations. The study was done in the department of internal medicine of Aristide Le Dantec teaching Hospital, in Senegal, during the period from August 2017 to December 2018. The statistical analysis was performed with SPSS 23.0 software and the level of significance was retained for a p-value Results: We recruited 100 subjects including 50 patients and 50 controls. The mean age was 33.5 ± 11.3 years in cases and 33.3 ± 11.3 years in controls. Dyslipidemia was significantly associated with systemic lupus erythematosus (p = 0.009). Levels of triglycerides (p Conclusion: Traditional cardiovascular risk factors including dyslipidemia and hyperuricemia were more common in patients. Similarly, renal failure was associated with lupus.
基金This work was supported by the Chinese Academy of Sciences and the National Natural Science Foundation of China No.10175068.
文摘The concept of the liquid Li17Pb83 and Helium gas dual-cooled Fuel Breeding Blanket (FBB) for the Fusion-Driven sub-critical System (FDS) is presented and analyzed. Taking self-sustaining tritium (TBR >1.05) and annual output of 100 kg or more fissile 239Pu (FBR > 0.238) as objective parameters, and based on the three-dimensional Monte Carlo neutron-photon transport code MCNP/4A, a neutronics-optimizated calculation of different cases was carried out and the concept is proved feasible. In addition, the total breeding ratio ( BR = TBR + FBR ) is listed corresponding to different cases.
基金China Postdoctotral Foundation and Shanghai Postdoctoral Foundation
文摘This paper deals with the problem of decentralized robustcontrol for a class of interconnected uncertain systemswith state delays.The parameter uncertainties are un-known but norm-bounded.A new sufficient condition isobtained for each subsystem and overall system to be sta-bilizable via linear memoryless state feedback robust de-centralized controllers.The results depend on the size of the delays and are given in terms of linear matrix ine-qualities,so they are less conservative than those of delay-independent.Moreover,matching condition is not a necessary condition.Finally,an example is presented to illustrative the effectiveness of the proposed method.
文摘This paper presents the design of a robust fixed-order H<sub>∞</sub> controller to damp out the inter-area oscillations and to enhance the stability of the power system. The proposed H<sub>∞</sub> approach is based on shaping the open-loop transfer function in the Nyquist diagram through minimizing the quadratic error between the actual and the desired open loop transfer functions in the frequency domain under linear constraints that guarantee robustness and stability. The proposed approach is robust with respect to multi-model uncertainty closed-loop sensitivity functions in the Nyquist diagram through the constraints on their infinity norm. The H<sub>∞</sub> constraints are linearized with the help of a desired open-loop transfer function. The controller is designed using the convex optimization techniques in which the difference between the open-loop transfer function and the desired one is minimized. The two-area four-machine test system is selected to evaluate the performance of the designed controller under different load conditions as well as different levels of wind penetrations.
基金Sponsored by the National Natural Science Foundation of China Grant No.61004038
文摘This paper is concerned with the problems of robust admissibility and static output feedback( SOF)stabilization for a class of discrete-time switched singular systems with norm-bounded parametric uncertainties.The objective is to design a suitable robust SOF controller guaranteeing the regularity,causality and asymptotic stability of the resulting closed-loop system under arbitrary switching laws. Based on the basic matrix inequality sufficient condition for checking the admissibility of switched singular systems,together with some matrix inequality convexifying techniques,the SOF controller synthesis is developed for the underlying systems. It is shown that the controller gains can be obtained by solving a set of strict linear matrix inequalities( LMIs). A simulation example is given to show the effectiveness of the proposed method.
文摘This article reviews the current works on ultra-compact double-degenerate binaries in the presence of magnetic interaction, in particular, unipolar induction. The orbital dynamics and evolution of compact white-dwarf pairs are discussed in detail. Models and predictions of electron cyclotron masers from unipolar-inductor compact binaries and unipolar-inductor white-dwarf planetary systems are presented. Einstein-Laub effects in compact binaries are briefly discussed.
