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Multi-layer network embedding on scc-based network with motif
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作者 Lu Sun Xiaona Li +4 位作者 Mingyue Zhang Liangtian Wan Yun Lin Xianpeng Wang Gang Xu 《Digital Communications and Networks》 SCIE CSCD 2024年第3期546-556,共11页
Interconnection of all things challenges the traditional communication methods,and Semantic Communication and Computing(SCC)will become new solutions.It is a challenging task to accurately detect,extract,and represent... Interconnection of all things challenges the traditional communication methods,and Semantic Communication and Computing(SCC)will become new solutions.It is a challenging task to accurately detect,extract,and represent semantic information in the research of SCC-based networks.In previous research,researchers usually use convolution to extract the feature information of a graph and perform the corresponding task of node classification.However,the content of semantic information is quite complex.Although graph convolutional neural networks provide an effective solution for node classification tasks,due to their limitations in representing multiple relational patterns and not recognizing and analyzing higher-order local structures,the extracted feature information is subject to varying degrees of loss.Therefore,this paper extends from a single-layer topology network to a multi-layer heterogeneous topology network.The Bidirectional Encoder Representations from Transformers(BERT)training word vector is introduced to extract the semantic features in the network,and the existing graph neural network is improved by combining the higher-order local feature module of the network model representation network.A multi-layer network embedding algorithm on SCC-based networks with motifs is proposed to complete the task of end-to-end node classification.We verify the effectiveness of the algorithm on a real multi-layer heterogeneous network. 展开更多
关键词 Semantic communication and computing multi-layer network Graph neural network MOTIF
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Target Controllability of Multi-Layer Networks With High-Dimensional Nodes
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作者 Lifu Wang Zhaofei Li +1 位作者 Ge Guo Zhi Kong 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2024年第9期1999-2010,共12页
This paper studies the target controllability of multilayer complex networked systems,in which the nodes are highdimensional linear time invariant(LTI)dynamical systems,and the network topology is directed and weighte... This paper studies the target controllability of multilayer complex networked systems,in which the nodes are highdimensional linear time invariant(LTI)dynamical systems,and the network topology is directed and weighted.The influence of inter-layer couplings on the target controllability of multi-layer networks is discussed.It is found that even if there exists a layer which is not target controllable,the entire multi-layer network can still be target controllable due to the inter-layer couplings.For the multi-layer networks with general structure,a necessary and sufficient condition for target controllability is given by establishing the relationship between uncontrollable subspace and output matrix.By the derived condition,it can be found that the system may be target controllable even if it is not state controllable.On this basis,two corollaries are derived,which clarify the relationship between target controllability,state controllability and output controllability.For the multi-layer networks where the inter-layer couplings are directed chains and directed stars,sufficient conditions for target controllability of networked systems are given,respectively.These conditions are easier to verify than the classic criterion. 展开更多
关键词 High-dimensional nodes inter-layer couplings multi-layer networks target controllability
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Dynamic interwell connectivity analysis of multi-layer waterflooding reservoirs based on an improved graph neural network
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作者 Zhao-Qin Huang Zhao-Xu Wang +4 位作者 Hui-Fang Hu Shi-Ming Zhang Yong-Xing Liang Qi Guo Jun Yao 《Petroleum Science》 SCIE EI CAS CSCD 2024年第2期1062-1080,共19页
