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Application of microfluidic technology based on surface-enhanced Raman scattering in cancer biomarker detection:A review
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作者 Changhong Nie Ibrahim Shaw Chuanpin Chen 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2023年第12期1429-1451,共23页
With the continuous discovery and research of predictive cancer-related biomarkers,liquid biopsy shows great potential in cancer diagnosis.Surface-enhanced Raman scattering(SERS)and microfluidic technology have receiv... With the continuous discovery and research of predictive cancer-related biomarkers,liquid biopsy shows great potential in cancer diagnosis.Surface-enhanced Raman scattering(SERS)and microfluidic technology have received much attention among the various cancer biomarker detection methods.The former has ultrahigh detection sensitivity and can provide a unique fingerprint.In contrast,the latter has the characteristics of miniaturization and integration,which can realize accurate control of the detection samples and high-throughput detection through design.Both have the potential for point-of-care testing(POCT),and their combination(lab-on-a-chip SERS(LoC-SERS))shows good compatibility.In this paper,the basic situation of circulating proteins,circulating tumor cells,exosomes,circulating tumor DNA(ctDNA),and microRNA(miRNA)in the diagnosis of various cancers is reviewed,and the detection research of these biomarkers by the LoC-SERS platform in recent years is described in detail.At the same time,the challenges and future development of the platform are discussed at the end of the review.Summarizing the current technology is expected to provide a reference for scholars engaged in related work and interested in this field. 展开更多
关键词 Cancer biomarkers Microfluidic technology surface-enhanced Raman scattering
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Label-free breast cancer detection and classification by convolutional neural network-based on exosomes surface-enhanced raman scattering
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作者 Xiao Ma Honglian Xiong +7 位作者 Jinhao Guo Zhiming Liu Yaru Han Mingdi Liu Yanxian Guo Mingyi Wang Huiqing Zhong Zhouyi Guo 《Journal of Innovative Optical Health Sciences》 SCIE EI CAS CSCD 2023年第2期3-15,共13页
Because the breast cancer is an important factor that threatens women's lives and health,early diagnosis is helpful for disease screening and a good prognosis.Exosomes are nanovesicles,secreted from cells and othe... Because the breast cancer is an important factor that threatens women's lives and health,early diagnosis is helpful for disease screening and a good prognosis.Exosomes are nanovesicles,secreted from cells and other body fluids,which can reflect the genetic and phenotypic status of parental cells.Compared with other methods for early diagnosis of cancer(such as circulating tumor cells(CTCs)and circulating tumor DNA),exosomes have a richer number and stronger biological stability,and have great potential in early diagnosis.Thus,it has been proposed as promising biomarkers for diagnosis of early-stage cancer.However,distinguishing different exosomes remain is a major biomedical challenge.In this paper,we used predictive Convolutional Neural model to detect and analyze exosomes of normal and cancer cells with surface-enhanced Raman scattering(SERS).As a result,it can be seen from the SERS spectra that the exosomes of MCF-7,MDA-MB-231 and MCF-10A cells have similar peaks(939,1145 and 1380 cm^(-1)).Based on this dataset,the predictive model can achieve 95%accuracy.Compared with principal component analysis(PCA),the trained CNN can classify exosomes from different breast cancer cells with a superior performance.The results indicate that using the sensitivity of Raman detection and exosomes stable presence in the incubation period of cancer cells,SERS detection combined with CNN screening may be used for the early diagnosis of breast cancer in the future. 展开更多
关键词 EXOSOMES surface-enhanced Raman scattering(SERS) breast cancer convolutional neural model LABEL-FREE
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Surface-enhanced Raman Scattering of Aflatoxin B1 on Silver by DFT Method
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作者 高思敏 王红艳 林月霞 《Chinese Journal of Chemical Physics》 SCIE CAS CSCD 2014年第2期131-136,I0003,共7页
