We retrospectively assessed long-term pulmonary function in adults surviving for ≥5 years after myeloablative allogeneic hematopoietic stem cell transplantation and identified risk factors for late-onset noninfectiou...We retrospectively assessed long-term pulmonary function in adults surviving for ≥5 years after myeloablative allogeneic hematopoietic stem cell transplantation and identified risk factors for late-onset noninfectious pulmonary complications. Among 174 patients undergoing transplantation for hematologic malignancies between May 1994 and December 2004, 81 long-term survivors were evaluated. Pulmonary function tests (PFTs) were performed before conditioning, 3 months and 1 year after transplantation, and then annually. Eight patients (10%) had abnormal pulmonary function before transplantation, but this was not associated with late changes in PFTs. Patients with chronic graft-versus-host disease (GVHD) showed a significant decline of lung function after 3 years when compared with patients without chronic GVHD. Abnormal pretransplantation lung function was associated with pulmonary chronic GVHD according to National Institutes of Health criteria (score 0, n = 58;score 1, n = 14;score 2, n = 6;score 3, n = 3). Five patients with late-onset noninfectious pulmonary complications showed a decline of lung function at 1 year after transplantation. Only chronic GVHD was significantly related to late-onset noninfectious pulmonary complications. In conclusion, abnormal lung function before transplantation may be associated with a decline in pulmonary function within 1 year after transplantation, but late-onset noninfectious pulmonary complications could not be predicted from pretransplantation lung function.展开更多
目的:系统评价院内及院外功能锻炼对重症监护室(ICU)后综合征病人的影响。方法:计算机检索the Cochrane Library、PubMed、Web of Science、EMbase、中国生物医学文献数据库、中国知网和万方数据库中有关院内及院外功能锻炼对ICU后综合...目的:系统评价院内及院外功能锻炼对重症监护室(ICU)后综合征病人的影响。方法:计算机检索the Cochrane Library、PubMed、Web of Science、EMbase、中国生物医学文献数据库、中国知网和万方数据库中有关院内及院外功能锻炼对ICU后综合征影响的随机对照试验,并辅以人工检索,采用RevMan 5.3软件进行Meta分析。结果:最终纳入14篇文献。Meta分析结果显示,院内及院外功能锻炼能有效改善病人出院后2~3个月和6个月时的生理机能,改善6个月时的精神健康和焦虑情绪,以及3个月时的认知功能,差异有统计学意义(P<0.05),但对抑郁情绪的疗效两组差异并不显著(P>0.05)。结论:现有证据表明,院内及院外功能锻炼能有效改善ICU病人的远期生理机能、精神健康和焦虑情绪,以及提高认知功能,但对于改善抑郁情绪及长期效果仍需开展更多研究予以验证。展开更多
Abstract In this paper we consider the risk process that is described by a piecewise deterministic Markov processes (PDMP). We first present the construction of the risk process and then discuss some ruin problems for...Abstract In this paper we consider the risk process that is described by a piecewise deterministic Markov processes (PDMP). We first present the construction of the risk process and then discuss some ruin problems for this new kind of risk model.展开更多
In this paper we consider the risk process described by a piecewise deterministic Markov processes (PDMP). We mainly discuss the distribution of the deficit at ruin for the risk process. We derive the integrodi differ...In this paper we consider the risk process described by a piecewise deterministic Markov processes (PDMP). We mainly discuss the distribution of the deficit at ruin for the risk process. We derive the integrodi differential equation satisfied by this distribution. We obtain the explicit expressions for it for certain choices of the claim amount distribution.展开更多
文摘We retrospectively assessed long-term pulmonary function in adults surviving for ≥5 years after myeloablative allogeneic hematopoietic stem cell transplantation and identified risk factors for late-onset noninfectious pulmonary complications. Among 174 patients undergoing transplantation for hematologic malignancies between May 1994 and December 2004, 81 long-term survivors were evaluated. Pulmonary function tests (PFTs) were performed before conditioning, 3 months and 1 year after transplantation, and then annually. Eight patients (10%) had abnormal pulmonary function before transplantation, but this was not associated with late changes in PFTs. Patients with chronic graft-versus-host disease (GVHD) showed a significant decline of lung function after 3 years when compared with patients without chronic GVHD. Abnormal pretransplantation lung function was associated with pulmonary chronic GVHD according to National Institutes of Health criteria (score 0, n = 58;score 1, n = 14;score 2, n = 6;score 3, n = 3). Five patients with late-onset noninfectious pulmonary complications showed a decline of lung function at 1 year after transplantation. Only chronic GVHD was significantly related to late-onset noninfectious pulmonary complications. In conclusion, abnormal lung function before transplantation may be associated with a decline in pulmonary function within 1 year after transplantation, but late-onset noninfectious pulmonary complications could not be predicted from pretransplantation lung function.
基金Supported by the National Natural Sciences Foundation of China (No.19971047)Doctoral Foundation of Suzhou University.
文摘Abstract In this paper we consider the risk process that is described by a piecewise deterministic Markov processes (PDMP). We first present the construction of the risk process and then discuss some ruin problems for this new kind of risk model.
基金the National Natural Science Foundation of China (Grant No. 10271087)National Science Foundation of Jiangsu education Ministry (Grant No. 02KJB110002).the National Natural Science Foundation of China (Grant No. 10271062)the Research Fund for th
文摘In this paper we consider the risk process described by a piecewise deterministic Markov processes (PDMP). We mainly discuss the distribution of the deficit at ruin for the risk process. We derive the integrodi differential equation satisfied by this distribution. We obtain the explicit expressions for it for certain choices of the claim amount distribution.