The analysis of interwell connectivity plays an important role in the formulation of oilfield development plans and the description of residual oil distribution. In fact, sandstone reservoirs in China's onshore oi... The analysis of interwell connectivity plays an important role in the formulation of oilfield development plans and the description of residual oil distribution. In fact, sandstone reservoirs in China's onshore oilfields generally have the characteristics of thin and many layers, so multi-layer joint production is usually adopted. It remains a challenge to ensure the accuracy of splitting and dynamic connectivity in each layer of the injection-production wells with limited field data. The three-dimensional well pattern of multi-layer reservoir and the relationship between injection-production wells can be equivalent to a directional heterogeneous graph. In this paper, an improved graph neural network is proposed to construct an interacting process mimics the real interwell flow regularity. In detail, this method is used to split injection and production rates by combining permeability, porosity and effective thickness, and to invert the dynamic connectivity in each layer of the injection-production wells by attention mechanism.Based on the material balance and physical information, the overall connectivity from the injection wells,through the water injection layers to the production layers and the output of final production wells is established. Meanwhile, the change of well pattern caused by perforation, plugging and switching of wells at different times is achieved by updated graph structure in spatial and temporal ways. The effectiveness of the method is verified by a combination of reservoir numerical simulation examples and field example. The method corresponds to the actual situation of the reservoir, has wide adaptability and low cost, has good practical value, and provides a reference for adjusting the injection-production relationship of the reservoir and the development of the remaining oil. 展开更多
关键词 Graph neural network Dynamic interwell connectivity Production-injection splitting Attention mechanism multi-layer reservoir
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Target layer state estimation in multi-layer complex dynamical networks considering nonlinear node dynamics
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作者 吴亚勇 王欣伟 蒋国平 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第4期245-252,共8页
In many engineering networks, only a part of target state variables are required to be estimated.On the other hand,multi-layer complex network exists widely in practical situations.In this paper, the state estimation ... In many engineering networks, only a part of target state variables are required to be estimated.On the other hand,multi-layer complex network exists widely in practical situations.In this paper, the state estimation of target state variables in multi-layer complex dynamical networks with nonlinear node dynamics is studied.A suitable functional state observer is constructed with the limited measurement.The parameters of the designed functional observer are obtained from the algebraic method and the stability of the functional observer is proven by the Lyapunov theorem.Some necessary conditions that need to be satisfied for the design of the functional state observer are obtained.Different from previous studies, in the multi-layer complex dynamical network with nonlinear node dynamics, the proposed method can estimate the state of target variables on some layers directly instead of estimating all the individual states.Thus, it can greatly reduce the placement of observers and computational cost.Numerical simulations with the three-layer complex dynamical network composed of three-dimensional nonlinear dynamical nodes are developed to verify the effectiveness of the method. 展开更多
关键词 multi-layer complex dynamical network nonlinear node dynamics target state estimation functional state observer
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Integrated Survivability Strategies of IP/GMPLS/Optical Multi-layer Network 被引量:2
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作者 ZHAO Ji jun 1,2 , JI Yue feng 1, XU Da xiong 1 (1. Opt.Commun.Center,Beijing University of Posts and telecommunications,Beijing 100876,CHN 2. Hebei Institute of Architectural Science and Technology, Handan 056038, CHN) 《Semiconductor Photonics and Technology》 CAS 2003年第3期141-147,共7页
In last decade,due to that the popularity of the internet, data-central traffic kept growing,some emerging networking requirements have been posed on the todays telecommunication networks,especially in the area of net... In last decade,due to that the popularity of the internet, data-central traffic kept growing,some emerging networking requirements have been posed on the todays telecommunication networks,especially in the area of network survivability.Obviously,as a key networking problem,network reliability will be more and more important.The integration of different technologies such as ATM,SDH,and WDM in multilayer transport networks raises many questions regarding the coordination of the individual network layers.This problem is referred as multilayer network survivability.The integrated multilayer network survivability is investingated as well as the representation of an interworking strategy between different single layer survivability schemes in IP via generalized multi-protocol label switching over optical network. 展开更多
