The comparison of intravenous and lymphotropic routes of ^99mTc ciprofloxacin in experimental pulmonary suppuration

Intravenously injected “99mTc-ciprofloxacin” is rapidly accumulated and washed from the septic focus. Lymphotropic injections provide targeted and long-lasting effect of antibiotics. After injection into the interspinous ligament the drug slowly enters the inflammation area (by-passing the urinary organs and liver), where it is maximally accumulated only after 24 h, which allows to reduce the number of injections and the total dose of the antibiotic.

Intracranial Suppuration at the Brazzaville Academic Hospital

Background: Intracranial suppurations (ICS) due to banal germs are medical-surgical emergencies, despite their little removed frequency. Represented by abscesses and empyemas, their management has been improved by the combined contributions of new diagnostic and therapeutic methods. Objective: Appreciate the management of intracranial suppurations banal germ in our service. Material and methods: A retrospective study of 41 cases of intra-cranial suppurations was conducted at Brazzaville University Hospital, from January 2007 to June 2019. Diagnostic, therapeutic and evolution aspects have been studied. Results: They are divided into 24 empyemas, 8 abscesses and 9 associations abscess-empyema. The average age was 20.2 years old in general. The male predominance is noted in all groups. The sex ratio is 3.1 for all of these intracranial suppurations (ICS). They frequently complicated Oto-Rhino-Laryngology (ORL) infections (41.4%). The clinic was mostly represented by the Bergman’s triad 51.2%, followed by headache 14.6% and seizures 12.2%. The lesions were predominant in supratentorial 97.5%. Frontal location was found in 67.4%. Germs were isolated in 29.4% of samples. There were 5 Streptococci, 3 Staphylococci and 2 Gram-negative Bacilli. The medico-surgical treatment indicated in 80.5% combined often probabilistic tri-antibiotherapy with the evacuation of the pus by the trepano-puncture. Evolution under this treatment was marked by healing in 90.2%. The lethality was 9.7%. Conclusion: The pursuit of the improvement of these infections requires the adequate treatment of their gateways, most of them loco-regional.

Intracranial Suppurations in Africa: Systematic Review

Background: Intracranial suppurations (ICS) due to common causative microorganisms are still an important health problem in Africa. Their management, which has certainly been improved by technological developments, varies according to neurosurgical teams. Objectives: To describe the clinical characteristics, the causative microorganisms, the outcome, and provide relevant data on the current modalities of the care of ICS. Methods: We conducted a systematic review of studies on intracranial suppurations published in Africa between January 2002 and December 2018. We included studies which had at least 6 patients with ICS. Pubmed, Google and Google scholar were searched for relevant studies. A total of 17 studies were found, from which we define the epidemiological aspects, therapeutic, and evolutionary diagnostics. Results: A total of 1166 patients were identified, and they were categorized as follows: 531 cases of abscess, 272 of empyema and 363 of intracranial suppurations with incomplete data (ICSDI). The average age in ICSDI was 10.9 years. In abscesses and empyema, 75% of patients were under 40 years. There was a male predominance of 2.4 to 1. These intra-cranial suppurations in general complicated mainly loco-regional infections. The classic triad was dominated by headache (66.5%), fever (59.4%) and neurological deficits (46.1%). The CT rarely associated with the MRI, had shown a predominance of supra-tentorial sites (92.5%) of which 37.5% was in frontal region. Of the 380 microorganisms isolated, Gram positive represented 68.9%, Gram negative 17.7% and anaerobic 13.4%. The treatment was medico-surgical (79.5%). It associated a triple antibiotherapy and a trepano-puncture. It had achieved healing in 88.2% of which 20.4% had sequelae. Case fatality rate was 11.8%. Conclusion: ICS constitute during this century, a health problem whose solution passes by the adequate treatment of loco-regional infections, their main sources.

