Timing of surgical operation for patients with intra-abdominal infection:A systematic review and meta-analysis

BACKGROUND Intra-abdominal infections(IAIs)is the most common type of surgical infection,with high associated morbidity and mortality rates.In recent years,due to the use of antibiotics,various drug-resistant bacteria have emerged,making the treatment of abdominal infections more challenging.Early surgical exploration can reduce the mortality of patients with abdominal infection and the occurrence of complications.However,available evidence regarding the optimal timing of IAI surgery is still weak.In study,we compared the effects of operation time on patients with abdominal cavity infection and tried to confirm the best timing of surgery.AIM To assess the efficacy of early vs delayed surgical exploration in the treatment of IAI,in terms of overall mortality.METHODS A systematic literature search was performed using PubMed,EMBASE,Cochrane Central Register of Controlled Trials,Ovid,and ScienceDirect.The systematic review was conducted using the Preferred Reporting Items for Systematic Reviews and Meta-analyses method.Based on the timing of the surgical operation,we divided the literature into two groups:Early surgery and delayed surgery.For the early and delayed surgery groups,the intervention was performed with and after 12 h of the initial surgical intervention,respectively.The main outcome measure was the mortality rate.The literature search was performed from May 5 to 20,2021.We also searched the World Health Organization International Clinical Trials Registry Platform search portal and ClinicalTrials.gov on May 20,2021,for ongoing trials.This study was registered with the International Prospective Register of Systematic Reviews.RESULTS We identified nine eligible trial comparisons.Early surgical exploration of patients with IAIs(performed within 12 h)has significantly reduced the mortality and complications of patients,improved the survival rate,and shortened the hospital stay.CONCLUSION Early surgical exploration within 12 h may be more effective for the treatment of IAIs relative to a delayed operation.

Effect of navigation endoscopy combined with threedimensional printing technology in the treatment of orbital blowout fractures

●AIM:To explore the combined application of surgical navigation nasal endoscopy(NNE)and three-dimensional printing technology(3DPT)for the adjunctive treatment of orbital blowout fractures(OBF).●METHODS:Retrospective analysis was conducted on the data of patients with OBF who underwent surgical treatment at the Affiliated Eye Hospital of Nanchang University between July 2012 and November 2022.The control group consisted of patients who received traditional surgical treatment(n=43),while the new surgical group(n=52)consisted of patients who received NNE with 3DPT.The difference in therapeutic effects between the two groups was evaluated by comparing the duration of the operation,best corrected visual acuity(BCVA),enophthalmos difference,recovery rate of eye movement disorder,recovery rate of diplopia,and incidence of postoperative complications.●RESULTS:The study included 95 cases(95 eyes),with 63 men and 32 women.The patients’age ranged from 5 to 67y(35.21±15.75y).The new surgical group and the control group exhibited no statistically significant differences in the duration of the operation,BCVA and enophthalmos difference.The recovery rates of diplopia in the new surgical group were significantly higher than those in the control group at 1mo[OR=0.03,95%CI(0.01–0.15),P<0.0000]and 3mo[OR=0.11,95%CI(0.03–0.36),P<0.0000]postoperation.Additionally,the recovery rates of eye movement disorders at 1 and 3mo after surgery were OR=0.08,95%CI(0.03–0.24),P<0.0000;and OR=0.01,95%CI(0.00–0.18),P<0.0000.The incidence of postoperative complications was lower in the new surgical group compared to the control group[OR=4.86,95%CI(0.95–24.78),P<0.05].●CONCLUSION:The combination of NNE and 3DPT can shorten the recovery time of diplopia and eye movement disorder in patients with OBF.

Hepatolithiasis and surgical operation

Reply to the Editor: With the development of the treatment hepatolithiasis, I, as the responsible author of the article, has discussed the merits of the new operation dealing with regional hepatolithiasis-subcutaneous tunnel and hepatocholangioplasty with the use of the gallbladder (STHG).