关键词 optical network multilayer survivability GMPLS
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Bayesian network-based survival prediction model for patients having undergone post-transjugular intrahepatic portosystemic shunt for portal hypertension
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作者 Rong Chen Ling Luo +3 位作者 Yun-Zhi Zhang Zhen Liu An-Lin Liu Yi-Wen Zhang 《World Journal of Gastroenterology》 SCIE CAS 2024年第13期1859-1870,共12页
BACKGROUND Portal hypertension(PHT),primarily induced by cirrhosis,manifests severe symptoms impacting patient survival.Although transjugular intrahepatic portosystemic shunt(TIPS)is a critical intervention for managi... BACKGROUND Portal hypertension(PHT),primarily induced by cirrhosis,manifests severe symptoms impacting patient survival.Although transjugular intrahepatic portosystemic shunt(TIPS)is a critical intervention for managing PHT,it carries risks like hepatic encephalopathy,thus affecting patient survival prognosis.To our knowledge,existing prognostic models for post-TIPS survival in patients with PHT fail to account for the interplay among and collective impact of various prognostic factors on outcomes.Consequently,the development of an innovative modeling approach is essential to address this limitation.AIM To develop and validate a Bayesian network(BN)-based survival prediction model for patients with cirrhosis-induced PHT having undergone TIPS.METHODS The clinical data of 393 patients with cirrhosis-induced PHT who underwent TIPS surgery at the Second Affiliated Hospital of Chongqing Medical University between January 2015 and May 2022 were retrospectively analyzed.Variables were selected using Cox and least absolute shrinkage and selection operator regression methods,and a BN-based model was established and evaluated to predict survival in patients having undergone TIPS surgery for PHT.RESULTS Variable selection revealed the following as key factors impacting survival:age,ascites,hypertension,indications for TIPS,postoperative portal vein pressure(post-PVP),aspartate aminotransferase,alkaline phosphatase,total bilirubin,prealbumin,the Child-Pugh grade,and the model for end-stage liver disease(MELD)score.Based on the above-mentioned variables,a BN-based 2-year survival prognostic prediction model was constructed,which identified the following factors to be directly linked to the survival time:age,ascites,indications for TIPS,concurrent hypertension,post-PVP,the Child-Pugh grade,and the MELD score.The Bayesian information criterion was 3589.04,and 10-fold cross-validation indicated an average log-likelihood loss of 5.55 with a standard deviation of 0.16.The model’s accuracy,precision,recall,and F1 score were 0.90,0.92,0.97,and 0.95 respectively,with the area under the receiver operating characteristic curve being 0.72.CONCLUSION This study successfully developed a BN-based survival prediction model with good predictive capabilities.It offers valuable insights for treatment strategies and prognostic evaluations in patients having undergone TIPS surgery for PHT. 展开更多
关键词 Bayesian network CIRRHOSIS Portal hypertension Transjugular intrahepatic portosystemic shunt survival prediction model
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Explosive synchronization of multi-layer complex networks based on star connection between layers with delay
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作者 金彦亮 韩钱源 +2 位作者 郭润珠 高塬 沈礼权 《Chinese Physics B》 SCIE EI CAS CSCD 2023年第10期343-349,共7页
Explosive synchronization(ES)is a kind of first-order jump phenomenon that exists in physical and biological systems.In recent years,researchers have focused on ES between single-layer and multi-layer networks.Most re... Explosive synchronization(ES)is a kind of first-order jump phenomenon that exists in physical and biological systems.In recent years,researchers have focused on ES between single-layer and multi-layer networks.Most research on complex networks with delay has focused on single-layer or double-layer networks,multi-layer networks are seldom explored.In this paper,we propose a Kuramoto model of frequency weights in multi-layer complex networks with delay and star connections between layers.Through theoretical analysis and numerical verification,the factors affecting the backward critical coupling strength are analyzed.The results show that the interaction between layers and the average node degree has a direct effect on the backward critical coupling strength of each layer network.The location of the delay,the size of the delay,the number of network layers,the number of nodes,and the network topology are revealed to have no direct impact on the backward critical coupling strength of the network.Delay is introduced to explore the influence of delay and other related parameters on ES. 展开更多