The structure, electrostatic properties, and Raman spectra of aflatoxin B1 (AFB1) and AFB1-Ag complex are studied by density functional theory with B3LYP/6- 311G(d,p)/Lan12dz basis set. The results show that the s... The structure, electrostatic properties, and Raman spectra of aflatoxin B1 (AFB1) and AFB1-Ag complex are studied by density functional theory with B3LYP/6- 311G(d,p)/Lan12dz basis set. The results show that the surface-enhanced Raman scattering (SERS) and pre-resonance Raman spectra of AFB1-Ag complex strongly depend on the adsorption site and the excitation wavelength found to enhance 102-103 order compared to of the incident light. The SERS factors are normal Raman spectrum of AFB1 molecule due to the larger static polarizabilities of the AFB1-Ag complex, which directly results in the stronger chemical enhancement in SERS spectra. The pre-resonance Raman spectra of AFB1-Ag complex are explored at 266, 482, 785, and 1064 nm incident light wavelength, in which the enhancement factors are about 10^2-10^4, mainly caused by the charge-transfer excitation resonance. The vibrational modes are analyzed to explain the relationship between the vibrational direction and the enhanced Raman intensities. 展开更多
关键词 Aflatoxin B1 surface-enhanced Raman scattering spectrum Pre-resonanceRaman spectra Density functional theory
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Chemical Enhancement on Surface-Enhanced Resonance Raman Scattering of Au3-1,4-BenzenedithioI-Au3 Junction
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作者 赵秀明 田小锐 +2 位作者 刘莎莎 李源作 陈茂笃 《Chinese Journal of Chemical Physics》 SCIE CAS CSCD 2011年第6期665-671,I0003,共8页
Surface-enhanced Raman scattering (SERS) and surface-enhanced resonance Raman scattering (SERRS) spectra of the 1,4-benzenedithiol molecule in the junction of two Au3 clusters have been calculated using density fu... Surface-enhanced Raman scattering (SERS) and surface-enhanced resonance Raman scattering (SERRS) spectra of the 1,4-benzenedithiol molecule in the junction of two Au3 clusters have been calculated using density functional theory (DFT) and time-dependent DFT method. In order to investigate the contribution of charge transfer (CT) enhancement, the wavelengths of incident light are chosen to be at resonance with four representative excited states, which correspond to CT in four different forms. Compared with SERS spectrum, SERRS spectra are enhanced enormously with distinct enhancement factors, which can be attributed to CT resonance in different forms. 展开更多
关键词 surface-enhanced Raman scattering 1 4-Benzenedithiol molecule Surfaceenhanced resonance Raman scattering Charge transfer
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Quantitative and sensitive detection of prohibited fish drugs by surface-enhanced Raman scattering 被引量:3
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作者 林世超 张鑫 +5 位作者 赵伟臣 陈朝阳 杜攀 赵永梅 吴正龙 许海军 《Chinese Physics B》 SCIE EI CAS CSCD 2018年第2期640-644,共5页
Rapid and simple detections of two kinds of prohibited fish drugs, crystal violet (CV) and malachite green (MG), were accomplished by surface-enhanced Raman scattering (SERS). Based on the optimized Au/cicada wi... Rapid and simple detections of two kinds of prohibited fish drugs, crystal violet (CV) and malachite green (MG), were accomplished by surface-enhanced Raman scattering (SERS). Based on the optimized Au/cicada wing, the detectable concentration of CV/MG can reach 10-7 M, and the linear logarithmic quantitative relationship curves between log/and logC allows for the determination of the unknown concentration of CV/MG solution. The detection of these two analytes in real environment was also achieved, demonstrating the application potential of SERS in the fast screening of the prohibited fish drugs, which is of great benefit for food safety and environmental monitoring. 展开更多
关键词 surface-enhanced Raman scattering crystal violet malachite green quantitative detection
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Surface-enhanced resonance Raman scattering spectroscopy of single R6G molecules 被引量:2
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作者 周增会 刘力 +1 位作者 王桂英 徐至展 《Chinese Physics B》 SCIE EI CAS CSCD 2006年第1期126-131,共6页