Endocranial Suppurations of Sinus Origin: Ratio of 3 Cases in Children at the Hospital in Mali

Introduction: Intracranial suppurations are neoformed purulent collections including, in decreasing order, cerebral abscesses, subdural empyemas and extradural empyemas. Otorhinolaryngologic infections are one of the main causes, especially in older children and adolescents. We report 3 clinical cases of endocranial suppurations treated at the Mali Hospital. Clinical Cases: 1) Observation 1. IK was a 14-year-old boy, who was hospitalized in our department for fever, headache and left hemiplegia. The emergency brain scan showed a right frontal and interhemispheric subdural empyema associated with multifocal sinusitis. Surgical drainage associated with ceftriaxone: 100 mg/Kg/d in direct intravenous (DI), metronidazole: 10 mg/Kgs/12hours in slow intravenous (SI) for 15 days, gentamycin: 3 mg/Kgs/d in SI for 3 days, paracetamol 15 mg/Kgs/6hours in SI, 10% glucose serum: 100 ml/Kg/d were given. The bacteriological analysis of the pus came back sterile. The postoperative period was calm. 2) Observation 2. This was a 14-year-old boy with a history of headaches who was admitted to our department for left hemiplegia. An emergency brain scan showed a right pre-suppurative encephalitis associated with a right fronto-ethmoidal and maxillary sinusitis. He was put on ceftriaxone 100 mg/kg/d in DI for 21 days, gentamycin: 3 mg/Kg/d in SI for 3 days;metronidazole: 10 mg/kg/12hours in SI for 21 days, paracetamol: 15 mg/kg/6hours in SI. After 3 weeks of medical treatment, a follow-up brain scan revealed an interhemispheric and right subdural empyema. Surgical drainage was associated with the triple antibiotic therapy initially instituted. The bacteriological analysis of the pus was sterile. The postoperative course was calm. 3) Observation 3. N.M was an 11-year-old boy, who was admitted with fever and left hemiplegia. An emergency brain scan revealed a right hemispheric subdural empyema associated with an intracerebral abscess and pansinusitis. Surgical drainage associated with ceftriaxone 100 mg/kg/d in DI for 15 days, gentamycin;3 mg/kg/d in SI for 3 days, metronidazole: 10 mg/kg/12hours in SI for 15 days and paracetamol: 15 mg/kg/6hours in SI were instituted. Staphylococcus aureus was isolated in the pus of the abscess. The postoperative course was calm. Conclusion: Endocranial suppurations of sinus origin are serious and frequent infections in children in developing countries. Its diagnosis must be evoked in front of any hemiplegia associated with a fever or headache and confirmed by a cerebral scanner.

Acute suppurative terminal cholangitis:Clinical characteristics of a new subtype of acute cholangitis

Background:Acute suppurative terminal cholangitis(ASTC)is rarer than acute obstructive cholangitis and is not well studied.To explore this subtype of acute cholangitis,we described our clinical experience with ASTC.Methods:We performed a retrospective review of patients with ASTC admitted to our center from September 2014 to August 2020.We analyzed their clinical characteristics,including etiology,clinical manifestations,imaging features,treatment and prognosis.Results:A total of 32 ASTC patients were included in the analysis.The majority of the patients had a history of biliary operations,and clinical manifestations were occult and atypical.The positive rate of bacterial culture was 46.9%.All the patients had typical imaging features on computed tomography and magnetic resonance imaging.Treatment with effective antibiotics was provided as soon as diagnosis was established.After treatment,most patients had a good outcome.Elevated levels of total bilirubin,aspartate aminotransferase,procalcitonin and gamma-glutamyltransferase were the characteristics of critically ill patients and were associated with relatively poor prognosis.Conclusions:Our results demonstrated that ASTC should be recognized as a new subtype of acute cholangitis,and that earlier diagnosis and more personalized treatments are needed.

Squamous Cell Carcinoma of the Middle Ear: Case Report and Literature Review

Malignant tumors originating from the middle ear are rare. The literature identifies chronic inflammation and Human Papillomavirus (HPV) infection as the most common risk factors. A CT scan to assess bony invasion and an MRI to evaluate soft tissue involvement, depth of invasion, and perineural invasion, followed by a biopsy, are indispensable for diagnosis and treatment. There is no standard treatment for squamous cell carcinoma of the middle ear, however, most reported cases are treated with surgical resection followed by postoperative radiotherapy. Given the challenges of achieving complete surgical excision, radiotherapy plays a crucial role in controlling middle ear cancers, as demonstrated in our case. We present a case of squamous cell carcinoma of the middle ear in a 63-year-old female with a history of chronic suppurative otitis media. The patient underwent a right subtotal petrosectomy without lymph node dissection followed by concurrent chemoradiotherapy. At the one-year follow visit, no recurrence or metastasis was detected.