关键词 multi-layer networks Kuramoto model explosive synchronization DELAY
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Survivability evaluation for networks carrying complex traffic flows
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作者 Amin Jamali Mehdi Berenjkoub +1 位作者 Hossein Saidi Behrouz Shahgholi Ghahfarokhi 《Digital Communications and Networks》 SCIE CSCD 2023年第2期534-544,共11页
The capability of a system to fulfill its mission promptly in the presence of attacks,failures,or accidents is one of the qualitative definitions of survivability.In this paper,we propose a model for survivability qua... The capability of a system to fulfill its mission promptly in the presence of attacks,failures,or accidents is one of the qualitative definitions of survivability.In this paper,we propose a model for survivability quantification,which is acceptable for networks carrying complex traffic flows.Complex network traffic is considered as general multi-rate,heterogeneous traffic,where the individual bandwidth demands may aggregate in complex,nonlinear ways.Blocking probability is the chosen measure for survivability analysis.We study an arbitrary topology and some other known topologies for the network.Independent and dependent failure scenarios as well as deterministic and random traffic models are investigated.Finally,we provide survivability evaluation results for different network configurations.The results show that by using about 50%of the link capacity in networks with a relatively high number of links,the blocking probability remains near zero in the case of a limited number of failures. 展开更多
关键词 Blocking probability Complex traffic Link failure network survivability Disaster recovery Information assurance
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Multi-layer Tectonic Model for Intraplate Deformation and Plastic-Flow Network in the Asian Continental Lithosphere 被引量:4
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作者 Wang Shengzu Institute of Geology, State Seismological Bureau, Beijing Liu Linqun 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 1993年第3期247-271,共25页
In a large area of the east—central Asian continent there is a unified seismic network system composed of two families of large—seismic belts that intersect conjugately. Such a seismic network in the middle—upper c... In a large area of the east—central Asian continent there is a unified seismic network system composed of two families of large—seismic belts that intersect conjugately. Such a seismic network in the middle—upper crust is actually a response to the plastic flow network in the lower lithosphere including the lower crust and lithospheric mantle. The existence of the unified plastic flow system confirms that the driving force for intraplate tectonic deformation results mainly from the compression of the India plate, while the long-range transmission of the force is carried out chiefly by means of plastic flow. The plastic flow network has a control over the intraplate tectonic deformation. 展开更多
关键词 Continental lithosphere tectonic deformation multi-layer tectonic model large-scale seismic belt seismic network plastic flow network
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Quantitative Survivability Analysis Using Probability Model Checking: A Study of Cluster-Based Vehicle Networks with Dual Cluster Heads 被引量:3
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作者 Li Jin Guoan Zhang +2 位作者 Jue Wang Hao Zhu Wei Duan 《China Communications》 SCIE CSCD 2020年第2期206-219,共14页
As an important part of future 5G wireless networks,a vehicular network demands safety,reliability and connectivity.In this context,networking survivability is usually considered an important metric to evaluate networ... As an important part of future 5G wireless networks,a vehicular network demands safety,reliability and connectivity.In this context,networking survivability is usually considered an important metric to evaluate network performance.In this paper,we propose a survivability model for vehicle communication networking based on dual cluster heads,wherein a backup cluster head(CH)will be activated if the primary CH fails,thereby effectively enhancing the network lifetime.Additionally,we introduce a software rejuvenation strategy for the prime CH to further improve the survivability of the entire network.Using the Probabilistic Symbolic Model Checker(PRISM),we verify and discuss the proposed survivability model via numerical simulations.The results show that network survivability can be effectively improved by introducing an additional CH and further enhanced by adopting the software rejuvenation technique. 展开更多
关键词 cluster head 5G software recovery survivability vehicle networks
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Laplacian energy maximizationfor multi-layer air transportation networks 被引量:2