Surface-enhanced resonance Raman scattering (SERRS) of Rhodamine 6G (R6G) adsorbed on colloidal silver clusters has been studied. Based on the great enhancement of the Raman signal and the quench of the fluorescen... Surface-enhanced resonance Raman scattering (SERRS) of Rhodamine 6G (R6G) adsorbed on colloidal silver clusters has been studied. Based on the great enhancement of the Raman signal and the quench of the fluorescence, the SERRS spectra of R6G were recorded for the samples of dye colloidal solution with different concentrations. Spectral inhomogeneity behaviours from single molecules in the dried sample films were observed with complementary evidences, such as spectral polarization, spectral diffusion, intensity fluctuation of vibrational lines and even "breathing" of the molecules. Sequential spectra observed from a liquid sample with an average of 0.3 dye molecules in the probed volume exhibited the expected Poisson distribution for actually measuring 0, 1 or 2 molecules. Difference between the SERRS spectra of R6G excited by linearly and circularly polarized light were experimentally measured. 展开更多
关键词 single-molecule spectroscopy surface-enhanced resonance Raman scattering spectral polarization Poisson distribution
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Raman and Surface-enhanced Raman Scattering of Chlorophenols 被引量:2
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作者 SONG Wei SHANG Xiao-hong +2 位作者 LU Yong LIU Bing-bing WANG Xu 《Chemical Research in Chinese Universities》 SCIE CAS CSCD 2011年第5期854-856,共3页
Raman spectrum is a powerful analytical tool for determining the chemical information of compounds. In this study, we obtained analytical results of chlorophenols(CPs) molecules including 4-chlorophenol(4-CP), 2,6... Raman spectrum is a powerful analytical tool for determining the chemical information of compounds. In this study, we obtained analytical results of chlorophenols(CPs) molecules including 4-chlorophenol(4-CP), 2,6-dich- lorophenol(2,6-DCP) and 2,4,6-trichlorophenol(2,4,6-TCP) on the surface of Ag dendrites by surface-enhanced Raman scattering(SERS) spectra. SEM images indicate that the SERS substrate of Ag dendrites is composed of a large number of polygonal nanocrystallites, which self-assembled into a 3D hierarchical structure. It was found that there were distinct differences for those three molecules from Raman and SERS spectra. This indicates that SERS could be a new tool of detection technique regarding trace amounts of CPs. 展开更多
关键词 surface-enhanced Raman scattering(SERS) Ag dendrite Chloropheno[
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Controllable Silver Plating on Silica for Surface-enhanced Raman Scattering 被引量:2
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作者 CHEN Lei HAN Xiao-xia +6 位作者 YANG Jing-xiu ZHOU Ji LU Zhi-cheng SONG Wei ZHAO Bing XU Wei-qing OZAKI Yukihiro 《Chemical Research in Chinese Universities》 SCIE CAS CSCD 2011年第4期683-687,共5页
We proposed a facile and rapid method for preparing silica-silver core-shell(SSCS) substrates to use Ag electroless plating on SiO2@Au-seed particles.UV-Vis-NIR absorption spectrometer and SEM were employed to monit... We proposed a facile and rapid method for preparing silica-silver core-shell(SSCS) substrates to use Ag electroless plating on SiO2@Au-seed particles.UV-Vis-NIR absorption spectrometer and SEM were employed to monitor the reaction process of the formation of Ag on the surfaces of silica beads,and the optical resonance of the substrate could shift from visible to NIR region.It has been found that surface-enhanced Raman scattering(SERS) enhancement changes with the electroless plating time and the SSCS substrate with the plating time of 90 s(90SSCS) shows the strongest SERS response under the laser excitation at 514.5 nm.Signals collected over multiple spots and substrate of rhodamine 6G(R6G) resulted in a relative standard deviation(RSD) of 9.75%.The calculated enhancement factor(EF) was approximately 105 "106.SSCS substrate exhibits high SERS performance,which is due to electromagnetic SERS enhancement with additional localization field within closely packed Ag nanoparticles decorated on the SiO2 nanoparticles.And this substrate presents tunable and broad localized surface plasmon resonance(LSPR),so this method may open a new way for SERS studies with other laser excitation. 展开更多
关键词 SiO2 nanoparticle Au seed Ag nanoparticle surface-enhanced Raman scattering(SERS)
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Molybdenum Nanoscrews:A Novel Non-coinage-Metal Substrate for Surface-Enhanced Raman Scattering 被引量:2
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作者 Di An Yan Shen +6 位作者 Jinxiu Wen Zebo Zheng Jun Chen Juncong She Huanjun Chen Shaozhi Deng Ningsheng Xu 《Nano-Micro Letters》 SCIE EI CAS 2017年第1期55-64,共10页
