Microbiome is an endocrine organ that refers to both the complicated biological system of microbial species that colonize our bodies and their genomes and surroundings.Recent studies confirm the connection between the...Microbiome is an endocrine organ that refers to both the complicated biological system of microbial species that colonize our bodies and their genomes and surroundings.Recent studies confirm the connection between the microbiome and eye diseases,which are involved in the pathogenesis of eye diseases,including age-related macular disorders,diabetic retinopathy,glaucoma,retinitis pigmentosa,dry eye,and uveitis.The aim of this review is to investigate the microbiome in relation to eye health.First,a brief introduction of the characteristics of the gut microorganisms terms of composition and work,the role of dysbiosis,the gut microbiome and the eye microbiome in the progression of eye illnesses are highlighted,then the relationship among the microbiome and the function of the immune system and eye diseases,the role of inflammation and aging and the immune system,It has been reviewed and finally,the control and treatment goals of microbiome and eye diseases,the role of food factors and supplements,biotherapy and antibiotics in relation to microbiome and eye health have been reviewed.展开更多
This project looks at a novel way to enhance the sensory experience of vitamin D ingestion by incorporating it into marshmallows. This investigation used a human panel taste test with twelve individuals, an index of s...This project looks at a novel way to enhance the sensory experience of vitamin D ingestion by incorporating it into marshmallows. This investigation used a human panel taste test with twelve individuals, an index of swelling, and a stability evaluation. Samples of vitamin D infused marshmallows were prepared and given to participants in the human panel taste test, which evaluated mouthfeel and flavor. By analyzing dissolving behavior, the swelling index test revealed unexpected erosion. In addition, a temperature threshold for storage conditions was found through a temperature sensitivity test. All of these techniques assessed the feasibility and palatability of vitamin D supplementation with marshmallow flavor, offering insights into both the possible advantages and difficulties. The marshmallow infusion technique effectively covered up the disagreeable taste of vitamin D pills, leading to reviews that were overwhelmingly favorable (“Moderate Sweet”) and that indicated a pleasant mouthfeel. During the swelling index test, it showed erosion behavior, suggesting a certain kind of dissolution that is advantageous for nutritional absorption. Furthermore, the study discovered a temperature sensitivity threshold, highlighting how crucial proper storage conditions are.展开更多
Although returning crop residue to fields is a recommended measure for improving soil carbon(C)stocks in agroecosystems,the response of newly formed soil C(NFC)to the integrated supply of residue and nutrients and the...Although returning crop residue to fields is a recommended measure for improving soil carbon(C)stocks in agroecosystems,the response of newly formed soil C(NFC)to the integrated supply of residue and nutrients and the microbial mechanisms involved in NFC are not fully understood.Therefore,an 84-day incubation experiment was conducted to ascertain the microbial mechanisms that underpin the NFC response to inputs of residue and nitrogen(N),phosphorus(P),and sulfur(S)in two black(Phaeozem)soils from experimental plots at Gongzhuling,Jilin Province and Hailun,Heilongjiang Province,China.The results showed that adding residue alone accelerated microbial nutrient mining,which was supported by decreases of 8^(-1)6%in the ratios of C:N and C:P enzyme activities,relative to soils with nutrient inputs.The NFC amounts increased from 1156 to 1722 mg kg^(−1) in Gongzhuling soil and from 725 to 1067 mg kg^(−1) in Hailun soil as the levels of nutrient supplementation increased.Boosted regression tree analysis suggested thatβ-glucosidase(BG),acid phosphatase(AP),microbial biomass C(MBC),and Acidobacteria accounted for 27.8,18.5,14.7,and 8.1%,respectively,of the NFC in Gongzhuling soil and for 25.9,29.5,10.1,and 13.9%,respectively,of the NFC in Hailun soil.Path analysis determined that Acidobacteria positively influenced NFC both directly and indirectly by regulating BG,AP,and MBC,in which MBC acquisition was regulated more by AP.The amount of NFC was lower in Hailun soil than in Gongzhuling soil and was directly affected by AP,indicating the importance of soil properties such as SOC and pH in determining NFC.Overall,our results reveal the response of NFC to supplementation by N,P,and S,which depends on Acidobacteria and Proteobacteria,and their investment in BG and AP in residue-amended soil.展开更多
