The sustainable use of renewable resources has become an important issue worldwide in the move towards a less fossil-fuel-intensive future.Mainstream method for fulfilling this aim is to increase the share of renewabl...The sustainable use of renewable resources has become an important issue worldwide in the move towards a less fossil-fuel-intensive future.Mainstream method for fulfilling this aim is to increase the share of renewable energy and materials to substitute fossil fuels and to become fully independent from fossil fuels over the long-term.However, the environmental sustainability of this endeavor has been questioned.In addition,economic and social sustainability issues are also much debated topics in this particular context.Forest resources are often thought to contribute partially to achieving a so-called ＂carbon-neutral society＂.In this review, we discuss sustainability issues of using forest biomass.We present several sustainability indicators for ecological,economic and social dimensions and discuss the issues in applying them in sustainability impact assessments（SIAs）.We also present a number of tools and methods previously used in conducting SIAs.We approach our study from the perspective of the Finnish forestry; in addition, various aspects regarding the application of SIAs in a broader context are also presented.One of the key conclusions of the study is that although sufficient data are available to measure many indicators accurately, the impacts may be very difficult to assess（e.g.impact of greenhouse gases on biodiversity） for conducting a holistic SIA.Furthermore, some indicators, such as ＂biodiversity＂, are difficult to quantify in the first place.Therefore, a mix of different methods, such as Multi-criteria Assessment, Life-cycle Assessment or Cost-Benefit Analysis, as well as different approaches（e.g.thresholds and strong/weak sustainability） are needed in aggregating the results of the impacts.SIAs are important in supporting and improving the acceptability of decision-making, but a certain degree of uncertainty will always have to be tolerated.展开更多
A paradox in cancer research is that the majority of patients enrolled in clinical trials are relatively young and fit while typical patients in daily practice are elderly and have comorbidities and impaired organ fun...A paradox in cancer research is that the majority of patients enrolled in clinical trials are relatively young and fit while typical patients in daily practice are elderly and have comorbidities and impaired organ function. Given these differences, many major studies provide an imperfect guide to optimizing the treatment of the majority of patients. Since cancer incidence is highly correlated with age, and since the world's population is rapidly ageing, this problem can only increase. For this reason, oncologists and geriatricians need to collaborate in developing tools to systematically assess the health status of elderly patients and their fitness to receive cancer therapies of various intensity. Tailoring anti-cancer treatments and supportive care to individual needs should be seen as part of the move towards personalized medicine. Achieving this goal is as much of a challenge to developing and middle-income countries as it is to western nations. The 2015 annual conference of the International Society of Geriatric Oncology(SIOG) held in Prague, Czech Republic, November 2015 and had a global focus on advancing the science of geriatric oncology and supportive care. Central to this approach is the systematic assessment of life expectancy, independent functioning, and the physical and psychological health of older cancer patients. The assumption behind comprehensive geriatric assessment is that elderly cancer patients have complex needs. The implication is that effective intervention will require a multidisciplinary team. Examples of effective geriatric assessment, multidisciplinary working and supportive care were presented at the SIOG conference.展开更多
Marinobufagenin(MBG)is a bufadienolide compound belonging to the cardiac glycosides class.The bufadienolides are present in humans as well as in some plants and animals.But the major source for these compounds is loca...Marinobufagenin(MBG)is a bufadienolide compound belonging to the cardiac glycosides class.The bufadienolides are present in humans as well as in some plants and animals.But the major source for these compounds is located in the parotid and skin gland secretions of some toad species.MBG is acting as a human endogenous cardiac inotrope and is demonstrating展开更多
基金supported by the research project“Sustainable,climate-neutral and resource-efficient forest-based bioeconomy”funded by the Strategic Research Council at the Academy of Finland(Council(Decision No.293380)
文摘The sustainable use of renewable resources has become an important issue worldwide in the move towards a less fossil-fuel-intensive future.Mainstream method for fulfilling this aim is to increase the share of renewable energy and materials to substitute fossil fuels and to become fully independent from fossil fuels over the long-term.However, the environmental sustainability of this endeavor has been questioned.In addition,economic and social sustainability issues are also much debated topics in this particular context.Forest resources are often thought to contribute partially to achieving a so-called ＂carbon-neutral society＂.In this review, we discuss sustainability issues of using forest biomass.We present several sustainability indicators for ecological,economic and social dimensions and discuss the issues in applying them in sustainability impact assessments（SIAs）.We also present a number of tools and methods previously used in conducting SIAs.We approach our study from the perspective of the Finnish forestry; in addition, various aspects regarding the application of SIAs in a broader context are also presented.One of the key conclusions of the study is that although sufficient data are available to measure many indicators accurately, the impacts may be very difficult to assess（e.g.impact of greenhouse gases on biodiversity） for conducting a holistic SIA.Furthermore, some indicators, such as ＂biodiversity＂, are difficult to quantify in the first place.Therefore, a mix of different methods, such as Multi-criteria Assessment, Life-cycle Assessment or Cost-Benefit Analysis, as well as different approaches（e.g.thresholds and strong/weak sustainability） are needed in aggregating the results of the impacts.SIAs are important in supporting and improving the acceptability of decision-making, but a certain degree of uncertainty will always have to be tolerated.
文摘A paradox in cancer research is that the majority of patients enrolled in clinical trials are relatively young and fit while typical patients in daily practice are elderly and have comorbidities and impaired organ function. Given these differences, many major studies provide an imperfect guide to optimizing the treatment of the majority of patients. Since cancer incidence is highly correlated with age, and since the world's population is rapidly ageing, this problem can only increase. For this reason, oncologists and geriatricians need to collaborate in developing tools to systematically assess the health status of elderly patients and their fitness to receive cancer therapies of various intensity. Tailoring anti-cancer treatments and supportive care to individual needs should be seen as part of the move towards personalized medicine. Achieving this goal is as much of a challenge to developing and middle-income countries as it is to western nations. The 2015 annual conference of the International Society of Geriatric Oncology(SIOG) held in Prague, Czech Republic, November 2015 and had a global focus on advancing the science of geriatric oncology and supportive care. Central to this approach is the systematic assessment of life expectancy, independent functioning, and the physical and psychological health of older cancer patients. The assumption behind comprehensive geriatric assessment is that elderly cancer patients have complex needs. The implication is that effective intervention will require a multidisciplinary team. Examples of effective geriatric assessment, multidisciplinary working and supportive care were presented at the SIOG conference.
文摘Marinobufagenin(MBG)is a bufadienolide compound belonging to the cardiac glycosides class.The bufadienolides are present in humans as well as in some plants and animals.But the major source for these compounds is located in the parotid and skin gland secretions of some toad species.MBG is acting as a human endogenous cardiac inotrope and is demonstrating