Analysis of the Clinical Value of Surgical Treatment and Postoperative Anti-Infection Treatment of Acute Suppurative Appendicitis

Objective: To explore the clinical value of surgical treatment and postoperative anti-infection treatment for acute suppurative appendicitis. Methods: A total of 116 patients with acute suppurative appendicitis were enrolled in this study. The collection period was from December 2021 to December 2023. The patients were randomly grouped into a control group (surgical treatment) and an observation group (surgical treatment and postoperative anti-infection treatment), of 58 patients each. At the end of the treatment, the results of each index of the two groups were compared. Results: The length of hospitalization time, exhaust time, and incidence of complications in the observation group were shorter than those of the control group (P < 0.05). The total effective rate of the observation group was higher than that of the control group (P < 0.05). Conclusion: It is crucial to perform anti-infective treatment promptly after surgical treatment in patients with acute suppurative appendicitis. It can effectively prevent the occurrence of complications and improve the clinical efficacy. Hence, it is worthy of research and promotion.

慢性化脓性中耳炎活动期并发耳后骨膜下脓肿的临床分析(附6例报告)

目的分析慢性化脓性中耳炎活动期并发耳后骨膜下脓肿的临床特点和治疗方案。方法回顾性分析2020年8月~2022年4月于青海大学附属医院耳鼻咽喉科就诊的6例耳后骨膜下脓肿患者的致病特点、治疗方式及效果。结果6例均为慢性化脓性中耳炎患者,1例伴有胆脂瘤形成,均表现为耳后红肿及明显疼痛,无全身症状。6例患者的听骨链及外耳道后壁均有不同程度的破坏,5例的手术方式为完壁式乳突根治及鼓室成形,1例中耳胆脂瘤为开放式乳突根治及鼓室成形。1例患者为混合性聋,5例患者为传导性聋。随诊12个月,术后听力较术前改善,预后良好,6例患者均无复发。结论慢性化脓性中耳炎活动期并发的耳后骨膜下脓肿破坏力强,容易出现听骨链、外耳道后壁的破坏,引起明显的听力下降。耳后骨膜下脓肿患者应尽早行脓肿切开,在鼓室成形的同时,应根据是否合并中耳胆脂瘤决定乳突根治为完壁式或开放式。

Sepsis after Administering an Intramuscular Iron Injection in the Arm of an Elder Patient with Multiple Comorbidities: A Case Report

Background: Skin reactions and musculoskeletal injuries caused by intramuscular injection are an increased risk for skin and soft tissue infections and may culminate in sepsis. Objective: To describe the history of an elderly patient who developed a lesion in her right arm after home administration of intramuscular iron injection in this arm and its outcome. Methods: This is a case report of a patient who participated in a study in an intensive care unit. Results: This study describes a 65-year-old patient with multiple comorbidities who was admitted to the hospital complaining of pain for two months and difficulty in moving her right shoulder associated with skin and soft tissue infections in her right arm after intramuscular iron administration by a relative for the treatment of multifactorial anemia and refractory melena. The patient worsened her general condition and was transferred to the intensive care unit. Despite the therapy instituted, the patient developed sepsis of cutaneous origin, multiple organ dysfunction, and death. Conclusions: The administration of intramuscular medication requires the participation of qualified professionals, such as nurses, mainly within the scope of the Brazilian public health system which commonly comprises patients in a context of vulnerability.

Gallbladder Carcinoma of the Thyroid Revealed by an Acute Festered Thyroiditis: A Literature Study about a Case

The cutaneous extension of gallbladder thyroid carcinoma is uncommon and is among the aggressive forms of the disease. We are reporting the case of a woman of 54 that shows acute festered thyroiditis worsened by a necrotic ulcer wound on the skin lasting 3 weeks amid a big neglected hetero-multinodular goitre, evolving since 20 years. The anatomopathological test showed a gallbladder thyroid carcinoma of the thyroid with severe inflammation. The treatment consisted of a complete thyroidectomy with recurrent bilateral dredging. There was a favourable evolution. Gallbladder carcinoma, in its aggressive aspect, may be linked to the occurrence of acute festered thyroiditis. Therefore, the prognosis of our patient was favourable.