文摘This paper deals with a multidimensional examination of the infrastructural, technical/technological, operational, economic, social, and environmental performances of high-speed rail (HSR) systems, including their overview, analysis of some real-life cases, and limited (analytical) modeling. The infrastructural performances reflect design and geometrical characteristics of the HSR lines and stations. The technical/technological performances relate to the characteristics of rolling stock, i.e., high-speed trains, and supportive facilities and equipment, i.e., the power supply, signaling, and traffic control and management system(s). The operational performances include the capacity and productivity of HSR lines and rolling stock, and quality of services. The economic per- formances refer to the HSR systems' costs, revenues, and their relationship. The social performances relate to the impacts of HSR systems on the society such as congestion, noise, and safety, and their externalities, and the effects in terms of contribution to the local and global/country social- economic development. Finally, the environmental performances of the HSR systems reflect their energy consumption and related emissions of green house gases, land use, and corresponding externalities.
文摘Scale-up synthesis of sub-micron ZSM-5 molecular sieve in a quasi-solid system was investigated. Compared with traditional hydrothermal synthesis, the synthesis in a quasi-solid system has the advantages of high yield, short crystallization time, low energy consumption as well as low emissions. However, the high solid content in the quasi-solid system can cause the mass and heat transfer problems and make scalable production difficult. In order to solve the problem, we have developed a method for the optimization of the mass and heat transfer. By this method one can vary the flow field in the reactor by changing the stirrer speed. Scale-up synthesis of the sub-micron ZSM-5 molecular sieve in a quasi-solid system was carried out in a 5 L reactor with double propeller-type agitators. The process was investigated with product characterization using X-ray diffraction (XRD) and scanning electron microscopy (SEM) and the flow field information was collected using laser Doppler velocimetry (LDV). The results showed that the flow field patterns can be tuned by using different stirrer speeds, the morphology and size of assynthesized of ZSM-5 can be effectively controlled.
文摘Besides pumped hydropower, Compressed Air Energy Storage (CAES) is the other solution for large energy storage capacity. It can balance fluctuations in supply and demand of electricity. CAES is essential part of smart power grids. Linked with the flow structure and dynamic characteristic of electricity generation subsystem and its components, a simulation model is proposed. Thermo-dynamical performance on off-design conditions have been analyzed with constant air mass flux and constant gas combustion temperature. Some simulation diagrams of curve are plotted too. The contrast of varied operation mode thermal performance is made between CAES power plant and simple gas turbine power plant.
文摘In this article, the peak to average power ratio (PAPR) performance of 8 quadrature amplitude modulation-orthogonal frequency division multiplexing (8QAM-OFDM) optical signals has been researched in broadband optical access system. The complementary cumulative distribution functions (CCDFs) are analyzed of two different 8QAM-OFDMsignals with 16, 32, 64, 128, 256, 512 sub- carriers by simulation. The simulation results show that, with the increase of the number of subcarrier, the PAPR value becomes higher. When the numbers of subcarrier are16 and 512, the PAPR of 8QAM-OFDM optical signals are smaller than 5.2 dB and 5.3 dB respectively. Hence, the number of sub-carriers should be chosen according to practical application.
基金supported by the National Natural Science Foundation of China(41471436,41601587)the National Science and Technology Support Program of China(2015BAC06B01)+1 种基金the National Key Research and Development Program of China(2016YFC0500909)the National Natural Science Foundation of China(41601587)
文摘Based on the statistical data, we analyzed and evaluated the degree of coupling and coordination of the eco-economic system in Yanchi County for the period spanning from 1983 to 2014. The eco-economic system can be divided into socioeconomic and ecological sub-systems and their relationship can reveal the interaction state between the two sub-systems and help the local government to establish a coordinated development mode. An index system was constructed to assess the development of the two sub-systems before the evaluation of the degree of coupling and coordination. The principal component regression analysis was adopted to quantitatively assess the influences of natural, economic and social factors on the degree of coupling and coordination of the eco-economic system. Results showed that, from 1983 to 2014, the development trends of both sub-systems were increasing with the ecological sub-system having more fluctuations. The degree of coupling and coordination of the eco-economic system in the study area increased gradually from 1983 to 2014, but experienced five different development stages from the verge of disorder to favorable coordination. The development of the local social and economic conditions was the most important factor influencing the degree of coupling and coordination. The second most important factor was the financial support from the local government. In addition, the environment protection policies also played undeniable roles. Due to the diversity of the influence factors, the government should take comprehensive measures to promote the sustainable development of the eco-economic system.