The Use of 3D laparoscopy in Surgical Operation

Purpose： studying and analyzing the application effect of three dimensional （3D） laparoscopy m surgical operation. Method： We select 126 patients who were diagnosed celiac disease in our hospital between May 2015 and April 2016 as our research subjects. All of these patients have indications for laparoscopic surgery, and we divide them into two groups randomly （observation and control group）. While the observation group is treated by 3D laparoscopic operation system, and the control group is treated by 2D laparoscopic system. During the treatment ,we observe the operation time, intra-operative bleeding and hospitalization time between the two different methods. Result： During the operation, the operation time of observation is （135.5±23.84） minutes and intra-operative bleeding time is （130.2±20. 11） milliliters, which both them are significantly lower than control group （163.8±25.22）min, （146.3±27.42）ml. This difference is statistically significant （P 〈0.05）. On the other hand, there is no obvious difference between observation and conlrol about indwelling catheter time, postoperative hospitalization time and postoperative exhaust time. For the observation, the datum were （2.3±0.31） d, （8.1±1. 32） d, （3.2±0.58） d and they were no statistical significance. Conclusion： Compared with traditional laparoscopic surgery, the image of 3D laparoscopic surgery is more clear and stereoscopic. What＇s more, operators can have a good command of it easily to shorten operation time, which avoid surgery vascular damage and reduce bleeding amounts to some extent. It is a good assistant for clinical use.

Safety and efficacy of wireless capsule endoscopy in patients with surgically altered upper gastrointestinal anatomy

Background:Wireless capsule endoscopy(WCE)is an effective,minimally invasive tool used for evaluation of the small intestine.To date,there are no studies evaluating the diagnostic yield of WCE in patients with surgically altered upper gastrointestinal anatomy.Aim:To evaluate the diagnostic yield,technical success and safety of WCE in patients with surgically altered upper gastrointestinal anatomy.Methods:Retrospective chart review of all patients with surgically altered upper GI anatomy who underwent WCE between 2006 and 2016 at the Medical University of South Carolina.Technical success,diagnostic yield,adverse events and therapeutic yield data was collected.Results:Thirty-one cases met inclusion criteria.Two were excluded as they did not undergo WCE due to failed patency capsule.The mean age was 58(69%female).The capsule was ingested in 18 cases and endoscopically placed in 11.The most common surgical anatomy was Roux-en-Y gastric bypass(n=13).Technical success,defined as the capsule reaching the cecum,was achieved in 89.7%of cases.The diagnostic yield was 44.8%,with the most common finding being angioectasia.No intra-or postprocedural adverse events were noted.Discussion:Capsule endoscopy in patients with surgically altered upper GI anatomy appears to show no elevated risk of adverse events and shows similar technical success and diagnostic yield as in patients with native anatomy.

Pediatric endoscopy across multiple clinical settings:Efficiency and adverse events

BACKGROUND Endoscopic procedures are becoming increasingly important for the diagnosis and treatment of gastrointestinal disorders during childhood,and have evolved from a more infrequent inpatient procedure in the operating room to a routine outpatient procedure conducted in multiple care settings.Demand for these procedures is rapidly increasing and thus there is a need to perform them in an efficient manner.However,there are little data comparing the efficiency of pediatric endoscopic procedures in diverse clinical environments.We hypothesized that there are significant differences in efficiency between settings.AIM To compare the efficiency and examine adverse effects of pediatric endoscopic procedures across three clinical settings.METHODS A retrospective chart review was conducted on 1623 cases of esophagogastroduodenoscopy(EGD)or combined EGD and colonoscopy performed between January 1,2014 and May 31,2018 by 6 experienced pediatric gastroenterologists in three different clinical settings,including a tertiary care hospital operating room,community hospital operating room,and free-standing pediatric ambulatory endoscopy center at a community hospital.The following strict guidelines were used to schedule patients at all three locations:age greater than 6 mo;American Society of Anesthesiologists class 1 or 2;normal craniofacial anatomy;no anticipated therapeutic intervention(e.g.,foreign body retrieval,stricture dilation);and,no planned or anticipated hospitalization post-procedure.Data on demographics,times,admission rates,and adverse events were collected.Endoscopist time(elapsed time from the endoscopist entering the operating room or endoscopy suite to the next patient entering)and patient time(elapsed time from patient registration to that patient exiting the operating room or endoscopy suite)were calculated to assess efficiency.RESULTS In total,58%of the cases were performed in the tertiary care operating room.The median age of patients was 12 years and the male-to-female ratio was nearly equal across all locations.Endoscopist time at the tertiary care operating room was 12 min longer compared to the community operating room(63.3±21.5 min vs 51.4±18.9 min,P<0.001)and 7 min longer compared to the endoscopy center(vs 56.6±19.3 min,P<0.001).Patient time at the tertiary care operating room was 11 min longer compared to the community operating room(133.2±39.9 min vs 122.3±39.5 min,P<0.001)and 9 min longer compared to the endoscopy center(vs 124.9±37.9 min;P<0.001).When comparing endoscopist and patient times for EGD and EGD/colonoscopies among the three locations,endoscopist,and patient times were again shorter in the community hospital and endoscopy center compared to the tertiary care operating room.Adverse events from procedures occurred in 0.1%(n=2)of cases performed in the tertiary care operating room,with 2.2%(n=35)of cases from all locations having required an unplanned admission after the endoscopy for management of a primary GI disorder.CONCLUSION Pediatric endoscopic procedures can be conducted more efficiently in select patients in a community operating room and endoscopy center compared to a tertiary care operating room.

