JESD204B Subclass1模式时钟设计与调试

JESD204B协议是用于数据转换器与FPGA/ASIC之间数据传输的高速串行协议,Subclass1模式是该协议完成确定性延时功能的重要模式。对JESD204B协议Subclass1模式的工作原理和时钟设计要求进行分析,并总结出Subclass1模式时钟调试方法。利用Xilinx Virtex-7系列FPGA搭建JESD204B自收发链路对该方法进行验证。结果表明,该时钟调试方法能够满足Subclass1模式的时钟设计要求,保证数据的稳定收发。

DISTORTION THEOREMS FOR SUBCLASSES OF STARLIKE MAPPINGS ALONG A UNIT DIRECTION IN C^n

In this paper, we obtain a distortion theorem of Jacobian matrix for biholomorphic subclasses of starlike mappings along a unit direction on the unit polydisc. These results extend the classical distortion theorem of starlike mappings to higher dimensions. We then give an upper bound estimate for biholomorphic subclasses of starlike mappings along a unit direction in a complex Banach space.

CERTAIN SUBCLASSES OF ANALYTIC p－VALENT FUNCTIONS FOR OPERATORS ON HILBERT SPACE

In this paper,We mainly discuss some subclasses of analytic functions for operators onac, and determine a representation formula and sufficient condition for the class 4;(a.p,r,E,7) and prove a sufficient and necessary condition.coefficient estimates and distortiontheorem for the subclass O;o (a,p,Y,e,9) of the class ac;(a,p,y,c,V).Furthermore,the analogues also are true for operators on Hilbert space.

Stochastic Model for Multiple Classes and Subclasses Simple Documents Processing

The issue of document management has been raised for a long time, especially with the appearance of office automation in the 1980s, which led to dematerialization and Electronic Document Management (EDM). In the same period, workflow management has experienced significant development, but has become more focused on the industry. However, it seems to us that document workflows have not had the same interest for the scientific community. But nowadays, the emergence and supremacy of the Internet in electronic exchanges are leading to a massive dematerialization of documents;which requires a conceptual reconsideration of the organizational framework for the processing of said documents in both public and private administrations. This problem seems open to us and deserves the interest of the scientific community. Indeed, EDM has mainly focused on the storage (referencing) and circulation of documents (traceability). It paid little attention to the overall behavior of the system in processing documents. The purpose of our researches is to model document processing systems. In the previous works, we proposed a general model and its specialization in the case of small documents (any document processed by a single person at a time during its processing life cycle), which represent 70% of documents processed by administrations, according to our study. In this contribution, we extend the model for processing small documents to the case where they are managed in a system comprising document classes organized in subclasses;which is the case for most administrations. We have thus observed that this model is a Markovian ML×K/ML×K/1 queues network. We have analyzed the constraints of this model and deduced certain characteristics and metrics. In fine, the ultimate objective of our work is to design a document workflow management system, integrating a component of global behavior prediction.

Comprehensive Genetic Analysis by Integration of Conventional Karyotyping and Interphase FISH Helps Refinement of Biological Subclasses with Clinical Impact in Chronic Lymphocytic Leukemia

Background: Various genetic technologies have been employed in the identification of genomic complexity and refinement of prognostic classification of clinically heterogeneous disease of chronic lymphocytic leukemia (CLL). Objective: The present study of interphase cytogenetics and conventional karyotyping was undertaken to perform comprehensive analysis of CLL genetics with an approach to refine early prognostication of disease. Material & Methods: Retrospective analysis by fluorescence in situ hybridization (FISH) was carried out on total 671 patients of CLL at diagnosis between 2008 and 2015. Conventional cytogenetics studies were performed in 50 of 671 patients using CPG Oligonucleotide + IL-2 and TPA (12-O-Tetradecanyl Phorbol 13-acetate) for stimulation of lymphocytes cultures. Results: Interphase cytogenetics could detect recurrent abnormalities such as del(13q14), +12, del(17p13), del(11q22), del(6q23) in 71% of cases. The incidence of del(13q) was higher in Rai stage 0, I, II (p = 0.0005);whereas patients with ≥2 aberrations were more common in advance stage III, IV (p = 0.001). Frequency of IgH translocation was 7%. Morphology and immunophenotypic analysis revealed atypical CLL with higher frequency of t(14;19) than t(14;18). Conventional karyotype could detect abnormal karyotype in 97% of cases which displayed targeted FISH abnormalities along with additional non-targeted chromosomal abnormalities. Patients with negative FISH markers showed clonal non-recurrent numerical and structural changes. The complex karyotype was identified in 24% cases which included targeted FISH aberrations as well as non-targeted numerical and structural abnormalities like deletions, and unbalanced translocations. A significant association was observed between complex karyotype and coexistence of ≥2 FISH markers (p = 0.009) and del(11q22) &/or del(17p) (p = 0.03). Conclusion: Our data of interphase FISH with integration of conventional karyotyping revealed genomic complexity that helped identification of biological subclasses with clinical impact at diagnosis. Further, these cytogenetic subclasses along with molecular markers are likely to evolve more refined prognostic groups, which will help design risk-adapted therapies in B-CLL.