For the first time, Mo nanoscrew was cultivated as a novel non-coinage-metal substrate for surface-enhanced Raman scattering(SERS). It was found that the nanoscrew is composed of many small screw threads stacking alon... For the first time, Mo nanoscrew was cultivated as a novel non-coinage-metal substrate for surface-enhanced Raman scattering(SERS). It was found that the nanoscrew is composed of many small screw threads stacking along its length direction with small separations. Under external light excitation, strong electromagnetic coupling was initiated within the gaps, and many hot-spots formed on the surface of the nanoscrew, which was confirmed by high-resolution scanning near-field optical microscope measurements and numerical simulations using finite element method. These hotspots are responsible for the observed SERS activity of the nanoscrews. Raman mapping characterizations further revealed the excellent reproducibility of the SERS activity. Our findings may pave the way for design of low-cost and stable SERS substrates. 展开更多
关键词 surface-enhanced Raman scattering(SERS) Molybdenum nanoscrews Quasi-one-dimensional nanostructures Electric field enhancements
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Surface-enhanced Raman scattering on nanodiamond-derived carbon onions 被引量:1
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作者 Ying Song Zongwei Xu +3 位作者 Andreas Rosenkranz Mathias Rommel Changkun Shi Fengzhou Fang 《Nanotechnology and Precision Engineering》 EI CAS CSCD 2019年第1期35-39,共5页
Annealing nanodiamonds(ND) at high temperatures up to 1700 ℃ is a common method to synthesize carbon onions. The transformation from NDs to carbon onions is particularly interesting because of carbon onions' pote... Annealing nanodiamonds(ND) at high temperatures up to 1700 ℃ is a common method to synthesize carbon onions. The transformation from NDs to carbon onions is particularly interesting because of carbon onions' potential in the field of tribology and their application in ultra-charge/discharge devices. In this paper, a novel surface-enhanced Raman scattering technique that involves coating the sample with nanoscopic gold particles is proposed to characterize the NDs after different annealing treatments. Conventional Raman and surfaceenhanced Raman spectra were obtained, and the changes of peak parameters as the function of annealing temperature were evaluated. It was found that the widths of the D and the G peaks decreased with increasing annealing temperature, reflecting an improved order in the sp^2-hybridized carbon during the transformation from NDs to carbon onions. After annealing at 1700 ℃, the sp^2?carbon was highly ordered, indicating desirable electrical conductivity and lubricity. With increasing annealing temperature, the D peak showed a blue shift of almost30 cm^(-1), while the G peak merely shifted by 5 cm^(-1). For annealing temperatures above 1100 ℃, an increase of intensity ratio ID/IGwas observed. Compared to the uncoated area, red shifts of 0.5-2 cm^(-1) and of 5-9 cm^(-1) for the G and D peaks, respectively, were detected for the gold-coated area, which was due to the coupling of the plasmons and the phonons of the samples. 展开更多
关键词 NANODIAMONDS CARBON onions surface-enhanced RAMAN scattering LOPC mode
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SURFACE-ENHANCED RAMAN SCATTERING:PRINCIPLES,NANOSTRUCTURES,FABRICATIONS,AND BIOMEDICAL APPLICATIONS 被引量:1
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作者 CLEMENT YUEN WEI ZHENG ZHIWEI HUANG 《Journal of Innovative Optical Health Sciences》 SCIE EI CAS 2008年第2期267-284,共18页
This article gives an overview of the development and applications of the surfaceenhanced Raman scattering(SERS)techniques in biomedicine.We first introduce the fundamental principles of the SERS mechanisms.We also pr... This article gives an overview of the development and applications of the surfaceenhanced Raman scattering(SERS)techniques in biomedicine.We first introduce the fundamental principles of the SERS mechanisms.We also present the different fabrication techniques of SERS nanostructures and substrates.Finally,the importance and potential roles of the SERS nanostructures and substrates in biomedical applications are summarized. 展开更多
关键词 surface-enhanced Raman scattering surface plasmon NANOTECHNOLOGY
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Preparation of nano-structured Ag solid materials and application to surface-enhanced Raman scattering 被引量:1
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作者 易早 陈艳 +5 位作者 陈善俊 谭秀兰 牛高 罗江山 唐永建 易有根 《Journal of Central South University》 SCIE EI CAS 2011年第6期1877-1882,共6页