Small bowel capsule endoscopy and treat-to-target in Crohn’s disease: A systematic review

BACKGROUND Crohn’s disease(CD)can affect the entire gastrointestinal tract.Proximal small bowel(SB)lesions are associated with a significant risk of stricturing disease and multiple abdominal surgeries.The assessment of SB in patients with CD is therefore necessary because it may have a significant impact on prognosis with potential therapeutic implications.Because of the weak correlation that exists between symptoms and endoscopic disease activity,the“treat-to-target”paradigm has been developed,and the associated treatment goal is to achieve and maintain deep remission,encompassing both clinical and endoscopic remission.Small bowel capsule endoscopy(SBCE)allows to visualize the mucosal surface of the entire SB.At that time,there is no recommendation regarding the use of SBCE during follow-up.AIM To investigate the impact of SBCE in a treat-to-target strategy in patients with CD.METHODS An electronic literature search was conducted in PubMed and Cochrane library using the following search terms:“capsule endoscopy”,in combination with“Crohn’s disease”and“treat-to-target”or synonyms.Two authors independently reviewed titles and abstracts identified by the search strategy after duplicates were removed.Following the initial screening of abstracts,all articles containing information about SBCE in the context of treat-to-target strategy in patients with CD were included.Full-text articles were retrieved,reference lists were screened manually to identify additional studies.RESULTS Forty-seven articles were included in this review.Two indexes are currently used to quantify disease activity using SBCE,and there is good correlation between them.SBCE was shown to be useful for disease reclassification in patients who are suspected of having or who are diagnosed with CD,with a significant incremental diagnostic yield compared to other diagnostic modalities.Nine studies also demonstrated that the mucosal healing can be evaluated by SBCE to monitor the effect of medical treatment in patients with CD.This review also demonstrated that SBCE can detect post-operative recurrence to a similar extent as ileocolonoscopy,and proximal SB lesions that are beyond the reach of the colonoscope in over half of the patients.CONCLUSION SBCE could be incorporated in the treat-to-target algorithm for patients with CD.Randomized controlled trials are required to confirm its usefulness and reliability in this indication.

Operating Room Nurses’ Role in Multidisciplinary Surgical Coordination for a Patient with a Large Abdominal Tumor and Multiple Pelvic Fractures

In this study,we have summarized the coordination of operating room nurses participating in the multidisciplinary team in diagnosing and treating a patient with a large abdominal tumor and multiple pelvic fractures.To perform surgical treatment on patients with various conditions,it is crucial to consider the patients from a holistic perspective.Thus,the existing medical model has shifted from a“disease-centered”approach focusing on single-disciplinary diagnosis and treatment,to a“patient-centered”approach that involves multiple disciplines in diagnosis and therapy.Operating room nurses,as crucial collaborators of surgeons,should make necessary adjustments to enhance their comprehension of patients,improving the overall quality of surgical coordination.

The Popularization and Application of Cold Storage Red Blood Cells or Whole Blood at -80 ℃ of the Rh(D) Negative Patients in Surgical Operation

Summary: The efficiency of cold storage red blood cells (CSRBC) or whole blood at -80 ℃ used in 27 Rh(D) negative patients during surgical operation was reported. The Rh(D) negative patients received the transfusion of CSRBC or whole blood stored at -80 ℃ for 180 to 360 days. The changes in the indexes, such as blood TB, DB, K +, Na +, BUN, Cr, urine protein (URPO), UOB, Hb, HCT, serum total protein, relative to hemolytic reaction and blood volume before and after transfusion were observed. The results showed that after transfusion of CSRBC or whole blood 27 cases were negative for urine protein and UOB, and the levels of BUN and Cr were normal (P>0.05). Blood TB, DB, Hb, and HCT were increased, while pH, blood K + and blood Na + was normal with the difference being not significant before and after operation (P>0.05). Plasma protein was decreased, but there was no significant difference before and after operation (P>0.05). It was suggested that CSRBC or whole blood at -80 ℃ could be safely infused to the Rh(D) negative patients without side effects during the surgical operation.

