环丙唑醇的新合成方法

Cyproconazole(5) is a good fungicide.In this paper,starting from p-chlorobenzonitrile and allylic bromide,the intermediate 1-(4-chlorophenyl)-2-cyclopropyl-1-ethanone(2) was obtained by Barbier-type reaction and Simmons-Smith reaction.The product 5 was synthesized form 2 via α-methyl reaction,Corey-Chaykovsky reaction,and substitution reaction with 1,2,4-triazole.The total yield was 30.8%.5 and all intermediates were characterized and confirmed with 1H NMR and MS spectra.This procedure was cost-effective and applicable on a multigram scale.

由对苯二酚合成2,5-二甲氧基对苯二苄氯锍盐

以对苯二酚为基本原料，通过改进的甲氧基化、氯甲基化、锍化３个反应合成，得到（２，５－二甲氧基对苯乙炔）单体双锍盐２，５－二甲氧基对苯二苄氯锍盐，且产率达８４％，并对每步反应的合成条件及原因进行了解释。

2，5－二甲氧基对苯乙炔前聚物单体的合成

以对苯二酚为基本原料，通过甲氧基化、氯甲基化、锍化三个反应合成得到了单体双锍盐且产率达８４％，并运用色谱／质谱联用仪和核磁共振仪对每步产物进行了表征．

1-(2-氟苯基)-1-(4-氟苯基)环氧乙烷的合成研究

以2,4’-二氟二苯酮和锍盐(CH3)3SHSO4为原料,在碱性条件下反应生成1-(2-氟苯基)-1-(4-氟苯基)环氧乙烷。通过正交实验确定最佳工艺条件为:氢氧化钾、甲醇和2,4’-二氟二苯酮的物质的量比为6∶1.25∶1,反应温度45℃。以2,4’-二氟二苯酮计,产品收率为91.23%,含量为97.45%。