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作者 Zheng Yue Li Wenquan +1 位作者 Qiu Feng Cao Xi 《Journal of Southeast University(English Edition)》 EI CAS 2017年第3期341-347,共7页
To increase airspace capacity, alleviate flight delay,and improve network robustness, an optimization method of multi-layer air transportation networks is put forward based on Laplacian energy maximization. The effect... To increase airspace capacity, alleviate flight delay,and improve network robustness, an optimization method of multi-layer air transportation networks is put forward based on Laplacian energy maximization. The effectiveness of taking Laplacian energy as a measure of network robustness is validated through numerical experiments. The flight routes addition optimization model is proposed with the principle of maximizing Laplacian energy. Three methods including the depth-first search( DFS) algorithm, greedy algorithm and Monte-Carlo tree search( MCTS) algorithm are applied to solve the proposed problem. The trade-off between system performance and computational efficiency is compared through simulation experiments. Finally, a case study on Chinese airport network( CAN) is conducted using the proposed model. Through encapsulating it into multi-layer infrastructure via k-core decomposition algorithm, Laplacian energy maximization for the sub-networks is discussed which can provide a useful tool for the decision-makers to optimize the robustness of the air transportation network on different scales. 展开更多
关键词 air TRANSPORTATION network LAPLACIAN ENERGY ROBUSTNESS multi-layer networkS
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A Novel Situation Assessment Method for Network Survivability 被引量:2
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作者 WANG Jian WANG Huiqiang ZHAO Guosheng 《Wuhan University Journal of Natural Sciences》 CAS 2006年第6期1785-1788,共4页
Survivability has emerged as a new phase for the development of network security technique, and quantifying survivability for network system helps to evaluate it exactly for the system in different environments. In th... Survivability has emerged as a new phase for the development of network security technique, and quantifying survivability for network system helps to evaluate it exactly for the system in different environments. In this paper, we adopt a stochastic method called sequential Monte Carlo and try to reflect dynamic evolvement process of network survivability situation from several time sequences. The experiment results show that this method has the features of quantitative description, real-time calculation and dynamic tracking, and it is a good situation assessment solution for network survivability. 展开更多
关键词 network survivability situation assessment sequential Monte Carlo
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Distributed Contact Plan Design for Multi-Layer Satellite-Terrestrial Network 被引量:3
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作者 Wenfeng Shi Deyun Gao +4 位作者 Huachun Zhou Bohao Feng Haifeng Li Guanwen Li Wei Quan 《China Communications》 SCIE CSCD 2018年第1期23-34,共12页
In multi-layer satellite-terrestrial network, Contact Graph Routing(CGR) uses the contact information among satellites to compute routes. However, due to the resource constraints in satellites, it is extravagant to co... In multi-layer satellite-terrestrial network, Contact Graph Routing(CGR) uses the contact information among satellites to compute routes. However, due to the resource constraints in satellites, it is extravagant to configure lots of the potential contacts into contact plans. What's more, a huge contact plan makes the computing more complex, which further increases computing time. As a result, how to design an efficient contact plan becomes crucial for multi-layer satellite network, which usually has a large scaled topology. In this paper, we propose a distributed contact plan design scheme for multi-layer satellite network by dividing a large contact plan into several partial parts. Meanwhile, a duration based inter-layer contact selection algorithm is proposed to handle contacts disruption problem. The performance of the proposed design was evaluated on our Identifier/Locator split based satellite-terrestrial network testbed with 79 simulation nodes. Experiments showed that the proposed design is able to reduce the data delivery delay. 展开更多
关键词 CONTACT GRAPH ROUTING distributedcontact PLAN multi-layered SATELLITE network inter-layer CONTACT selection
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Survivability modeling and analysis on 3D mobile ad-hoc networks 被引量:2
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作者 彭三城 王国军 +1 位作者 胡忠望 陈建平 《Journal of Central South University》 SCIE EI CAS 2011年第4期1144-1152,共9页