New Identification of Sericite Subclass Minerals Using Airborne Hyperspectral Data in the Xitan Region of Gansu Province and its Significance in Gold Ore Prospecting

Objective Hyperspectral remote sensing has attracted much attention in remote sensing research during recent years. It can elaborately identiry spectral characteristics of different objects by acquiring continuous spectral curves of ground objects, and can thus provide more information for geological research （Zhao Yingjun et al., 2015）. With the deepening hyperspectral remote sensing research, scholars have focused from the classification of alteration minerals to the identification of subclass minerals in order to explore their significance fbr ore prospecting. This work utilized hyperspectral remote sensing technology in the Xitan region of Gansu Province to identify limonite and two types of sericite subclass minerals, and conducted field verification and geochemical survey. In addition, we analyzed the geological environment of subclass sericite minerals （Van Ruitenbeek et al., 2006） to provide evidence for gold ore prospecting.

ON REFINEMENT OF THE COEFFICIENT INEQUALITIES FOR A SUBCLASS OF QUASI-CONVEX MAPPINGS IN SEVERAL COMPLEX VARIABLES

Let K be the familiar class of normalized convex functions in the unit disk.In[14],Keogh and Merkes proved that for a function f(z)=z+∑k=2∞a k z k in the class K,|a 3−λa 22|≤max{13,|λ−1|},λ∈C.The above estimate is sharp for eachλ.In this article,we establish the corresponding inequality for a normalized convex function f on U such that z=0 is a zero of order k+1 of f(z)−z,and then we extend this result to higher dimensions.These results generalize some known results.

Wrist Septic Arthritis Due to <i>Streptococcus pneumoniae</i>Revealing a Selective Immunoglobulin G4 Subclass Deficiciency: A Case Report

The pneumococcal septic arthritis is uncommon in healthy adults. In most cases, it occurs in patients with immune deficiency. Its exceptional location at the wrist can maintain doubt with rheumatic causes which are more frequent. IgG4 deficiency found in this patient was the only cause that could be impugned. We report the case of a young woman of 46 years without any evident cause of immunodeficiency and any particular risk factor, managed for septic arthritis of the wrist due to Streptococcus pneumoniae. This case without any apparent risk factors demonstrates that pneumococcal infection in a more distant articulation of the ENT is still possible. Scan has been a very significant contribution in confirming the positive diagnosis that leads to surgical drainage. The approach of the systematic search for the gateway must be done. In the study of the patient’s immune status, the realization of the protein profile could be interesting and then guide the practitioner in the decision to vaccinate the patient against Streptococcus pneumoniae if he was not. We recommend looking always for a cause of immunodeficiency including primary Ig defiencies even among adult.