<strong>Introduction</strong>:<span><span style="font-family:;" "=""><span style="font-family:Verdana;"> Naturally based treatments for osteoporosis are...<strong>Introduction</strong>:<span><span style="font-family:;" "=""><span style="font-family:Verdana;"> Naturally based treatments for osteoporosis are currently limited. The purpose of this investigation was to ascertain whether bovine colostrum supplementation can improve bone health in humans. </span><b><span style="font-family:Verdana;">Methods:</span></b><span style="font-family:Verdana;"> In tot</span><span style="font-family:Verdana;"></span><span style="font-family:Verdana;">al 63 individuals volunteered in a 4-month supplementation project. They were stratified into three groups: </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;">1</span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;">) healthy post-menopausal women (n = 24)</span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;">;</span></span><span><span style="font-family:;" "=""> </span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;">2</span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;">) individuals with osteopenia (n = 25)</span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;">;</span></span><span><span style="font-family:;" "=""> </span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;">3</span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;">) people with osteoporosis (n = 14). Participants of each group were randomly assigned into two experimental sub-groups: </span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;">a</span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;">) the bovine colostrum (BC) supplementation (200</span></span><span><span style="font-family:;" "=""> </span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;">mL/day;5 days/week)</span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;">;</span></span><span><span style="font-family:;" "=""> </span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;">b</span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;">) the placebo sub-group. Before and after the 4-month supplementation, blood samples were obtained and bone mineral density (BMD) was measured. Dual-Energy X-ray Absorptiometry (DXA) was performed on three different anatomical sites: lumbar spine (LS), left femur neck (FN), and left forearm (Arm). Bone health markers </span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;">(</span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;">bone alkaline phosphatase (BAP), osteocalcin, C-terminal telopeptide (CTX-I), deoxypyridinoline (DPD)</span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;">)</span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"> as well as immunological markers </span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;">(</span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;">interleukin 6 (IL6) and immunoglobulin E (IgE)</span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;">)</span></span><span><span style="font-family:;" "=""><span style="font-family:Verdana;">, were assessed in blood serum with enzyme immunoassays, at baseline and</span><span><span style="font-family:Verdana;"> 4-months after BC supplementation. </span><b><span style="font-family:Verdana;">Results:</span></b><span style="font-family:Verdana;"> No significant </span></span><span style="font-family:Verdana;">changes were found in bone densitometry factors (p > 0.05), for all studied blood parameters and their calculated effect sizes. </span><b><span style="font-family:Verdana;">Conclusions:</span></b><span style="font-family:Verdana;"> It is concluded that, as studied herein, BC does not seem to affect human bone health. This pilot study though warrant the need for further research into the efficacy of BC in patients with osteoporosis.展开更多
文摘Microbiome is an endocrine organ that refers to both the complicated biological system of microbial species that colonize our bodies and their genomes and surroundings.Recent studies confirm the connection between the microbiome and eye diseases,which are involved in the pathogenesis of eye diseases,including age-related macular disorders,diabetic retinopathy,glaucoma,retinitis pigmentosa,dry eye,and uveitis.The aim of this review is to investigate the microbiome in relation to eye health.First,a brief introduction of the characteristics of the gut microorganisms terms of composition and work,the role of dysbiosis,the gut microbiome and the eye microbiome in the progression of eye illnesses are highlighted,then the relationship among the microbiome and the function of the immune system and eye diseases,the role of inflammation and aging and the immune system,It has been reviewed and finally,the control and treatment goals of microbiome and eye diseases,the role of food factors and supplements,biotherapy and antibiotics in relation to microbiome and eye health have been reviewed.
文摘This project looks at a novel way to enhance the sensory experience of vitamin D ingestion by incorporating it into marshmallows. This investigation used a human panel taste test with twelve individuals, an index of swelling, and a stability evaluation. Samples of vitamin D infused marshmallows were prepared and given to participants in the human panel taste test, which evaluated mouthfeel and flavor. By analyzing dissolving behavior, the swelling index test revealed unexpected erosion. In addition, a temperature threshold for storage conditions was found through a temperature sensitivity test. All of these techniques assessed the feasibility and palatability of vitamin D supplementation with marshmallow flavor, offering insights into both the possible advantages and difficulties. The marshmallow infusion technique effectively covered up the disagreeable taste of vitamin D pills, leading to reviews that were overwhelmingly favorable (“Moderate Sweet”) and that indicated a pleasant mouthfeel. During the swelling index test, it showed erosion behavior, suggesting a certain kind of dissolution that is advantageous for nutritional absorption. Furthermore, the study discovered a temperature sensitivity threshold, highlighting how crucial proper storage conditions are.