Most existing work on survivability in mobile ad-hoc networks(MANETs) focuses on two dimensional(2D) networks.However,many real applications run in three dimensional(3D) networks,e.g.,climate and ocean monitoring,and ... Most existing work on survivability in mobile ad-hoc networks(MANETs) focuses on two dimensional(2D) networks.However,many real applications run in three dimensional(3D) networks,e.g.,climate and ocean monitoring,and air defense systems.The impact on network survivability due to node behaviors was presented,and a quantitative analysis method on survivability was developed in 3D MANETs by modeling node behaviors and analyzing 3D network connectivity.Node behaviors were modeled by using a semi-Markov process.The node minimum degree of 3D MANETs was discussed.An effective approach to derive the survivability of k-connected networks was proposed through analyzing the connectivity of 3D MANETs caused by node misbehaviors,based on the model of node isolation.The quantitative analysis of node misbehaviors on the survivability in 3D MANETs is obtained through mathematical description,and the effectiveness and rationality of the proposed approach are verified through numerical analysis.The analytical results show that the effect from black and gray attack on network survivability is much severer than other misbehaviors. 展开更多
关键词 mobile ad-hoc networks (MANETs) survivability node behaviors semi-Markov process network connectivity
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Software-Defined Space-Air-Ground Integrated Network Architecture with the Multi-Layer Satellite Backbone Network 被引量:1
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作者 Chao Guo Cheng Gong +3 位作者 Juan Guo Zhanzhen Wei Yanyan Han Sher Zaman Khan 《Computers, Materials & Continua》 SCIE EI 2020年第7期527-540,共14页
Under the background of the rapid development of ground mobile communication,the advantages of high coverage,survivability,and flexibility of satellite communication provide air support to the construction of space in... Under the background of the rapid development of ground mobile communication,the advantages of high coverage,survivability,and flexibility of satellite communication provide air support to the construction of space information network.According to the requirements of the future space information communication,a software-defined Space-Air-Ground Integrated network architecture was proposed.It consisted of layered structure satellite backbone network,deep space communication network,the stratosphere communication network and the ground network.The Space-Air-Ground Integrated network was supported by the satellite backbone network.It provided data relay for the missions such as deep space exploration and controlled the deep-space spacecraft when needed.In addition,it safeguarded the anti-destructibility of stratospheric communication and assisted the stratosphere to supplement ground network communication.In this paper,algorithm requirements of the congestion control and routing of satellite backbone protocols for heterogeneous users’services were proposed.The algorithm requirements of distinguishing different service objects for the deep space communication and stratospheric communication network protocols were described.Considering the realistic demand for the dynamic coverage of the satellite backbone network and node cost,the multi-layer satellite backbone network architecture was constructed.On this basis,the proposed Software-defined Space-Air-Ground Integrated network architecture could be built as a large,scalable and efficient communication network that could be integrated into space,air,and ground. 展开更多
关键词 Space-Air-Ground integrated network network architecture software-defined network multi-layer satellite backbone network
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Efficient Training of Multi-Layer Neural Networks to Achieve Faster Validation 被引量:1
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作者 Adel Saad Assiri 《Computer Systems Science & Engineering》 SCIE EI 2021年第3期435-450,共16页
Artificial neural networks(ANNs)are one of the hottest topics in computer science and artificial intelligence due to their potential and advantages in analyzing real-world problems in various disciplines,including but... Artificial neural networks(ANNs)are one of the hottest topics in computer science and artificial intelligence due to their potential and advantages in analyzing real-world problems in various disciplines,including but not limited to physics,biology,chemistry,and engineering.However,ANNs lack several key characteristics of biological neural networks,such as sparsity,scale-freeness,and small-worldness.The concept of sparse and scale-free neural networks has been introduced to fill this gap.Network sparsity is implemented by removing weak weights between neurons during the learning process and replacing them with random weights.When the network is initialized,the neural network is fully connected,which means the number of weights is four times the number of neurons.In this study,considering that a biological neural network has some degree of initial sparsity,we design an ANN with a prescribed level of initial sparsity.The neural network is tested on handwritten digits,Arabic characters,CIFAR-10,and Reuters newswire topics.Simulations show that it is possible to reduce the number of weights by up to 50%without losing prediction accuracy.Moreover,in both cases,the testing time is dramatically reduced compared with fully connected ANNs. 展开更多