The Study for Some Subclasses of Biholomorphic Mappings by an Unified Method

让 Cn 是有 0 的一个围住的星形的圆形的领域。在这份报纸，我们上介绍 holomorphic mappings Mg 的一个班。让 f (z) 一局部地使 biholomorphic 印射在上正常化以便 J-1f (z) f (z) Mg 和 z=0 是 f (z) 的零顺序 k+1 - z。我们为 f (z) 获得生长和盖住的定理。作为推论，特别，我们统一并且概括许多已知的结果。而且鉴于推论的证明，在星形的 mappings 的子类之中的必要关系被显示出。

On the Coefficient Inequality for A Subclass of Starlike Mappings in Several Complex Variables

Let S~* be the familiar class of normalized univalent functions in the unit disk.In [9], Keogh and Merkes proved that for a function f(z) = z +∑k=2∞ a_kz^k in the class S~*,then |a_3-λa_2~2| ≤ max{1, |3-4λ|}, λ∈ C. In this article, we investigate the corresponding problem for the subclass of starlike mappings defined on the unit ball in a complex Banach space, on the unit polydisk in Cnand the bounded starlike circular domain in C~■, respectively.

High-resolution global mature and young oil palm plantation subclass maps for 2020

Accurate high-resolution maps of oil palm plantations underpin effective management of environmental and socio-economic impacts at global,regional,and national levels.However,young industrial and highly irregular small-holder plantations are mostly unmapped and not included in official FAO statistics.This issue is addressed here by discriminating global oil palm plantation in 2020 into four subclasses:Industrial Mature Oil Palm(IMOP);Industrial Young Oil Palm(IYOP);Smallholder Mature Oil Palm(SMOP);and Smallholder Young Oil Palm(SYOP).Data,resolved to 4.77 m,from Planet&NICFI,Sentinel-1/2,were combined with other layers using the image-oriented classification and regression tree(CART)algorithm which performed best in classification tests.Results show that SMOP dominates distributional extent,but it was also the most accurately mapped subclass typically found at 500–1000 m altitude.IMOP had the most extensive altitude range of 500–1300 m,while IYOP and SYOP were found at similar altitudes of 500–800 m and 500–900 m respectively.Recent developments in South East Asia show oil palm plantations expanding into new areas with a slope of 24 degrees.Results provide data to support Sustainable Development Goal by assisting future oil palm-related development planning and monitoring in the world’s major oil palm-growing countries.

INFLUENCE OF IRON DEFICIENCY ON SERUM IgG SUBCLASS AND PNEUMOCOCCAL POLYSACCHARIDES SPECIFIC IgG SUBCLASS ANTIBODIES

The serum IgG subclass concentrations in 47 cases and specific IgG subclass antibodies against pneumococcal polysaccharides (PnPs) were measured in 18 cases with iron deficiency. IgG subclass deficiencies were found in 28 (59.6%) cases with the frequency in order as IgG4 (27.7%, 13 / 47), IgGl (21.3%, 10/47), IgG3 (14.9%, 7/47), and IgG2 (2.1%, 1 / 47). Compared with age-atched healthy children, the mean concentration of serum IgG4 and IgGl, and PnPs specific IgGl, IgG2 antibodies were decreased in children with iron deficiency. Decreased CD4 cells and CD4 / CD8 ratio in peripheral blood, low interleukin? (IL-6) activity, reduced lymphocyte proliferative responsiveness and increased recurrent respiratory tract infections (RRTI) were found in iron deticiency children. These results suggested that serum IgG subclass and PnPs specific IgG subclass antibody deficiencies caused by dysfunction of the regulation of T lymphocyte on B lymphocyte may be related to the susceptibility to RRTI in children with iron deficiency.

Anti-donor immunoglobulin G subclass in liver transplantation

Immunoglobulin G(IgG)subclasses in human health and immunity have only be sporadically studied in the half century since their discovery.Different patterns of IgG subclass production are seen if the immune response is deviated towards type 1 versus type 2.The current state of our knowledge of IgG subclasses in liver transplantation is reviewed here.While several studies have been conducted in liver disease,only four relatively small studies have been undertaken in liver transplant recipients.Total IgG4 elevation in serum is related to sclerosing pancreatico-cholangiopathy that is sensitive to treatment with steroids.Conventional immunosuppressive regimes,especially with a combination of tacrolimus and sirolimus,reduce the production of all IgG subclasses after transplantation but it is not known if they deviate the immune response.Presence of anti-donor IgG3 before transplantation,or its expansion after transplantation,has been associated with rejection and liver graft loss.Anti-GSTT1 IgG4 production after transplantation is associated with de-novo immune hepatitis.Greater knowledge of anti-donor IgG subclass responses after transplantation will allow us tailor novel treatments for greater effect.