Cardiac surgical operation after renal transplantation

Several studies reported the impact of cardiac surgical operation on morbidity and mortality in renal transplant recipients as well as on renal graft function and safety and effect of immunosuppressant medication.1-3 However,few data are available about the risk and immunosuppressant medication in patients who undergo cardiac surgical operation after successful renal transplantation,especially in patients who underwent offpump coronary artery bypass grafting （CABG） with previous renal transplantation.This research provides important insights into the immunosuppressive management of a patient requiring valve replacement or CABG after renal transplantation during the perioperative period.

Acupuncture Treatment for the 88 Cases of Retention of Urine After Surgical Operation

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Preventing surgical site infection using operating room bundle of care in patients undergoing elective exploratory laparotomy cholecystectomy surgery

Objective:Surgical procedures manifest immense risks to patients.One of the adverse events that healthcare professionals see as a threat to the patient’s health is the development of complications known as surgical site infection(SSI).Although several effor ts are being under taken to determine the proper means to reduce such complications,there is still a high incidence of SSI worldwide.Surgery requires knowledge in infection control and high precision in maintaining a clean surgical site.This study tested the effectiveness of an operating room(OR)bundle of care in preventing SSI in patients undergoing elective exploratory laparotomy cholecystectomy surgery.Methods:A quasi-experimental pretest and posttest design was utilized to determine its effectiveness.The study was composed of 60 par ticipants divided into two groups:30 subjects were selected to receive the OR bundle of care,while the other 30 subjects received the usual care.The groupings were determined through a systematic random sampling technique.The OR bundle of care had three interventions,namely:(1)maintaining perioperative normothermia,(2)no pre-operative surgical site hair removal,and(3)changing gloves before abdominal wall closure.These patients were evaluated using the standard instrument,Bates–Jensen Wound Assessment Tool(BWAT)in the post-intervention phases of the wound healing process,which are as follows:hemostasis,inflammatory,and proliferative phases.To describe the difference in the patients’wound status after implementation of the OR bundle of care in each post-intervention phase,Friedman’s test was used.To describe the difference in the patients’wound status in both groups after implementation of the OR bundle of care,the Mann–Whitney U test was used.Results:The patient’s wound status was lower,indicating a more healing process.Differences between the wound status of the control and the experimental group were observed on the third postoperative day.This indicates that the experimental group’s wound status healed much faster and more effectively than the control group based on the BWAT scoring severity scoring.A significant difference in the patient’s wound status from the hemostasis phase compared with the proliferative phase was observed.Conclusions:The OR bundle of care has been shown to be effective in preventing SSI in patients who had undergone exploratory laparotomy cholecystectomy surgery in the selected hospital,if there is uniform and consistent implementation of the said intervention.

实时跟踪和虚拟成像技术辅助创伤骨科手术机器人治疗股骨颈骨折

目的:探究实时跟踪和虚拟成像技术(real-time tracking and virtual reality technology,RTVI)辅助创伤骨科手术机器人术中配准治疗股骨颈骨折的治疗效果。方法:回顾分析2020年9月至2022年9月应用创伤骨科机器人手术治疗的60例股骨颈骨折患者,根据术中是否使用RTVI技术辅助机器人手术将患者分成两组:RTVI组28例,男12例,女16例;年龄28~60(46.2±9.3)岁。单纯天玑手术机器人组32例,男15例,女17例;年龄32~58(48.2±7.8)岁。观察并记录两组配准透视次数、手术时间、术中透视次数、术中出血量、住院时间。所有患者术后接受定期随访,常规复查髋关节X线片,记录Garden对线指数、骨折愈合时间、术后并发症、Harris评分。结果:60例患者均获得随访,其中RTVI组随访9~16(13.0±1.2)个月,单纯天玑手术机器人组随访10~14(12.0±1.3)个月,两组比较差异无统计学意义(P>0.05)。随访期间两组股骨颈骨折均愈合良好,无内固定松动、切口感染等并发症发生。RTVI组配准透视次数、手术时间、术中透视次数优于单纯天玑手术机器人组(P<0.01)。而两组术中出血量、住院时间、Garden对线指数、骨折愈合时间、髋关节Harris评分比较,差异无统计学意义(P>0.05)。总结:RTVI技术辅助天玑手术机器人治疗股骨颈骨折手术虽然对其术后疗效影响不大,但可以有效减少手术时间,减低术中X线投射次数,降低患者术中辐射暴露风险。同时也缩短了术者的学习曲线,更好体现创伤骨科手术机器人的精准和高效。