关键词 SPARSITY weak weights multi-layer neural network NN training with initial sparsity
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Recommendation System Based on Perceptron and Graph Convolution Network
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作者 Zuozheng Lian Yongchao Yin Haizhen Wang 《Computers, Materials & Continua》 SCIE EI 2024年第6期3939-3954,共16页
The relationship between users and items,which cannot be recovered by traditional techniques,can be extracted by the recommendation algorithm based on the graph convolution network.The current simple linear combinatio... The relationship between users and items,which cannot be recovered by traditional techniques,can be extracted by the recommendation algorithm based on the graph convolution network.The current simple linear combination of these algorithms may not be sufficient to extract the complex structure of user interaction data.This paper presents a new approach to address such issues,utilizing the graph convolution network to extract association relations.The proposed approach mainly includes three modules:Embedding layer,forward propagation layer,and score prediction layer.The embedding layer models users and items according to their interaction information and generates initial feature vectors as input for the forward propagation layer.The forward propagation layer designs two parallel graph convolution networks with self-connections,which extract higher-order association relevance from users and items separately by multi-layer graph convolution.Furthermore,the forward propagation layer integrates the attention factor to assign different weights among the hop neighbors of the graph convolution network fusion,capturing more comprehensive association relevance between users and items as input for the score prediction layer.The score prediction layer introduces MLP(multi-layer perceptron)to conduct non-linear feature interaction between users and items,respectively.Finally,the prediction score of users to items is obtained.The recall rate and normalized discounted cumulative gain were used as evaluation indexes.The proposed approach effectively integrates higher-order information in user entries,and experimental analysis demonstrates its superiority over the existing algorithms. 展开更多
关键词 Recommendation system graph convolution network attention mechanism multi-layer perceptron
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Impact of asymptomatic infected individuals on epidemic transmission dynamics in multiplex networks with partial coupling
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作者 Xin Hu Jiaxing Chen Chengyi Xia 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第10期80-87,共8页
The theory of network science has attracted great interest of many researchers in the realm of biomathematics and public health,and numerous valuable epidemic models have been developed.In previous studies,it is commo... The theory of network science has attracted great interest of many researchers in the realm of biomathematics and public health,and numerous valuable epidemic models have been developed.In previous studies,it is common to set up a one-to-one correspondence between the nodes of a multi-layer network,ignoring the more complex situations in reality.In the present work,we explore this situation by setting up a partially coupled model of a two-layer network and investigating the impact of asymptomatic infected individuals on epidemics.We propose a self-discovery mechanism for asymptomatic infected individuals,taking into account situations such as nucleic acid testing in the community and individuals performing self-antigen testing during the epidemic.Considering these factors together,through the microscopic Markov chain approach(MMCA)and extensive Monte Carlo(MC)numerical simulations,we find that the greater the coupling between the networks,the more information dissemination is facilitated.In order to control the epidemics,more asymptomatic infected individuals should be made aware of their infection.Massive adoption of nucleic acid testing and individual adoption of antigenic self-testing can help to contain epidemic outbreaks.Meanwhile,the epidemic threshold of the proposed model is derived,and then miscellaneous factors affecting the epidemic threshold are also discussed.Current results are conducive to devising the prevention and control policies of pandemics. 展开更多