Identification of hedgehog signaling as a potential oncogenic driver in an aggressive subclass of human hepatocellular carcinoma: A reanalysis of the TCGA cohort

Hepatocellular carcinoma(HCC)is a heterogeneous disease and the second most common cause of cancer-related death worldwide.Marked developments in genomic technologies helped scientists to understand the heterogeneity of HCC and identified multiple HCC-related molecular subclasses.An integrative analysis of genomic datasets including 196 patients from The Cancer Genome Atlas(TCGA)group has recently reported a new HCC subclass,which contains three subgroups(iCluster1,iCluster2,and iCluster3).However,the transcriptional molecular characteristics underlying the iClusters have not been thoroughly investigated.Herein,we identified a more aggressive subset of HCC patients in the iCluster1,and re-clustered the TCGA samples into novel HCC subclasses referred to as aggressive(Ag),moderate-aggressive(M-Ag),and less-aggressive(L-Ag)subclasses.The Ag subclass had a greater predictive power than the TCGA iCluster1,and a higher level of alpha fetoprotein,microscopic vascular invasion,immune infiltration,isocitrate dehydrogenase 1/2 mutation status,and a worse survival than MAg and L-Ag subclasses.Global transcriptomic analysis showed that activation of hedgehog signaling in the Ag subclass may play key roles in tumor development of aggressive HCC.GLI1,a key transcriptional regulator of hedgehog signaling upregulated in the Ag subclass,was correlated with poor prognosis of HCC,and may be a potential prognostic biomarker and therapeutic target for Ag subclass HCC patients.

THE LIMITING DISTRIBUTIONS OF SOME SUBCLASSES OF THE GENERALIZED NON-CENTRAL t-DISTRIBUTION

A general theorem on the limiting distribution of the generalized t-distribution is obtained,many applications of this theorem to some subclasses of elliptically contoured distributions in cluding multivariate normal and multivariate t distributions are discussed.Further,their limiting distributions by density function are derived.

Subclasses of warm autoantibody Ig Gin patients with autoim m unehemolytic anemia and their clinicalim plications

Objective To explore the mechanism of autoimmune hemolysis and establish a more sensitive test for autoimmune hemolytic anemia (AIHA) Methods IgG subclasses were tested in 40 patients with idiopathic or secondary AIHA by Coombs test with monoclonal antibodies Hb, TBil, RC and FHb, as hemolytic parameters, were used to analyze the clinical implications of subclasses of AIHA warm autoantibody IgG Results In most patients IgG incomplete warm autoantibody was IgG1(27 patients), but IgG3(20 patients), rarely IgG2(14 patients) and IgG4(9 patients) also occurred Three groups were analyzed: Group A included 20 patients with IgG3; Group B included 14 patients with IgG1 but without IgG3; Group C included 6 patients without IgG1 and IgG3 There were significant differences ( P <0 01) between groups in Hb, TBil, RC and FHb Moreover, we also found that the sensitivity of Coombs test with polyclonal antiserums was 90 0%, while that of Coombs test with monoclonal antibodies was 97 5% The effect of treatment was worst in patients with positive IgG3 autoantibody, whose hemolysis recurred frequently Conclusion IgG3 autoantibody was the most effective in bringing about red cell destruction, IgG1 autoantibody was less effective, IgG2 even less, whereas IgG4 autoantibody was shown to hardly affect red cell survival Coombs test with monoclonal antibodies was more sensitive than that with polyclonal antiserums Patients’ respondence to treatment correlated with the type of IgG subclasses