慢性化脓性中耳炎再次手术及原因分析

慢性化脓性中耳炎是耳科常见疾病,临床表现主要为耳流脓及不同程度的听力损失。乳突改良根治术是治疗胆脂瘤型及骨疡型中耳炎的主要方法,手术目的是清除病变组织,获得干耳;但术后仍有部分患者出现持续或间断流脓,

以化脓性中耳炎为首发症状的韦格纳肉芽肿1例

韦格纳肉芽肿是一种自身免疫性小血管炎,常见的病变器官为上呼吸道、肺部、肾脏。耳部症状为首发表现者少见,容易误诊及漏诊。我科近期诊治1例以化脓性中耳炎为首发症状的韦格纳肉芽肿,现报道如下。1临床资料患者,男,48岁。因左耳流脓1个月,加重伴左眼闭合差、口角向右歪斜1 d于2014-06-25入院。该患者1个月前无明显诱因出现左耳流脓,伴耳痛、耳闷及听力下降,当地医院予抗生素治疗未见明显好转,半月前就诊于我院,诊断为'急性化脓性中耳炎(左)',行鼓膜切开,继续抗感染治疗无明显缓解。入院前1 d上述症状加重,

Facial Cellulitis of Dental Origin: Experiments from the University of BouakéHealth Centre (Cote d’Ivoire)

Context: Facial cellulitis of dental origin is relatively frequent and severe. Objective: The aim of this document to describe the epidemiological, clinical, therapeutic and evolutionary aspects of facial cellulitis of dental origin in Bouaké. Methodology: This was a retrospective and descriptive study carried out in the stomatology and maxillofacial surgery department of the University of Bouaké Health centre over a period of 19 months (January 2018 to October 2019). All patients with facial cellulitis of dental origin were included. The parameters studied were epidemiological, clinical, therapeutic and evolutionary. Results: 179 patients were collected (hospital prevalence of 20.79%). The average age was 34 years (min 1-year-old and max 80-year-old). The sex ratio was 1.18. Among the patients, some were craftsmen (31.28%) and others were farmers (21.79%). The favourable factors included the nonsteroidal anti-inflammatory (77.65%) and traditional therapeutics (44.13%). The average number of days before consultation was 13 days (min 1 day and max 75 days). There were 7 cases of chronic cellulitis (3.91%) and 172 cases of acute cellulitis, including 107 (62.21%) circumscribed cellulitis, 51 (29.65%) diffused cellulitis, and 14 (8.14%) necrotizing fasciitis. The causal lesion was tooth decay (96.09%) and dental avulsion without antibiotherapy (3.91%). Incision and drainage was made in 145 patients (81%) necrosectomy surgery in 54 patients (30.17%). The mortality rate was 13.96%. Conclusion: Facial cellulitis of dental origin are clinically polymorphic with significant mortality prompting increased dental decay prevention actions.

中耳炎外科之未来

20世纪50年代,由于显微镜的引入,使得耳科手术进入了耳显微外科时代。抗生素的广泛应用、电钻和显微器械不断推陈出新,使得中耳炎手术由经典乳突根治手术向功能重建术式转变,由有创逐渐趋向微创。

手术治疗伴腭裂的中耳炎

腭裂是一种常见的先天性颌面畸形,由于颌面畸形使得腭咽部肌肉解剖异常,造成咽鼓管功能障碍,致使分泌性中耳炎患者发病率升高,继而引起听力下降。虽多数患者幼年行腭裂修复术及鼓膜置管术等方式进行治疗,但仍有部分患者因中耳病情迁延而变为慢性中耳炎,需要手术治疗。

Pyeloplasty According to Küss-Anderson-Hynes: Results and Complications at the Urology-Andrology Department of the Sino-Guinean Friendship Hospital

Objective: Evaluate pyeloplasty according to Küss-Anderson-Hynes at the urology-andrology department of the Sino-Guinean Friendship Hospital. Patient and Method: This is a 3-year prospective descriptive study from January 1, 2018 to December 31, 2020. It focused on a sample of 21 patients, who had undergone pyeloplasty according to Küss-Anderson-Hynes. Results: The averages age of the patients was 24.24 years. Lumbar pain was the main reason for consultation in 71.43% of cases. pyeloplasty according to Küss-Anderson-Hynes alone was performed in 76.20% of cases. It was associated with lower pole vessel uncrossing in 14.29% of cases and in 9.52% of cases with pyelolithotomy. The main Postoperative complications consisted of surgical site infections (23.81%) and fistula of the pyelo-ureteral junction (9.52%). The result of the pyeloplasty evaluated after three years, was qualified as good in 13 patients (86.67%), conversely the result was declared bad in 2 patients or 13.33%. During the follow-up period, postoperatively, we had lost sight of 6 patients. Conclusion: Pyeloplasty according to Küss-Anderson-Hynes in addition to its excellent results reported by the literature was the only therapeutic alternative performed during this study. However, its indications are considerably reduced with the advancement of laparoscopy.