关键词 asymptomatic infected individuals multi-layer networks partial interdependence
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Curcumin for gastric cancer:Mechanism prediction via network pharmacology,docking,and in vitro experiments
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作者 Peng-Hui Yang Ya-Nan Wei +5 位作者 Bi-Juan Xiao Si-Yi Li Xin-Long Li Liang-Jun Yang Hua-Feng Pan Geng-Xin Chen 《World Journal of Gastrointestinal Oncology》 SCIE 2024年第8期3635-3650,共16页
BACKGROUND Curcumin originates from the natural herb turmeric,and its antitumor effects have been known about for a long time.However,the mechanism by which curcumin affects gastric cancer(GC)has not been elucidated.A... BACKGROUND Curcumin originates from the natural herb turmeric,and its antitumor effects have been known about for a long time.However,the mechanism by which curcumin affects gastric cancer(GC)has not been elucidated.AIM To elucidate the potential mechanisms of curcumin in the treatment of GC.METHODS Network pharmacological approaches were used to perform network analysis of Curcumin.We first analyzed Lipinski’s Rule of Five for the use of Curcumin.Curcumin latent targets were predicted using the PharmMapper,SwissTargetPrediction and DrugBank network databases.GC disease targets were mined through the GeneCard,OMIM,DrugBank and TTD network databases.Then,GO enrichment,KEGG enrichment,protein-protein interaction(PPI),and overall survival analyses were performed.The results were further verified through molecular docking,differential expression analysis and cell experiments.RESULTS We identified a total of 48 curcumin-related genes with 31 overlapping GC-related targets.The intersection targets between curcumin and GC have been enriched in 81 GO biological processes and 22 significant pathways.Following PPI analysis,6 hub targets were identified,namely,estrogen receptor 1(ESR1),epidermal growth factor receptor(EGFR),cytochrome P450 family 3 subfamily A member 4(CYP3A4),mitogen-activated protein kinase 14(MAPK-14),cytochrome P450 family 1 subfamily A member 2(CYP1A2),and cytochrome p450 family 2 subfamily B member 6(CYP2B6).These factors are correlated with decreased survival rates among patients diagnosed with GC.Molecular docking analysis further substantiated the strong binding interactions between Curcumin and the hub target genes.The experimental findings demonstrated that curcumin not only effectively inhibits the growth of BGC-823 cells but also suppresses their proliferation.mRNA levels of hub targets CYP3A4,MAPK14,CYP1A2,and CYP2B6 in BGC-823 cells were significantly increased in each dose group.CONCLUSION Curcumin can play an anti-GC role through a variety of targets,pathways and biological processes. 展开更多
关键词 CURCUMIN Gastric cancer network pharmacology Molecular docking survival analysis
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Global forward-predicting dynamic routing for traffic concurrency space stereo multi-layer scale-free network
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作者 解维浩 周斌 +2 位作者 刘恩晓 卢为党 周婷 《Chinese Physics B》 SCIE EI CAS CSCD 2015年第9期603-610,共8页
Many real communication networks, such as oceanic monitoring network and land environment observation network,can be described as space stereo multi-layer structure, and the traffic in these networks is concurrent. Un... Many real communication networks, such as oceanic monitoring network and land environment observation network,can be described as space stereo multi-layer structure, and the traffic in these networks is concurrent. Understanding how traffic dynamics depend on these real communication networks and finding an effective routing strategy that can fit the circumstance of traffic concurrency and enhance the network performance are necessary. In this light, we propose a traffic model for space stereo multi-layer complex network and introduce two kinds of global forward-predicting dynamic routing strategies, global forward-predicting hybrid minimum queue(HMQ) routing strategy and global forward-predicting hybrid minimum degree and queue(HMDQ) routing strategy, for traffic concurrency space stereo multi-layer scale-free networks. By applying forward-predicting strategy, the proposed routing strategies achieve better performances in traffic concurrency space stereo multi-layer scale-free networks. Compared with the efficient routing strategy and global dynamic routing strategy, HMDQ and HMQ routing strategies can optimize the traffic distribution, alleviate the number of congested packets effectively and reach much higher network capacity. 展开更多
关键词 multi-layer complex network SCALE-FREE routing strategy network capacity
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