慕课在普通外科住院医师规范化培训中的应用效果

目的分析慕课在普通外科住院医师规范化培训中的应用效果。方法选择2021年1月—2022年1月在佳木斯大学院临床医学院轮转的100名普通外科住培医师为研究对象,采用随机数字表法分为对照组(传统临床教学模式)和观察组(慕课结合传统临床教学模式),每组50名。比较2组的评判性思维、理论考核、操作技能、手术技巧、医患沟通能力评分及满意度。结果开课前,2组住培医师的评判性思维评分比较,差异无统计学意义(P>0.05);开课后,观察组住培医师的评判性思维评分高于对照组,差异有统计学意义(P<0.05)。观察组住培医师的理论考核、操作技能、手术技巧、医患沟通能力评分[(91.32±5.23)分、(94.66±3.54)分、(8.96±1.15)分、(9.32±0.23)分]高于对照组[(86.69±4.56)分、(88.67±5.64)分、(7.01±1.12)分、(7.69±1.56)分],差异均有统计学意义(P<0.05)。观察组住培医师的满意度高于对照组,差异有统计学意义(P<0.05)。结论慕课对普通外科住院医师规范化培训的综合应用价值更高,在对住培医师的临床教学中,采用慕课的教学模式能进一步提升外科住院医师的批判性思维、理论知识以及实践技能,同时外科住院医师对培训结果的满意度更高,该临床教学模式的综合价值较高。

术中超声临床应用进展:创新及发展精准外科

术中超声(IOUS)因其便利、可重复性好、成本较低等优势广泛用于外科手术。近年来,随着超声设备不断发展,IOUS对实现精准外科手术越来越重要。本文就IOUS临床应用进展进行述评。

低温等离子治疗儿童鼻咽部第二鳃裂囊肿分析

目的探讨儿童鼻咽部第二鳃裂囊肿的临床特征和治疗方式,提高诊治能力。方法回顾性分析河北省儿童医院收治的4例儿童鼻咽部第二鳃裂囊肿的临床资料,包括年龄、性别、症状、影像学资料和治疗过程。总结分析病变部位特点,B超、CT或MRI特征,术后病理结果及治疗方式。结果4例鼻咽部第二鳃裂囊肿患儿均表现为鼻咽侧壁咽鼓管咽口与腭咽弓后上方连线上的囊性肿物,囊壁较厚,影像学检查结果均为囊性病变。4例患儿选择内镜下低温等离子病变切除术,其中2例为内侧囊壁大部分切除术,将囊腔充分敞开,2例为囊肿全部切除术。术后病理提示衬覆纤毛柱状上皮或复层上皮,周围淋巴组织增生。术后随访1.5~3年无复发。结论儿童鼻咽部第二鳃裂囊肿临床罕见,诊断主要依靠病变部位及术后病理结果,内镜下低温等离子切除病变组织是微创、安全、有效的治疗方式。

多灶性肝母细胞瘤手术切除的单中心研究

目的探讨多灶性肝母细胞瘤(hepatoblastoma,HB)手术切除治疗的可行性及有效性。方法本研究为回顾性研究,以2014年4月至2022年12月首都医科大学附属北京儿童医院肿瘤外科收治的21例多灶性HB患儿为研究对象,收集患儿临床特征、手术方式及远期预后等资料,并与同期收治的58例中高危单灶性HB患儿进行疗效对比。结果21例多灶性HB患儿中,11例为2个瘤灶,4例为3个瘤灶,1例为5个瘤灶,5例肝内瘤灶超过5个且无法明确计数。21例均接受肿瘤切除手术,其中9例行解剖性肝切除术,11例行不规则肝切除或瘤灶剜除术,1例行联合肝脏离断及门静脉结扎的分次肝切除术(associating liver partition and portal vein ligation for staged hepatectomy,ALPPS)。20例为R0切除,1例为R1切除,术后无一例发生严重并发症。本组多灶性HB患儿接受手术联合化疗的多学科综合治疗后,中位随访时间57个月,18例患儿无瘤生存,3例死亡。本组多灶性HB患儿3年无事件生存率(event-free survival,EFS)为57.58%,3年总生存率(overall survival,OS)为82.00%,局部进展累积发生率(cumulative incidence of local progression,CILP)为38.00%。同期收治的单灶性中高危HB患儿上述指标分别为91.84%、74.96%、20.04%。两组数据对比,差异无统计学意义(P>0.05)。结论多灶性HB经规范外科手术切除辅助术前、术后化疗,可以获得较为满意的预后。