慢性化脓性中耳炎常见病原菌的耐药性

慢性化脓性中耳炎(chronic suppurative otitis media,CSOM)是耳鼻咽喉科常见病,选择敏感的抗生素是主要治疗方法之一,对常见病原菌耐药性分析在临床治疗CSOM有重要意义。本文对168例CSOM的脓性分泌物进行培养并对其耐药性进行分析。

Urgent endoscopic ultrasound-guided choledochoduodenostomy for acute obstructive suppurative cholangitis-induced sepsis

Acute obstructive suppurative cholangitis(AOSC) due to biliary lithiasis is a life-threatening condition that requires urgent biliary decompression. Although endoscopic retrograde cholangiopancreatography(ERCP) with stent placement is the current gold standard for biliary decompression, it can sometimes be difficult because of failed biliary cannulation. In this retrospective case series, we describe three cases of successful biliary drainage with recovery from septic shock after urgent endoscopic ultrasound-guided choledochoduodenostomy(EUS-CDS) was performed for AOSC due to biliary lithiasis. In all three cases, technical success in inserting the stents was achieved and the patients completely recovered from AOSC with sepsis in a few days after EUS-CDS. There were no procedure-related complications. When initial ERCP fails, EUS-CDS can be an effective life-saving endoscopic biliary decompression procedure that shortens the procedure time and prevents post-ERCP pancreatitis, particularly in patients with AOSC-induced sepsis.

Risk factors and incidence of acute pyogenic cholangitis

BACKGROUND: Acute cholangitis varies from mild to severe form. Acute suppurative cholangitis (ASC), the severe form of acute cholangitis, is a fatal disease and requires urgent biliary decompression. Which patients are at a high risk of ASC and need emergency drainage is still unclear. The present study aimed to identify the factors for determining early-stage ASC and distinguishing ASC from acute cholangitis. METHODS: We analyzed 359 consecutive patients with acute cholangitis who had been admitted to the First Affiliated Hospital, Zhejiang University School of Medicine from January 2004 to May 2011. Emergency endoscopic retrograde cholangiopancreatography (ERCP) was carried out in all patients to decompress or clear the stones by experienced endoscopists Clinical and therapeutic data were collected, and univariate and multivariate analyses were performed to identify the potential risk factors of ASC. RESULTS: Of the 359 patients, 1 was excluded because of failure of ERCP drainage. Of the remaining 358 patients with an average age of 62.7 years (range 17-90), 162 were diagnosed with ASC, and 196 with non-ASC. ENBD catheters were placed in 343 patients (95.8%), of whom 182 patients had stones removed at the same time, and plastic stent was placed in 25 patients (7.0%) Clinical conditions were improved quickly after emergency biliary drainage in all patients. Complications were identified in 11 patients (3.1%): mild pancreatitis occurred in 8 patients and hemorrhage in 3 patients. There was no mortality. Univariate analysis showed that several variables were associated with ASC: age, fever, decreased urine output, hypotension, tachycardia abnormal white blood cell count (WBC), low platelet, high C reactive protein (CRP), and duration of the disease. Multivariateanalysis revealed that advanced age, hypotension, abnormal WBC, high CRP, and duration of the disease were independent risk factors for ASC. CONCLUSIONS: This study demonstrates that advanced age, hypotension, abnormal WBC, high CRP, and long duration of antibiotic therapy are significantly associated with ASC. We recommend decompression by ERCP should be carried out in patients as early as possible.

Gastric subepithelial lesion complicated with abscess: Case report and literature review

Gastric abscess is a localized pyogenic inflammation of the gastric wall, which is a rare form of suppurative gastritis. The rarity of gastric abscess may be associated with the difficulty of early diagnosis and high mortality as a result. In general, subepithelial lesions (SELs) of the stomach are incidentally detected during the course of upper endoscopy without specific clinical symptoms and signs. However, some gastric SELs present rarely as a form of hemorrhage, obstruction, perforation, and abscess. Here we report a 45-year-old man with gastric SEL presenting as a gastric abscess, which was diagnosed as an ectopic pancreas of the stomach, along with a review of the literature. Although gastric SEL presenting as an abscess is known as a serious and life-threatening lesion, the patient made a complete recovery through surgical resection as well as medical treatment.