基金financially supported by the Agro-scientific Research in the Public Interest of China (201503122)the Agricultural Science and Technology Innovation Program of the Chinese Academy of Agricultural Sciences (CAASXTCX2016008)the National Natural Science Foundation of China (41620104006)
文摘Although returning crop residue to fields is a recommended measure for improving soil carbon(C)stocks in agroecosystems,the response of newly formed soil C(NFC)to the integrated supply of residue and nutrients and the microbial mechanisms involved in NFC are not fully understood.Therefore,an 84-day incubation experiment was conducted to ascertain the microbial mechanisms that underpin the NFC response to inputs of residue and nitrogen(N),phosphorus(P),and sulfur(S)in two black(Phaeozem)soils from experimental plots at Gongzhuling,Jilin Province and Hailun,Heilongjiang Province,China.The results showed that adding residue alone accelerated microbial nutrient mining,which was supported by decreases of 8^(-1)6%in the ratios of C:N and C:P enzyme activities,relative to soils with nutrient inputs.The NFC amounts increased from 1156 to 1722 mg kg^(−1) in Gongzhuling soil and from 725 to 1067 mg kg^(−1) in Hailun soil as the levels of nutrient supplementation increased.Boosted regression tree analysis suggested thatβ-glucosidase(BG),acid phosphatase(AP),microbial biomass C(MBC),and Acidobacteria accounted for 27.8,18.5,14.7,and 8.1%,respectively,of the NFC in Gongzhuling soil and for 25.9,29.5,10.1,and 13.9%,respectively,of the NFC in Hailun soil.Path analysis determined that Acidobacteria positively influenced NFC both directly and indirectly by regulating BG,AP,and MBC,in which MBC acquisition was regulated more by AP.The amount of NFC was lower in Hailun soil than in Gongzhuling soil and was directly affected by AP,indicating the importance of soil properties such as SOC and pH in determining NFC.Overall,our results reveal the response of NFC to supplementation by N,P,and S,which depends on Acidobacteria and Proteobacteria,and their investment in BG and AP in residue-amended soil.
文摘<strong>Introduction</strong>:<span><span style="font-family:;" "=""><span style="font-family:Verdana;"> Naturally based treatments for osteoporosis are currently limited. The purpose of this investigation was to ascertain whether bovine colostrum supplementation can improve bone health in humans. </span><b><span style="font-family:Verdana;">Methods:</span></b><span style="font-family:Verdana;"> In tot</span><span style="font-family:Verdana;"></span><span style="font-family:Verdana;">al 63 individuals volunteered in a 4-month supplementation project. They were stratified into three groups: </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;">1</span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;">) healthy post-menopausal women (n = 24)</span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;">;</span></span><span><span style="font-family:;" "=""> </span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;">2</span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;">) individuals with osteopenia (n = 25)</span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;">;</span></span><span><span style="font-family:;" "=""> </span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;">3</span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;">) people with osteoporosis (n = 14). Participants of each group were randomly assigned into two experimental sub-groups: </span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;">a</span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;">) the bovine colostrum (BC) supplementation (200</span></span><span><span style="font-family:;" "=""> </span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;">mL/day;5 days/week)</span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;">;</span></span><span><span style="font-family:;" "=""> </span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;">b</span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;">) the placebo sub-group. Before and after the 4-month supplementation, blood samples were obtained and bone mineral density (BMD) was measured. Dual-Energy X-ray Absorptiometry (DXA) was performed on three different anatomical sites: lumbar spine (LS), left femur neck (FN), and left forearm (Arm). Bone health markers </span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;">(</span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;">bone alkaline phosphatase (BAP), osteocalcin, C-terminal telopeptide (CTX-I), deoxypyridinoline (DPD)</span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;">)</span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"> as well as immunological markers </span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;">(</span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;">interleukin 6 (IL6) and immunoglobulin E (IgE)</span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;">)</span></span><span><span style="font-family:;" "=""><span style="font-family:Verdana;">, were assessed in blood serum with enzyme immunoassays, at baseline and</span><span><span style="font-family:Verdana;"> 4-months after BC supplementation. </span><b><span style="font-family:Verdana;">Results:</span></b><span style="font-family:Verdana;"> No significant </span></span><span style="font-family:Verdana;">changes were found in bone densitometry factors (p > 0.05), for all studied blood parameters and their calculated effect sizes. </span><b><span style="font-family:Verdana;">Conclusions:</span></b><span style="font-family:Verdana;"> It is concluded that, as studied herein, BC does not seem to affect human bone health. This pilot study though warrant the need for further research into the efficacy of BC in patients with osteoporosis.