Silver nano-particles with average diameter of about 60 nm were compacted in a high-strength mold under different pressures at 523 K to produce nano-structured Ag solid materials. The structure and characteristic of t... Silver nano-particles with average diameter of about 60 nm were compacted in a high-strength mold under different pressures at 523 K to produce nano-structured Ag solid materials. The structure and characteristic of the nano-structured Ag solid materials (NSS-Ag) were studied using X-ray diffraction (XRD), scanning electron microscope (SEM) and Raman spectrometer. The NSS-Ag could be used as highly efficient surface-enhanced Raman scattering (SERS) active substrates. The common probe molecules Rhodamine 6G (R6G, 1×10-10 mol/L) were used to test the SERS activity on these substrates at very low concentrations. It is found that the SERS enhancement ability is dependent on the density of NSS-Ag. When the relative density of NSS-Ag is 83.87%, the materials reveal great SERS signal. 展开更多
关键词 nano-structured Ag solid material flow-levitation method relative density Rhodamine 6G surface-enhanced Raman scattering
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Ultraviolet-visible and Surface-enhanced Raman Scattering Spectroscopy Studies on Ruthenium Phthalocyanine Monolayer Films Formed on Terephthalonitrile-modified Silver Substrates
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作者 LIXiao-ling XUWei-qing +4 位作者 JIAHui-ying WANGXu ZHAOBing LIBo-fu OZAKIYukihiro 《Chemical Research in Chinese Universities》 SCIE CAS CSCD 2004年第3期345-349,共5页
A self\|assembled monolayer film(SAM) of ruthenium phthalocyanine(RuPc) fabricated on a silver substrate premodified with an SAM of terephthalonitrile(TPN) was studied by means of surface\|enhanced Raman scattering(SE... A self\|assembled monolayer film(SAM) of ruthenium phthalocyanine(RuPc) fabricated on a silver substrate premodified with an SAM of terephthalonitrile(TPN) was studied by means of surface\|enhanced Raman scattering(SERS) and ultraviolet\|visible(UV\|Vis) spectroscopies. TPN was used as a ligand to link RuPc since it can not only modify the silver substrate but also deliver the nitrile groups protruding from the silver surface. Therefore,we can explore the relationship between the structure and the orientation of RuPc and the TPN\|modified substrate. The UV\|Vis spectra indicate a strong interaction between RuPc and TPN in the composite film. The result is further confirmed by the SERS spectra of RuPc\|TPN SAM,in which the vibrational bands arising from both the RuPc and TPN moieties appear clearly,indicating that the RuPc is successfully assembled on the TPN film. 展开更多
关键词 SELF-ASSEMBLY PHTHALOCYANINE surface-enhanced Raman scattering
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An effective surface-enhanced Raman scattering template based on gold nanoparticle/silicon nanowire arrays
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作者 王明利 张常兴 +2 位作者 吴正龙 井西利 许海军 《Chinese Physics B》 SCIE EI CAS CSCD 2014年第6期547-553,共7页
A large-scale Si nanowire array (SiNWA) is fabricated with gold (Au) nanoparticles by simple metal-assisted chemical etching and metal reduction processes. The three-dimensional nanostructured Au/SiNWA is evaluate... A large-scale Si nanowire array (SiNWA) is fabricated with gold (Au) nanoparticles by simple metal-assisted chemical etching and metal reduction processes. The three-dimensional nanostructured Au/SiNWA is evaluated as an active substrate for surface-enhanced Raman scattering (SERS). The results show that the detection limit for rhodamine 6G is as low as 10-7 M, and the Raman enhancement factor is as large as 105 with a relative standard deviation of less than 25%. After the calibration of the Raman peak intensifies of rhodamine 6G and thiram, organic molecules could be quantitatively detected. These results indicate that Au/SiNWA is a promising SERS-active substrate for the detection of biomolecules present in low concentrations. Our findings are an important advance in SERS substrates to allow fast and quantitative detection of trace organic contaminants. 展开更多
关键词 surface-enhanced Raman scattering nanowire array quantitative detection
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Selective synthesis of three-dimensional ZnO@Ag/SiO2@Ag nanorod arrays as surface-enhanced Raman scattering substrates with tunable interior dielectric layer
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作者 Jia-Jia Mu Chang-Yi He +1 位作者 Wei-Jie Sun Yue Guan 《Chinese Physics B》 SCIE EI CAS CSCD 2019年第12期165-169,共5页