脂蛋白及其亚类在机体中的功能

脂蛋白是一类由胆固醇酯、甘油三酯、载脂蛋白、磷脂和游离胆固醇等组成的复杂球状微粒,作为血液中水不溶性脂质载体,在脂质的转运和代谢中具有重要作用。因粒径、密度和载脂蛋白组成不同,脂蛋白常被分为高密度脂蛋白、低密度脂蛋白、中密度脂蛋白、极低密度脂蛋白和乳糜微粒。依靠不同的分离技术,脂蛋白又可被进一步细分为不同的亚类且功能各异。传统临床检测以高密度脂蛋白胆固醇、低密度脂蛋白胆固醇和载脂蛋白等作为常规指标,并用于评价各类心血管类疾病的患病风险、发展状况和治疗效果。但近年来,随着对脂蛋白及其亚类功能研究的深入,常规指标已不能满足对心血管类疾病进行精准预测和高效治疗的需求,寻求更为可靠的评价指标变得尤为重要。对脂蛋白及其亚类功能的研究是解决这一瓶颈的关键所在,更有助于脂质代谢异常导致的高血脂和动脉粥样硬化等心血管疾病的治疗,也是拓宽其在营养、代谢、疾病等研究领域应用的前提。近年来,脂蛋白亚类一直作为研究的热点,除脂质运输和代谢外,不断有新的功能被发现。本文对高密度脂蛋白、低密度脂蛋白、极低密度脂蛋白和乳糜微粒在机体脂质代谢中的功能进行了综述和展望,以期为脂蛋白亚类在营养、代谢、疾病等功能研究提供参考。

DNA双加氧酶TET家族蛋白1抑制上皮性卵巢癌转移的作用机制研究

目的探讨TET家族蛋白1(TET1)在调控上皮性卵巢癌(EOC)转移中的作用机制。方法在EOC细胞系中瞬时转染TET1过表达质粒,通过Transwell实验检测EOC细胞迁移能力变化。通过蛋白质免疫印迹检测上皮细胞黏附分子(EpCAM)的表达。通过蛋白质免疫荧光实验检测EpCAM上游转录因子β-连环蛋白的亚细胞定位变化。检测β-连环蛋白的上游抑制因子叉头框基因O4(FOXO4)基因启动子区5hmC和5mC含量变化。通过染色质免疫共沉淀实验检测TET1与FOXO4基因启动子区域结合情况。利用EOC组织芯片对TET1与β-连环蛋白进行免疫组织化学染色,探讨二者表达的相关性。结果过表达TET1明显抑制EOC细胞系OVSAHO和JHOS4的细胞迁移能力,且明显抑制EpCAM的表达。TET1过表达后促进β-连环蛋白的亚细胞定位发生变化,其核内聚集明显减少,β-连环蛋白与EpCAM基因启动子区域结合亦明显减少。TET1过表达可以促进FOXO4的表达,进而抑制β-连环蛋白进入细胞核发挥转录因子作用。当FOXO4表达被敲低后,β-连环蛋白的细胞核内分布明显增加。在浆液性卵巢腺癌组织样本中,71.8%(28/39)TET1表达呈阳性,15.4%(6/39)β-连环蛋白表达呈阳性,TET1与β-连环蛋白的表达呈负相关(χ^(2)=4.745,P=0.030)。结论TET1通过调控FOXO4/β-连环蛋白/EpCAM轴抑制EOC转移。

BP神经网络在玻璃文物分类及亚类中的应用

针对玻璃文物分类及其亚类划分的问题,采用BP神经网络模型,通过MATLAB导入玻璃文物实际数据集对模型进行训练和学习,结合玻璃文物各化学成分的特征对BP神经网络的权值进行调整,得出玻璃文物的分类结果及其亚类划分,其结果与实际结果进行对比,验证出BP神经网络在玻璃文物分类领域中具有较强的实际应用价值。以氧化铝与氧化钡为不确定因素对亚类划分结果进行敏感性分析,计算得出敏感性指标。

基于CLR的玻璃文物成分分析与分类模型

对具有成分数据特征的古代玻璃成分数据集进行风化前成分含量预测以及类别划分.首先,对成分数据进行中心对数比变换预处理,从“成分相对重要性”的角度提取了成分数据的信息,并通过对变换后的玻璃文物化学成分数据分析:一方面,实现了对已风化的铅钡和高钾两类玻璃风化前化学成分的预测,即成分还原;另一方面,在铅钡和高钾两大类的基础上,拣选出可用于对玻璃文物进一步分出亚类的化学成分,构建了稳健的玻璃亚类分类模型.该模型可以实现在风化导致玻璃文物偏移其原始化学成分的情况下,对玻璃的亚类有大致正确的判断,即对风化文物原始成分的预测偏差不会显著影响分类结果.