急性A型主动脉夹层合并Neri C型冠状动脉受累细化分型的外科治疗策略

目的探讨急性A型主动脉夹层(acute type A aortic dissection,ATAAD)合并Neri C型冠状动脉(冠脉)受累细化分型的外科治疗策略。方法回顾性分析我院2020年11月~2024年2月21例ATAAD合并Neri C型冠脉受累的病例资料。夹层累及冠脉,发病时间<1周,行全主动脉弓替换、降主动脉支架象鼻人工血管置入、升主动脉置换及冠脉处理。细化分型及冠脉处理方法:C1型(冠脉开口局部损伤破裂,与假腔部分连接,冠脉开口内外膜无分离)7例以人工材料“铜钱样”修复;C2型(冠脉开口严重损伤撕脱,与假腔完全连接,冠脉近段累及轻微,内外膜局部分离,未形成套袖)3例以8 mm人工血管置换;C3型(冠脉开口严重损伤撕脱,与假腔完全连接,冠脉近段累及严重,内外膜完全分离,且形成套袖)11例以大隐静脉旁路移植。结果院内死亡2例(均为C3型),均心脏复跳困难,体外膜氧合(extracorporeal membrane oxygenation,ECMO)辅助循环,分别于术后当天、第2天死亡。19例出院患者出院前复查主动脉及冠脉CTA,无冠脉开口狭窄和桥血管狭窄。术后6、12、18个月复查主动脉及冠脉CTA。19例随访6~36个月,平均21个月,无冠脉开口狭窄和桥血管狭窄病例。纽约心脏协会(NYHA)心功能分级Ⅰ级15例,Ⅱ级4例。结论ATAAD合并Neri C型冠脉受累的细化分型对外科实施精准治疗具有指导性意义。

智能化手术安全核查流程的设计与应用

目的构建智能化手术安全核查流程,探讨其应用效果。方法将2023年8-10月的11204例手术设为改进前组,采用常规手术安全核查方式;2023年11月至2024年1月的11012例手术设为改进后组,采用智能化手术安全核查系统,实现手术安全核查执行情况的全流程闭环管理。结果流程改进后,手术安全核查的规范执行率显著高于改进前,护理安全隐患事件发生率显著低于改进前(均P<0.05)。结论智能化手术安全核查的构建与实施,能有效提升手术安全核查的规范率,减少护理安全隐患事件发生率,保障手术患者安全。

细胞减灭术联合腹腔热灌注化疗在局部反复复发肾母细胞瘤治疗中的应用

目的观察细胞减灭术(cytoreductive surgery,CRS)联合腹腔热灌注化疗(hyperthermic intraperitoneal chemotherapy,HIPEC)对反复复发肾母细胞瘤的腹腔局部控制情况。方法本研究为回顾性研究,以2019年1月至2022年1月首都医科大学附属北京儿童医院肿瘤外科及北京儿童医院保定医院肿瘤外科收治的6例反复复发的肾母细胞瘤患儿为研究对象,收集患儿基本信息(性别、年龄、发病部位等)、既往治疗经过、治疗方案以及本中心(北京与保定两个病区)手术、热灌注、术后治疗及随访情况。结果6例反复复发的肾母细胞瘤患儿均为单侧病变,5例行根治性瘤肾切除术,1例行保留肾脏肿瘤剥除术。4例直接接受手术,参考COG分期,其中2例为Ⅲ期,行化疗+放疗;2例为Ⅱ期,予以化疗;另2例术前予以化疗,参考SIOP分期,术后诊断为Ⅱ期,术后仅行化疗。初次复发时间最短为术后1.5个月,最长为术后10个月,其中3例为原位复发,2例为腹盆腔单发种植病灶,1例为肠系膜多发病变。在治疗过程中,6例复发部位均位于腹盆腔,未见远处转移,且均接受了手术切除;5例进行了局部放疗;6例术后均采用了强于初次化疗的个体化治疗方案。6例在本中心治疗过程中均接受了细胞减灭术+术中腹腔热灌注化疗,术中、术后均未见危及生命的严重并发症;随访时间为14(2,32)个月,其中4例长期生存,2例死于肿瘤进展。结论局部反复复发的肾母细胞瘤预后差,在化疗的辅助下,CRS+HIPEC可以最大程度杀灭可能残存的肿瘤细胞,更有利于肿瘤局部控制。