We describe the synthesis of three-dimensional(3D) multilayer ZnO@Ag/SiO2@Ag nanorod arrays by the physico–chemical method. The surface-enhanced Raman scattering(SERS) performance of the 3D multilayer Zn O@Ag/SiO2@Ag... We describe the synthesis of three-dimensional(3D) multilayer ZnO@Ag/SiO2@Ag nanorod arrays by the physico–chemical method. The surface-enhanced Raman scattering(SERS) performance of the 3D multilayer Zn O@Ag/SiO2@Ag nanorod arrays is studied by varying the thickness of dielectric layer SiO2 and outer-layer noble Ag. The 3D Zn O@Ag/SiO2@Ag nanorod arrays create a huge number of SERS "hot spots" that mainly contribute to the high SERS sensitivity. The great enhancement of SERS results from the electron transfer between ZnO and Ag and different electromagnetic enhancements of Ag nanoparticles(NPs) with different thicknesses. Through the finite-difference time-domain(FDTD) theoretical simulation, the enhancement of SERS signal can be ascribed to a strong electric field enhancement produced in the 3D framework. The simplicity and generality of our method offer great advantages for further understanding the SERS mechanism induced by the surface plasmon resonance(SPR) effect. 展开更多
关键词 ZNO multilayer composite structure surface-enhanced Raman scattering(SERS) dielectric layer electromagnetic field enhancement
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Comparison of Surface-enhanced Raman Scattering Spectra of Two Kinds of Silver Nanoplate Films
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作者 TAO Jin-long TANG Bin +2 位作者 XU Shu-ping PAN Ling-yun XU Wei-qing 《Chemical Research in Chinese Universities》 SCIE CAS CSCD 2012年第3期488-492,共5页
Surface-enhanced Raman scattering(SERS) spectra of different silver nanoplate selt-assembled tllmS at different excitation wavelengths were fairly compared. Shape conversion from silver nanoprisms to nanodisks on sl... Surface-enhanced Raman scattering(SERS) spectra of different silver nanoplate selt-assembled tllmS at different excitation wavelengths were fairly compared. Shape conversion from silver nanoprisms to nanodisks on slides was in situ carried out. The SERS spectra of 4-mercaptopyridine(4-MPY) on these anisotropic silver nanopar- ticle self-assembled films present that strong enhancement appeared when the excitation line and the surface plasmon resonance(SPR) band of silver substrate overlapped. In this model, the influence of the crystal planes of silver na- noplates on SERS enhancement could be ignored because the basal planes were nearly unchanged in two kinds of silver nanoplate self-assembled films. 展开更多
关键词 surface-enhanced Raman scattering(SERS) Surface plasmon resonance(SPR) Shape-dependant Silvernanoprism Silver nanodisk
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Surface-enhanced Raman scattering sensor based on fused biconical taper zone of optical fiber
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作者 陈振宜 柏华 +3 位作者 张琨 陈娜 庞拂飞 王廷云 《Journal of Shanghai University(English Edition)》 CAS 2011年第1期26-30,共5页
In this paper, a novel surface-enhanced Raman scattering (SERS) sensor combined with fused biconical taper fiber (FBTF) and film coated with silver sols is proposed. This structure is designed to significantly inc... In this paper, a novel surface-enhanced Raman scattering (SERS) sensor combined with fused biconical taper fiber (FBTF) and film coated with silver sols is proposed. This structure is designed to significantly increase the SERS active surface when the length of the taper is increased and the radius is reduced, since the penetration depth is inversely proportional to the taper radius and proportional to the taper length according to the fiber-optic evanescent-wave theory. Based on the SERS sensing principle, the feasibility of FBTF sensor is analyzed in this paper. As a result, the Raman spectrum of R6G is obtained from the fused biconical taper zone surface coating with the silver sols in our experiments. The detected concentration is up to 10-7mol/L. 展开更多
关键词 surface-enhanced Raman scattering (SERS) fused biconical taper fiber (FBTF) evanescent wave penetration depth SERS-active surface
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A distinction of gliomas at cellular and tissue level by surface-enhanced Raman scattering spectroscopy
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作者 Chengde Wang Liping Huang +3 位作者 Shanshan Wang Lihao Wu Yi Wang Jun Dong 《Chinese Chemical Letters》 SCIE CAS CSCD 2024年第5期423-427,共5页
Glioblastoma multiforme(GBM)is the most common malignant primary brain tumor in adults.The precise identification and distinction of GBM heterogeneity from surrounding brain parenchyma at the cellular level and even a... Glioblastoma multiforme(GBM)is the most common malignant primary brain tumor in adults.The precise identification and distinction of GBM heterogeneity from surrounding brain parenchyma at the cellular level and even at the tissue level are important for GBM therapy.In this study,GBM cells are distinguished from normal astrocytes and non-central nervous system(CNS)tumor cells by surface-enhanced Raman scattering(SERS)based on gold nanoshell(SiO_(2)@Au)particles and support vector machine(SVM)algorithm.In addition,the gold nanoisland(AuNI)SERS substrates are further developed and explored for accurate detection of GBM at the tissue level.The distinction between glioma and trauma tissues,identification of different tumor grades,and IDH mutation are realized with the assistance of orthogonal partial least squares discriminant analysis(OPLS-DA)in a rapid,non-invasive,and convenient method.The results show that the developed SERS-based analytical method has the potential for practical application for the detection of GBM at the single-cell and tissue levels and even for real-time intraoperative diagnosis. 展开更多
关键词 Glioblastoma multiforme(GBM) surface-enhanced Raman scattering(SERS) NANOPARTICLE Nanoisland Machine learning
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Recent advances in crystal phase induced surface-enhanced Raman scattering
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作者 Ce Liang Qiuhui Sun +2 位作者 Adel Al-Salihy Mengxin Chen Ping Xu 《Chinese Chemical Letters》 SCIE CAS CSCD 2024年第9期111-118,共8页
Surface-enhanced Raman scattering(SERS)spectroscopy has emerged as a powerful analytical technique for detecting and identifying trace chemical and biological molecules.In this review,we present an indepth discussion ... Surface-enhanced Raman scattering(SERS)spectroscopy has emerged as a powerful analytical technique for detecting and identifying trace chemical and biological molecules.In this review,we present an indepth discussion of recent advances in the field of crystal phase manipulation to achieve exceptional SERS performance.Focusing on transition metal dichalcogenides,(hydr)oxides,and carbides as exemplary materials,we illustrate the pivotal role of crystal phase regulation in enhancing SERS signals.By exploring the correlation between crystal phases and SERS responses,we uncover the underlying principles behind these strategies,thereby shedding light on their potential for future SERS applications.By addressing the current challenges and limitations,we also propose the prospects of the crystal phase strategy to facilitate the development of cutting-edge SERS-based sensing technologies. 展开更多
关键词 surface-enhanced Raman scattering Crystal phase manipulation Transition metal dichalcogenides Transition metal oxides Transition metal carbides
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Advancing Energy Systems with In-Situ and Operando Surface-Enhanced Raman Scattering Spectroscopy
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作者 Haoming Bao Shi Xuan Leong +6 位作者 Jaslyn Ru Ting Chen Zhenhai Shi Suli Chen Yan Lv Tianxi Liu In Yee Phang Xing Yi Ling 《CCS Chemistry》 CSCD 2024年第6期1403-1421,共19页
Surface-enhanced Raman scattering spectroscopy(SERS)has emerged as a powerful analytical technique to enable nanoscale investigations of energy systems.This mini-review focuses on the applications of in-situ and opera... Surface-enhanced Raman scattering spectroscopy(SERS)has emerged as a powerful analytical technique to enable nanoscale investigations of energy systems.This mini-review focuses on the applications of in-situ and operando SERS in energy-related research,highlighting its unique capabilities and significant contributions to understanding energy storage and conversion processes.We first introduce the fundamental principles of SERS,key SERS-derived techniques,and commonly employed platforms.Subsequently,we delve into the diverse applications of in-situ and operando SERS across various energy systems,encompassing photocatalytic and electrocatalytic systems,fuel cells,solar cells,and batteries.Finally,we conclude with our perspective on the current challenges and prospects in this area.We hope thismini-review serves as an essential overview to guide the design and implementation of in-situ and operando SERS studies of energy systems. 展开更多
关键词 surface-enhanced Raman scattering spectroscopy IN-SITU OPERANDO energy systems PHOTOCATALYSIS ELECTROCATALYSIS fuel cells solar cells BATTERIES
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